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Q07890

- SOS2_HUMAN

UniProt

Q07890 - SOS2_HUMAN

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Protein

Son of sevenless homolog 2

Gene

SOS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Promotes the exchange of Ras-bound GDP by GTP.By similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. apoptotic signaling pathway Source: Reactome
  2. axon guidance Source: Reactome
  3. neurotrophin TRK receptor signaling pathway Source: Reactome
  4. positive regulation of apoptotic process Source: Reactome
  5. positive regulation of small GTPase mediated signal transduction Source: Ensembl
  6. regulation of small GTPase mediated signal transduction Source: Reactome
  7. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.
REACT_13638. NRAGE signals death through JNK.
REACT_18407. G alpha (12/13) signalling events.
REACT_19226. Activation of Rac.

Names & Taxonomyi

Protein namesi
Recommended name:
Son of sevenless homolog 2
Short name:
SOS-2
Gene namesi
Name:SOS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:11188. SOS2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36025.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13321332Son of sevenless homolog 2PRO_0000068896Add
BLAST

Proteomic databases

MaxQBiQ07890.
PaxDbiQ07890.
PRIDEiQ07890.

PTM databases

PhosphoSiteiQ07890.

Expressioni

Gene expression databases

BgeeiQ07890.
CleanExiHS_SOS2.
ExpressionAtlasiQ07890. baseline and differential.
GenevestigatoriQ07890.

Organism-specific databases

HPAiCAB004577.
HPA047368.
HPA052689.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABL1P005192EBI-298181,EBI-375543
CRKP461082EBI-298181,EBI-886
GRB2P629938EBI-298181,EBI-401755
NCK1P163333EBI-298181,EBI-389883
PACSIN3Q9UKS62EBI-298181,EBI-77926
PLCG1P191744EBI-298181,EBI-79387
SNX9Q9Y5X12EBI-298181,EBI-77848

Protein-protein interaction databases

BioGridi112538. 12 interactions.
IntActiQ07890. 16 interactions.
MINTiMINT-1782446.
STRINGi9606.ENSP00000216373.

Structurei

3D structure databases

ProteinModelPortaliQ07890.
SMRiQ07890. Positions 7-179, 196-1044.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini198 – 388191DHPROSITE-ProRule annotationAdd
BLAST
Domaini442 – 546105PHPROSITE-ProRule annotationAdd
BLAST
Domaini595 – 739145N-terminal Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini778 – 1017240Ras-GEFPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi755 – 7584Poly-Pro
Compositional biasi1180 – 11834Poly-Pro
Compositional biasi1203 – 12086Poly-Pro

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG265981.
GeneTreeiENSGT00770000120448.
HOGENOMiHOG000013040.
HOVERGENiHBG017831.
InParanoidiQ07890.
KOiK03099.
OMAiYVFNIRH.
OrthoDBiEOG7XSTD0.
PhylomeDBiQ07890.
TreeFamiTF317296.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF00169. PH. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q07890-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQAPQPYEF FSEENSPKWR GLLVSALRKV QEQVHPTLSA NEESLYYIEE
60 70 80 90 100
LIFQLLNKLC MAQPRTVQDV EERVQKTFPH PIDKWAIADA QSAIEKRKRR
110 120 130 140 150
NPLLLPVDKI HPSLKEVLGY KVDYHVSLYI VAVLEYISAD ILKLAGNYVF
160 170 180 190 200
NIRHYEISQQ DIKVSMCADK VLMDMFDQDD IGLVSLCEDE PSSSGELNYY
210 220 230 240 250
DLVRTEIAEE RQYLRELNMI IKVFREAFLS DRKLFKPSDI EKIFSNISDI
260 270 280 290 300
HELTVKLLGL IEDTVEMTDE SSPHPLAGSC FEDLAEEQAF DPYETLSQDI
310 320 330 340 350
LSPEFHEHFN KLMARPAVAL HFQSIADGFK EAVRYVLPRL MLVPVYHCWH
360 370 380 390 400
YFELLKQLKA CSEEQEDREC LNQAITALMN LQGSMDRIYK QYSPRRRPGD
410 420 430 440 450
PVCPFYSHQL RSKHLAIKKM NEIQKNIDGW EGKDIGQCCN EFIMEGPLTR
460 470 480 490 500
IGAKHERHIF LFDGLMISCK PNHGQTRLPG YSSAEYRLKE KFVMRKIQIC
510 520 530 540 550
DKEDTCEHKH AFELVSKDEN SIIFAAKSAE EKNNWMAALI SLHYRSTLDR
560 570 580 590 600
MLDSVLLKEE NEQPLRLPSP EVYRFVVKDS EENIVFEDNL QSRSGIPIIK
610 620 630 640 650
GGTVVKLIER LTYHMYADPN FVRTFLTTYR SFCKPQELLS LLIERFEIPE
660 670 680 690 700
PEPTDADKLA IEKGEQPISA DLKRFRKEYV QPVQLRILNV FRHWVEHHFY
710 720 730 740 750
DFERDLELLE RLESFISSVR GKAMKKWVES IAKIIRRKKQ AQANGVSHNI
760 770 780 790 800
TFESPPPPIE WHISKPGQFE TFDLMTLHPI EIARQLTLLE SDLYRKVQPS
810 820 830 840 850
ELVGSVWTKE DKEINSPNLL KMIRHTTNLT LWFEKCIVEA ENFEERVAVL
860 870 880 890 900
SRIIEILQVF QDLNNFNGVL EIVSAVNSVS VYRLDHTFEA LQERKRKILD
910 920 930 940 950
EAVELSQDHF KKYLVKLKSI NPPCVPFFGI YLTNILKTEE GNNDFLKKKG
960 970 980 990 1000
KDLINFSKRR KVAEITGEIQ QYQNQPYCLR IEPDMRRFFE NLNPMGSASE
1010 1020 1030 1040 1050
KEFTDYLFNK SLEIEPRNCK QPPRFPRKST FSLKSPGIRP NTGRHGSTSG
1060 1070 1080 1090 1100
TLRGHPTPLE REPCKISFSR IAETELESTV SAPTSPNTPS TPPVSASSDL
1110 1120 1130 1140 1150
SVFLDVDLNS SCGSNSIFAP VLLPHSKSFF SSCGSLHKLS EEPLIPPPLP
1160 1170 1180 1190 1200
PRKKFDHDAS NSKGNMKSDD DPPAIPPRQP PPPKVKPRVP VPTGAFDGPL
1210 1220 1230 1240 1250
HSPPPPPPRD PLPDTPPPVP LRPPEHFINC PFNLQPPPLG HLHRDSDWLR
1260 1270 1280 1290 1300
DISTCPNSPS TPPSTPSPRV PRRCYVLSSS QNNLAHPPAP PVPPRQNSSP
1310 1320 1330
HLPKLPPKTY KRELSHPPLY RLPLLENAET PQ
Length:1,332
Mass (Da):152,979
Last modified:February 10, 2009 - v2
Checksum:i0D1D4FAB8E37C371
GO
Isoform 2 (identifier: Q07890-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     324-356: Missing.

Note: No experimental confirmation available.

Show »
Length:1,299
Mass (Da):149,002
Checksum:iCDA5F7026EC96928
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321E → V in AAA35914. (PubMed:8493579)Curated
Sequence conflicti192 – 1921S → C in AAA35914. (PubMed:8493579)Curated
Sequence conflicti239 – 2402DI → VY in AAA35914. (PubMed:8493579)Curated
Sequence conflicti381 – 3811L → H in AAA35914. (PubMed:8493579)Curated
Sequence conflicti482 – 4821S → T in AAA35914. (PubMed:8493579)Curated
Sequence conflicti687 – 6871I → V in AAA35914. (PubMed:8493579)Curated
Sequence conflicti696 – 6961E → D in AAA35914. (PubMed:8493579)Curated
Sequence conflicti699 – 6991F → Y in AAA35914. (PubMed:8493579)Curated
Sequence conflicti778 – 7781H → D in AAA35914. (PubMed:8493579)Curated
Sequence conflicti861 – 8611Q → R in AAA91852. 1 PublicationCurated
Sequence conflicti948 – 9481K → R in AAA35914. (PubMed:8493579)Curated
Sequence conflicti999 – 9991S → C in AAA91852. 1 PublicationCurated
Sequence conflicti1032 – 10321S → E in AAA91852. 1 PublicationCurated
Sequence conflicti1042 – 10421T → A in AAA91852. 1 PublicationCurated
Sequence conflicti1112 – 11143CGS → LC in AAA91852. 1 PublicationCurated
Sequence conflicti1159 – 11591A → G in AAA91852. 1 PublicationCurated
Sequence conflicti1296 – 12961Q → E in AAA91852. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti483 – 4831S → N.
Corresponds to variant rs17122201 [ dbSNP | Ensembl ].
VAR_054327
Natural varianti508 – 5081H → Y.
Corresponds to variant rs8010237 [ dbSNP | Ensembl ].
VAR_054328
Natural varianti672 – 6721L → I.
Corresponds to variant rs34139502 [ dbSNP | Ensembl ].
VAR_034441

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei324 – 35633Missing in isoform 2. 1 PublicationVSP_054492Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13858 mRNA. Translation: AAA35914.1.
AL109758 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65727.1.
CH471078 Genomic DNA. Translation: EAW65728.1.
BC143367 mRNA. Translation: AAI43368.1.
BC117261 mRNA. Translation: AAI17262.1.
L20686 mRNA. Translation: AAA91852.1.
CCDSiCCDS9697.1. [Q07890-1]
RefSeqiNP_008870.2. NM_006939.2. [Q07890-1]
UniGeneiHs.291533.

Genome annotation databases

EnsembliENST00000216373; ENSP00000216373; ENSG00000100485. [Q07890-1]
ENST00000543680; ENSP00000445328; ENSG00000100485. [Q07890-2]
GeneIDi6655.
KEGGihsa:6655.
UCSCiuc001wxs.4. human. [Q07890-1]
uc010tql.2. human.

Polymorphism databases

DMDMi223634694.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Son of sevenless entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13858 mRNA. Translation: AAA35914.1 .
AL109758 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65727.1 .
CH471078 Genomic DNA. Translation: EAW65728.1 .
BC143367 mRNA. Translation: AAI43368.1 .
BC117261 mRNA. Translation: AAI17262.1 .
L20686 mRNA. Translation: AAA91852.1 .
CCDSi CCDS9697.1. [Q07890-1 ]
RefSeqi NP_008870.2. NM_006939.2. [Q07890-1 ]
UniGenei Hs.291533.

3D structure databases

ProteinModelPortali Q07890.
SMRi Q07890. Positions 7-179, 196-1044.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112538. 12 interactions.
IntActi Q07890. 16 interactions.
MINTi MINT-1782446.
STRINGi 9606.ENSP00000216373.

PTM databases

PhosphoSitei Q07890.

Polymorphism databases

DMDMi 223634694.

Proteomic databases

MaxQBi Q07890.
PaxDbi Q07890.
PRIDEi Q07890.

Protocols and materials databases

DNASUi 6655.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000216373 ; ENSP00000216373 ; ENSG00000100485 . [Q07890-1 ]
ENST00000543680 ; ENSP00000445328 ; ENSG00000100485 . [Q07890-2 ]
GeneIDi 6655.
KEGGi hsa:6655.
UCSCi uc001wxs.4. human. [Q07890-1 ]
uc010tql.2. human.

Organism-specific databases

CTDi 6655.
GeneCardsi GC14M050583.
H-InvDB HIX0037776.
HGNCi HGNC:11188. SOS2.
HPAi CAB004577.
HPA047368.
HPA052689.
MIMi 601247. gene.
neXtProti NX_Q07890.
PharmGKBi PA36025.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG265981.
GeneTreei ENSGT00770000120448.
HOGENOMi HOG000013040.
HOVERGENi HBG017831.
InParanoidi Q07890.
KOi K03099.
OMAi YVFNIRH.
OrthoDBi EOG7XSTD0.
PhylomeDBi Q07890.
TreeFami TF317296.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.
REACT_13638. NRAGE signals death through JNK.
REACT_18407. G alpha (12/13) signalling events.
REACT_19226. Activation of Rac.

Miscellaneous databases

ChiTaRSi SOS2. human.
GenomeRNAii 6655.
NextBioi 25943.
PROi Q07890.
SOURCEi Search...

Gene expression databases

Bgeei Q07890.
CleanExi HS_SOS2.
ExpressionAtlasi Q07890. baseline and differential.
Genevestigatori Q07890.

Family and domain databases

Gene3Di 1.10.20.10. 1 hit.
1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR000219. DH-domain.
IPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
[Graphical view ]
Pfami PF00125. Histone. 1 hit.
PF00169. PH. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF47113. SSF47113. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 1 hit.
PROSITEi PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2."
    Chardin P., Camonis J.H., Gale N.W., van Aelst L., Wigler M.H., Bar-Sagi D.
    Science 260:1338-1343(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  5. Fath I., Apiou F., Dutrillaux B., Tocque B.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 724-1296 (ISOFORM 1/2).
    Tissue: Placenta.

Entry informationi

Entry nameiSOS2_HUMAN
AccessioniPrimary (citable) accession number: Q07890
Secondary accession number(s): B7ZKT6
, D3DSB4, Q15503, Q17RN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 10, 2009
Last modified: November 26, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3