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Protein

Interleukin-2

Gene

IL2

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
Gene namesi
Name:IL2
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Chromosome B1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001548121 – 154Interleukin-2Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 126By similarity
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000012696

Structurei

3D structure databases

ProteinModelPortaliQ07885
SMRiQ07885
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J049 Eukaryota
ENOG41119SF LUCA
GeneTreeiENSGT00390000003555
HOGENOMiHOG000048727
HOVERGENiHBG007496
InParanoidiQ07885
KOiK05429
OMAiKWITFCQ
OrthoDBiEOG091G0VTZ
TreeFamiTF338200

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000779 IL-2
IPR030477 IL-2_CS
PANTHERiPTHR45426 PTHR45426, 1 hit
PfamiView protein in Pfam
PF00715 IL2, 1 hit
PRINTSiPR00265 INTERLEUKIN2
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649 Interleukin-2, 1 hit
SMARTiView protein in SMART
SM00189 IL2, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00424 INTERLEUKIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKIQLLSCI ALTLILVTNS APASSSTKET QQQLEQLLLD LRLLLNGVNN
60 70 80 90 100
PENPKLSRML TFKFYVPKKA TELTHLQCLV EELKPLEEVL YLAQSKNFHL
110 120 130 140 150
NHIKELMSNI NVTVLKLKGS ETRFTCNYDD ETATIVEFLN KWITFCQSIF

STLT
Length:154
Mass (Da):17,654
Last modified:October 1, 1994 - v1
Checksum:i2E71E3BD8B9665EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3 – 4KI → RM in AAA51431 (Ref. 2) Curated2
Sequence conflicti150F → I in AAA51431 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19402 mRNA Translation: AAA02865.1
L25408 mRNA Translation: AAA51431.1
PIRiJN0698
RefSeqiNP_001036802.1, NM_001043337.1

Genome annotation databases

EnsembliENSFCAT00000013692; ENSFCAP00000012696; ENSFCAG00000013688
GeneIDi751114
KEGGifca:751114

Similar proteinsi

Entry informationi

Entry nameiIL2_FELCA
AccessioniPrimary (citable) accession number: Q07885
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health