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Q07916 (PO6F1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 6, transcription factor 1
Alternative name(s):
Octamer-binding transcription factor EMB
Transcription regulatory protein MCP-1
Gene names
Name:Pou6f1
Synonyms:Emb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3') By similarity.

Subcellular location

Nucleus.

Tissue specificity

Isoform C1 and isoform C2 are found in the brain, while isoform C7 is found in the testis.

Developmental stage

Expressed in the embryo throughout post-implantation stages with the most prominent expression in the developing CNS. In the adult, it is highly expressed in brain whereas weaker expression can be detected in other organs.

Sequence similarities

Belongs to the POU transcription factor family. Class-6 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform C2 (identifier: Q07916-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform C1 (identifier: Q07916-2)

The sequence of this isoform differs from the canonical sequence as follows:
     131-131: K → SLE
Isoform C7 (identifier: Q07916-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: MPGISSQILT...TPTVSQLVSK → MCQHTLIFMHVSLVPPSGLE

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301POU domain, class 6, transcription factor 1
PRO_0000100760

Regions

Domain139 – 21375POU-specific
DNA binding234 – 29360Homeobox
Compositional bias1 – 139139Gln/Pro-rich

Natural variations

Alternative sequence1 – 131131MPGIS…QLVSK → MCQHTLIFMHVSLVPPSGLE in isoform C7.
VSP_002335
Alternative sequence1311K → SLE in isoform C1.
VSP_002334

Sequences

Sequence LengthMass (Da)Tools
Isoform C2 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 9FC71EE845982AD4

FASTA30132,852
        10         20         30         40         50         60 
MPGISSQILT NAQGQVIGAL PWVVNSASVA TPAPAQSLQV QAVTPQLLLN AQGQVIATLA 

        70         80         90        100        110        120 
SSPLPQPVAV RKPNTPESPA KSEVQPIQPT QAVPQPAVIL TSPTPALKPS AATPIPITCS 

       130        140        150        160        170        180 
ETPTVSQLVS KPHTPSLDED GINLEEIREF AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY 

       190        200        210        220        230        240 
SQSAICRFEK LDITPKSAQK LKPVLEKWLM EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS 

       250        260        270        280        290        300 
FTPQAIEALN AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI 


P 

« Hide

Isoform C1 [UniParc].

Checksum: 847408491C9C9CAD
Show »

FASTA30333,053
Isoform C7 [UniParc].

Checksum: 0F170B4F62CF99F4
Show »

FASTA19021,772

References

« Hide 'large scale' references
[1]"A novel class of murine POU gene predominantly expressed in central nervous system."
Okamoto K., Wakamiya M., Noji S., Koyama E., Taniguchi S., Takemura R., Copeland N.G., Gilbert D.J., Jenkins N.A., Muramatsu M., Hamada H.
J. Biol. Chem. 268:7449-7457(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain and Testis.
[2]"NMDA receptor activation in differentiating cerebellar cell cultures regulates the expression of a new POU gene, Cns-1."
Bulleit R.F., Cui H., Wang J., Lin X.
J. Neurosci. 14:1584-1595(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
Tissue: Brain.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C7).
Strain: C57BL/6J.
Tissue: Testis.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C2).
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D13801 mRNA. Translation: BAA02959.1.
L13763 mRNA. Translation: AAA53044.1.
AK006732 mRNA. Translation: BAB24718.1.
BC059830 mRNA. Translation: AAH59830.1.
PIRB46078.
I56543.
RefSeqNP_034257.1. NM_010127.3.
UniGeneMm.28825.

3D structure databases

ProteinModelPortalQ07916.
SMRQ07916. Positions 143-291.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202314. 4 interactions.

PTM databases

PhosphoSiteQ07916.

Proteomic databases

PaxDbQ07916.
PRIDEQ07916.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000184908; ENSMUSP00000139023; ENSMUSG00000098598. [Q07916-1]
GeneID19009.
KEGGmmu:19009.
UCSCuc007xro.1. mouse. [Q07916-3]
uc007xrp.1. mouse. [Q07916-1]

Organism-specific databases

CTD5463.
MGIMGI:102935. Pou6f1.

Phylogenomic databases

eggNOGNOG241882.
GeneTreeENSGT00750000117373.
HOGENOMHOG000115597.
HOVERGENHBG008230.
InParanoidQ07916.
KOK09368.
PhylomeDBQ07916.

Gene expression databases

ArrayExpressQ07916.
BgeeQ07916.
CleanExMM_EMB.
MM_POU6F1.
GenevestigatorQ07916.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPOU6F1. mouse.
NextBio295414.
PROQ07916.
SOURCESearch...

Entry information

Entry namePO6F1_MOUSE
AccessionPrimary (citable) accession number: Q07916
Secondary accession number(s): Q91XK3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot