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Q07885

- IL2_FELCA

UniProt

Q07885 - IL2_FELCA

Protein

Interleukin-2

Gene

IL2

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

    GO - Biological processi

    1. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    2. immune response Source: InterPro
    3. negative regulation of B cell apoptotic process Source: Ensembl
    4. negative regulation of inflammatory response Source: Ensembl
    5. negative regulation of lymphocyte proliferation Source: Ensembl
    6. positive regulation of activated T cell proliferation Source: Ensembl
    7. positive regulation of B cell proliferation Source: Ensembl
    8. positive regulation of immunoglobulin secretion Source: Ensembl
    9. positive regulation of interferon-gamma production Source: Ensembl
    10. positive regulation of interleukin-17 production Source: Ensembl
    11. positive regulation of isotype switching to IgG isotypes Source: Ensembl
    12. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    13. positive regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
    14. regulation of T cell homeostatic proliferation Source: Ensembl

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-2
    Short name:
    IL-2
    Alternative name(s):
    T-cell growth factor
    Short name:
    TCGF
    Gene namesi
    Name:IL2
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Chromosome B1

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 154134Interleukin-2PRO_0000015481Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi78 ↔ 126By similarity
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ07885.
    SMRiQ07885. Positions 21-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41211.
    GeneTreeiENSGT00390000003555.
    HOGENOMiHOG000048727.
    HOVERGENiHBG007496.
    KOiK05429.
    OMAiKWITFCQ.
    TreeFamiTF338200.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000779. IL-2.
    [Graphical view]
    PANTHERiPTHR11443. PTHR11443. 1 hit.
    PfamiPF00715. IL2. 1 hit.
    [Graphical view]
    PRINTSiPR00265. INTERLEUKIN2.
    ProDomiPD003649. Interleukin-2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00189. IL2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q07885-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYKIQLLSCI ALTLILVTNS APASSSTKET QQQLEQLLLD LRLLLNGVNN    50
    PENPKLSRML TFKFYVPKKA TELTHLQCLV EELKPLEEVL YLAQSKNFHL 100
    NHIKELMSNI NVTVLKLKGS ETRFTCNYDD ETATIVEFLN KWITFCQSIF 150
    STLT 154
    Length:154
    Mass (Da):17,654
    Last modified:October 1, 1994 - v1
    Checksum:i2E71E3BD8B9665EF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 42KI → RM in AAA51431. 1 PublicationCurated
    Sequence conflicti150 – 1501F → I in AAA51431. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19402 mRNA. Translation: AAA02865.1.
    L25408 mRNA. Translation: AAA51431.1.
    PIRiJN0698.
    RefSeqiNP_001036802.1. NM_001043337.1.

    Genome annotation databases

    EnsembliENSFCAT00000013692; ENSFCAP00000012696; ENSFCAG00000013688.
    GeneIDi751114.
    KEGGifca:751114.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19402 mRNA. Translation: AAA02865.1 .
    L25408 mRNA. Translation: AAA51431.1 .
    PIRi JN0698.
    RefSeqi NP_001036802.1. NM_001043337.1.

    3D structure databases

    ProteinModelPortali Q07885.
    SMRi Q07885. Positions 21-154.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSFCAT00000013692 ; ENSFCAP00000012696 ; ENSFCAG00000013688 .
    GeneIDi 751114.
    KEGGi fca:751114.

    Organism-specific databases

    CTDi 3558.

    Phylogenomic databases

    eggNOGi NOG41211.
    GeneTreei ENSGT00390000003555.
    HOGENOMi HOG000048727.
    HOVERGENi HBG007496.
    KOi K05429.
    OMAi KWITFCQ.
    TreeFami TF338200.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000779. IL-2.
    [Graphical view ]
    PANTHERi PTHR11443. PTHR11443. 1 hit.
    Pfami PF00715. IL2. 1 hit.
    [Graphical view ]
    PRINTSi PR00265. INTERLEUKIN2.
    ProDomi PD003649. Interleukin-2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00189. IL2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00424. INTERLEUKIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Litman R., Gibbs C., Good R.A., Day N.K.
      Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiIL2_FELCA
    AccessioniPrimary (citable) accession number: Q07885
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3