Reviewed, UniProtKB/Swiss-Prot Q07866 (KLC1_HUMAN)

Names and origin

Protein names

Recommended name:
    Kinesin light chain 1
      Short name(s)=KLC 1

Gene names

Name:	KLC1
Synonyms:	KLC, KNS2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	569 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
Subunit structure	Oligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9 By similarity.
Tissue specificity	Found in a variety of tissues. Mostly abundant in brain and spine.
Post-translational modification	Isoform I is phosphorylated on Ser-596. Isoform J is phosphorylated on Ser-627.
Sequence similarities	Belongs to the kinesin light chain family. Contains 6 TPR repeats.

Ontologies

Keywords
Cellular component	Microtubule
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat TPR repeat
Molecular function	Motor protein
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	cytosol Inferred from sequence or structural similarity. Source: HGNC kinesin complex Inferred from sequence or structural similarity. Source: HGNC
Molecular function	motor activity Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
YWHAB	P31946	1	EBI-721019,EBI-359815
YWHAG	P61981	1	EBI-721019,EBI-359832
YWHAZ	P63104	1	EBI-721019,EBI-347088

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Notes: Additional isoforms seem to exist. Has the potential to produce 285'919 splice forms.

Isoform A (identifier: Q07866-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform C (identifier: Q07866-2)

Also known as: KLC1C; R; KLC1R;

The sequence of this isoform differs from the canonical sequence as follows:
     547-569: GVSGRASFCGKRQQQQWPGRRHR → MRKMKLGLVN

Isoform G (identifier: Q07866-3)

Also known as: KLC1G;

The sequence of this isoform differs from the canonical sequence as follows:
     538-546: Missing.

Isoform J (identifier: Q07866-4)

Also known as: KLC1J;

The sequence of this isoform differs from the canonical sequence as follows:
     547-547: G → DGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPG
     548-569: VSGRASFCGKRQQQQWPGRRHR → MKRASSLNVLNVGGKAAEDRFQERNNCLADSRALSASHTDLAH

Notes: Phosphorylated on Ser-596 (Probable). Phosphorylated on Ser-627.

Isoform K (identifier: Q07866-5)

Also known as: KLC1K;

The sequence of this isoform differs from the canonical sequence as follows:
     547-547: G → DGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPG

Isoform N (identifier: Q07866-6)

Also known as: KLC1N;

The sequence of this isoform differs from the canonical sequence as follows:
     538-546: Missing.
     547-547: G → DGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPG
     548-569: VSGRASFCGKRQQQQWPGRRHR → MKRASSLNVLNVGGKAAEDRFQERNNCLADSRALSASHTDLAH

Notes: Phosphorylated on Ser-587 and Ser-618 (Probable).

Isoform P (identifier: Q07866-7)

Also known as: KLC1P;

The sequence of this isoform differs from the canonical sequence as follows:
     538-569: VSMSVEWNGGVSGRASFCGKRQQQQWPGRRHR → MKRASSLNVLNVGGKAAEDRFQERNNCLADSRALSASHTDLAH

Notes: Phosphorylated on Ser-543 (Probable).

Isoform S (identifier: Q07866-8)

Also known as: KLC1S; Q; KLC1Q;

The sequence of this isoform differs from the canonical sequence as follows:
     538-546: Missing.
     547-569: GVSGRASFCGKRQQQQWPGRRHR → MRKMKLGLVN

Isoform I (identifier: Q07866-9)

The sequence of this isoform differs from the canonical sequence as follows:
     546-546: G → GDGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPGMKRASSLNVLNVGGKAAEDRFQ

Notes: Phosphorylated on Ser-596.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 569	569	Kinesin light chain 1
Regions
	Repeat	209 – 242	34	TPR 1
	Repeat	251 – 284	34	TPR 2
	Repeat	293 – 326	34	TPR 3
	Repeat	335 – 368	34	TPR 4
	Repeat	377 – 410	34	TPR 5
	Repeat	460 – 493	34	TPR 6
	Coiled coil	23 – 152	130
Amino acid modifications
	Modified residue	445	1	Phosphotyrosine By similarity
	Modified residue	456	1	Phosphoserine
Natural variations
	Alternative sequence	538 – 569	32	VSMSV…GRRHR → MKRASSLNVLNVGGKAAEDR FQERNNCLADSRALSASHTD LAH in isoform P.
	Alternative sequence	538 – 546	9	Missing in isoform G, isoform N and isoform S.
	Alternative sequence	546	1	G → GDGTGSLKRSGSFSKLRASI RRSSEKLVRKLKGGSSRESE PKNPGMKRASSLNVLNVGGK AAEDRFQ in isoform I.
	Alternative sequence	547 – 569	23	GVSGR…GRRHR → MRKMKLGLVN in isoform C and isoform S.
	Alternative sequence	547	1	G → DGTGSLKRSGSFSKLRASIR RSSEKLVRKLKGGSSRESEP KNPG in isoform J, isoform K and isoform N.
	Alternative sequence	548 – 569	22	VSGRA…GRRHR → MKRASSLNVLNVGGKAAEDR FQERNNCLADSRALSASHTD LAH in isoform J and isoform N.

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 5D9376C3EEDD00FE	FASTA	569	64,786
	10 20 30 40 50 60 MSTMVYIKED KLEKLTQDEI ISKTKQVIQG LEALKNEHNS ILQSLLETLK CLKKDDESNL 70 80 90 100 110 120 VEEKSNMIRK SLEMLELGLS EAQVMMALSN HLNAVESEKQ KLRAQVRRLC QENQWLRDEL 130 140 150 160 170 180 ANTQQKLQKS EQSVAQLEEE KKHLEFMNQL KKYDDDISPS EDKDTDSTKE PLDDLFPNDE 190 200 210 220 230 240 DDPGQGIQQQ HSSAAAAAQQ GGYEIPARLR TLHNLVIQYA SQGRYEVAVP LCKQALEDLE 250 260 270 280 290 300 KTSGHDHPDV ATMLNILALV YRDQNKYKDA ANLLNDALAI REKTLGKDHP AVAATLNNLA 310 320 330 340 350 360 VLYGKRGKYK EAEPLCKRAL EIREKVLGKD HPDVAKQLNN LALLCQNQGK YEEVEYYYQR 370 380 390 400 410 420 ALEIYQTKLG PDDPNVAKTK NNLASCYLKQ GKFKQAETLY KEILTRAHER EFGSVDDENK 430 440 450 460 470 480 PIWMHAEERE ECKGKQKDGT SFGEYGGWYK ACKVDSPTVT TTLKNLGALY RRQGKFEAAE 490 500 510 520 530 540 TLEEAAMRSR KQGLDNVHKQ RVAEVLNDPE NMEKRRSRES LNVDVVKYES GPDGGEEVSM 550 560 SVEWNGGVSG RASFCGKRQQ QQWPGRRHR
	Isoform C (KLC1C) (R) (KLC1R) [UniParc]. Checksum: 65F578D8A3FFA740		556	63,292
	10 20 30 40 50 60 MSTMVYIKED KLEKLTQDEI ISKTKQVIQG LEALKNEHNS ILQSLLETLK CLKKDDESNL 70 80 90 100 110 120 VEEKSNMIRK SLEMLELGLS EAQVMMALSN HLNAVESEKQ KLRAQVRRLC QENQWLRDEL 130 140 150 160 170 180 ANTQQKLQKS EQSVAQLEEE KKHLEFMNQL KKYDDDISPS EDKDTDSTKE PLDDLFPNDE 190 200 210 220 230 240 DDPGQGIQQQ HSSAAAAAQQ GGYEIPARLR TLHNLVIQYA SQGRYEVAVP LCKQALEDLE 250 260 270 280 290 300 KTSGHDHPDV ATMLNILALV YRDQNKYKDA ANLLNDALAI REKTLGKDHP AVAATLNNLA 310 320 330 340 350 360 VLYGKRGKYK EAEPLCKRAL EIREKVLGKD HPDVAKQLNN LALLCQNQGK YEEVEYYYQR 370 380 390 400 410 420 ALEIYQTKLG PDDPNVAKTK NNLASCYLKQ GKFKQAETLY KEILTRAHER EFGSVDDENK 430 440 450 460 470 480 PIWMHAEERE ECKGKQKDGT SFGEYGGWYK ACKVDSPTVT TTLKNLGALY RRQGKFEAAE 490 500 510 520 530 540 TLEEAAMRSR KQGLDNVHKQ RVAEVLNDPE NMEKRRSRES LNVDVVKYES GPDGGEEVSM 550 SVEWNGMRKM KLGLVN
	Isoform G (KLC1G) [UniParc]. Checksum: 119ECDAC26846154		560	63,796
	10 20 30 40 50 60 MSTMVYIKED KLEKLTQDEI ISKTKQVIQG LEALKNEHNS ILQSLLETLK CLKKDDESNL 70 80 90 100 110 120 VEEKSNMIRK SLEMLELGLS EAQVMMALSN HLNAVESEKQ KLRAQVRRLC QENQWLRDEL 130 140 150 160 170 180 ANTQQKLQKS EQSVAQLEEE KKHLEFMNQL KKYDDDISPS EDKDTDSTKE PLDDLFPNDE 190 200 210 220 230 240 DDPGQGIQQQ HSSAAAAAQQ GGYEIPARLR TLHNLVIQYA SQGRYEVAVP LCKQALEDLE 250 260 270 280 290 300 KTSGHDHPDV ATMLNILALV YRDQNKYKDA ANLLNDALAI REKTLGKDHP AVAATLNNLA 310 320 330 340 350 360 VLYGKRGKYK EAEPLCKRAL EIREKVLGKD HPDVAKQLNN LALLCQNQGK YEEVEYYYQR 370 380 390 400 410 420 ALEIYQTKLG PDDPNVAKTK NNLASCYLKQ GKFKQAETLY KEILTRAHER EFGSVDDENK 430 440 450 460 470 480 PIWMHAEERE ECKGKQKDGT SFGEYGGWYK ACKVDSPTVT TTLKNLGALY RRQGKFEAAE 490 500 510 520 530 540 TLEEAAMRSR KQGLDNVHKQ RVAEVLNDPE NMEKRRSRES LNVDVVKYES GPDGGEEGVS 550 560 GRASFCGKRQ QQQWPGRRHR
	Isoform J (KLC1J) [UniParc]. Checksum: 3C1670614D276563		633	71,472
