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Q07885 (IL2_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-2

Short name=IL-2
Alternative name(s):
T-cell growth factor
Short name=TCGF
Gene names
Name:IL2
OrganismFelis catus (Cat) (Felis silvestris catus) [Reference proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Subcellular location

Secreted.

Sequence similarities

Belongs to the IL-2 family.

Ontologies

Keywords
   Biological processAdaptive immunity
Immunity
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
Growth factor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processextrinsic apoptotic signaling pathway in absence of ligand

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from electronic annotation. Source: InterPro

negative regulation of B cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of inflammatory response

Inferred from electronic annotation. Source: Ensembl

negative regulation of lymphocyte proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of B cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of activated T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of immunoglobulin secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of interferon-gamma production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-17 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of isotype switching to IgG isotypes

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat5 protein

Inferred from electronic annotation. Source: Ensembl

regulation of T cell homeostatic proliferation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Chain21 – 154134Interleukin-2
PRO_0000015481

Amino acid modifications

Glycosylation1111N-linked (GlcNAc...) Potential
Disulfide bond78 ↔ 126 By similarity

Experimental info

Sequence conflict3 – 42KI → RM in AAA51431. Ref.2
Sequence conflict1501F → I in AAA51431. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q07885 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 2E71E3BD8B9665EF

FASTA15417,654
        10         20         30         40         50         60 
MYKIQLLSCI ALTLILVTNS APASSSTKET QQQLEQLLLD LRLLLNGVNN PENPKLSRML 

        70         80         90        100        110        120 
TFKFYVPKKA TELTHLQCLV EELKPLEEVL YLAQSKNFHL NHIKELMSNI NVTVLKLKGS 

       130        140        150 
ETRFTCNYDD ETATIVEFLN KWITFCQSIF STLT 

« Hide

References

[1]"Sequence and functional characterization of feline interleukin 2."
Cozzi P.J., Padrid P.A., Takeda J., Alegre M.-A., Yuhki N., Leff A.R.
Biochem. Biophys. Res. Commun. 194:1038-1043(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Litman R., Gibbs C., Good R.A., Day N.K.
Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L19402 mRNA. Translation: AAA02865.1.
L25408 mRNA. Translation: AAA51431.1.
PIRJN0698.
RefSeqNP_001036802.1. NM_001043337.1.

3D structure databases

ProteinModelPortalQ07885.
SMRQ07885. Positions 21-154.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSFCAT00000013692; ENSFCAP00000012696; ENSFCAG00000013688.
GeneID751114.
KEGGfca:751114.

Organism-specific databases

CTD3558.

Phylogenomic databases

eggNOGNOG41211.
GeneTreeENSGT00390000003555.
HOGENOMHOG000048727.
HOVERGENHBG007496.
KOK05429.
OMAKWITFCQ.
TreeFamTF338200.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
[Graphical view]
PANTHERPTHR11443. PTHR11443. 1 hit.
PfamPF00715. IL2. 1 hit.
[Graphical view]
PRINTSPR00265. INTERLEUKIN2.
ProDomPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIL2_FELCA
AccessionPrimary (citable) accession number: Q07885
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families