SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q07890

- SOS2_HUMAN

UniProt

Q07890 - SOS2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Son of sevenless homolog 2
Gene
SOS2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Promotes the exchange of Ras-bound GDP by GTP By similarity.

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. Rho guanyl-nucleotide exchange factor activity Source: InterPro
  3. protein binding Source: IntAct

GO - Biological processi

  1. apoptotic signaling pathway Source: Reactome
  2. axon guidance Source: Reactome
  3. neurotrophin TRK receptor signaling pathway Source: Reactome
  4. positive regulation of apoptotic process Source: Reactome
  5. positive regulation of small GTPase mediated signal transduction Source: Ensembl
  6. regulation of small GTPase mediated signal transduction Source: Reactome
  7. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.
REACT_13638. NRAGE signals death through JNK.
REACT_18407. G alpha (12/13) signalling events.
REACT_19226. Activation of Rac.

Names & Taxonomyi

Protein namesi
Recommended name:
Son of sevenless homolog 2
Short name:
SOS-2
Gene namesi
Name:SOS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:11188. SOS2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36025.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13321332Son of sevenless homolog 2
PRO_0000068896Add
BLAST

Proteomic databases

MaxQBiQ07890.
PaxDbiQ07890.
PRIDEiQ07890.

PTM databases

PhosphoSiteiQ07890.

Expressioni

Gene expression databases

ArrayExpressiQ07890.
BgeeiQ07890.
CleanExiHS_SOS2.
GenevestigatoriQ07890.

Organism-specific databases

HPAiCAB004577.
HPA047368.
HPA052689.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABL1P005192EBI-298181,EBI-375543
CRKP461082EBI-298181,EBI-886
GRB2P629938EBI-298181,EBI-401755
NCK1P163333EBI-298181,EBI-389883
PACSIN3Q9UKS62EBI-298181,EBI-77926
PLCG1P191744EBI-298181,EBI-79387
SNX9Q9Y5X12EBI-298181,EBI-77848

Protein-protein interaction databases

BioGridi112538. 12 interactions.
IntActiQ07890. 15 interactions.
MINTiMINT-1782446.
STRINGi9606.ENSP00000216373.

Structurei

3D structure databases

ProteinModelPortaliQ07890.
SMRiQ07890. Positions 7-179, 196-1044.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini198 – 388191DH
Add
BLAST
Domaini442 – 546105PH
Add
BLAST
Domaini595 – 739145N-terminal Ras-GEF
Add
BLAST
Domaini778 – 1017240Ras-GEF
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi755 – 7584Poly-Pro
Compositional biasi1180 – 11834Poly-Pro
Compositional biasi1203 – 12086Poly-Pro

Sequence similaritiesi

Contains 1 PH domain.
Contains 1 Ras-GEF domain.