	10 20 30 40 50 60 MSTMVYIKED KLEKLTQDEI ISKTKQVIQG LEALKNEHNS ILQSLLETLK CLKKDDESNL 70 80 90 100 110 120 VEEKSNMIRK SLEMLELGLS EAQVMMALSN HLNAVESEKQ KLRAQVRRLC QENQWLRDEL 130 140 150 160 170 180 ANTQQKLQKS EQSVAQLEEE KKHLEFMNQL KKYDDDISPS EDKDTDSTKE PLDDLFPNDE 190 200 210 220 230 240 DDPGQGIQQQ HSSAAAAAQQ GGYEIPARLR TLHNLVIQYA SQGRYEVAVP LCKQALEDLE 250 260 270 280 290 300 KTSGHDHPDV ATMLNILALV YRDQNKYKDA ANLLNDALAI REKTLGKDHP AVAATLNNLA 310 320 330 340 350 360 VLYGKRGKYK EAEPLCKRAL EIREKVLGKD HPDVAKQLNN LALLCQNQGK YEEVEYYYQR 370 380 390 400 410 420 ALEIYQTKLG PDDPNVAKTK NNLASCYLKQ GKFKQAETLY KEILTRAHER EFGSVDDENK 430 440 450 460 470 480 PIWMHAEERE ECKGKQKDGT SFGEYGGWYK ACKVDSPTVT TTLKNLGALY RRQGKFEAAE 490 500 510 520 530 540 TLEEAAMRSR KQGLDNVHKQ RVAEVLNDPE NMEKRRSRES LNVDVVKYES GPDGGEEVSM 550 560 570 580 590 600 SVEWNGDGTG SLKRSGSFSK LRASIRRSSE KLVRKLKGGS SRESEPKNPG MKRASSLNVL 610 620 630 NVGGKAAEDR FQERNNCLAD SRALSASHTD LAH
	Isoform K (KLC1K) [UniParc]. Checksum: B194E4BBAEC27FA0		612	69,443
	10 20 30 40 50 60 MSTMVYIKED KLEKLTQDEI ISKTKQVIQG LEALKNEHNS ILQSLLETLK CLKKDDESNL 70 80 90 100 110 120 VEEKSNMIRK SLEMLELGLS EAQVMMALSN HLNAVESEKQ KLRAQVRRLC QENQWLRDEL 130 140 150 160 170 180 ANTQQKLQKS EQSVAQLEEE KKHLEFMNQL KKYDDDISPS EDKDTDSTKE PLDDLFPNDE 190 200 210 220 230 240 DDPGQGIQQQ HSSAAAAAQQ GGYEIPARLR TLHNLVIQYA SQGRYEVAVP LCKQALEDLE 250 260 270 280 290 300 KTSGHDHPDV ATMLNILALV YRDQNKYKDA ANLLNDALAI REKTLGKDHP AVAATLNNLA 310 320 330 340 350 360 VLYGKRGKYK EAEPLCKRAL EIREKVLGKD HPDVAKQLNN LALLCQNQGK YEEVEYYYQR 370 380 390 400 410 420 ALEIYQTKLG PDDPNVAKTK NNLASCYLKQ GKFKQAETLY KEILTRAHER EFGSVDDENK 430 440 450 460 470 480 PIWMHAEERE ECKGKQKDGT SFGEYGGWYK ACKVDSPTVT TTLKNLGALY RRQGKFEAAE 490 500 510 520 530 540 TLEEAAMRSR KQGLDNVHKQ RVAEVLNDPE NMEKRRSRES LNVDVVKYES GPDGGEEVSM 550 560 570 580 590 600 SVEWNGDGTG SLKRSGSFSK LRASIRRSSE KLVRKLKGGS SRESEPKNPG VSGRASFCGK 610 RQQQQWPGRR HR
	Isoform N (KLC1N) [UniParc]. Checksum: 5227FD494B00890F		624	70,482
	10 20 30 40 50 60 MSTMVYIKED KLEKLTQDEI ISKTKQVIQG LEALKNEHNS ILQSLLETLK CLKKDDESNL 70 80 90 100 110 120 VEEKSNMIRK SLEMLELGLS EAQVMMALSN HLNAVESEKQ KLRAQVRRLC QENQWLRDEL 130 140 150 160 170 180 ANTQQKLQKS EQSVAQLEEE KKHLEFMNQL KKYDDDISPS EDKDTDSTKE PLDDLFPNDE 190 200 210 220 230 240 DDPGQGIQQQ HSSAAAAAQQ GGYEIPARLR TLHNLVIQYA SQGRYEVAVP LCKQALEDLE 250 260 270 280 290 300 KTSGHDHPDV ATMLNILALV YRDQNKYKDA ANLLNDALAI REKTLGKDHP AVAATLNNLA 310 320 330 340 350 360 VLYGKRGKYK EAEPLCKRAL EIREKVLGKD HPDVAKQLNN LALLCQNQGK YEEVEYYYQR 370 380 390 400 410 420 ALEIYQTKLG PDDPNVAKTK NNLASCYLKQ GKFKQAETLY KEILTRAHER EFGSVDDENK 430 440 450 460 470 480 PIWMHAEERE ECKGKQKDGT SFGEYGGWYK ACKVDSPTVT TTLKNLGALY RRQGKFEAAE 490 500 510 520 530 540 TLEEAAMRSR KQGLDNVHKQ RVAEVLNDPE NMEKRRSRES LNVDVVKYES GPDGGEEDGT 550 560 570 580 590 600 GSLKRSGSFS KLRASIRRSS EKLVRKLKGG SSRESEPKNP GMKRASSLNV LNVGGKAAED 610 620 RFQERNNCLA DSRALSASHT DLAH
	Isoform P (KLC1P) [UniParc]. Checksum: 82D9B6A8DC210643		580	65,768
