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Q07916

- PO6F1_MOUSE

UniProt

Q07916 - PO6F1_MOUSE

Protein

POU domain, class 6, transcription factor 1

Gene

Pou6f1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi234 – 29360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. sequence-specific DNA binding Source: MGI
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 6, transcription factor 1
    Alternative name(s):
    Octamer-binding transcription factor EMB
    Transcription regulatory protein MCP-1
    Gene namesi
    Name:Pou6f1
    Synonyms:Emb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:102935. Pou6f1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301POU domain, class 6, transcription factor 1PRO_0000100760Add
    BLAST

    Proteomic databases

    PaxDbiQ07916.
    PRIDEiQ07916.

    PTM databases

    PhosphoSiteiQ07916.

    Expressioni

    Tissue specificityi

    Isoform C1 and isoform C2 are found in the brain, while isoform C7 is found in the testis.

    Developmental stagei

    Expressed in the embryo throughout post-implantation stages with the most prominent expression in the developing CNS. In the adult, it is highly expressed in brain whereas weaker expression can be detected in other organs.

    Gene expression databases

    ArrayExpressiQ07916.
    BgeeiQ07916.
    CleanExiMM_EMB.
    MM_POU6F1.
    GenevestigatoriQ07916.

    Interactioni

    Protein-protein interaction databases

    BioGridi202314. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07916.
    SMRiQ07916. Positions 143-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini139 – 21375POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1 – 139139Gln/Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG241882.
    GeneTreeiENSGT00750000117373.
    HOGENOMiHOG000115597.
    HOVERGENiHBG008230.
    InParanoidiQ07916.
    KOiK09368.
    PhylomeDBiQ07916.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform C2 (identifier: Q07916-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPGISSQILT NAQGQVIGAL PWVVNSASVA TPAPAQSLQV QAVTPQLLLN    50
    AQGQVIATLA SSPLPQPVAV RKPNTPESPA KSEVQPIQPT QAVPQPAVIL 100
    TSPTPALKPS AATPIPITCS ETPTVSQLVS KPHTPSLDED GINLEEIREF 150
    AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY SQSAICRFEK LDITPKSAQK 200
    LKPVLEKWLM EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS FTPQAIEALN 250
    AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI 300
    P 301
    Length:301
    Mass (Da):32,852
    Last modified:November 1, 1996 - v1
    Checksum:i9FC71EE845982AD4
    GO
    Isoform C1 (identifier: Q07916-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         131-131: K → SLE

    Show »
    Length:303
    Mass (Da):33,053
    Checksum:i847408491C9C9CAD
    GO
    Isoform C7 (identifier: Q07916-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-131: MPGISSQILT...TPTVSQLVSK → MCQHTLIFMHVSLVPPSGLE

    Show »
    Length:190
    Mass (Da):21,772
    Checksum:i0F170B4F62CF99F4
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 131131MPGIS…QLVSK → MCQHTLIFMHVSLVPPSGLE in isoform C7. 1 PublicationVSP_002335Add
    BLAST
    Alternative sequencei131 – 1311K → SLE in isoform C1. CuratedVSP_002334

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13801 mRNA. Translation: BAA02959.1.
    L13763 mRNA. Translation: AAA53044.1.
    AK006732 mRNA. Translation: BAB24718.1.
    BC059830 mRNA. Translation: AAH59830.1.
    CCDSiCCDS57009.1. [Q07916-1]
    PIRiB46078.
    I56543.
    RefSeqiNP_034257.1. NM_010127.3. [Q07916-1]
    UniGeneiMm.28825.

    Genome annotation databases

    EnsembliENSMUST00000184908; ENSMUSP00000139023; ENSMUSG00000098598. [Q07916-1]
    GeneIDi19009.
    KEGGimmu:19009.
    UCSCiuc007xro.1. mouse. [Q07916-3]
    uc007xrp.1. mouse. [Q07916-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13801 mRNA. Translation: BAA02959.1 .
    L13763 mRNA. Translation: AAA53044.1 .
    AK006732 mRNA. Translation: BAB24718.1 .
    BC059830 mRNA. Translation: AAH59830.1 .
    CCDSi CCDS57009.1. [Q07916-1 ]
    PIRi B46078.
    I56543.
    RefSeqi NP_034257.1. NM_010127.3. [Q07916-1 ]
    UniGenei Mm.28825.

    3D structure databases

    ProteinModelPortali Q07916.
    SMRi Q07916. Positions 143-291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202314. 4 interactions.

    PTM databases

    PhosphoSitei Q07916.

    Proteomic databases

    PaxDbi Q07916.
    PRIDEi Q07916.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000184908 ; ENSMUSP00000139023 ; ENSMUSG00000098598 . [Q07916-1 ]
    GeneIDi 19009.
    KEGGi mmu:19009.
    UCSCi uc007xro.1. mouse. [Q07916-3 ]
    uc007xrp.1. mouse. [Q07916-1 ]

    Organism-specific databases

    CTDi 5463.
    MGIi MGI:102935. Pou6f1.

    Phylogenomic databases

    eggNOGi NOG241882.
    GeneTreei ENSGT00750000117373.
    HOGENOMi HOG000115597.
    HOVERGENi HBG008230.
    InParanoidi Q07916.
    KOi K09368.
    PhylomeDBi Q07916.

    Miscellaneous databases

    ChiTaRSi POU6F1. mouse.
    NextBioi 295414.
    PROi Q07916.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q07916.
    Bgeei Q07916.
    CleanExi MM_EMB.
    MM_POU6F1.
    Genevestigatori Q07916.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel class of murine POU gene predominantly expressed in central nervous system."
      Okamoto K., Wakamiya M., Noji S., Koyama E., Taniguchi S., Takemura R., Copeland N.G., Gilbert D.J., Jenkins N.A., Muramatsu M., Hamada H.
      J. Biol. Chem. 268:7449-7457(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain and Testis.
    2. "NMDA receptor activation in differentiating cerebellar cell cultures regulates the expression of a new POU gene, Cns-1."
      Bulleit R.F., Cui H., Wang J., Lin X.
      J. Neurosci. 14:1584-1595(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C7).
      Strain: C57BL/6J.
      Tissue: Testis.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C2).
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiPO6F1_MOUSE
    AccessioniPrimary (citable) accession number: Q07916
    Secondary accession number(s): Q91XK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3