Reviewed, UniProtKB/Swiss-Prot Q07889 (SOS1_HUMAN)

Names and origin

Protein names

Recommended name:
    Son of sevenless homolog 1
      Short name=SOS-1

Gene names

Name:

SOS1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1333 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Promotes the exchange of Ras-bound GDP by GTP.
Subunit structure	Interacts with GRB2. Forms a complex with phosphorylated MUC1 and GRB2 (via its SH3 domains). Interacts with phosphorylated LAT2. Ref.4 Ref.5
Tissue specificity	Expressed in gingival tissues. Ref.11
Involvement in disease	Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also known as GINGF1. Gingival fibromatosis is a rare overgrowth condition characterized by a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva. GGF1 is usually transmitted as an autosomal dominant trait, although sporadic cases are common. Ref.11 Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Rarely, NS4 is associated with juvenile myelomonocytic leukemia (JMML). SOS1 mutations engender a high prevalence of pulmonary valve disease; atrial septal defects are less common. Ref.12 Ref.13
Sequence similarities	Contains 1 DH (DBL-homology) domain. Contains 1 N-terminal Ras-GEF domain. Contains 1 PH domain. Contains 1 Ras-GEF domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Disease	Disease mutation
Molecular function	Guanine-nucleotide releasing factor
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	Ras protein signal transduction Ref.1 Inferred from Experiment. Source: Reactome apoptosis Inferred from Experiment. Source: Reactome induction of apoptosis by extracellular signals Inferred from Experiment. Source: Reactome regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Ref.1 Inferred from Experiment. Source: Reactome
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro Rho GTPase activator activity Ref.10 Traceable author statement. Source: ProtInc Rho guanyl-nucleotide exchange factor activity Ref.10 Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CD2AP	Q9Y5K6	1	EBI-297487,EBI-298152
CRK	P46108	1	EBI-297487,EBI-886
FYN	P06241	1	EBI-297487,EBI-515315
GRB2	P62993	3	EBI-297487,EBI-401755
HCK	P08631	1	EBI-297487,EBI-346340
HRAS	P01112	1	EBI-297487,EBI-350145
NCK1	P16333	2	EBI-297487,EBI-389883
PACSIN3	Q9UKS6	2	EBI-297487,EBI-77926
PIK3R1	P27986	1	EBI-297487,EBI-79464
PLCG1	P19174	1	EBI-297487,EBI-79387
SNX18	Q96RF0	1	EBI-297487,EBI-298169
SNX9	Q9Y5X1	2	EBI-297487,EBI-77848
SRC	P12931	1	EBI-297487,EBI-621482

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1333

1333

Son of sevenless homolog 1

PRO_0000068894

Regions

Domain

200 – 390

191

DH

Domain

444 – 548

105

PH

Domain

597 – 741

145

N-terminal Ras-GEF

Domain

780 – 1019

240

Ras-GEF

Compositional bias

1258 – 1261

4

Poly-Pro

Amino acid modifications

Modified residue

1043

1

Phosphoserine

Modified residue

1078

1

Phosphoserine By similarity

Modified residue

1082

1

Phosphoserine Ref.6

Modified residue

1134

1

Phosphoserine Ref.7

Modified residue

1137

1

Phosphoserine Ref.7

Modified residue

1210

1

Phosphoserine Ref.6

Natural variations

Natural variant

108

1

E → K in NS4. Ref.13

VAR_030423

Natural variant

266

1

T → K in NS4. Ref.12

VAR_030424

Natural variant

269

1

M → R in NS4. Ref.12 Ref.13

VAR_030425

Natural variant

309

1

D → Y in NS4. Ref.12

VAR_030426

Natural variant

337

1

Y → C in NS4. Ref.12

VAR_030427

Natural variant

432

1

W → R in NS4. Ref.13

VAR_030428

Natural variant

433

1

E → K in NS4. Ref.13

VAR_030429

Natural variant

434

1

G → R in NS4. Ref.12

VAR_030430

Natural variant

441

1

C → Y in NS4. Ref.13

VAR_030431

Natural variant

548

1

S → R in NS4. Ref.12 Ref.13

VAR_030432

Natural variant

550

1

L → P in NS4. Ref.13

VAR_030433

Natural variant

552

1

R → G in NS4; increases the basal level of active RAS; prolonges RAS activation after EGF stimulation and enhances ERK activation. Ref.12 Ref.13

VAR_030434

Natural variant

552

1

R → K in NS4. Ref.13

VAR_030435

Natural variant

552

1

R → S in NS4. Ref.13

VAR_030436

Natural variant

655

1

P → L: dbSNP rs56219475. Ref.12 Ref.13

VAR_030437

Natural variant

702

1

Y → H in NS4. Ref.13

VAR_030438

Natural variant

729

1

W → L in NS4; promotes constitutive RAS activation and enhances ERK activation. Ref.13

VAR_030439

Natural variant

733

1

I → F in NS4. Ref.13

VAR_030440

Natural variant

846

1

E → K in NS4. Ref.12 Ref.13

VAR_030441

Natural variant

977

1

Q → R

VAR_030442

Natural variant

1320

1

H → R

VAR_030443

Secondary structure

1

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1333

Helix Strand Turn

Details...

Turn

13 – 15

3

Helix

16 – 19

4

Helix

24 – 34

11

Beta strand

36 – 39

4

Helix

42 – 60

19

Helix

69 – 76

8

Helix

82 – 94

13

Helix

107 – 118

12

Helix

124 – 152

29

Helix

159 – 167

9

Helix

170 – 175

6

Helix

201 – 224

24

Turn

225 – 227

3

Helix

228 – 232

5

Turn

234 – 236

3

Helix

239 – 246

8

Helix

249 – 268

20

Beta strand

274 – 276

3

Helix

280 – 288

9

Turn

289 – 292

4

Helix

293 – 302

10

Helix

307 – 316

10

Helix

320 – 327

8

Helix

331 – 337

7

Helix

339 – 342

4

Helix

345 – 363

19

Helix

367 – 379

13

Helix

381 – 392

12

Helix

394 – 402

9

Helix

420 – 426

7

Beta strand

429 – 431

3

Helix

437 – 439

3

Beta strand

444 – 452

9

Beta strand

459 – 473

15

Beta strand

487 – 496

10

Beta strand

500 – 503

4

Beta strand

507 – 509

3

Beta strand

512 – 516

5

Beta strand

524 – 527

4

Helix

531 – 545

15

Turn

546 – 549

4

Helix

551 – 561

11

Turn

572 – 574

3

Helix

576 – 578

3

Turn

583 – 585

3

Beta strand

586 – 588

3

Beta strand

601 – 604

4

Helix

606 – 613

8

Helix

621 – 630

10

Helix

631 – 633

3

Helix

637 – 648

12

Helix

657 – 664

8

Helix

672 – 680

9

Helix

682 – 699

18

Helix

702 – 706

5

Helix

708 – 720

13

Turn

724 – 726

3

Helix

727 – 742

16

Turn

771 – 773

3

Turn

776 – 778

3

Helix

781 – 797

17

Helix

801 – 803

3

Helix

805 – 810

6

Helix

814 – 817

4

Helix

819 – 840

22

Helix

845 – 864

20

Helix

868 – 878

11

Helix

881 – 884

4

Helix

887 – 891

5

Helix

895 – 921

27

Helix

931 – 942

12

Beta strand

946 – 950

5

Beta strand

953 – 957

5

Helix

958 – 975

18

Helix

985 – 992

8

Turn

996 – 999

4

Helix

1002 – 1016

15

Sequences

	Sequence		Length	Mass (Da)
	Q07889-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C6B99CCA11A8DE45	FASTA	1,333	152,464
	10 20 30 40 50 60 MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES NDDALQYVEE LILQLLNMLC 70 80 90 100 110 120 QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR NPLSLPVEKI HPLLKEVLGY 130 140 150 160 170 180 KIDHQVSVYI VAVLEYISAD ILKLVGNYVR NIRHYEITKQ DIKVAMCADK VLMDMFHQDV 190 200 210 220 230 240 EDINILSLTD EEPSTSGEQT YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSAN 250 260 270 280 290 300 DVENIFSRIV DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR 310 320 330 340 350 360 DILRPGFHDR FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC LHYFELLKQL 370 380 390 400 410 420 EEKSEDQEDK ECLKQAITAL LNVQSGMEKI CSKSLAKRRL SESACRFYSQ QMKGKQLAIK 430 440 450 460 470 480 KMNEIQKNID GWEGKDIGQC CNEFIMEGTL TRVGAKHERH IFLFDGLMIC CKSNHGQPRL 490 500 510 520 530 540 PGASNAEYRL KEKFFMRKVQ INDKDDTNEY KHAFEIILKD ENSVIFSAKS AEEKNNWMAA 550 560 570 580 590 600 LISLQYRSTL ERMLDVTMLQ EEKEEQMRLP SADVYRFAEP DSEENIIFEE NMQPKAGIPI 610 620 630 640 650 660 IKAGTVIKLI ERLTYHMYAD PNFVRTFLTT YRSFCKPQEL LSLIIERFEI PEPEPTEADR 670 680 690 700 710 720 IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH FYDFERDAYL LQRMEEFIGT 730 740 750 760 770 780 VRGKAMKKWV ESITKIIQRK KIARDNGPGH NITFQSSPPT VEWHISRPGH IETFDLLTLH 790 800 810 820 830 840 PIEIARQLTL LESDLYRAVQ PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV 850 860 870 880 890 900 ETENLEERVA VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI 910 920 930 940 950 960 LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLKR HGKELINFSK 970 980 990 1000 1010 1020 RRKVAEITGE IQQYQNQPYC LRVESDIKRF FENLNPMGNS MEKEFTDYLF NKSLEIEPRN 1030 1040 1050 1060 1070 1080 PKPLPRFPKK YSYPLKSPGV RPSNPRPGTM RHPTPLQQEP RKISYSRIPE SETESTASAP 1090 1100 1110 1120 1130 1140 NSPRTPLTPP PASGASSTTD VCSVFDSDHS SPFHSSNDTV FIQVTLPHGP RSASVSSISL 1150 1160 1170 1180 1190 1200 TKGTDEVPVP PPVPPRRRPE SAPAESSPSK IMSKHLDSPP AIPPRQPTSK AYSPRYSISD 1210 1220 1230 1240 1250 1260 RTSISDPPES PPLLPPREPV RTPDVFSSSP LHLQPPPLGK KSDHGNAFFP NSPSPFTPPP 1270 1280 1290 1300 1310 1320 PQTPSPHGTR RHLPSPPLTQ EVDLHSIAGP PVPPRQSTSQ HIPKLPPKTY KREHTHPSMH 1330 RDGPPLLENA HSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2." Chardin P., Camonis J.H., Gale N.W., van Aelst L., Wigler M.H., Bar-Sagi D. Science 260:1338-1343(1993) [PubMed: 8493579] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thalamus.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein." Pandey P., Kharbanda S., Kufe D. Cancer Res. 55:4000-4003(1995) [PubMed: 7664271] [Abstract] Cited for: IDENTIFICATION IN A COMPLEX WITH MUC1 AND GRB2, INTERACTION WITH MUC1.
[5]	"Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling." Brdicka T., Imrich M., Angelisova P., Brdickova N., Horvath O., Spicka J., Hilgert I., Luskova P., Draber P., Novak P., Engels N., Wienands J., Simeoni L., Oesterreicher J., Aguado E., Malissen M., Schraven B., Horejsi V. J. Exp. Med. 196:1617-1626(2002) [PubMed: 12486104] [Abstract] Cited for: INTERACTION WITH LAT2.
[6]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1082 AND SER-1210, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1134 AND SER-1137, MASS SPECTROMETRY.
[8]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[9]	"The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains." Zheng J., Chen R.H., Corblan-Garcia S., Cahill S.M., Bar-Sagi D., Cowburn D. J. Biol. Chem. 272:30340-30344(1997) [PubMed: 9374522] [Abstract] Cited for: STRUCTURE BY NMR OF 422-551.
[10]	"Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein." Soisson S.M., Nimnual A.S., Uy M., Bar-Sagi D., Kuriyan J. Cell 95:259-268(1998) [PubMed: 9790532] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 198-551.
[11]	"A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1." Hart T.C., Zhang Y., Gorry M.C., Hart P.S., Cooper M., Marazita M.L., Marks J.M., Cortelli J.R., Pallos D. Am. J. Hum. Genet. 70:943-954(2002) [PubMed: 11868160] [Abstract] Cited for: INVOLVEMENT IN GGF1, TISSUE SPECIFICITY.
[12]	"Germline gain-of-function mutations in SOS1 cause Noonan syndrome." Roberts A.E., Araki T., Swanson K.D., Montgomery K.T., Schiripo T.A., Joshi V.A., Li L., Yassin Y., Tamburino A.M., Neel B.G., Kucherlapati R.S. Nat. Genet. 39:70-74(2007) [PubMed: 17143285] [Abstract] Cited for: VARIANTS NS4 LYS-266; ARG-269; TYR-309; CYS-337; ARG-434; ARG-548; GLY-552 AND LYS-846, VARIANT LEU-655.
[13]	"Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome." Tartaglia M., Pennacchio L.A., Zhao C., Yadav K.K., Fodale V., Sarkozy A., Pandit B., Oishi K., Martinelli S., Schackwitz W., Ustaszewska A., Martin J., Bristow J., Carta C., Lepri F., Neri C., Vasta I., Gibson K. , Curry C.J., Lopez Siguero J.P., Digilio M.C., Zampino G., Dallapiccola B., Bar-Sagi D., Gelb B.D. Nat. Genet. 39:75-79(2007) [PubMed: 17143282] [Abstract] Cited for: VARIANTS NS4 LYS-108; ARG-269; ARG-432; LYS-433; TYR-441; ARG-548; PRO-550; GLY-552; LYS-552; SER-552; HIS-702; LEU-729; PHE-733 AND LYS-846, VARIANTS LEU-655; ARG-977 AND ARG-1320, CHARACTERIZATION OF VARIANTS NS4 GLY-552 AND LEU-729.
+	Additional computationally mapped references.

Web resources

GeneReviews

Wikipedia

Son of sevenless entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L13857 mRNA. Translation: AAA35913.1.
AK290228 mRNA. Translation: BAF82917.1.
CH471053 Genomic DNA. Translation: EAX00351.1.

IPI

IPI00020131.

PIR

A37488.

RefSeq

NP_005624.2.

UniGene

Hs.709893

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1AWE	NMR	-	A	422-551	[»]
1BKD	X-ray	2.80	S	568-1044	[»]
1DBH	X-ray	2.30	A	198-551	[»]
1NVU	X-ray	2.20	S	566-1046	[»]
1NVV	X-ray	2.18	S	566-1046	[»]
1NVW	X-ray	2.70	S	566-1046	[»]
1NVX	X-ray	3.20	S	566-1046	[»]
1Q9C	X-ray	3.21	A/B/C/D/E/F/G/H/I	1-191	[»]
1XD2	X-ray	2.70	C	566-1049	[»]
1XD4	X-ray	3.64	A/B	198-1049	[»]
1XDV	X-ray	4.10	A/B	198-1044	[»]
2II0	X-ray	2.02	A	564-1049	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q07889. 16 interactions.

STRING

Q07889.

PTM databases

PhosphoSite

Q07889.

Proteomic databases

PRIDE

Q07889.

Genome annotation databases

Ensembl

ENST00000402219; ENSP00000384675; ENSG00000115904; Homo sapiens. [Genome view]
ENST00000426016; ENSP00000387784; ENSG00000115904; Homo sapiens. [Genome view]

GeneID

6654.

KEGG

hsa:6654.

UCSC

uc002rrk.2. human.

Organism-specific databases

CTD

6654.

GeneCards

GC02M039124.

H-InvDB

HIX0001994.

HGNC

HGNC:11187. SOS1.

HPA

CAB005396.
HPA012613.

MIM

135300. phenotype.
182530. gene.
610733. phenotype.

Orphanet

2024. Gingival fibromatosis, dominant.
648. Noonan syndrome.

PharmGKB

PA36024.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG16201.

HOGENOM

HBG356861.

HOVERGEN

Q07889.

InParanoid

Q07889.

OMA

GPPLLEN.

OrthoDB

EOG92NMKT.

PhylomeDB

Q07889.

Enzyme and pathway databases

Pathway_Interaction_DB

bcr_5pathway. BCR signaling pathway.
pi3kcipathway. Class I PI3K signaling events.
endothelinpathway. Endothelins.
epopathway. EPO signaling pathway.
fcer1pathway. Fc-epsilon receptor I signaling in mast cells.
fgf_pathway. FGF signaling pathway.
igf1_pathway. IGF1 pathway.
il2_pi3kpathway. IL2 signaling events mediated by PI3K.
il2_stat5pathway. IL2 signaling events mediated by STAT5.
il2_1pathway. IL2-mediated signaling events.
il6_7pathway. IL6-mediated signaling events.
insulin_pathway. Insulin Pathway.
trkrpathway. Neurotrophic factor-mediated Trk receptor signaling.
pdgfrapathway. PDGFR-alpha signaling pathway.
pdgfrbpathway. PDGFR-beta signaling pathway.
er_nongenomic_pathway. Plasma membrane estrogen receptor signaling.
met_pathway. Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met).
kitpathway. Signaling events mediated by Stem cell factor receptor (c-Kit).
vegfr1_2_pathway. Signaling events mediated by VEGFR1 and VEGFR2.
ret_pathway. Signaling events regulated by Ret tyrosine kinase.
tcrpathway. TCR signaling in naive CD4+ T cells.
cd8tcrpathway. TCR signaling in naive CD8+ T cells.
tgfbrpathway. TGF-beta receptor signaling.
pi3kplctrkpathway. Trk receptor signaling mediated by PI3K and PLC-gamma.
lymphangiogenesis_pathway. VEGFR3 signaling in lymphatic endothelium.

Reactome

REACT_11044. Signaling by Rho GTPases.
REACT_11061. Signalling by NGF.
REACT_13552. Integrin cell surface interactions.
REACT_14797. Signaling by GPCR.
REACT_16888. Signaling by PDGF.
REACT_18266. Axon guidance.
REACT_498. Signaling by Insulin receptor.
REACT_508. Signal attenuation.
REACT_604. Hemostasis.
REACT_6900. Signaling in Immune system.
REACT_9417. Signaling by EGFR.

Gene expression databases

ArrayExpress

Q07889.

Bgee

Q07889.

CleanEx

HS_SOS1.

Genevestigator

Q07889.

GermOnline

ENSG00000115904. Homo sapiens.

Family and domain databases

InterPro

IPR000219. DH-domain.
IPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR011993. PH_type.
IPR001849. Pleckstrin_homology.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR008937. Ras_GEF.
IPR001895. RasGRF_CDC25.
IPR015759. Sos.
[Graphical view]

Gene3D

G3DSA:1.10.20.10. Histone-fold. 1 hit.
G3DSA:2.30.29.30. PH_type. 1 hit.
G3DSA:1.10.840.10. RasGRF_CDC25. 2 hits.
G3DSA:1.20.900.10. RhoGEF. 1 hit.

PANTHER

PTHR23113. Ras_GEF. 1 hit.
PTHR23113:SF47. Sos. 1 hit.

Pfam

PF00125. Histone. 1 hit.
PF00169. PH. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]

SMART

SM00233. PH. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]

PROSITE

PS00741. DH_1. False negative.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

ProtoNet

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Other Resources

NextBio

25939.

SOURCE

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Entry information

Entry name

SOS1_HUMAN

Accession

Primary (citable) accession number: Q07889
Secondary accession number(s): A8K2G3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.