	10 20 30 40 50 60 MSTMVYIKED KLEKLTQDEI ISKTKQVIQG LEALKNEHNS ILQSLLETLK CLKKDDESNL 70 80 90 100 110 120 VEEKSNMIRK SLEMLELGLS EAQVMMALSN HLNAVESEKQ KLRAQVRRLC QENQWLRDEL 130 140 150 160 170 180 ANTQQKLQKS EQSVAQLEEE KKHLEFMNQL KKYDDDISPS EDKDTDSTKE PLDDLFPNDE 190 200 210 220 230 240 DDPGQGIQQQ HSSAAAAAQQ GGYEIPARLR TLHNLVIQYA SQGRYEVAVP LCKQALEDLE 250 260 270 280 290 300 KTSGHDHPDV ATMLNILALV YRDQNKYKDA ANLLNDALAI REKTLGKDHP AVAATLNNLA 310 320 330 340 350 360 VLYGKRGKYK EAEPLCKRAL EIREKVLGKD HPDVAKQLNN LALLCQNQGK YEEVEYYYQR 370 380 390 400 410 420 ALEIYQTKLG PDDPNVAKTK NNLASCYLKQ GKFKQAETLY KEILTRAHER EFGSVDDENK 430 440 450 460 470 480 PIWMHAEERE ECKGKQKDGT SFGEYGGWYK ACKVDSPTVT TTLKNLGALY RRQGKFEAAE 490 500 510 520 530 540 TLEEAAMRSR KQGLDNVHKQ RVAEVLNDPE NMEKRRSRES LNVDVVKYES GPDGGEEMKR 550 560 570 580 ASSLNVLNVG GKAAEDRFQE RNNCLADSRA LSASHTDLAH
	Isoform S (KLC1S) (Q) (KLC1Q) [UniParc]. Checksum: 747A51A7FA043A3F		547	62,302
	10 20 30 40 50 60 MSTMVYIKED KLEKLTQDEI ISKTKQVIQG LEALKNEHNS ILQSLLETLK CLKKDDESNL 70 80 90 100 110 120 VEEKSNMIRK SLEMLELGLS EAQVMMALSN HLNAVESEKQ KLRAQVRRLC QENQWLRDEL 130 140 150 160 170 180 ANTQQKLQKS EQSVAQLEEE KKHLEFMNQL KKYDDDISPS EDKDTDSTKE PLDDLFPNDE 190 200 210 220 230 240 DDPGQGIQQQ HSSAAAAAQQ GGYEIPARLR TLHNLVIQYA SQGRYEVAVP LCKQALEDLE 250 260 270 280 290 300 KTSGHDHPDV ATMLNILALV YRDQNKYKDA ANLLNDALAI REKTLGKDHP AVAATLNNLA 310 320 330 340 350 360 VLYGKRGKYK EAEPLCKRAL EIREKVLGKD HPDVAKQLNN LALLCQNQGK YEEVEYYYQR 370 380 390 400 410 420 ALEIYQTKLG PDDPNVAKTK NNLASCYLKQ GKFKQAETLY KEILTRAHER EFGSVDDENK 430 440 450 460 470 480 PIWMHAEERE ECKGKQKDGT SFGEYGGWYK ACKVDSPTVT TTLKNLGALY RRQGKFEAAE 490 500 510 520 530 540 TLEEAAMRSR KQGLDNVHKQ RVAEVLNDPE NMEKRRSRES LNVDVVKYES GPDGGEEMRK MKLGLVN
	Isoform I [UniParc]. Checksum: 4C5EBA2F24B3C4C4		635	71,874
	10 20 30 40 50 60 MSTMVYIKED KLEKLTQDEI ISKTKQVIQG LEALKNEHNS ILQSLLETLK CLKKDDESNL 70 80 90 100 110 120 VEEKSNMIRK SLEMLELGLS EAQVMMALSN HLNAVESEKQ KLRAQVRRLC QENQWLRDEL 130 140 150 160 170 180 ANTQQKLQKS EQSVAQLEEE KKHLEFMNQL KKYDDDISPS EDKDTDSTKE PLDDLFPNDE 190 200 210 220 230 240 DDPGQGIQQQ HSSAAAAAQQ GGYEIPARLR TLHNLVIQYA SQGRYEVAVP LCKQALEDLE 250 260 270 280 290 300 KTSGHDHPDV ATMLNILALV YRDQNKYKDA ANLLNDALAI REKTLGKDHP AVAATLNNLA 310 320 330 340 350 360 VLYGKRGKYK EAEPLCKRAL EIREKVLGKD HPDVAKQLNN LALLCQNQGK YEEVEYYYQR 370 380 390 400 410 420 ALEIYQTKLG PDDPNVAKTK NNLASCYLKQ GKFKQAETLY KEILTRAHER EFGSVDDENK 430 440 450 460 470 480 PIWMHAEERE ECKGKQKDGT SFGEYGGWYK ACKVDSPTVT TTLKNLGALY RRQGKFEAAE 490 500 510 520 530 540 TLEEAAMRSR KQGLDNVHKQ RVAEVLNDPE NMEKRRSRES LNVDVVKYES GPDGGEEVSM 550 560 570 580 590 600 SVEWNGDGTG SLKRSGSFSK LRASIRRSSE KLVRKLKGGS SRESEPKNPG MKRASSLNVL 610 620 630 NVGGKAAEDR FQGVSGRASF CGKRQQQQWP GRRHR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and genetic characterization of the human kinesin light-chain (KLC) gene." Cabeza-Arvelaiz Y., Shih L.-C.N., Hardman N., Asselbergs F., Bilbe G., Schmitz A., White B., Siciliano M.J., Lachman L.B. DNA Cell Biol. 12:881-892(1993) [PubMed: 8274221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
