Son of sevenless homolog 2 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q07890 (SOS2_HUMAN)

Last modified July 7, 2009. Version 81. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Son of sevenless homolog 2
Short name=SOS-2

Gene names

Name:

SOS2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	1332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function

Promotes the exchange of Ras-bound GDP by GTP By similarity.

Sequence similarities

Contains 1 DH (DBL-homology) domain.

Contains 1 N-terminal Ras-GEF domain.

Contains 1 PH domain.

Contains 1 Ras-GEF domain.

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Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Guanine-nucleotide releasing factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro small GTPase mediated signal transduction Non-traceable author statement. Source: UniProtKB
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
ABL1	P00519	1	EBI-298181,EBI-375543
CD2AP	Q9Y5K6	1	EBI-298181,EBI-298152
CRK	P46108	1	EBI-298181,EBI-886
FYN	P06241	1	EBI-298181,EBI-515315
GRB2	P62993	3	EBI-298181,EBI-401755
NCK1	P16333	1	EBI-298181,EBI-389883
PACSIN3	Q9UKS6	2	EBI-298181,EBI-77926
PIK3R1	P27986	1	EBI-298181,EBI-79464
PLCG1	P19174	2	EBI-298181,EBI-79387
SNX18	Q96RF0	1	EBI-298181,EBI-298169
SNX9	Q9Y5X1	2	EBI-298181,EBI-77848
SRC	P12931	1	EBI-298181,EBI-621482

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1332

1332

Son of sevenless homolog 2

PRO_0000068896

Regions

Domain

198 – 388

191

Domain

442 – 546

105

Domain

595 – 739

145

N-terminal Ras-GEF

Domain

778 – 1017

240

Ras-GEF

Compositional bias

755 – 758

Poly-Pro

Compositional bias

1180 – 1183

Poly-Pro

Compositional bias

1203 – 1208

Poly-Pro

Natural variations

Natural variant

483

S → N: dbSNP rs17122201.

VAR_054327

Natural variant

508

H → Y: dbSNP rs8010237.

VAR_054328

Natural variant

672

L → I: dbSNP rs34139502.

VAR_034441

Experimental info

Sequence conflict

E → V in AAA35914. Ref.1

Sequence conflict

192

S → C in AAA35914. Ref.1

Sequence conflict

239 – 240

DI → VY in AAA35914. Ref.1

Sequence conflict

381

L → H in AAA35914. Ref.1

Sequence conflict

482

S → T in AAA35914. Ref.1

Sequence conflict

687

I → V in AAA35914. Ref.1

Sequence conflict

696

E → D in AAA35914. Ref.1

Sequence conflict

699

F → Y in AAA35914. Ref.1

Sequence conflict

778

H → D in AAA35914. Ref.1

Sequence conflict

861

Q → R in AAA91852. Ref.4

Sequence conflict

948

K → R in AAA35914. Ref.1

Sequence conflict

999

S → C in AAA91852. Ref.4

Sequence conflict

1032

S → E in AAA91852. Ref.4

Sequence conflict

1042

T → A in AAA91852. Ref.4

Sequence conflict

1112 – 1114

CGS → LC in AAA91852. Ref.4

Sequence conflict

1159

A → G in AAA91852. Ref.4

Sequence conflict

1296

Q → E in AAA91852. Ref.4

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Sequences

Sequence

Length

Mass (Da)

Tools

Q07890-1 [UniParc].

Last modified February 10, 2009. Version 2.
Checksum: 0D1D4FAB8E37C371
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FASTA

1,332

152,979

        10         20         30         40         50         60 
MQQAPQPYEF FSEENSPKWR GLLVSALRKV QEQVHPTLSA NEESLYYIEE LIFQLLNKLC 

        70         80         90        100        110        120 
MAQPRTVQDV EERVQKTFPH PIDKWAIADA QSAIEKRKRR NPLLLPVDKI HPSLKEVLGY 

       130        140        150        160        170        180 
KVDYHVSLYI VAVLEYISAD ILKLAGNYVF NIRHYEISQQ DIKVSMCADK VLMDMFDQDD 

       190        200        210        220        230        240 
IGLVSLCEDE PSSSGELNYY DLVRTEIAEE RQYLRELNMI IKVFREAFLS DRKLFKPSDI 

       250        260        270        280        290        300 
EKIFSNISDI HELTVKLLGL IEDTVEMTDE SSPHPLAGSC FEDLAEEQAF DPYETLSQDI 

       310        320        330        340        350        360 
LSPEFHEHFN KLMARPAVAL HFQSIADGFK EAVRYVLPRL MLVPVYHCWH YFELLKQLKA 

       370        380        390        400        410        420 
CSEEQEDREC LNQAITALMN LQGSMDRIYK QYSPRRRPGD PVCPFYSHQL RSKHLAIKKM 

       430        440        450        460        470        480 
NEIQKNIDGW EGKDIGQCCN EFIMEGPLTR IGAKHERHIF LFDGLMISCK PNHGQTRLPG 

       490        500        510        520        530        540 
YSSAEYRLKE KFVMRKIQIC DKEDTCEHKH AFELVSKDEN SIIFAAKSAE EKNNWMAALI 

       550        560        570        580        590        600 
SLHYRSTLDR MLDSVLLKEE NEQPLRLPSP EVYRFVVKDS EENIVFEDNL QSRSGIPIIK 

       610        620        630        640        650        660 
GGTVVKLIER LTYHMYADPN FVRTFLTTYR SFCKPQELLS LLIERFEIPE PEPTDADKLA 

