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Q07885

- IL2_FELCA

UniProt

Q07885 - IL2_FELCA

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Protein

Interleukin-2

Gene

IL2

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

GO - Biological processi

  1. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  2. immune response Source: InterPro
  3. negative regulation of B cell apoptotic process Source: Ensembl
  4. negative regulation of inflammatory response Source: Ensembl
  5. negative regulation of lymphocyte proliferation Source: Ensembl
  6. positive regulation of activated T cell proliferation Source: Ensembl
  7. positive regulation of B cell proliferation Source: Ensembl
  8. positive regulation of immunoglobulin secretion Source: Ensembl
  9. positive regulation of interferon-gamma production Source: Ensembl
  10. positive regulation of interleukin-17 production Source: Ensembl
  11. positive regulation of isotype switching to IgG isotypes Source: Ensembl
  12. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  13. positive regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
  14. regulation of T cell homeostatic proliferation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
Gene namesi
Name:IL2
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Chromosome B1

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 154134Interleukin-2PRO_0000015481Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 126By similarity
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ07885.
SMRiQ07885. Positions 21-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41211.
GeneTreeiENSGT00390000003555.
HOGENOMiHOG000048727.
HOVERGENiHBG007496.
InParanoidiQ07885.
KOiK05429.
OMAiKWITFCQ.
TreeFamiTF338200.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
[Graphical view]
PANTHERiPTHR11443. PTHR11443. 1 hit.
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07885-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYKIQLLSCI ALTLILVTNS APASSSTKET QQQLEQLLLD LRLLLNGVNN
60 70 80 90 100
PENPKLSRML TFKFYVPKKA TELTHLQCLV EELKPLEEVL YLAQSKNFHL
110 120 130 140 150
NHIKELMSNI NVTVLKLKGS ETRFTCNYDD ETATIVEFLN KWITFCQSIF

STLT
Length:154
Mass (Da):17,654
Last modified:October 1, 1994 - v1
Checksum:i2E71E3BD8B9665EF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 42KI → RM in AAA51431. 1 PublicationCurated
Sequence conflicti150 – 1501F → I in AAA51431. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19402 mRNA. Translation: AAA02865.1.
L25408 mRNA. Translation: AAA51431.1.
PIRiJN0698.
RefSeqiNP_001036802.1. NM_001043337.1.

Genome annotation databases

EnsembliENSFCAT00000013692; ENSFCAP00000012696; ENSFCAG00000013688.
GeneIDi751114.
KEGGifca:751114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19402 mRNA. Translation: AAA02865.1 .
L25408 mRNA. Translation: AAA51431.1 .
PIRi JN0698.
RefSeqi NP_001036802.1. NM_001043337.1.

3D structure databases

ProteinModelPortali Q07885.
SMRi Q07885. Positions 21-154.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSFCAT00000013692 ; ENSFCAP00000012696 ; ENSFCAG00000013688 .
GeneIDi 751114.
KEGGi fca:751114.

Organism-specific databases

CTDi 3558.

Phylogenomic databases

eggNOGi NOG41211.
GeneTreei ENSGT00390000003555.
HOGENOMi HOG000048727.
HOVERGENi HBG007496.
InParanoidi Q07885.
KOi K05429.
OMAi KWITFCQ.
TreeFami TF338200.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
[Graphical view ]
PANTHERi PTHR11443. PTHR11443. 1 hit.
Pfami PF00715. IL2. 1 hit.
[Graphical view ]
PRINTSi PR00265. INTERLEUKIN2.
ProDomi PD003649. Interleukin-2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00189. IL2. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00424. INTERLEUKIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Litman R., Gibbs C., Good R.A., Day N.K.
    Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL2_FELCA
AccessioniPrimary (citable) accession number: Q07885
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3