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Q07885

- IL2_FELCA

UniProt

Q07885 - IL2_FELCA

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Protein

Interleukin-2

Gene
IL2
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

GO - Biological processi

  1. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  2. immune response Source: InterPro
  3. negative regulation of B cell apoptotic process Source: Ensembl
  4. negative regulation of inflammatory response Source: Ensembl
  5. negative regulation of lymphocyte proliferation Source: Ensembl
  6. positive regulation of activated T cell proliferation Source: Ensembl
  7. positive regulation of B cell proliferation Source: Ensembl
  8. positive regulation of immunoglobulin secretion Source: Ensembl
  9. positive regulation of interferon-gamma production Source: Ensembl
  10. positive regulation of interleukin-17 production Source: Ensembl
  11. positive regulation of isotype switching to IgG isotypes Source: Ensembl
  12. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  13. positive regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
  14. regulation of T cell homeostatic proliferation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
Gene namesi
Name:IL2
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Chromosome B1

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 By similarityAdd
BLAST
Chaini21 – 154134Interleukin-2PRO_0000015481Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 126 By similarity
Glycosylationi111 – 1111N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ07885.
SMRiQ07885. Positions 21-154.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41211.
GeneTreeiENSGT00390000003555.
HOGENOMiHOG000048727.
HOVERGENiHBG007496.
KOiK05429.
OMAiKWITFCQ.
TreeFamiTF338200.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
[Graphical view]
PANTHERiPTHR11443. PTHR11443. 1 hit.
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07885-1 [UniParc]FASTAAdd to Basket

« Hide

MYKIQLLSCI ALTLILVTNS APASSSTKET QQQLEQLLLD LRLLLNGVNN    50
PENPKLSRML TFKFYVPKKA TELTHLQCLV EELKPLEEVL YLAQSKNFHL 100
NHIKELMSNI NVTVLKLKGS ETRFTCNYDD ETATIVEFLN KWITFCQSIF 150
STLT 154
Length:154
Mass (Da):17,654
Last modified:October 1, 1994 - v1
Checksum:i2E71E3BD8B9665EF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 42KI → RM in AAA51431. 1 Publication
Sequence conflicti150 – 1501F → I in AAA51431. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19402 mRNA. Translation: AAA02865.1.
L25408 mRNA. Translation: AAA51431.1.
PIRiJN0698.
RefSeqiNP_001036802.1. NM_001043337.1.

Genome annotation databases

EnsembliENSFCAT00000013692; ENSFCAP00000012696; ENSFCAG00000013688.
GeneIDi751114.
KEGGifca:751114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19402 mRNA. Translation: AAA02865.1 .
L25408 mRNA. Translation: AAA51431.1 .
PIRi JN0698.
RefSeqi NP_001036802.1. NM_001043337.1.

3D structure databases

ProteinModelPortali Q07885.
SMRi Q07885. Positions 21-154.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSFCAT00000013692 ; ENSFCAP00000012696 ; ENSFCAG00000013688 .
GeneIDi 751114.
KEGGi fca:751114.

Organism-specific databases

CTDi 3558.

Phylogenomic databases

eggNOGi NOG41211.
GeneTreei ENSGT00390000003555.
HOGENOMi HOG000048727.
HOVERGENi HBG007496.
KOi K05429.
OMAi KWITFCQ.
TreeFami TF338200.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
[Graphical view ]
PANTHERi PTHR11443. PTHR11443. 1 hit.
Pfami PF00715. IL2. 1 hit.
[Graphical view ]
PRINTSi PR00265. INTERLEUKIN2.
ProDomi PD003649. Interleukin-2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00189. IL2. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00424. INTERLEUKIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Litman R., Gibbs C., Good R.A., Day N.K.
    Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL2_FELCA
AccessioniPrimary (citable) accession number: Q07885
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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