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Protein

Peroxisome proliferator-activated receptor alpha

Gene

PPARA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.5 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei280 – 2801Synthetic agonist5 Publications
Binding sitei314 – 3141Synthetic agonist5 Publications
Sitei433 – 4331Essential for heterodimerization with RXRA
Binding sitei440 – 4401Synthetic agonist5 Publications
Binding sitei464 – 4641Synthetic agonist5 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi99 – 17375Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri102 – 12221NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri139 – 16123NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • drug binding Source: UniProtKB
  • lipid binding Source: UniProtKB
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II repressing transcription factor binding Source: BHF-UCL
  • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding Source: UniProtKB
  • sequence-specific DNA binding Source: BHF-UCL
  • steroid hormone receptor activity Source: BHF-UCL
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II transcription factor binding Source: Ensembl
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription factor activity, sequence-specific DNA binding Source: BHF-UCL
  • transcription factor binding Source: UniProtKB
  • ubiquitin conjugating enzyme binding Source: BHF-UCL
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Lipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1368082. RORA activates gene expression.
R-HSA-1368108. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
R-HSA-1989781. PPARA activates gene expression.
R-HSA-2032785. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
R-HSA-2151201. Transcriptional activation of mitochondrial biogenesis.
R-HSA-2426168. Activation of gene expression by SREBF (SREBP).
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
R-HSA-383280. Nuclear Receptor transcription pathway.
R-HSA-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
R-HSA-400253. Circadian Clock.
SignaLinkiQ07869.
SIGNORiQ07869.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor alpha
Short name:
PPAR-alpha
Alternative name(s):
Nuclear receptor subfamily 1 group C member 1
Gene namesi
Name:PPARA
Synonyms:NR1C1, PPAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:9232. PPARA.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi122 – 1221C → G: Prevents DNA binding but no effect on heterodimerization with RXRA. 1 Publication
Mutagenesisi304 – 3041D → A: Reduced heterodimerization with RXRA. Reduced DNA binding. 1 Publication
Mutagenesisi370 – 3701L → R: Abolishes heterodimerization with RXRA. No DNA binding. 1 Publication
Mutagenesisi391 – 3911L → R: Abolishes heterodimerization with RXRA. No DNA binding. 1 Publication
Mutagenesisi422 – 4221L → R: No effect on heterodimerization with RXRA nor on DNA binding and transactivation activity. 1 Publication
Mutagenesisi431 – 4311A → T: No effect on heterodimerization with RXRA nor on DNA binding. 1 Publication
Mutagenesisi433 – 4331L → R: Abolishes heterodimerization with RXRA, DNA binding and transactivation activity. 1 Publication

Organism-specific databases

MIMi170998. gene+phenotype.
PharmGKBiPA280.

Chemistry

ChEMBLiCHEMBL3559683.
DrugBankiDB01393. Bezafibrate.
DB00636. Clofibrate.
DB01039. Fenofibrate.
DB01241. Gemfibrozil.
DB00328. Indomethacin.
GuidetoPHARMACOLOGYi593.

Polymorphism and mutation databases

BioMutaiPPARA.
DMDMi3041727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Peroxisome proliferator-activated receptor alphaPRO_0000053481Add
BLAST

Proteomic databases

PaxDbiQ07869.
PeptideAtlasiQ07869.
PRIDEiQ07869.

PTM databases

iPTMnetiQ07869.
PhosphoSiteiQ07869.

Expressioni

Tissue specificityi

Skeletal muscle, liver, heart and kidney.2 Publications

Gene expression databases

BgeeiENSG00000186951.
CleanExiHS_PPARA.
ExpressionAtlasiQ07869. baseline and differential.
GenevisibleiQ07869. HS.

Organism-specific databases

HPAiCAB025473.

Interactioni

Subunit structurei

Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator. Interacts with CITED2; the interaction stimulates its transcriptional activity. Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6. Interacts with ASXL1 and ASXL2. Interacts with PER2. Interacts with SIRT1; the interaction seems to be modulated by NAD+ levels (PubMed:24043310).By similarity12 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CHD9Q3L8U1-32EBI-78615,EBI-960730
GRB2P629933EBI-78615,EBI-401755
NCOR1O753762EBI-78615,EBI-347233

GO - Molecular functioni

  • RNA polymerase II repressing transcription factor binding Source: BHF-UCL
  • transcription factor binding Source: UniProtKB
  • ubiquitin conjugating enzyme binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi111461. 42 interactions.
DIPiDIP-241N.
IntActiQ07869. 14 interactions.
MINTiMINT-232229.
STRINGi9606.ENSP00000262735.

Chemistry

BindingDBiQ07869.

Structurei

Secondary structure

1
468
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi203 – 21715Combined sources
Helixi222 – 2298Combined sources
Beta strandi233 – 2353Combined sources
Beta strandi239 – 2413Combined sources
Helixi244 – 25411Combined sources
Helixi256 – 2594Combined sources
Helixi263 – 2653Combined sources
Helixi268 – 29023Combined sources
Helixi291 – 2933Combined sources
Turni295 – 2995Combined sources
Helixi302 – 32120Combined sources
Helixi322 – 3243Combined sources
Beta strandi329 – 3324Combined sources
Turni333 – 3364Combined sources
Beta strandi337 – 3404Combined sources
Helixi341 – 3466Combined sources
Turni349 – 3513Combined sources
Helixi352 – 36615Combined sources
Helixi372 – 38312Combined sources
Helixi394 – 41522Combined sources
Helixi422 – 45029Combined sources
Beta strandi453 – 4564Combined sources
Helixi458 – 4647Combined sources
Turni465 – 4673Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I7GX-ray2.20A196-468[»]
1K7LX-ray2.50A/C/E/G192-468[»]
1KKQX-ray3.00A/B/C/D200-468[»]
2NPAX-ray2.30A/C199-468[»]
2P54X-ray1.79A202-468[»]
2REWX-ray2.35A196-468[»]
2ZNNX-ray2.01A200-468[»]
3ET1X-ray2.50A/B199-468[»]
3FEIX-ray2.40A202-468[»]
3G8IX-ray2.20A199-468[»]
3KDTX-ray2.70A/B196-468[»]
3KDUX-ray2.07A/B196-468[»]
3SP6X-ray2.21A196-468[»]
3VI8X-ray1.75A200-468[»]
4BCRX-ray2.50A/B195-468[»]
4CI4X-ray2.30A195-468[»]
ProteinModelPortaliQ07869.
SMRiQ07869. Positions 95-468.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07869.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni280 – 468189Ligand-bindingAdd
BLAST
Regioni304 – 433130Required for heterodimerization with RXRAAdd
BLAST

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri102 – 12221NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri139 – 16123NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00840000129707.
HOGENOMiHOG000261626.
HOVERGENiHBG106004.
InParanoidiQ07869.
KOiK07294.
OMAiYGSGFIT.
OrthoDBiEOG091G05U8.
PhylomeDBiQ07869.
TreeFamiTF316304.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003076. 1Cnucl_rcpt_A.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01289. PROXISOMPAAR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q07869-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVDTESPLCP LSPLEAGDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFG
60 70 80 90 100
FTEYQYLGSC PGSDGSVITD TLSPASSPSS VTYPVVPGSV DESPSGALNI
110 120 130 140 150
ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR
160 170 180 190 200
NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE KAKLKAEILT CEHDIEDSET
210 220 230 240 250
ADLKSLAKRI YEAYLKNFNM NKVKARVILS GKASNNPPFV IHDMETLCMA
260 270 280 290 300
EKTLVAKLVA NGIQNKEAEV RIFHCCQCTS VETVTELTEF AKAIPGFANL
310 320 330 340 350
DLNDQVTLLK YGVYEAIFAM LSSVMNKDGM LVAYGNGFIT REFLKSLRKP
360 370 380 390 400
FCDIMEPKFD FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNVGHIEKM
410 420 430 440 450
QEGIVHVLRL HLQSNHPDDI FLFPKLLQKM ADLRQLVTEH AQLVQIIKKT
460
ESDAALHPLL QEIYRDMY
Length:468
Mass (Da):52,225
Last modified:July 15, 1998 - v2
Checksum:i850846FD51ADA883
GO
Isoform 2 (identifier: Q07869-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-174: IRFG → FCHT
     175-468: Missing.

Show »
Length:174
Mass (Da):18,942
Checksum:i8587321146D06A03
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711T → M in CAA68898 (PubMed:8993548).Curated
Sequence conflicti123 – 1231K → M in CAA68898 (PubMed:8993548).Curated
Sequence conflicti296 – 2961G → A in AAA36468 (PubMed:7684926).Curated
Sequence conflicti444 – 4441V → A in CAA68898 (PubMed:8993548).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti127 – 1271R → Q.
Corresponds to variant rs1800204 [ dbSNP | Ensembl ].
VAR_016110
Natural varianti162 – 1621L → V.1 Publication
Corresponds to variant rs1800206 [ dbSNP | Ensembl ].
VAR_016111
Natural varianti227 – 2271V → A.
Corresponds to variant rs1800234 [ dbSNP | Ensembl ].
VAR_016112
Natural varianti268 – 2681A → V.1 Publication
Corresponds to variant rs1042311 [ dbSNP | Ensembl ].
VAR_016113
Natural varianti304 – 3041D → N.
Corresponds to variant rs1800242 [ dbSNP | Ensembl ].
VAR_016114
Natural varianti395 – 3951G → R.
Corresponds to variant rs2229245 [ dbSNP | Ensembl ].
VAR_050578
Natural varianti409 – 4091R → T.
Corresponds to variant rs1800243 [ dbSNP | Ensembl ].
VAR_016115

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei171 – 1744IRFG → FCHT in isoform 2. 1 PublicationVSP_047571
Alternative sequencei175 – 468294Missing in isoform 2. 1 PublicationVSP_047572Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02932 mRNA. Translation: AAA36468.1.
S74349 mRNA. Translation: AAB32649.1.
Y07619 mRNA. Translation: CAA68898.1.
AB307690 mRNA. Translation: BAH02281.1.
EU650667 mRNA. Translation: ACD12656.1.
EU395809 mRNA. Translation: ABY73535.1.
CR456547 mRNA. Translation: CAG30433.1.
AK289821 mRNA. Translation: BAF82510.1.
CR457435 mRNA. Translation: CAG33716.1.
AY206718 Genomic DNA. Translation: AAO13489.1.
AL049856, AL078611 Genomic DNA. Translation: CAI22450.1.
Z94161 Genomic DNA. No translation available.
CH471138 Genomic DNA. Translation: EAW73402.1.
CCDSiCCDS33669.1. [Q07869-1]
PIRiA49289.
I56603.
RefSeqiNP_001001928.1. NM_001001928.2. [Q07869-1]
NP_005027.2. NM_005036.4. [Q07869-1]
XP_005261712.1. XM_005261655.3. [Q07869-1]
XP_005261713.1. XM_005261656.3. [Q07869-1]
XP_006724332.1. XM_006724269.3. [Q07869-1]
XP_006724333.1. XM_006724270.3. [Q07869-1]
XP_011528541.1. XM_011530239.2. [Q07869-1]
XP_011528542.1. XM_011530240.2. [Q07869-1]
XP_011528543.1. XM_011530241.2. [Q07869-1]
XP_011528544.1. XM_011530242.2. [Q07869-1]
XP_011528545.1. XM_011530243.2. [Q07869-1]
UniGeneiHs.103110.
Hs.710044.

