Reviewed, UniProtKB/Swiss-Prot Q07866 (KLC1_HUMAN)

Names and origin

Protein names

Recommended name:
    Kinesin light chain 1
      Short name=KLC 1

Gene names

Name:	KLC1
Synonyms:	KLC, KNS2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	573 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
Subunit structure	Oligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9 By similarity.
Tissue specificity	Found in a variety of tissues. Mostly abundant in brain and spine.
Post-translational modification	Isoform I is phosphorylated on Ser-600. Isoform J is phosphorylated on Ser-631. Ref.7 Ref.8 Ref.9 Ref.10 Ref.11
Sequence similarities	Belongs to the kinesin light chain family. Contains 6 TPR repeats.
Caution	It is uncertain whether Met-1 or Met-5 is the initiator.

Ontologies

Keywords
Cellular component	Microtubule
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat TPR repeat
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytosol Inferred from sequence or structural similarity. Source: HGNC kinesin complex Inferred from sequence or structural similarity. Source: HGNC microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	microtubule motor activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
YWHAB	P31946	1	EBI-721019,EBI-359815
YWHAG	P61981	1	EBI-721019,EBI-359832
YWHAZ	P63104	1	EBI-721019,EBI-347088

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select] Note: Additional isoforms seem to exist. Has the potential to produce 285'919 splice forms.
Isoform A (identifier: Q07866-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform C (identifier: Q07866-2) Also known as: KLC1C; R; KLC1R; The sequence of this isoform differs from the canonical sequence as follows:      551-573: GVSGRASFCGKRQQQQWPGRRHR → MRKMKLGLVN
Isoform G (identifier: Q07866-3) Also known as: KLC1G; The sequence of this isoform differs from the canonical sequence as follows:      542-550: Missing.
Isoform J (identifier: Q07866-4) Also known as: KLC1J; The sequence of this isoform differs from the canonical sequence as follows:      551-551: G → DGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPG      552-573: VSGRASFCGKRQQQQWPGRRHR → MKRASSLNVLNVGGKAAEDRFQERNNCLADSRALSASHTDLAH
Note: Phosphorylated on Ser-600 (Probable). Phosphorylated on Ser-631.
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	631	1	S → T in AAO62555. Ref.2
Isoform K (identifier: Q07866-5) Also known as: KLC1K; The sequence of this isoform differs from the canonical sequence as follows:      551-551: G → DGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPG
Isoform N (identifier: Q07866-6) Also known as: KLC1N; The sequence of this isoform differs from the canonical sequence as follows:      542-550: Missing.      551-551: G → DGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPG      552-573: VSGRASFCGKRQQQQWPGRRHR → MKRASSLNVLNVGGKAAEDRFQERNNCLADSRALSASHTDLAH
Note: Phosphorylated on Ser-591 and Ser-622 (Probable).
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	622	1	S → T in AAO62551. Ref.2
Isoform P (identifier: Q07866-7) Also known as: KLC1P; The sequence of this isoform differs from the canonical sequence as follows:      542-573: VSMSVEWNGGVSGRASFCGKRQQQQWPGRRHR → MKRASSLNVLNVGGKAAEDRFQERNNCLADSRALSASHTDLAH
Note: Phosphorylated on Ser-547 and Ser-578 (Probable).
Isoform S (identifier: Q07866-8) Also known as: KLC1S; Q; KLC1Q; The sequence of this isoform differs from the canonical sequence as follows:      542-550: Missing.      551-573: GVSGRASFCGKRQQQQWPGRRHR → MRKMKLGLVN
Isoform I (identifier: Q07866-9) The sequence of this isoform differs from the canonical sequence as follows:      550-550: G → GDGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPGMKRASSLNVLNVGGKAAEDRFQ
Note: Phosphorylated on Ser-600.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 573	573	Kinesin light chain 1		PRO_0000215092
Regions
	Repeat	213 – 246	34	TPR 1
	Repeat	255 – 288	34	TPR 2
	Repeat	297 – 330	34	TPR 3
	Repeat	339 – 372	34	TPR 4
	Repeat	381 – 414	34	TPR 5
	Repeat	464 – 497	34	TPR 6
	Coiled coil	27 – 156	130
Amino acid modifications
	Modified residue	162	1	Phosphoserine By similarity
	Modified residue	449	1	Phosphotyrosine By similarity
	Modified residue	460	1	Phosphoserine Ref.8 Ref.10 Ref.11
	Modified residue	521	1	Phosphoserine Ref.11
	Modified residue	524	1	Phosphoserine Ref.11
Natural variations
	Alternative sequence	542 – 573	32	VSMSV…GRRHR → MKRASSLNVLNVGGKAAEDR FQERNNCLADSRALSASHTD LAH in isoform P.		VSP_008021
	Alternative sequence	542 – 550	9	Missing in isoform G, isoform N and isoform S.		VSP_008017
	Alternative sequence	550	1	G → GDGTGSLKRSGSFSKLRASI RRSSEKLVRKLKGGSSRESE PKNPGMKRASSLNVLNVGGK AAEDRFQ in isoform I.		VSP_023323
	Alternative sequence	551 – 573	23	GVSGR…GRRHR → MRKMKLGLVN in isoform C and isoform S.		VSP_008018
	Alternative sequence	551	1	G → DGTGSLKRSGSFSKLRASIR RSSEKLVRKLKGGSSRESEP KNPG in isoform J, isoform K and isoform N.		VSP_008019
	Alternative sequence	552 – 573	22	VSGRA…GRRHR → MKRASSLNVLNVGGKAAEDR FQERNNCLADSRALSASHTD LAH in isoform J and isoform N.		VSP_008020
Experimental info
	Sequence conflict	4	1	N → T in AAA16576. Ref.1
	Sequence conflict	4	1	N → T in AAO62548. Ref.2
	Sequence conflict	4	1	N → T in AAO62549. Ref.2
	Sequence conflict	4	1	N → T in AAO62550. Ref.2
	Sequence conflict	4	1	N → T in AAO62551. Ref.2
	Sequence conflict	4	1	N → T in AAO62553. Ref.2
	Sequence conflict	4	1	N → T in AAO62552. Ref.2
	Sequence conflict	4	1	N → T in AAO62554. Ref.2
	Sequence conflict	4	1	N → T in AAO62555. Ref.2
	Sequence conflict	4	1	N → T in AAO64641. Ref.2
	Sequence conflict	4	1	N → T in AAF72543. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified February 10, 2009. Version 2. Checksum: A66E3915C57C2764	FASTA	573	65,310
	10 20 30 40 50 60 MYDNMSTMVY IKEDKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL ETLKCLKKDD 70 80 90 100 110 120 ESNLVEEKSN MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE SEKQKLRAQV RRLCQENQWL 130 140 150 160 170 180 RDELANTQQK LQKSEQSVAQ LEEEKKHLEF MNQLKKYDDD ISPSEDKDTD STKEPLDDLF 190 200 210 220 230 240 PNDEDDPGQG IQQQHSSAAA AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL 250 260 270 280 290 300 EDLEKTSGHD HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG KDHPAVAATL 310 320 330 340 350 360 NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ NQGKYEEVEY 370 380 390 400 410 420 YYQRALEIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA ETLYKEILTR AHEREFGSVD 430 440 450 460 470 480 DENKPIWMHA EEREECKGKQ KDGTSFGEYG GWYKACKVDS PTVTTTLKNL GALYRRQGKF 490 500 510 520 530 540 EAAETLEEAA MRSRKQGLDN VHKQRVAEVL NDPENMEKRR SRESLNVDVV KYESGPDGGE 550 560 570 EVSMSVEWNG GVSGRASFCG KRQQQQWPGR RHR
	Isoform C (KLC1C) (R) (KLC1R). Checksum: FF62962AF112575C	FASTA	560	63,816
