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Protein

POU domain, class 6, transcription factor 1

Gene

Pou6f1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi234 – 293HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 6, transcription factor 1
Alternative name(s):
Octamer-binding transcription factor EMB
Transcription regulatory protein MCP-1
Gene namesi
Name:Pou6f1
Synonyms:Emb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:102935 Pou6f1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007601 – 301POU domain, class 6, transcription factor 1Add BLAST301

Proteomic databases

PaxDbiQ07916
PRIDEiQ07916

PTM databases

PhosphoSitePlusiQ07916

Expressioni

Tissue specificityi

Isoform C1 and isoform C2 are found in the brain, while isoform C7 is found in the testis.

Developmental stagei

Expressed in the embryo throughout post-implantation stages with the most prominent expression in the developing CNS. In the adult, it is highly expressed in brain whereas weaker expression can be detected in other organs.

Gene expression databases

BgeeiENSMUSG00000009739
CleanExiMM_EMB
MM_POU6F1
ExpressionAtlasiQ07916 baseline and differential
GenevisibleiQ07916 MM

Interactioni

Protein-protein interaction databases

BioGridi202314, 4 interactors
STRINGi10090.ENSMUSP00000134760

Structurei

3D structure databases

ProteinModelPortaliQ07916
SMRiQ07916
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 213POU-specificPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 139Gln/Pro-richAdd BLAST139

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
GeneTreeiENSGT00760000118935
HOGENOMiHOG000115597
HOVERGENiHBG008230
InParanoidiQ07916
OrthoDBiEOG091G04YJ
PhylomeDBiQ07916

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform C2 (identifier: Q07916-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGISSQILT NAQGQVIGAL PWVVNSASVA TPAPAQSLQV QAVTPQLLLN
60 70 80 90 100
AQGQVIATLA SSPLPQPVAV RKPNTPESPA KSEVQPIQPT QAVPQPAVIL
110 120 130 140 150
TSPTPALKPS AATPIPITCS ETPTVSQLVS KPHTPSLDED GINLEEIREF
160 170 180 190 200
AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY SQSAICRFEK LDITPKSAQK
210 220 230 240 250
LKPVLEKWLM EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS FTPQAIEALN
260 270 280 290 300
AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI

P
Length:301
Mass (Da):32,852
Last modified:November 1, 1996 - v1
Checksum:i9FC71EE845982AD4
GO
Isoform C1 (identifier: Q07916-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-131: K → SLE

Show »
Length:303
Mass (Da):33,053
Checksum:i847408491C9C9CAD
GO
Isoform C7 (identifier: Q07916-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: MPGISSQILT...TPTVSQLVSK → MCQHTLIFMHVSLVPPSGLE

Show »
Length:190
Mass (Da):21,772
Checksum:i0F170B4F62CF99F4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0023351 – 131MPGIS…QLVSK → MCQHTLIFMHVSLVPPSGLE in isoform C7. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_002334131K → SLE in isoform C1. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13801 mRNA Translation: BAA02959.1
L13763 mRNA Translation: AAA53044.1
AK006732 mRNA Translation: BAB24718.1
BC059830 mRNA Translation: AAH59830.1
PIRiB46078
I56543
RefSeqiNP_034257.1, NM_010127.3 [Q07916-1]
XP_011243814.1, XM_011245512.2 [Q07916-1]
XP_011243815.1, XM_011245513.2 [Q07916-1]
UniGeneiMm.28825

Genome annotation databases

EnsembliENSMUST00000176271; ENSMUSP00000145707; ENSMUSG00000009739 [Q07916-1]
GeneIDi19009
UCSCiuc007xro.1 mouse [Q07916-3]
uc007xrp.1 mouse [Q07916-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPO6F1_MOUSE
AccessioniPrimary (citable) accession number: Q07916
Secondary accession number(s): Q91XK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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