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Q07890

- SOS2_HUMAN

UniProt

Q07890 - SOS2_HUMAN

Protein

Son of sevenless homolog 2

Gene

SOS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Promotes the exchange of Ras-bound GDP by GTP.By similarity

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. protein binding Source: IntAct
    3. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. apoptotic signaling pathway Source: Reactome
    2. axon guidance Source: Reactome
    3. neurotrophin TRK receptor signaling pathway Source: Reactome
    4. positive regulation of apoptotic process Source: Reactome
    5. positive regulation of small GTPase mediated signal transduction Source: Ensembl
    6. regulation of small GTPase mediated signal transduction Source: Reactome
    7. small GTPase mediated signal transduction Source: Reactome

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.
    REACT_13638. NRAGE signals death through JNK.
    REACT_18407. G alpha (12/13) signalling events.
    REACT_19226. Activation of Rac.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Son of sevenless homolog 2
    Short name:
    SOS-2
    Gene namesi
    Name:SOS2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:11188. SOS2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36025.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13321332Son of sevenless homolog 2PRO_0000068896Add
    BLAST

    Proteomic databases

    MaxQBiQ07890.
    PaxDbiQ07890.
    PRIDEiQ07890.

    PTM databases

    PhosphoSiteiQ07890.

    Expressioni

    Gene expression databases

    ArrayExpressiQ07890.
    BgeeiQ07890.
    CleanExiHS_SOS2.
    GenevestigatoriQ07890.

    Organism-specific databases

    HPAiCAB004577.
    HPA047368.
    HPA052689.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ABL1P005192EBI-298181,EBI-375543
    CRKP461082EBI-298181,EBI-886
    GRB2P629938EBI-298181,EBI-401755
    NCK1P163333EBI-298181,EBI-389883
    PACSIN3Q9UKS62EBI-298181,EBI-77926
    PLCG1P191744EBI-298181,EBI-79387
    SNX9Q9Y5X12EBI-298181,EBI-77848

    Protein-protein interaction databases

    BioGridi112538. 12 interactions.
    IntActiQ07890. 15 interactions.
    MINTiMINT-1782446.
    STRINGi9606.ENSP00000216373.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07890.
    SMRiQ07890. Positions 7-179, 196-1044.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini198 – 388191DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini442 – 546105PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini595 – 739145N-terminal Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini778 – 1017240Ras-GEFPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi755 – 7584Poly-Pro
    Compositional biasi1180 – 11834Poly-Pro
    Compositional biasi1203 – 12086Poly-Pro

    Sequence similaritiesi

    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG265981.
    HOGENOMiHOG000013040.
    HOVERGENiHBG017831.
    InParanoidiQ07890.
    KOiK03099.
    OMAiYVFNIRH.
    OrthoDBiEOG7XSTD0.
    PhylomeDBiQ07890.
    TreeFamiTF317296.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    1.10.840.10. 1 hit.
    1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR000219. DH-domain.
    IPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view]
    PfamiPF00125. Histone. 1 hit.
    PF00169. PH. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    SM00325. RhoGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 1 hit.
    SSF48065. SSF48065. 1 hit.
    SSF48366. SSF48366. 1 hit.
    PROSITEiPS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q07890-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQQAPQPYEF FSEENSPKWR GLLVSALRKV QEQVHPTLSA NEESLYYIEE     50
    LIFQLLNKLC MAQPRTVQDV EERVQKTFPH PIDKWAIADA QSAIEKRKRR 100
    NPLLLPVDKI HPSLKEVLGY KVDYHVSLYI VAVLEYISAD ILKLAGNYVF 150
    NIRHYEISQQ DIKVSMCADK VLMDMFDQDD IGLVSLCEDE PSSSGELNYY 200
    DLVRTEIAEE RQYLRELNMI IKVFREAFLS DRKLFKPSDI EKIFSNISDI 250
    HELTVKLLGL IEDTVEMTDE SSPHPLAGSC FEDLAEEQAF DPYETLSQDI 300
    LSPEFHEHFN KLMARPAVAL HFQSIADGFK EAVRYVLPRL MLVPVYHCWH 350
    YFELLKQLKA CSEEQEDREC LNQAITALMN LQGSMDRIYK QYSPRRRPGD 400
    PVCPFYSHQL RSKHLAIKKM NEIQKNIDGW EGKDIGQCCN EFIMEGPLTR 450
    IGAKHERHIF LFDGLMISCK PNHGQTRLPG YSSAEYRLKE KFVMRKIQIC 500
    DKEDTCEHKH AFELVSKDEN SIIFAAKSAE EKNNWMAALI SLHYRSTLDR 550
    MLDSVLLKEE NEQPLRLPSP EVYRFVVKDS EENIVFEDNL QSRSGIPIIK 600
    GGTVVKLIER LTYHMYADPN FVRTFLTTYR SFCKPQELLS LLIERFEIPE 650
    PEPTDADKLA IEKGEQPISA DLKRFRKEYV QPVQLRILNV FRHWVEHHFY 700
    DFERDLELLE RLESFISSVR GKAMKKWVES IAKIIRRKKQ AQANGVSHNI 750
    TFESPPPPIE WHISKPGQFE TFDLMTLHPI EIARQLTLLE SDLYRKVQPS 800
    ELVGSVWTKE DKEINSPNLL KMIRHTTNLT LWFEKCIVEA ENFEERVAVL 850
    SRIIEILQVF QDLNNFNGVL EIVSAVNSVS VYRLDHTFEA LQERKRKILD 900
    EAVELSQDHF KKYLVKLKSI NPPCVPFFGI YLTNILKTEE GNNDFLKKKG 950
    KDLINFSKRR KVAEITGEIQ QYQNQPYCLR IEPDMRRFFE NLNPMGSASE 1000
    KEFTDYLFNK SLEIEPRNCK QPPRFPRKST FSLKSPGIRP NTGRHGSTSG 1050
    TLRGHPTPLE REPCKISFSR IAETELESTV SAPTSPNTPS TPPVSASSDL 1100
    SVFLDVDLNS SCGSNSIFAP VLLPHSKSFF SSCGSLHKLS EEPLIPPPLP 1150
    PRKKFDHDAS NSKGNMKSDD DPPAIPPRQP PPPKVKPRVP VPTGAFDGPL 1200
    HSPPPPPPRD PLPDTPPPVP LRPPEHFINC PFNLQPPPLG HLHRDSDWLR 1250
    DISTCPNSPS TPPSTPSPRV PRRCYVLSSS QNNLAHPPAP PVPPRQNSSP 1300
    HLPKLPPKTY KRELSHPPLY RLPLLENAET PQ 1332
    Length:1,332
    Mass (Da):152,979
    Last modified:February 10, 2009 - v2
    Checksum:i0D1D4FAB8E37C371
    GO
    Isoform 2 (identifier: Q07890-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         324-356: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,299
    Mass (Da):149,002
    Checksum:iCDA5F7026EC96928
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321E → V in AAA35914. (PubMed:8493579)Curated
    Sequence conflicti192 – 1921S → C in AAA35914. (PubMed:8493579)Curated
    Sequence conflicti239 – 2402DI → VY in AAA35914. (PubMed:8493579)Curated
    Sequence conflicti381 – 3811L → H in AAA35914. (PubMed:8493579)Curated
    Sequence conflicti482 – 4821S → T in AAA35914. (PubMed:8493579)Curated
    Sequence conflicti687 – 6871I → V in AAA35914. (PubMed:8493579)Curated
    Sequence conflicti696 – 6961E → D in AAA35914. (PubMed:8493579)Curated
    Sequence conflicti699 – 6991F → Y in AAA35914. (PubMed:8493579)Curated
    Sequence conflicti778 – 7781H → D in AAA35914. (PubMed:8493579)Curated
    Sequence conflicti861 – 8611Q → R in AAA91852. 1 PublicationCurated
    Sequence conflicti948 – 9481K → R in AAA35914. (PubMed:8493579)Curated
    Sequence conflicti999 – 9991S → C in AAA91852. 1 PublicationCurated
    Sequence conflicti1032 – 10321S → E in AAA91852. 1 PublicationCurated
    Sequence conflicti1042 – 10421T → A in AAA91852. 1 PublicationCurated
    Sequence conflicti1112 – 11143CGS → LC in AAA91852. 1 PublicationCurated
    Sequence conflicti1159 – 11591A → G in AAA91852. 1 PublicationCurated
    Sequence conflicti1296 – 12961Q → E in AAA91852. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti483 – 4831S → N.
    Corresponds to variant rs17122201 [ dbSNP | Ensembl ].
    VAR_054327
    Natural varianti508 – 5081H → Y.
    Corresponds to variant rs8010237 [ dbSNP | Ensembl ].
    VAR_054328
    Natural varianti672 – 6721L → I.
    Corresponds to variant rs34139502 [ dbSNP | Ensembl ].
    VAR_034441

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei324 – 35633Missing in isoform 2. 1 PublicationVSP_054492Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13858 mRNA. Translation: AAA35914.1.
    AL109758 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65727.1.
    CH471078 Genomic DNA. Translation: EAW65728.1.
    BC143367 mRNA. Translation: AAI43368.1.
    BC117261 mRNA. Translation: AAI17262.1.
    L20686 mRNA. Translation: AAA91852.1.
    CCDSiCCDS9697.1. [Q07890-1]
    RefSeqiNP_008870.2. NM_006939.2. [Q07890-1]
    UniGeneiHs.291533.

    Genome annotation databases

    EnsembliENST00000216373; ENSP00000216373; ENSG00000100485. [Q07890-1]
    ENST00000543680; ENSP00000445328; ENSG00000100485. [Q07890-2]
    GeneIDi6655.
    KEGGihsa:6655.
    UCSCiuc001wxs.4. human. [Q07890-1]

    Polymorphism databases

    DMDMi223634694.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Son of sevenless entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13858 mRNA. Translation: AAA35914.1 .
    AL109758 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65727.1 .
    CH471078 Genomic DNA. Translation: EAW65728.1 .
    BC143367 mRNA. Translation: AAI43368.1 .
    BC117261 mRNA. Translation: AAI17262.1 .
    L20686 mRNA. Translation: AAA91852.1 .
    CCDSi CCDS9697.1. [Q07890-1 ]
    RefSeqi NP_008870.2. NM_006939.2. [Q07890-1 ]
    UniGenei Hs.291533.

    3D structure databases

    ProteinModelPortali Q07890.
    SMRi Q07890. Positions 7-179, 196-1044.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112538. 12 interactions.
    IntActi Q07890. 15 interactions.
    MINTi MINT-1782446.
    STRINGi 9606.ENSP00000216373.

    PTM databases

    PhosphoSitei Q07890.

    Polymorphism databases

    DMDMi 223634694.

    Proteomic databases

    MaxQBi Q07890.
    PaxDbi Q07890.
    PRIDEi Q07890.

    Protocols and materials databases

    DNASUi 6655.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216373 ; ENSP00000216373 ; ENSG00000100485 . [Q07890-1 ]
    ENST00000543680 ; ENSP00000445328 ; ENSG00000100485 . [Q07890-2 ]
    GeneIDi 6655.
    KEGGi hsa:6655.
    UCSCi uc001wxs.4. human. [Q07890-1 ]

    Organism-specific databases

    CTDi 6655.
    GeneCardsi GC14M050583.
    H-InvDB HIX0037776.
    HGNCi HGNC:11188. SOS2.
    HPAi CAB004577.
    HPA047368.
    HPA052689.
    MIMi 601247. gene.
    neXtProti NX_Q07890.
    PharmGKBi PA36025.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG265981.
    HOGENOMi HOG000013040.
    HOVERGENi HBG017831.
    InParanoidi Q07890.
    KOi K03099.
    OMAi YVFNIRH.
    OrthoDBi EOG7XSTD0.
    PhylomeDBi Q07890.
    TreeFami TF317296.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.
    REACT_13638. NRAGE signals death through JNK.
    REACT_18407. G alpha (12/13) signalling events.
    REACT_19226. Activation of Rac.

    Miscellaneous databases

    ChiTaRSi SOS2. human.
    GenomeRNAii 6655.
    NextBioi 25943.
    PROi Q07890.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q07890.
    Bgeei Q07890.
    CleanExi HS_SOS2.
    Genevestigatori Q07890.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    1.10.840.10. 1 hit.
    1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR000219. DH-domain.
    IPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view ]
    Pfami PF00125. Histone. 1 hit.
    PF00169. PH. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    SM00325. RhoGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    SSF48065. SSF48065. 1 hit.
    SSF48366. SSF48366. 1 hit.
    PROSITEi PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2."
      Chardin P., Camonis J.H., Gale N.W., van Aelst L., Wigler M.H., Bar-Sagi D.
      Science 260:1338-1343(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    5. Fath I., Apiou F., Dutrillaux B., Tocque B.
      Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 724-1296 (ISOFORM 1/2).
      Tissue: Placenta.

    Entry informationi

    Entry nameiSOS2_HUMAN
    AccessioniPrimary (citable) accession number: Q07890
    Secondary accession number(s): B7ZKT6
    , D3DSB4, Q15503, Q17RN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3