       670        680        690        700        710        720 
IEKGEQPISA DLKRFRKEYV QPVQLRILNV FRHWVEHHFY DFERDLELLE RLESFISSVR 

       730        740        750        760        770        780 
GKAMKKWVES IAKIIRRKKQ AQANGVSHNI TFESPPPPIE WHISKPGQFE TFDLMTLHPI 

       790        800        810        820        830        840 
EIARQLTLLE SDLYRKVQPS ELVGSVWTKE DKEINSPNLL KMIRHTTNLT LWFEKCIVEA 

       850        860        870        880        890        900 
ENFEERVAVL SRIIEILQVF QDLNNFNGVL EIVSAVNSVS VYRLDHTFEA LQERKRKILD 

       910        920        930        940        950        960 
EAVELSQDHF KKYLVKLKSI NPPCVPFFGI YLTNILKTEE GNNDFLKKKG KDLINFSKRR 

       970        980        990       1000       1010       1020 
KVAEITGEIQ QYQNQPYCLR IEPDMRRFFE NLNPMGSASE KEFTDYLFNK SLEIEPRNCK 

      1030       1040       1050       1060       1070       1080 
QPPRFPRKST FSLKSPGIRP NTGRHGSTSG TLRGHPTPLE REPCKISFSR IAETELESTV 

      1090       1100       1110       1120       1130       1140 
SAPTSPNTPS TPPVSASSDL SVFLDVDLNS SCGSNSIFAP VLLPHSKSFF SSCGSLHKLS 

      1150       1160       1170       1180       1190       1200 
EEPLIPPPLP PRKKFDHDAS NSKGNMKSDD DPPAIPPRQP PPPKVKPRVP VPTGAFDGPL 

      1210       1220       1230       1240       1250       1260 
HSPPPPPPRD PLPDTPPPVP LRPPEHFINC PFNLQPPPLG HLHRDSDWLR DISTCPNSPS 

      1270       1280       1290       1300       1310       1320 
TPPSTPSPRV PRRCYVLSSS QNNLAHPPAP PVPPRQNSSP HLPKLPPKTY KRELSHPPLY 

      1330 
RLPLLENAET PQ

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2." Chardin P., Camonis J.H., Gale N.W., van Aelst L., Wigler M.H., Bar-Sagi D. Science 260:1338-1343(1993) [PubMed: 8493579] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	Fath I., Apiou F., Dutrillaux B., Tocque B. Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 724-1296. Tissue: Placenta.
+	Additional computationally mapped references.

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Web resources

Wikipedia

Son of sevenless entry

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Cross-references

Sequence databases
	L13858 mRNA. Translation: AAA35914.1. CH471078 Genomic DNA. Translation: EAW65727.1. BC117261 mRNA. Translation: AAI17262.1. L20686 mRNA. Translation: AAA91852.1.
IPI	IPI00020134.
RefSeq	NP_008870.2.
UniGene	Hs.291533
3D structure databases
HSSP	HSSP built from PDB template 1NVU based on UniProtKB Q07889.
SMR	Q07890. Positions 7-179, 196-1044.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q07890. 12 interactions.
PTM databases
PhosphoSite	Q07890.
Proteomic databases
PRIDE	Q07890.
Genome annotation databases
Ensembl	ENSG00000100485. Homo sapiens. [Contig view]
GeneID	6655.
Organism-specific databases
GeneCards	GC14M049654.
H-InvDB	HIX0037776.
HGNC	HGNC:11188. SOS2.
HPA	CAB004577.
MIM	601247. gene.
PharmGKB	PA36025.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q07890.
HOVERGEN	Q07890.
OMA	Q07890. GLMISCK.
Enzyme and pathway databases
Reactome	REACT_11044. Signaling by Rho GTPases.
Gene expression databases
ArrayExpress	Q07890.
Bgee	Q07890.
CleanEx	HS_SOS2.
GermOnline	ENSG00000100485. Homo sapiens.
Family and domain databases
InterPro	IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR009072. Histone-fold. IPR007125. Histone_core_D. IPR011993. PH_type. IPR001849. Pleckstrin_homology. IPR019804. Ras_G-nucl-exch_fac_CS. IPR008937. Ras_GEF. IPR000651. RasGef_N. IPR001895. RasGRF_CDC25. IPR015759. Sos. [Graphical view]
Gene3D	G3DSA:1.10.20.10. Histone-fold. 1 hit. G3DSA:2.30.29.30. PH_type. 1 hit. G3DSA:1.10.840.10. RasGRF_CDC25. 1 hit. G3DSA:1.20.900.10. RhoGEF. 1 hit.
PANTHER	PTHR23113. Ras_GEF. 1 hit. PTHR23113:SF47. Sos. 1 hit.
Pfam	PF00125. Histone. 1 hit. PF00169. PH. 1 hit. PF00617. RasGEF. 1 hit. PF00618. RasGEF_N. 1 hit. PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. SM00147. RasGEF. 1 hit. SM00229. RasGEFN. 1 hit. SM00325. RhoGEF. 1 hit. [Graphical view]
PROSITE	PS00741. DH_1. False negative. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00720. RASGEF. 1 hit. PS50009. RASGEF_CAT. 1 hit. PS50212. RASGEF_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

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Entry information

Entry name

SOS2_HUMAN

Accession

Primary (citable) accession number: Q07890
Secondary accession number(s): Q15503, Q17RN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	February 10, 2009
Last modified:	July 7, 2009
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents