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Q07916

- PO6F1_MOUSE

UniProt

Q07916 - PO6F1_MOUSE

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Protein

POU domain, class 6, transcription factor 1

Gene

Pou6f1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi234 – 29360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 6, transcription factor 1
Alternative name(s):
Octamer-binding transcription factor EMB
Transcription regulatory protein MCP-1
Gene namesi
Name:Pou6f1
Synonyms:Emb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:102935. Pou6f1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301POU domain, class 6, transcription factor 1PRO_0000100760Add
BLAST

Proteomic databases

PaxDbiQ07916.
PRIDEiQ07916.

PTM databases

PhosphoSiteiQ07916.

Expressioni

Tissue specificityi

Isoform C1 and isoform C2 are found in the brain, while isoform C7 is found in the testis.

Developmental stagei

Expressed in the embryo throughout post-implantation stages with the most prominent expression in the developing CNS. In the adult, it is highly expressed in brain whereas weaker expression can be detected in other organs.

Gene expression databases

BgeeiQ07916.
CleanExiMM_EMB.
MM_POU6F1.
GenevestigatoriQ07916.

Interactioni

Protein-protein interaction databases

BioGridi202314. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ07916.
SMRiQ07916. Positions 143-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini139 – 21375POU-specificPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 139139Gln/Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG241882.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000115597.
HOVERGENiHBG008230.
InParanoidiQ07916.
KOiK09368.
PhylomeDBiQ07916.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform C2 (identifier: Q07916-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGISSQILT NAQGQVIGAL PWVVNSASVA TPAPAQSLQV QAVTPQLLLN
60 70 80 90 100
AQGQVIATLA SSPLPQPVAV RKPNTPESPA KSEVQPIQPT QAVPQPAVIL
110 120 130 140 150
TSPTPALKPS AATPIPITCS ETPTVSQLVS KPHTPSLDED GINLEEIREF
160 170 180 190 200
AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY SQSAICRFEK LDITPKSAQK
210 220 230 240 250
LKPVLEKWLM EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS FTPQAIEALN
260 270 280 290 300
AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI

P
Length:301
Mass (Da):32,852
Last modified:November 1, 1996 - v1
Checksum:i9FC71EE845982AD4
GO
Isoform C1 (identifier: Q07916-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-131: K → SLE

Show »
Length:303
Mass (Da):33,053
Checksum:i847408491C9C9CAD
GO
Isoform C7 (identifier: Q07916-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: MPGISSQILT...TPTVSQLVSK → MCQHTLIFMHVSLVPPSGLE

Show »
Length:190
Mass (Da):21,772
Checksum:i0F170B4F62CF99F4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 131131MPGIS…QLVSK → MCQHTLIFMHVSLVPPSGLE in isoform C7. 1 PublicationVSP_002335Add
BLAST
Alternative sequencei131 – 1311K → SLE in isoform C1. CuratedVSP_002334

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13801 mRNA. Translation: BAA02959.1.
L13763 mRNA. Translation: AAA53044.1.
AK006732 mRNA. Translation: BAB24718.1.
BC059830 mRNA. Translation: AAH59830.1.
CCDSiCCDS57009.1. [Q07916-1]
PIRiB46078.
I56543.
RefSeqiNP_034257.1. NM_010127.3. [Q07916-1]
UniGeneiMm.28825.

Genome annotation databases

EnsembliENSMUST00000184908; ENSMUSP00000139023; ENSMUSG00000098598. [Q07916-1]
GeneIDi19009.
KEGGimmu:19009.
UCSCiuc007xro.1. mouse. [Q07916-3]
uc007xrp.1. mouse. [Q07916-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13801 mRNA. Translation: BAA02959.1 .
L13763 mRNA. Translation: AAA53044.1 .
AK006732 mRNA. Translation: BAB24718.1 .
BC059830 mRNA. Translation: AAH59830.1 .
CCDSi CCDS57009.1. [Q07916-1 ]
PIRi B46078.
I56543.
RefSeqi NP_034257.1. NM_010127.3. [Q07916-1 ]
UniGenei Mm.28825.

3D structure databases

ProteinModelPortali Q07916.
SMRi Q07916. Positions 143-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202314. 4 interactions.

PTM databases

PhosphoSitei Q07916.

Proteomic databases

PaxDbi Q07916.
PRIDEi Q07916.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000184908 ; ENSMUSP00000139023 ; ENSMUSG00000098598 . [Q07916-1 ]
GeneIDi 19009.
KEGGi mmu:19009.
UCSCi uc007xro.1. mouse. [Q07916-3 ]
uc007xrp.1. mouse. [Q07916-1 ]

Organism-specific databases

CTDi 5463.
MGIi MGI:102935. Pou6f1.

Phylogenomic databases

eggNOGi NOG241882.
GeneTreei ENSGT00760000118935.
HOGENOMi HOG000115597.
HOVERGENi HBG008230.
InParanoidi Q07916.
KOi K09368.
PhylomeDBi Q07916.

Miscellaneous databases

ChiTaRSi Pou6f1. mouse.
NextBioi 295414.
PROi Q07916.
SOURCEi Search...

Gene expression databases

Bgeei Q07916.
CleanExi MM_EMB.
MM_POU6F1.
Genevestigatori Q07916.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel class of murine POU gene predominantly expressed in central nervous system."
    Okamoto K., Wakamiya M., Noji S., Koyama E., Taniguchi S., Takemura R., Copeland N.G., Gilbert D.J., Jenkins N.A., Muramatsu M., Hamada H.
    J. Biol. Chem. 268:7449-7457(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain and Testis.
  2. "NMDA receptor activation in differentiating cerebellar cell cultures regulates the expression of a new POU gene, Cns-1."
    Bulleit R.F., Cui H., Wang J., Lin X.
    J. Neurosci. 14:1584-1595(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C7).
    Strain: C57BL/6J.
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C2).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiPO6F1_MOUSE
AccessioniPrimary (citable) accession number: Q07916
Secondary accession number(s): Q91XK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3