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Protein

Nucleolar complex-associated protein 3

Gene

NOC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Also required for initiation of DNA replication. May function downstream of the origin recognition complex (ORC complex) in the loading of CDC6 and the minichromosome maintenance complex (MCM complex) onto chromatin during the G1 phase of the cell cycle. Essential for growth.2 Publications

GO - Molecular functioni

  • chromatin binding Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • DNA replication initiation Source: SGD
  • pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: SGD
  • rRNA processing Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA replication, Ribosome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-32163-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar complex-associated protein 3
Gene namesi
Name:NOC3
Ordered Locus Names:YLR002C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR002C.
SGDiS000003992. NOC3.

Subcellular locationi

GO - Cellular componenti

  • Noc2p-Noc3p complex Source: SGD
  • nuclear pre-replicative complex Source: SGD
  • nucleolus Source: SGD
  • nucleoplasm Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734831 – 663Nucleolar complex-associated protein 3Add BLAST663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei395PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ07896.
PRIDEiQ07896.

PTM databases

iPTMnetiQ07896.

Interactioni

Subunit structurei

Forms a heterodimer with NOC2. This complex may be associated with pre-ribosomal particles. Also interacts with MCM2, MCM5 and ORC1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NOC2P397447EBI-36093,EBI-29259
SPB1P255823EBI-36093,EBI-17814

Protein-protein interaction databases

BioGridi31275. 110 interactors.
DIPiDIP-4839N.
IntActiQ07896. 24 interactors.
MINTiMINT-490945.

Structurei

3D structure databases

ProteinModelPortaliQ07896.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili363 – 408Sequence analysisAdd BLAST46

Sequence similaritiesi

Belongs to the CBF/MAK21 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000008540.
HOGENOMiHOG000168453.
InParanoidiQ07896.
KOiK14834.
OMAiIFSQKAR.
OrthoDBiEOG092C2BA1.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
IPR011501. Noc3_N.
IPR016903. Nucleolar_cplx-assoc_3.
[Graphical view]
PfamiPF03914. CBF. 1 hit.
PF07540. NOC3p. 1 hit.
[Graphical view]
PIRSFiPIRSF028977. Nucleolar_complex_p3. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Q07896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRNRSQFR IQERTAKKRK HEDSLLEGNV FQNAPEDMDE NTIYSAKGSS
60 70 80 90 100
WDEEEQDYEM VPRKNRSDTS NLVEGLPIKV NGKVERKLHK AQEKPKDDDE
110 120 130 140 150
EDEDSNDSSE DDEGPNEEQE AEAKEDEPDT EEKILQLKED IADLVTKVME
160 170 180 190 200
EPEENTAALG RLCKMVESKN PNTCKFSMLA LVPVFKSIIP GYRIRPLTET
210 220 230 240 250
EKKEKVSKEV SKLRNFEQAL VYNYKNYVGR LQSLSKTPSN AAPIQVSLGI
260 270 280 290 300
LATQAAKELI STASHFNFRT DIFTLLLRRI CKPRISTDPT SIQIIQTFET
310 320 330 340 350
LLNEDEEGSI SFEILRIFNK ILKTRNFNIE ESVLNMLLSL DVLHDYDPNT
360 370 380 390 400
KLKGNVSAPK LKKKDRVHLS KKQRKARKEM QQIEEEMRNA EQAVSAEERE
410 420 430 440 450
RNQSEILKIV FTIYLNILKN NAKTLIGSVL EGLTKFGNMA NFDLLGDFLE
460 470 480 490 500
VMKELISDTE FDNLSSAEVR KALLCIVSAF SLISNTQYMK VNVDLSKFVD
510 520 530 540 550
GLYALLPYIC LDADIELSYR SLRLADPLNN EIIKPSVNVS TKAELLLKAL
560 570 580 590 600
DHVFFRSKSG TKERATAFTK RLYMCISHTP EKTSIAILKF IDKLMNRYPE
610 620 630 640 650
ISGLYSSEDR IGNGHFIMEA DNPSRSNPEA ATLWDNALLE KHYCPVVTKG
660
LRSLSSRSKE CSK
Length:663
Mass (Da):75,582
Last modified:November 1, 1996 - v1
Checksum:i4CA9461A4A1F1E9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73174 Genomic DNA. Translation: CAA97524.1.
X91488 Genomic DNA. Translation: CAA62771.1.
BK006945 Genomic DNA. Translation: DAA09320.1.
PIRiS64824.
RefSeqiNP_013102.1. NM_001181889.1.

Genome annotation databases

EnsemblFungiiYLR002C; YLR002C; YLR002C.
GeneIDi850688.
KEGGisce:YLR002C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73174 Genomic DNA. Translation: CAA97524.1.
X91488 Genomic DNA. Translation: CAA62771.1.
BK006945 Genomic DNA. Translation: DAA09320.1.
PIRiS64824.
RefSeqiNP_013102.1. NM_001181889.1.

3D structure databases

ProteinModelPortaliQ07896.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31275. 110 interactors.
DIPiDIP-4839N.
IntActiQ07896. 24 interactors.
MINTiMINT-490945.

PTM databases

iPTMnetiQ07896.

Proteomic databases

MaxQBiQ07896.
PRIDEiQ07896.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR002C; YLR002C; YLR002C.
GeneIDi850688.
KEGGisce:YLR002C.

Organism-specific databases

EuPathDBiFungiDB:YLR002C.
SGDiS000003992. NOC3.

Phylogenomic databases

GeneTreeiENSGT00390000008540.
HOGENOMiHOG000168453.
InParanoidiQ07896.
KOiK14834.
OMAiIFSQKAR.
OrthoDBiEOG092C2BA1.

Enzyme and pathway databases

BioCyciYEAST:G3O-32163-MONOMER.

Miscellaneous databases

PROiQ07896.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
IPR011501. Noc3_N.
IPR016903. Nucleolar_cplx-assoc_3.
[Graphical view]
PfamiPF03914. CBF. 1 hit.
PF07540. NOC3p. 1 hit.
[Graphical view]
PIRSFiPIRSF028977. Nucleolar_complex_p3. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiNOC3_YEAST
AccessioniPrimary (citable) accession number: Q07896
Secondary accession number(s): D6VY04, Q92280
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 11700 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.