	10 20 30 40 50 60 MYDNMSTMVY IKEDKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL ETLKCLKKDD 70 80 90 100 110 120 ESNLVEEKSN MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE SEKQKLRAQV RRLCQENQWL 130 140 150 160 170 180 RDELANTQQK LQKSEQSVAQ LEEEKKHLEF MNQLKKYDDD ISPSEDKDTD STKEPLDDLF 190 200 210 220 230 240 PNDEDDPGQG IQQQHSSAAA AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL 250 260 270 280 290 300 EDLEKTSGHD HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG KDHPAVAATL 310 320 330 340 350 360 NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ NQGKYEEVEY 370 380 390 400 410 420 YYQRALEIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA ETLYKEILTR AHEREFGSVD 430 440 450 460 470 480 DENKPIWMHA EEREECKGKQ KDGTSFGEYG GWYKACKVDS PTVTTTLKNL GALYRRQGKF 490 500 510 520 530 540 EAAETLEEAA MRSRKQGLDN VHKQRVAEVL NDPENMEKRR SRESLNVDVV KYESGPDGGE 550 560 EVSMSVEWNG MRKMKLGLVN
	Isoform G (KLC1G). Checksum: 6576A4BCFC138FA6	FASTA	564	64,319
	10 20 30 40 50 60 MYDNMSTMVY IKEDKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL ETLKCLKKDD 70 80 90 100 110 120 ESNLVEEKSN MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE SEKQKLRAQV RRLCQENQWL 130 140 150 160 170 180 RDELANTQQK LQKSEQSVAQ LEEEKKHLEF MNQLKKYDDD ISPSEDKDTD STKEPLDDLF 190 200 210 220 230 240 PNDEDDPGQG IQQQHSSAAA AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL 250 260 270 280 290 300 EDLEKTSGHD HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG KDHPAVAATL 310 320 330 340 350 360 NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ NQGKYEEVEY 370 380 390 400 410 420 YYQRALEIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA ETLYKEILTR AHEREFGSVD 430 440 450 460 470 480 DENKPIWMHA EEREECKGKQ KDGTSFGEYG GWYKACKVDS PTVTTTLKNL GALYRRQGKF 490 500 510 520 530 540 EAAETLEEAA MRSRKQGLDN VHKQRVAEVL NDPENMEKRR SRESLNVDVV KYESGPDGGE 550 560 EGVSGRASFC GKRQQQQWPG RRHR
	Isoform J (KLC1J). Checksum: DCCD9D3E561F7A23	FASTA	637	71,996
	10 20 30 40 50 60 MYDNMSTMVY IKEDKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL ETLKCLKKDD 70 80 90 100 110 120 ESNLVEEKSN MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE SEKQKLRAQV RRLCQENQWL 130 140 150 160 170 180 RDELANTQQK LQKSEQSVAQ LEEEKKHLEF MNQLKKYDDD ISPSEDKDTD STKEPLDDLF 190 200 210 220 230 240 PNDEDDPGQG IQQQHSSAAA AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL 250 260 270 280 290 300 EDLEKTSGHD HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG KDHPAVAATL 310 320 330 340 350 360 NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ NQGKYEEVEY 370 380 390 400 410 420 YYQRALEIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA ETLYKEILTR AHEREFGSVD 430 440 450 460 470 480 DENKPIWMHA EEREECKGKQ KDGTSFGEYG GWYKACKVDS PTVTTTLKNL GALYRRQGKF 490 500 510 520 530 540 EAAETLEEAA MRSRKQGLDN VHKQRVAEVL NDPENMEKRR SRESLNVDVV KYESGPDGGE 550 560 570 580 590 600 EVSMSVEWNG DGTGSLKRSG SFSKLRASIR RSSEKLVRKL KGGSSRESEP KNPGMKRASS 610 620 630 LNVLNVGGKA AEDRFQERNN CLADSRALSA SHTDLAH
	Isoform K (KLC1K). Checksum: 40C895F6BAC6EC56	FASTA	616	69,967
