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Protein

Thiamine pathway transporter THI73

Gene

THI73

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transports either thiamine or, rather, a related metabolite involved in the thiamine biosynthesis pathway.1 Publication

GO - Molecular functioni

  • transmembrane transporter activity Source: GO_Central
  • transporter activity Source: SGD

GO - Biological processi

  • anion transport Source: GO_Central
  • transmembrane transport Source: GO_Central
  • transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32165-MONOMER.

Protein family/group databases

TCDBi2.A.1.14.36. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine pathway transporter THI73
Gene namesi
Name:THI73
Ordered Locus Names:YLR004C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR004C.
SGDiS000003994. THI73.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7979CytoplasmicSequence analysisAdd
BLAST
Transmembranei80 – 10021HelicalSequence analysisAdd
BLAST
Topological domaini101 – 11818ExtracellularSequence analysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence analysisAdd
BLAST
Topological domaini140 – 1412CytoplasmicSequence analysis
Transmembranei142 – 16221HelicalSequence analysisAdd
BLAST
Topological domaini163 – 17614ExtracellularSequence analysisAdd
BLAST
Transmembranei177 – 19721HelicalSequence analysisAdd
BLAST
Topological domaini198 – 20710CytoplasmicSequence analysis
Transmembranei208 – 22821HelicalSequence analysisAdd
BLAST
Topological domaini229 – 23911ExtracellularSequence analysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence analysisAdd
BLAST
Topological domaini261 – 31252CytoplasmicSequence analysisAdd
BLAST
Transmembranei313 – 33321HelicalSequence analysisAdd
BLAST
Topological domaini334 – 34512ExtracellularSequence analysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence analysisAdd
BLAST
Topological domaini367 – 3715CytoplasmicSequence analysis
Transmembranei372 – 39221HelicalSequence analysisAdd
BLAST
Topological domaini393 – 4008ExtracellularSequence analysis
Transmembranei401 – 42121HelicalSequence analysisAdd
BLAST
Topological domaini422 – 43211CytoplasmicSequence analysisAdd
BLAST
Transmembranei433 – 45220HelicalSequence analysisAdd
BLAST
Topological domaini453 – 46614ExtracellularSequence analysisAdd
BLAST
Transmembranei467 – 48721HelicalSequence analysisAdd
BLAST
Topological domaini488 – 52336CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Thiamine pathway transporter THI73PRO_0000247182Add
BLAST

Expressioni

Inductioni

Induced by limited extracellular thiamine levels.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi31277. 28 interactions.
DIPiDIP-8846N.

Structurei

3D structure databases

ProteinModelPortaliQ07904.
SMRiQ07904. Positions 248-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00620000088258.
HOGENOMiHOG000171758.
InParanoidiQ07904.
OMAiFYLPDNV.
OrthoDBiEOG74BK1T.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07904-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNMSQRSMD VEKKAANADS CSVSTSSINV DDADVALRFL KQNGLDESST
60 70 80 90 100
ANEDDVVAGE EANFYGSHEL SPKVLRKVDL FILPFLCCTY LLMFLDKALL
110 120 130 140 150
NYAASMGIKD HLKGNEFSNL GTIFSAAYIF MEPVVTYLIQ KFPISKILGT
160 170 180 190 200
FITVWGIVLA CHAACKTYAS LMVVRTLLGL FESSSAVGCI AISGMYYTKS
210 220 230 240 250
EQSARIGFWA TQAGTGYIVG GLISFGFLHY HGTAFTSWQI MFLVVGLVTV
260 270 280 290 300
AFGVLTFLYL PDNVTNAWFL NKEEKIQVVE HIRANQTGLE TKKFKKQQVK
310 320 330 340 350
ELFLHDKFTW PMLLLTACSQ ISTGAIGTFS VTITGTFGFD KYETALLQLP
360 370 380 390 400
IGAITAMIIL ITTQMLSRWG HITLITTSMY IPAIIGCIVL ISLPLSHKIG
410 420 430 440 450
NLFSLYLLYS GSCVITNIYI WNSCNTSGYT KRVFRNAITM IVYNVSCIIA
460 470 480 490 500
PQMFRAYSAP RYIPAKIALL VTQCVCVPLQ LYIGYICKKE NEKRDKEQEG
510 520
QERKKYQFLD LTDIENRNFR YIY
Length:523
Mass (Da):58,531
Last modified:November 1, 1996 - v1
Checksum:i8D6289D98C2ED493
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73176 Genomic DNA. Translation: CAA97526.1.
BK006945 Genomic DNA. Translation: DAA09322.1.
PIRiS64826.
RefSeqiNP_013104.1. NM_001181891.1.

Genome annotation databases

EnsemblFungiiYLR004C; YLR004C; YLR004C.
GeneIDi850690.
KEGGisce:YLR004C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73176 Genomic DNA. Translation: CAA97526.1.
BK006945 Genomic DNA. Translation: DAA09322.1.
PIRiS64826.
RefSeqiNP_013104.1. NM_001181891.1.

3D structure databases

ProteinModelPortaliQ07904.
SMRiQ07904. Positions 248-277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31277. 28 interactions.
DIPiDIP-8846N.

Protein family/group databases

TCDBi2.A.1.14.36. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR004C; YLR004C; YLR004C.
GeneIDi850690.
KEGGisce:YLR004C.

Organism-specific databases

EuPathDBiFungiDB:YLR004C.
SGDiS000003994. THI73.

Phylogenomic databases

GeneTreeiENSGT00620000088258.
HOGENOMiHOG000171758.
InParanoidiQ07904.
OMAiFYLPDNV.
OrthoDBiEOG74BK1T.

Enzyme and pathway databases

BioCyciYEAST:G3O-32165-MONOMER.

Miscellaneous databases

PROiQ07904.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Transcriptional regulation of the Saccharomyces cerevisiae DAL5 gene family and identification of the high affinity nicotinic acid permease TNA1 (YGR260w)."
    Llorente B., Dujon B.
    FEBS Lett. 475:237-241(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  4. "Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae."
    Nosaka K., Onozuka M., Konno H., Kawasaki Y., Nishimura H., Sano M., Akaji K.
    Mol. Microbiol. 58:467-479(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae."
    Mojzita D., Hohmann S.
    Mol. Genet. Genomics 276:147-161(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiTHI73_YEAST
AccessioniPrimary (citable) accession number: Q07904
Secondary accession number(s): D6VY06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.