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Protein

Nucleolar complex-associated protein 3

Gene

NOC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Also required for initiation of DNA replication. May function downstream of the origin recognition complex (ORC complex) in the loading of CDC6 and the minichromosome maintenance complex (MCM complex) onto chromatin during the G1 phase of the cell cycle. Essential for growth.2 Publications

Miscellaneous

Present with 11700 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • chromatin binding Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • DNA replication initiation Source: SGD
  • pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: SGD
  • rRNA processing Source: SGD

Keywordsi

Biological processCell cycle, Cell division, DNA replication, Ribosome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-32163-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar complex-associated protein 3
Gene namesi
Name:NOC3
Ordered Locus Names:YLR002C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR002C
SGDiS000003992 NOC3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734831 – 663Nucleolar complex-associated protein 3Add BLAST663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei395PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ07896
PaxDbiQ07896
PRIDEiQ07896

PTM databases

iPTMnetiQ07896

Interactioni

Subunit structurei

Forms a heterodimer with NOC2. This complex may be associated with pre-ribosomal particles. Also interacts with MCM2, MCM5 and ORC1.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31275, 232 interactors
DIPiDIP-4839N
IntActiQ07896, 45 interactors
MINTiQ07896
STRINGi4932.YLR002C

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6ELZelectron microscopy3.30I1-663[»]
6EM5electron microscopy4.30I1-663[»]
ProteinModelPortaliQ07896
SMRiQ07896
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili363 – 408Sequence analysisAdd BLAST46

Sequence similaritiesi

Belongs to the CBF/MAK21 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000008540
HOGENOMiHOG000168453
InParanoidiQ07896
KOiK14834
OMAiLWNTEER
OrthoDBiEOG092C2BA1

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR005612 CCAAT-binding_factor
IPR011501 Noc3_N
IPR016903 Nucleolar_cplx-assoc_3
PfamiView protein in Pfam
PF03914 CBF, 1 hit
PF07540 NOC3p, 1 hit
PIRSFiPIRSF028977 Nucleolar_complex_p3, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits

Sequencei

Sequence statusi: Complete.

Q07896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRNRSQFR IQERTAKKRK HEDSLLEGNV FQNAPEDMDE NTIYSAKGSS
60 70 80 90 100
WDEEEQDYEM VPRKNRSDTS NLVEGLPIKV NGKVERKLHK AQEKPKDDDE
110 120 130 140 150
EDEDSNDSSE DDEGPNEEQE AEAKEDEPDT EEKILQLKED IADLVTKVME
160 170 180 190 200
EPEENTAALG RLCKMVESKN PNTCKFSMLA LVPVFKSIIP GYRIRPLTET
210 220 230 240 250
EKKEKVSKEV SKLRNFEQAL VYNYKNYVGR LQSLSKTPSN AAPIQVSLGI
260 270 280 290 300
LATQAAKELI STASHFNFRT DIFTLLLRRI CKPRISTDPT SIQIIQTFET
310 320 330 340 350
LLNEDEEGSI SFEILRIFNK ILKTRNFNIE ESVLNMLLSL DVLHDYDPNT
360 370 380 390 400
KLKGNVSAPK LKKKDRVHLS KKQRKARKEM QQIEEEMRNA EQAVSAEERE
410 420 430 440 450
RNQSEILKIV FTIYLNILKN NAKTLIGSVL EGLTKFGNMA NFDLLGDFLE
460 470 480 490 500
VMKELISDTE FDNLSSAEVR KALLCIVSAF SLISNTQYMK VNVDLSKFVD
510 520 530 540 550
GLYALLPYIC LDADIELSYR SLRLADPLNN EIIKPSVNVS TKAELLLKAL
560 570 580 590 600
DHVFFRSKSG TKERATAFTK RLYMCISHTP EKTSIAILKF IDKLMNRYPE
610 620 630 640 650
ISGLYSSEDR IGNGHFIMEA DNPSRSNPEA ATLWDNALLE KHYCPVVTKG
660
LRSLSSRSKE CSK
Length:663
Mass (Da):75,582
Last modified:November 1, 1996 - v1
Checksum:i4CA9461A4A1F1E9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73174 Genomic DNA Translation: CAA97524.1
X91488 Genomic DNA Translation: CAA62771.1
BK006945 Genomic DNA Translation: DAA09320.1
PIRiS64824
RefSeqiNP_013102.1, NM_001181889.1

Genome annotation databases

EnsemblFungiiYLR002C; YLR002C; YLR002C
GeneIDi850688
KEGGisce:YLR002C

Similar proteinsi

Entry informationi

Entry nameiNOC3_YEAST
AccessioniPrimary (citable) accession number: Q07896
Secondary accession number(s): D6VY04, Q92280
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health