Phylogenomic databases

eggNOGiNOG265981.
HOGENOMiHOG000013040.
HOVERGENiHBG017831.
InParanoidiQ07890.
KOiK03099.
OMAiYVFNIRH.
OrthoDBiEOG7XSTD0.
PhylomeDBiQ07890.
TreeFamiTF317296.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF00169. PH. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q07890-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQQAPQPYEF FSEENSPKWR GLLVSALRKV QEQVHPTLSA NEESLYYIEE     50
LIFQLLNKLC MAQPRTVQDV EERVQKTFPH PIDKWAIADA QSAIEKRKRR 100
NPLLLPVDKI HPSLKEVLGY KVDYHVSLYI VAVLEYISAD ILKLAGNYVF 150
NIRHYEISQQ DIKVSMCADK VLMDMFDQDD IGLVSLCEDE PSSSGELNYY 200
DLVRTEIAEE RQYLRELNMI IKVFREAFLS DRKLFKPSDI EKIFSNISDI 250
HELTVKLLGL IEDTVEMTDE SSPHPLAGSC FEDLAEEQAF DPYETLSQDI 300
LSPEFHEHFN KLMARPAVAL HFQSIADGFK EAVRYVLPRL MLVPVYHCWH 350
YFELLKQLKA CSEEQEDREC LNQAITALMN LQGSMDRIYK QYSPRRRPGD 400
PVCPFYSHQL RSKHLAIKKM NEIQKNIDGW EGKDIGQCCN EFIMEGPLTR 450
IGAKHERHIF LFDGLMISCK PNHGQTRLPG YSSAEYRLKE KFVMRKIQIC 500
DKEDTCEHKH AFELVSKDEN SIIFAAKSAE EKNNWMAALI SLHYRSTLDR 550
MLDSVLLKEE NEQPLRLPSP EVYRFVVKDS EENIVFEDNL QSRSGIPIIK 600
GGTVVKLIER LTYHMYADPN FVRTFLTTYR SFCKPQELLS LLIERFEIPE 650
PEPTDADKLA IEKGEQPISA DLKRFRKEYV QPVQLRILNV FRHWVEHHFY 700
DFERDLELLE RLESFISSVR GKAMKKWVES IAKIIRRKKQ AQANGVSHNI 750
TFESPPPPIE WHISKPGQFE TFDLMTLHPI EIARQLTLLE SDLYRKVQPS 800
ELVGSVWTKE DKEINSPNLL KMIRHTTNLT LWFEKCIVEA ENFEERVAVL 850
SRIIEILQVF QDLNNFNGVL EIVSAVNSVS VYRLDHTFEA LQERKRKILD 900
EAVELSQDHF KKYLVKLKSI NPPCVPFFGI YLTNILKTEE GNNDFLKKKG 950
KDLINFSKRR KVAEITGEIQ QYQNQPYCLR IEPDMRRFFE NLNPMGSASE 1000
KEFTDYLFNK SLEIEPRNCK QPPRFPRKST FSLKSPGIRP NTGRHGSTSG 1050
TLRGHPTPLE REPCKISFSR IAETELESTV SAPTSPNTPS TPPVSASSDL 1100
SVFLDVDLNS SCGSNSIFAP VLLPHSKSFF SSCGSLHKLS EEPLIPPPLP 1150
PRKKFDHDAS NSKGNMKSDD DPPAIPPRQP PPPKVKPRVP VPTGAFDGPL 1200
HSPPPPPPRD PLPDTPPPVP LRPPEHFINC PFNLQPPPLG HLHRDSDWLR 1250
DISTCPNSPS TPPSTPSPRV PRRCYVLSSS QNNLAHPPAP PVPPRQNSSP 1300
HLPKLPPKTY KRELSHPPLY RLPLLENAET PQ 1332
Length:1,332
Mass (Da):152,979
Last modified:February 10, 2009 - v2
Checksum:i0D1D4FAB8E37C371
GO
Isoform 2 (identifier: Q07890-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     324-356: Missing.

Note: No experimental confirmation available.

Show »
Length:1,299
Mass (Da):149,002
Checksum:iCDA5F7026EC96928
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti483 – 4831S → N.
Corresponds to variant rs17122201 [ dbSNP | Ensembl ].
VAR_054327
Natural varianti508 – 5081H → Y.
Corresponds to variant rs8010237 [ dbSNP | Ensembl ].
VAR_054328
Natural varianti672 – 6721L → I.
Corresponds to variant rs34139502 [ dbSNP | Ensembl ].
VAR_034441

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei324 – 35633Missing in isoform 2.
VSP_054492Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321E → V in AAA35914. 1 Publication
Sequence conflicti192 – 1921S → C in AAA35914. 1 Publication
Sequence conflicti239 – 2402DI → VY in AAA35914. 1 Publication
Sequence conflicti381 – 3811L → H in AAA35914. 1 Publication
Sequence conflicti482 – 4821S → T in AAA35914. 1 Publication
Sequence conflicti687 – 6871I → V in AAA35914. 1 Publication
Sequence conflicti696 – 6961E → D in AAA35914. 1 Publication
Sequence conflicti699 – 6991F → Y in AAA35914. 1 Publication
Sequence conflicti778 – 7781H → D in AAA35914. 1 Publication
Sequence conflicti861 – 8611Q → R in AAA91852. 1 Publication
Sequence conflicti948 – 9481K → R in AAA35914. 1 Publication
Sequence conflicti999 – 9991S → C in AAA91852. 1 Publication
Sequence conflicti1032 – 10321S → E in AAA91852. 1 Publication
Sequence conflicti1042 – 10421T → A in AAA91852. 1 Publication
Sequence conflicti1112 – 11143CGS → LC in AAA91852. 1 Publication
Sequence conflicti1159 – 11591A → G in AAA91852. 1 Publication
Sequence conflicti1296 – 12961Q → E in AAA91852. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13858 mRNA. Translation: AAA35914.1.
AL109758 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65727.1.
CH471078 Genomic DNA. Translation: EAW65728.1.
BC143367 mRNA. Translation: AAI43368.1.
BC117261 mRNA. Translation: AAI17262.1.
L20686 mRNA. Translation: AAA91852.1.
CCDSiCCDS9697.1. [Q07890-1]
RefSeqiNP_008870.2. NM_006939.2. [Q07890-1]
UniGeneiHs.291533.

Genome annotation databases

EnsembliENST00000216373; ENSP00000216373; ENSG00000100485.
ENST00000543680; ENSP00000445328; ENSG00000100485.
GeneIDi6655.
KEGGihsa:6655.
UCSCiuc001wxs.4. human. [Q07890-1]

Polymorphism databases

DMDMi223634694.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Son of sevenless entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13858 mRNA. Translation: AAA35914.1 .
AL109758 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65727.1 .
CH471078 Genomic DNA. Translation: EAW65728.1 .
BC143367 mRNA. Translation: AAI43368.1 .
BC117261 mRNA. Translation: AAI17262.1 .
L20686 mRNA. Translation: AAA91852.1 .
CCDSi CCDS9697.1. [Q07890-1 ]
RefSeqi NP_008870.2. NM_006939.2. [Q07890-1 ]
UniGenei Hs.291533.

3D structure databases

ProteinModelPortali Q07890.
SMRi Q07890. Positions 7-179, 196-1044.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112538. 12 interactions.
IntActi Q07890. 15 interactions.
MINTi MINT-1782446.
STRINGi 9606.ENSP00000216373.

PTM databases

PhosphoSitei Q07890.

Polymorphism databases

DMDMi 223634694.

Proteomic databases

MaxQBi Q07890.
PaxDbi Q07890.
PRIDEi Q07890.

Protocols and materials databases

DNASUi 6655.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000216373 ; ENSP00000216373 ; ENSG00000100485 .
ENST00000543680 ; ENSP00000445328 ; ENSG00000100485 .
GeneIDi 6655.
KEGGi hsa:6655.
UCSCi uc001wxs.4. human. [Q07890-1 ]

Organism-specific databases

CTDi 6655.
GeneCardsi GC14M050583.
H-InvDB HIX0037776.
HGNCi HGNC:11188. SOS2.
HPAi CAB004577.
HPA047368.
HPA052689.
MIMi 601247. gene.
neXtProti NX_Q07890.
PharmGKBi PA36025.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG265981.
HOGENOMi HOG000013040.
HOVERGENi HBG017831.
InParanoidi Q07890.
KOi K03099.
OMAi YVFNIRH.
OrthoDBi EOG7XSTD0.
PhylomeDBi Q07890.
TreeFami TF317296.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.
REACT_13638. NRAGE signals death through JNK.
REACT_18407. G alpha (12/13) signalling events.
REACT_19226. Activation of Rac.

Miscellaneous databases

ChiTaRSi SOS2. human.
GenomeRNAii 6655.
NextBioi 25943.
PROi Q07890.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q07890.
Bgeei Q07890.
CleanExi HS_SOS2.
Genevestigatori Q07890.

Family and domain databases

Gene3Di 1.10.20.10. 1 hit.
1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR000219. DH-domain.
IPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view ]
Pfami PF00125. Histone. 1 hit.
PF00169. PH. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF47113. SSF47113. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 1 hit.
PROSITEi PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2."
    Chardin P., Camonis J.H., Gale N.W., van Aelst L., Wigler M.H., Bar-Sagi D.
    Science 260:1338-1343(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  5. Fath I., Apiou F., Dutrillaux B., Tocque B.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 724-1296 (ISOFORM 1/2).
    Tissue: Placenta.

Entry informationi

Entry nameiSOS2_HUMAN
AccessioniPrimary (citable) accession number: Q07890
Secondary accession number(s): B7ZKT6
, D3DSB4, Q15503, Q17RN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi