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Q07890 (SOS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Son of sevenless homolog 2

Short name=SOS-2
Gene names
Name:SOS2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1332 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Promotes the exchange of Ras-bound GDP by GTP By similarity.

Sequence similarities

Contains 1 DH (DBL-homology) domain.

Contains 1 N-terminal Ras-GEF domain.

Contains 1 PH domain.

Contains 1 Ras-GEF domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q07890-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q07890-2)

The sequence of this isoform differs from the canonical sequence as follows:
     324-356: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13321332Son of sevenless homolog 2
PRO_0000068896

Regions

Domain198 – 388191DH
Domain442 – 546105PH
Domain595 – 739145N-terminal Ras-GEF
Domain778 – 1017240Ras-GEF
Compositional bias755 – 7584Poly-Pro
Compositional bias1180 – 11834Poly-Pro
Compositional bias1203 – 12086Poly-Pro

Natural variations

Alternative sequence324 – 35633Missing in isoform 2.
VSP_054492
Natural variant4831S → N.
Corresponds to variant rs17122201 [ dbSNP | Ensembl ].
VAR_054327
Natural variant5081H → Y.
Corresponds to variant rs8010237 [ dbSNP | Ensembl ].
VAR_054328
Natural variant6721L → I.
Corresponds to variant rs34139502 [ dbSNP | Ensembl ].
VAR_034441

Experimental info

Sequence conflict321E → V in AAA35914. Ref.1
Sequence conflict1921S → C in AAA35914. Ref.1
Sequence conflict239 – 2402DI → VY in AAA35914. Ref.1
Sequence conflict3811L → H in AAA35914. Ref.1
Sequence conflict4821S → T in AAA35914. Ref.1
Sequence conflict6871I → V in AAA35914. Ref.1
Sequence conflict6961E → D in AAA35914. Ref.1
Sequence conflict6991F → Y in AAA35914. Ref.1
Sequence conflict7781H → D in AAA35914. Ref.1
Sequence conflict8611Q → R in AAA91852. Ref.5
Sequence conflict9481K → R in AAA35914. Ref.1
Sequence conflict9991S → C in AAA91852. Ref.5
Sequence conflict10321S → E in AAA91852. Ref.5
Sequence conflict10421T → A in AAA91852. Ref.5
Sequence conflict1112 – 11143CGS → LC in AAA91852. Ref.5
Sequence conflict11591A → G in AAA91852. Ref.5
Sequence conflict12961Q → E in AAA91852. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 10, 2009. Version 2.
Checksum: 0D1D4FAB8E37C371

FASTA1,332152,979
        10         20         30         40         50         60 
MQQAPQPYEF FSEENSPKWR GLLVSALRKV QEQVHPTLSA NEESLYYIEE LIFQLLNKLC 

        70         80         90        100        110        120 
MAQPRTVQDV EERVQKTFPH PIDKWAIADA QSAIEKRKRR NPLLLPVDKI HPSLKEVLGY 

       130        140        150        160        170        180 
KVDYHVSLYI VAVLEYISAD ILKLAGNYVF NIRHYEISQQ DIKVSMCADK VLMDMFDQDD 

       190        200        210        220        230        240 
IGLVSLCEDE PSSSGELNYY DLVRTEIAEE RQYLRELNMI IKVFREAFLS DRKLFKPSDI 

       250        260        270        280        290        300 
EKIFSNISDI HELTVKLLGL IEDTVEMTDE SSPHPLAGSC FEDLAEEQAF DPYETLSQDI 

       310        320        330        340        350        360 
LSPEFHEHFN KLMARPAVAL HFQSIADGFK EAVRYVLPRL MLVPVYHCWH YFELLKQLKA 

       370        380        390        400        410        420 
CSEEQEDREC LNQAITALMN LQGSMDRIYK QYSPRRRPGD PVCPFYSHQL RSKHLAIKKM 

       430        440        450        460        470        480 
NEIQKNIDGW EGKDIGQCCN EFIMEGPLTR IGAKHERHIF LFDGLMISCK PNHGQTRLPG 

       490        500        510        520        530        540 
YSSAEYRLKE KFVMRKIQIC DKEDTCEHKH AFELVSKDEN SIIFAAKSAE EKNNWMAALI 

       550        560        570        580        590        600 
SLHYRSTLDR MLDSVLLKEE NEQPLRLPSP EVYRFVVKDS EENIVFEDNL QSRSGIPIIK 

       610        620        630        640        650        660 
GGTVVKLIER LTYHMYADPN FVRTFLTTYR SFCKPQELLS LLIERFEIPE PEPTDADKLA 

       670        680        690        700        710        720 
IEKGEQPISA DLKRFRKEYV QPVQLRILNV FRHWVEHHFY DFERDLELLE RLESFISSVR 

       730        740        750        760        770        780 
GKAMKKWVES IAKIIRRKKQ AQANGVSHNI TFESPPPPIE WHISKPGQFE TFDLMTLHPI 

       790        800        810        820        830        840 
EIARQLTLLE SDLYRKVQPS ELVGSVWTKE DKEINSPNLL KMIRHTTNLT LWFEKCIVEA 

       850        860        870        880        890        900 
ENFEERVAVL SRIIEILQVF QDLNNFNGVL EIVSAVNSVS VYRLDHTFEA LQERKRKILD 

       910        920        930        940        950        960 
EAVELSQDHF KKYLVKLKSI NPPCVPFFGI YLTNILKTEE GNNDFLKKKG KDLINFSKRR 

       970        980        990       1000       1010       1020 
KVAEITGEIQ QYQNQPYCLR IEPDMRRFFE NLNPMGSASE KEFTDYLFNK SLEIEPRNCK 

      1030       1040       1050       1060       1070       1080 
QPPRFPRKST FSLKSPGIRP NTGRHGSTSG TLRGHPTPLE REPCKISFSR IAETELESTV 

      1090       1100       1110       1120       1130       1140 
SAPTSPNTPS TPPVSASSDL SVFLDVDLNS SCGSNSIFAP VLLPHSKSFF SSCGSLHKLS 

      1150       1160       1170       1180       1190       1200 
EEPLIPPPLP PRKKFDHDAS NSKGNMKSDD DPPAIPPRQP PPPKVKPRVP VPTGAFDGPL 

      1210       1220       1230       1240       1250       1260 
HSPPPPPPRD PLPDTPPPVP LRPPEHFINC PFNLQPPPLG HLHRDSDWLR DISTCPNSPS 

      1270       1280       1290       1300       1310       1320 
TPPSTPSPRV PRRCYVLSSS QNNLAHPPAP PVPPRQNSSP HLPKLPPKTY KRELSHPPLY 

      1330 
RLPLLENAET PQ 

« Hide

Isoform 2 [UniParc].

Checksum: CDA5F7026EC96928
Show »

FASTA1,299149,002

References

« Hide 'large scale' references
[1]"Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2."
Chardin P., Camonis J.H., Gale N.W., van Aelst L., Wigler M.H., Bar-Sagi D.
Science 260:1338-1343(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.
[5]Fath I., Apiou F., Dutrillaux B., Tocque B.
Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 724-1296 (ISOFORM 1/2).
Tissue: Placenta.
+Additional computationally mapped references.

Web resources

Wikipedia

Son of sevenless entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L13858 mRNA. Translation: AAA35914.1.
AL109758 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65727.1.
CH471078 Genomic DNA. Translation: EAW65728.1.
BC143367 mRNA. Translation: AAI43368.1.
BC117261 mRNA. Translation: AAI17262.1.
L20686 mRNA. Translation: AAA91852.1.
CCDSCCDS9697.1.
RefSeqNP_008870.2. NM_006939.2. [Q07890-1]
UniGeneHs.291533.

3D structure databases

ProteinModelPortalQ07890.
SMRQ07890. Positions 7-179, 196-1044.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112538. 12 interactions.
IntActQ07890. 15 interactions.
MINTMINT-1782446.
STRING9606.ENSP00000216373.

PTM databases

PhosphoSiteQ07890.

Polymorphism databases

DMDM223634694.

Proteomic databases

MaxQBQ07890.
PaxDbQ07890.
PRIDEQ07890.

Protocols and materials databases

DNASU6655.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000216373; ENSP00000216373; ENSG00000100485.
ENST00000543680; ENSP00000445328; ENSG00000100485.
GeneID6655.
KEGGhsa:6655.
UCSCuc001wxs.4. human. [Q07890-1]

Organism-specific databases

CTD6655.
GeneCardsGC14M050583.
H-InvDBHIX0037776.
HGNCHGNC:11188. SOS2.
HPACAB004577.
HPA047368.
HPA052689.
MIM601247. gene.
neXtProtNX_Q07890.
PharmGKBPA36025.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG265981.
HOGENOMHOG000013040.
HOVERGENHBG017831.
InParanoidQ07890.
KOK03099.
OMAYVFNIRH.
OrthoDBEOG7XSTD0.
PhylomeDBQ07890.
TreeFamTF317296.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ07890.
BgeeQ07890.
CleanExHS_SOS2.
GenevestigatorQ07890.

Family and domain databases

Gene3D1.10.20.10. 1 hit.
1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProIPR000219. DH-domain.
IPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view]
PfamPF00125. Histone. 1 hit.
PF00169. PH. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTSM00233. PH. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMSSF47113. SSF47113. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 1 hit.
PROSITEPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSOS2. human.
GenomeRNAi6655.
NextBio25943.
PROQ07890.
SOURCESearch...

Entry information

Entry nameSOS2_HUMAN
AccessionPrimary (citable) accession number: Q07890
Secondary accession number(s): B7ZKT6 expand/collapse secondary AC list , D3DSB4, Q15503, Q17RN1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 10, 2009
Last modified: July 9, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM