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Protein

Thiamine pathway transporter THI73

Gene

THI73

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports either thiamine or, rather, a related metabolite involved in the thiamine biosynthesis pathway.1 Publication

GO - Molecular functioni

  • transporter activity Source: SGD

GO - Biological processi

  • transmembrane transport Source: InterPro
  • transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-32165-MONOMER

Protein family/group databases

TCDBi2.A.1.14.36 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine pathway transporter THI73
Gene namesi
Name:THI73
Ordered Locus Names:YLR004C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR004C
SGDiS000003994 THI73

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 79CytoplasmicSequence analysisAdd BLAST79
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 118ExtracellularSequence analysisAdd BLAST18
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 141CytoplasmicSequence analysis2
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 176ExtracellularSequence analysisAdd BLAST14
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 207CytoplasmicSequence analysis10
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 239ExtracellularSequence analysisAdd BLAST11
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 312CytoplasmicSequence analysisAdd BLAST52
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 345ExtracellularSequence analysisAdd BLAST12
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Topological domaini367 – 371CytoplasmicSequence analysis5
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 400ExtracellularSequence analysis8
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Topological domaini422 – 432CytoplasmicSequence analysisAdd BLAST11
Transmembranei433 – 452HelicalSequence analysisAdd BLAST20
Topological domaini453 – 466ExtracellularSequence analysisAdd BLAST14
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 523CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471821 – 523Thiamine pathway transporter THI73Add BLAST523

Proteomic databases

PaxDbiQ07904

Expressioni

Inductioni

Induced by limited extracellular thiamine levels.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi31277, 47 interactors
DIPiDIP-8846N
STRINGi4932.YLR004C

Structurei

3D structure databases

ProteinModelPortaliQ07904
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00620000088258
HOGENOMiHOG000171758
InParanoidiQ07904
OMAiFYLPDNV
OrthoDBiEOG092C1U5C

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit

Sequencei

Sequence statusi: Complete.

Q07904-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNMSQRSMD VEKKAANADS CSVSTSSINV DDADVALRFL KQNGLDESST
60 70 80 90 100
ANEDDVVAGE EANFYGSHEL SPKVLRKVDL FILPFLCCTY LLMFLDKALL
110 120 130 140 150
NYAASMGIKD HLKGNEFSNL GTIFSAAYIF MEPVVTYLIQ KFPISKILGT
160 170 180 190 200
FITVWGIVLA CHAACKTYAS LMVVRTLLGL FESSSAVGCI AISGMYYTKS
210 220 230 240 250
EQSARIGFWA TQAGTGYIVG GLISFGFLHY HGTAFTSWQI MFLVVGLVTV
260 270 280 290 300
AFGVLTFLYL PDNVTNAWFL NKEEKIQVVE HIRANQTGLE TKKFKKQQVK
310 320 330 340 350
ELFLHDKFTW PMLLLTACSQ ISTGAIGTFS VTITGTFGFD KYETALLQLP
360 370 380 390 400
IGAITAMIIL ITTQMLSRWG HITLITTSMY IPAIIGCIVL ISLPLSHKIG
410 420 430 440 450
NLFSLYLLYS GSCVITNIYI WNSCNTSGYT KRVFRNAITM IVYNVSCIIA
460 470 480 490 500
PQMFRAYSAP RYIPAKIALL VTQCVCVPLQ LYIGYICKKE NEKRDKEQEG
510 520
QERKKYQFLD LTDIENRNFR YIY
Length:523
Mass (Da):58,531
Last modified:November 1, 1996 - v1
Checksum:i8D6289D98C2ED493
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73176 Genomic DNA Translation: CAA97526.1
BK006945 Genomic DNA Translation: DAA09322.1
PIRiS64826
RefSeqiNP_013104.1, NM_001181891.1

Genome annotation databases

EnsemblFungiiYLR004C; YLR004C; YLR004C
GeneIDi850690
KEGGisce:YLR004C

Similar proteinsi

Entry informationi

Entry nameiTHI73_YEAST
AccessioniPrimary (citable) accession number: Q07904
Secondary accession number(s): D6VY06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health