Genome annotation databases

EnsembliENST00000262735; ENSP00000262735; ENSG00000186951. [Q07869-1]
ENST00000402126; ENSP00000385246; ENSG00000186951. [Q07869-1]
ENST00000407236; ENSP00000385523; ENSG00000186951. [Q07869-1]
GeneIDi5465.
KEGGihsa:5465.
UCSCiuc003bgx.1. human. [Q07869-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Peroxisome proliferator-activated receptor entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02932 mRNA. Translation: AAA36468.1.
S74349 mRNA. Translation: AAB32649.1.
Y07619 mRNA. Translation: CAA68898.1.
AB307690 mRNA. Translation: BAH02281.1.
EU650667 mRNA. Translation: ACD12656.1.
EU395809 mRNA. Translation: ABY73535.1.
CR456547 mRNA. Translation: CAG30433.1.
AK289821 mRNA. Translation: BAF82510.1.
CR457435 mRNA. Translation: CAG33716.1.
AY206718 Genomic DNA. Translation: AAO13489.1.
AL049856, AL078611 Genomic DNA. Translation: CAI22450.1.
Z94161 Genomic DNA. No translation available.
CH471138 Genomic DNA. Translation: EAW73402.1.
CCDSiCCDS33669.1. [Q07869-1]
PIRiA49289.
I56603.
RefSeqiNP_001001928.1. NM_001001928.2. [Q07869-1]
NP_005027.2. NM_005036.4. [Q07869-1]
XP_005261712.1. XM_005261655.3. [Q07869-1]
XP_005261713.1. XM_005261656.3. [Q07869-1]
XP_006724332.1. XM_006724269.3. [Q07869-1]
XP_006724333.1. XM_006724270.3. [Q07869-1]
XP_011528541.1. XM_011530239.2. [Q07869-1]
XP_011528542.1. XM_011530240.2. [Q07869-1]
XP_011528543.1. XM_011530241.2. [Q07869-1]
XP_011528544.1. XM_011530242.2. [Q07869-1]
XP_011528545.1. XM_011530243.2. [Q07869-1]
UniGeneiHs.103110.
Hs.710044.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I7GX-ray2.20A196-468[»]
1K7LX-ray2.50A/C/E/G192-468[»]
1KKQX-ray3.00A/B/C/D200-468[»]
2NPAX-ray2.30A/C199-468[»]
2P54X-ray1.79A202-468[»]
2REWX-ray2.35A196-468[»]
2ZNNX-ray2.01A200-468[»]
3ET1X-ray2.50A/B199-468[»]
3FEIX-ray2.40A202-468[»]
3G8IX-ray2.20A199-468[»]
3KDTX-ray2.70A/B196-468[»]
3KDUX-ray2.07A/B196-468[»]
3SP6X-ray2.21A196-468[»]
3VI8X-ray1.75A200-468[»]
4BCRX-ray2.50A/B195-468[»]
4CI4X-ray2.30A195-468[»]
ProteinModelPortaliQ07869.
SMRiQ07869. Positions 95-468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111461. 42 interactions.
DIPiDIP-241N.
IntActiQ07869. 14 interactions.
MINTiMINT-232229.
STRINGi9606.ENSP00000262735.

Chemistry

BindingDBiQ07869.
ChEMBLiCHEMBL3559683.
DrugBankiDB01393. Bezafibrate.
DB00636. Clofibrate.
DB01039. Fenofibrate.
DB01241. Gemfibrozil.
DB00328. Indomethacin.
GuidetoPHARMACOLOGYi593.

PTM databases

iPTMnetiQ07869.
PhosphoSiteiQ07869.

Polymorphism and mutation databases

BioMutaiPPARA.
DMDMi3041727.

Proteomic databases

PaxDbiQ07869.
PeptideAtlasiQ07869.
PRIDEiQ07869.

Protocols and materials databases

DNASUi5465.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262735; ENSP00000262735; ENSG00000186951. [Q07869-1]
ENST00000402126; ENSP00000385246; ENSG00000186951. [Q07869-1]
ENST00000407236; ENSP00000385523; ENSG00000186951. [Q07869-1]
GeneIDi5465.
KEGGihsa:5465.
UCSCiuc003bgx.1. human. [Q07869-1]

Organism-specific databases

CTDi5465.
GeneCardsiPPARA.
HGNCiHGNC:9232. PPARA.
HPAiCAB025473.
MIMi170998. gene+phenotype.
neXtProtiNX_Q07869.
PharmGKBiPA280.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00840000129707.
HOGENOMiHOG000261626.
HOVERGENiHBG106004.
InParanoidiQ07869.
KOiK07294.
OMAiYGSGFIT.
OrthoDBiEOG091G05U8.
PhylomeDBiQ07869.
TreeFamiTF316304.

Enzyme and pathway databases

ReactomeiR-HSA-1368082. RORA activates gene expression.
R-HSA-1368108. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
R-HSA-1989781. PPARA activates gene expression.
R-HSA-2032785. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
R-HSA-2151201. Transcriptional activation of mitochondrial biogenesis.
R-HSA-2426168. Activation of gene expression by SREBF (SREBP).
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
R-HSA-383280. Nuclear Receptor transcription pathway.
R-HSA-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
R-HSA-400253. Circadian Clock.
SignaLinkiQ07869.
SIGNORiQ07869.

Miscellaneous databases

ChiTaRSiPPARA. human.
EvolutionaryTraceiQ07869.
GeneWikiiPeroxisome_proliferator-activated_receptor_alpha.
GenomeRNAii5465.
PROiQ07869.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186951.
CleanExiHS_PPARA.
ExpressionAtlasiQ07869. baseline and differential.
GenevisibleiQ07869. HS.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003076. 1Cnucl_rcpt_A.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01289. PROXISOMPAAR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPARA_HUMAN
AccessioniPrimary (citable) accession number: Q07869
Secondary accession number(s): B0G0X3
, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 15, 1998
Last modified: September 7, 2016
This is version 196 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.