	10 20 30 40 50 60 MYDNMSTMVY IKEDKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL ETLKCLKKDD 70 80 90 100 110 120 ESNLVEEKSN MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE SEKQKLRAQV RRLCQENQWL 130 140 150 160 170 180 RDELANTQQK LQKSEQSVAQ LEEEKKHLEF MNQLKKYDDD ISPSEDKDTD STKEPLDDLF 190 200 210 220 230 240 PNDEDDPGQG IQQQHSSAAA AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL 250 260 270 280 290 300 EDLEKTSGHD HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG KDHPAVAATL 310 320 330 340 350 360 NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ NQGKYEEVEY 370 380 390 400 410 420 YYQRALEIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA ETLYKEILTR AHEREFGSVD 430 440 450 460 470 480 DENKPIWMHA EEREECKGKQ KDGTSFGEYG GWYKACKVDS PTVTTTLKNL GALYRRQGKF 490 500 510 520 530 540 EAAETLEEAA MRSRKQGLDN VHKQRVAEVL NDPENMEKRR SRESLNVDVV KYESGPDGGE 550 560 570 580 590 600 EVSMSVEWNG DGTGSLKRSG SFSKLRASIR RSSEKLVRKL KGGSSRESEP KNPGVSGRAS 610 FCGKRQQQQW PGRRHR
	Isoform N (KLC1N). Checksum: DA665C9E7DCC89D9	FASTA	628	71,006
	10 20 30 40 50 60 MYDNMSTMVY IKEDKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL ETLKCLKKDD 70 80 90 100 110 120 ESNLVEEKSN MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE SEKQKLRAQV RRLCQENQWL 130 140 150 160 170 180 RDELANTQQK LQKSEQSVAQ LEEEKKHLEF MNQLKKYDDD ISPSEDKDTD STKEPLDDLF 190 200 210 220 230 240 PNDEDDPGQG IQQQHSSAAA AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL 250 260 270 280 290 300 EDLEKTSGHD HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG KDHPAVAATL 310 320 330 340 350 360 NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ NQGKYEEVEY 370 380 390 400 410 420 YYQRALEIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA ETLYKEILTR AHEREFGSVD 430 440 450 460 470 480 DENKPIWMHA EEREECKGKQ KDGTSFGEYG GWYKACKVDS PTVTTTLKNL GALYRRQGKF 490 500 510 520 530 540 EAAETLEEAA MRSRKQGLDN VHKQRVAEVL NDPENMEKRR SRESLNVDVV KYESGPDGGE 550 560 570 580 590 600 EDGTGSLKRS GSFSKLRASI RRSSEKLVRK LKGGSSRESE PKNPGMKRAS SLNVLNVGGK 610 620 AAEDRFQERN NCLADSRALS ASHTDLAH
	Isoform P (KLC1P). Checksum: 7E92734C1FB43CDA	FASTA	584	66,292
	10 20 30 40 50 60 MYDNMSTMVY IKEDKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL ETLKCLKKDD 70 80 90 100 110 120 ESNLVEEKSN MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE SEKQKLRAQV RRLCQENQWL 130 140 150 160 170 180 RDELANTQQK LQKSEQSVAQ LEEEKKHLEF MNQLKKYDDD ISPSEDKDTD STKEPLDDLF 190 200 210 220 230 240 PNDEDDPGQG IQQQHSSAAA AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL 250 260 270 280 290 300 EDLEKTSGHD HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG KDHPAVAATL 310 320 330 340 350 360 NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ NQGKYEEVEY 370 380 390 400 410 420 YYQRALEIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA ETLYKEILTR AHEREFGSVD 430 440 450 460 470 480 DENKPIWMHA EEREECKGKQ KDGTSFGEYG GWYKACKVDS PTVTTTLKNL GALYRRQGKF 490 500 510 520 530 540 EAAETLEEAA MRSRKQGLDN VHKQRVAEVL NDPENMEKRR SRESLNVDVV KYESGPDGGE 550 560 570 580 EMKRASSLNV LNVGGKAAED RFQERNNCLA DSRALSASHT DLAH
	Isoform S (KLC1S) (Q) (KLC1Q). Checksum: 8754DC7FBB75E8C3	FASTA	551	62,826
	10 20 30 40 50 60 MYDNMSTMVY IKEDKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL ETLKCLKKDD 70 80 90 100 110 120 ESNLVEEKSN MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE SEKQKLRAQV RRLCQENQWL 130 140 150 160 170 180 RDELANTQQK LQKSEQSVAQ LEEEKKHLEF MNQLKKYDDD ISPSEDKDTD STKEPLDDLF 190 200 210 220 230 240 PNDEDDPGQG IQQQHSSAAA AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL 250 260 270 280 290 300 EDLEKTSGHD HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG KDHPAVAATL 310 320 330 340 350 360 NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ NQGKYEEVEY 370 380 390 400 410 420 YYQRALEIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA ETLYKEILTR AHEREFGSVD 430 440 450 460 470 480 DENKPIWMHA EEREECKGKQ KDGTSFGEYG GWYKACKVDS PTVTTTLKNL GALYRRQGKF 490 500 510 520 530 540 EAAETLEEAA MRSRKQGLDN VHKQRVAEVL NDPENMEKRR SRESLNVDVV KYESGPDGGE 550 EMRKMKLGLV N
