Q07911 (FLAB_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Flagellin B

Alternative name(s):
Flagellin N

Gene names

Name:	flaB
Ordered Locus Names:	HP_0115

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	514 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. Important for motility and virulence.
Subunit structure	Heteropolymer of flaA and flaB. FlaB is located proximal to the hook while the remainder of the filament is composed of the predominant flaA.
Subcellular location	Secreted. Bacterial flagellum.
Sequence similarities	Belongs to the bacterial flagellin family.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Bacterial flagellum Secreted
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	ciliary or flagellar motility Inferred from electronic annotation. Source: InterPro flagellum organization Inferred from electronic annotation. Source: InterPro pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	bacterial-type flagellum filament Inferred from electronic annotation. Source: InterPro extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.3
	Chain	2 – 514	513	Flagellin B		PRO_0000182612
Natural variations
	Natural variant	155	1	A → T in strain: 85P.
	Natural variant	182	1	A → E in strain: 85P.
	Natural variant	190 – 191	2	AQ → GA in strain: 85P.
	Natural variant	335	1	A → T in strain: 85P.

Sequences

	Sequence		Length	Mass (Da)
	Q07911 [UniParc]. Last modified January 23, 2007. Version 4. Checksum: 1E3D0728BD14A584	FASTA	514	53,882
	10 20 30 40 50 60 MSFRINTNIA ALTSHAVGVQ NNRDLSSSLE KLSSGLRINK AADDSSGMAI ADSLRSQSAN 70 80 90 100 110 120 LGQAIRNAND AIGMVQTADK AMDEQIKILD TIKTKAVQAA QDGQTLESRR ALQSDIQRLL 130 140 150 160 170 180 EELDNIANTT SFNGQQMLSG SFSNKEFQIG AYSNATVKAS IGSTSSDKIG HVRMETSSFS 190 200 210 220 230 240 GAGMLASAAA QNLTEVGLNF KQVNGVNDYK IETVRISTSA GTGIGALSEI INRFSNTLGV 250 260 270 280 290 300 RASYNVMATG GTPVQSGTVR ELTINGVEIG TVNDVHKNDA DGRLTNAINS VKDRTGVEAS 310 320 330 340 350 360 LDIQGRINLH SIDGRAISVH AASASGQVFG GGNFAGISGT QHAVIGRLTL TRTDARDIIV 370 380 390 400 410 420 SGVNFSHVGF HSAQGVAEYT VNLRAVRGIF DANVASAAGA NANGAQAETN SQGIGAGVTS 430 440 450 460 470 480 LKGAMIVMDM ADSARTQLDK IRSDMGSVQM ELVTTINNIS VTQVNVKAAE SQIRDVDFAE 490 500 510 ESANFSKYNI LAQSGSFAMA QANAVQQNVL RLLQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and genetic characterization of the Helicobacter pylori and Helicobacter mustelae flaB flagellin genes and construction of H. pylori flaA- and flaB-negative mutants by electroporation-mediated allelic exchange." Suerbaum S., Josenhans C., Labigne A. J. Bacteriol. 175:3278-3288(1993) [PubMed: 8501031] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 85P.
[2]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.
[3]	"Identification, characterization, and spatial localization of two flagellin species in Helicobacter pylori flagella." Kostrzynska M., Betts J.D., Austin J.W., Trust T.J. J. Bacteriol. 173:937-946(1991) [PubMed: 1704004] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-21. Strain: NTCC 11637 / Isolate 915.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L08907 Genomic DNA. Translation: AAA25016.1. AE000511 Genomic DNA. Translation: AAD07183.1.
PIR	C64534.
RefSeq	NP_206915.1. NC_000915.1.
3D structure databases
ProteinModelPortal	Q07911.
SMR	Q07911. Positions 475-513.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3194N.
MINT	MINT-162512.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	900158.
GenomeReviews	Gene locus HP_0115 in contig AE000511_GR.
KEGG	hpy:HP0115.
NMPDR	fig|85962.1.peg.113.
PATRIC	20591445. VBIHelPyl33062_0122.
TIGR	HP_0115.
Phylogenomic databases
HOGENOM	HBG758847.
OMA	ANSNQTI.
ProtClustDB	PRK13588.
Family and domain databases
InterPro	IPR001492. Flagellin. IPR001029. Flagellin_D0/D1. IPR010810. Flagellin_hook_IN_motif. [Graphical view]
KO	K02406.
Pfam	PF00700. Flagellin_C. 1 hit. PF07196. Flagellin_IN. 2 hits. PF00669. Flagellin_N. 1 hit. [Graphical view]
PRINTS	PR00207. FLAGELLIN.
ProtoNet	Search...

Entry information

Entry name

FLAB_HELPY

Accession

Primary (citable) accession number: Q07911

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 81 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program