[2]	Gerber S., Rozet J.-M., Perrault I., Ducroq D., Souied E., Munnich A., Kaplan J. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Alternatively spliced products of the human kinesin light chain 1 (KNS2) gene." McCart A.E., Mahony D., Rothnagel J.A. Traffic 4:576-580(2003) [PubMed: 12839500] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS C; G; I; J; K; N; P AND S). Tissue: Brain, Foreskin and Liver.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C). Tissue: Uterus.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-596 (ISOFORM I), MASS SPECTROMETRY. Tissue: Epithelium.
[6]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-456, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-627 (ISOFORM J), MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L04733 mRNA. Translation: AAA16576.1. AF267530 , AF267518, AF267519, AF267520, AF267521, AF267522, AF267523, AF267524, AF267525, AF267526, AF267527, AF267528, AF267529 Genomic DNA. Translation: AAF72543.1. AY180163 mRNA. Translation: AAO62548.1. AY180164 mRNA. Translation: AAO62549.1. AY180165 mRNA. Translation: AAO62550.1. AY180166 mRNA. Translation: AAO62551.1. AY180168 mRNA. Translation: AAO62553.1. AY180167 mRNA. Translation: AAO62552.1. AY180169 mRNA. Translation: AAO62554.1. AY180170 mRNA. Translation: AAO62555.1. AY244715 mRNA. Translation: AAO64641.1. BK000681 mRNA. Translation: DAA01265.1. BK000682 mRNA. Translation: DAA01266.1. BK000684 mRNA. Translation: DAA01268.1. BK001165 mRNA. Translation: DAA01291.1. BK001166 mRNA. Translation: DAA01292.1. BK001169 mRNA. Translation: DAA01295.1. BK001170 mRNA. Translation: DAA01296.1. BK001171 mRNA. Translation: DAA01297.1. BC008881 mRNA. Translation: AAH08881.1. Different initiation.
PIR	I53013.
RefSeq	NP_005543.2. NP_891553.2.
UniGene	Hs.20107 Hs.657678
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q07866.
Genome annotation databases
Ensembl	ENSG00000126214. Homo sapiens. [Contig view]
GeneID	3831.
KEGG	hsa:3831.
Organism-specific databases
H-InvDB	HIX0012004.
HGNC	HGNC:6387. KLC1.
HPA	CAB009798.
MIM	600025. gene.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOVERGEN	Q07866.
Gene expression databases
ArrayExpress	Q07866.
GermOnline	ENSG00000126214. Homo sapiens.
Family and domain databases
InterPro	IPR002151. Kinesin_light. IPR015792. Kinesin_light_repeat. IPR015390. Rabaptin_Rab5-bd. IPR001440. TPR-1. IPR011990. TPR-like_helical. IPR013026. TPR_region. [Graphical view]
Gene3D	G3DSA:1.25.40.10. TPR-like_helical. 1 hit.
Pfam	PF09311. Rab5-bind. 1 hit. PF00515. TPR_1. 5 hits. [Graphical view]
PRINTS	PR00381. KINESINLIGHT.
SMART	SM00028. TPR. 5 hits. [Graphical view]
PROSITE	PS01160. KINESIN_LIGHT. 4 hits. PS50005. TPR. 6 hits. PS50293. TPR_REGION. 2 hits. [Graphical view]
ProDom	Q07866. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

KLC1_HUMAN

Accession

Primary (citable) accession number: Q07866
Secondary accession number(s): Q7RTM2 , Q7RTM3, Q7RTM5, Q7RTP9, Q7RTQ5, Q7RTQ6, Q86SF5, Q86TF5, Q86V74, Q86V75, Q86V76, Q86V77, Q86V78, Q86V79, Q96H62

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	July 22, 2008
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)