	Isoform I. Checksum: 5EA25AF4C9ECDFFC	FASTA	639	72,398
	10 20 30 40 50 60 MYDNMSTMVY IKEDKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL ETLKCLKKDD 70 80 90 100 110 120 ESNLVEEKSN MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE SEKQKLRAQV RRLCQENQWL 130 140 150 160 170 180 RDELANTQQK LQKSEQSVAQ LEEEKKHLEF MNQLKKYDDD ISPSEDKDTD STKEPLDDLF 190 200 210 220 230 240 PNDEDDPGQG IQQQHSSAAA AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL 250 260 270 280 290 300 EDLEKTSGHD HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG KDHPAVAATL 310 320 330 340 350 360 NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ NQGKYEEVEY 370 380 390 400 410 420 YYQRALEIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA ETLYKEILTR AHEREFGSVD 430 440 450 460 470 480 DENKPIWMHA EEREECKGKQ KDGTSFGEYG GWYKACKVDS PTVTTTLKNL GALYRRQGKF 490 500 510 520 530 540 EAAETLEEAA MRSRKQGLDN VHKQRVAEVL NDPENMEKRR SRESLNVDVV KYESGPDGGE 550 560 570 580 590 600 EVSMSVEWNG DGTGSLKRSG SFSKLRASIR RSSEKLVRKL KGGSSRESEP KNPGMKRASS 610 620 630 LNVLNVGGKA AEDRFQGVSG RASFCGKRQQ QQWPGRRHR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and genetic characterization of the human kinesin light-chain (KLC) gene." Cabeza-Arvelaiz Y., Shih L.-C.N., Hardman N., Asselbergs F., Bilbe G., Schmitz A., White B., Siciliano M.J., Lachman L.B. DNA Cell Biol. 12:881-892(1993) [PubMed: 8274221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
[2]	"Alternatively spliced products of the human kinesin light chain 1 (KNS2) gene." McCart A.E., Mahony D., Rothnagel J.A. Traffic 4:576-580(2003) [PubMed: 12839500] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; C; G; I; P AND S), NUCLEOTIDE SEQUENCE [MRNA] OF 444-573 (ISOFORMS J; K AND N). Tissue: Brain, Foreskin and Liver.
[3]	Gerber S., Rozet J.-M., Perrault I., Ducroq D., Souied E., Munnich A., Kaplan J. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C). Tissue: Uterus.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-600 (ISOFORM I), MASS SPECTROMETRY. Tissue: Epithelium.
[8]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460, MASS SPECTROMETRY. Tissue: Epithelium.
[9]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-631 (ISOFORM J), MASS SPECTROMETRY.
[10]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460, MASS SPECTROMETRY.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460; SER-521 AND SER-524, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L04733 mRNA. Translation: AAA16576.1. Different initiation. AY180163 mRNA. Translation: AAO62548.1. AY180164 mRNA. Translation: AAO62549.1. Different initiation. AY180165 mRNA. Translation: AAO62550.1. AY180166 mRNA. Translation: AAO62551.1. AY180168 mRNA. Translation: AAO62553.1. AY180167 mRNA. Translation: AAO62552.1. AY180169 mRNA. Translation: AAO62554.1. AY180170 mRNA. Translation: AAO62555.1. AY244715 mRNA. Translation: AAO64641.1. AF267530 , AF267518, AF267519, AF267520, AF267521, AF267522, AF267523, AF267524, AF267525, AF267526, AF267527, AF267528, AF267529 Genomic DNA. Translation: AAF72543.1. Different initiation. AL139300 Genomic DNA. No translation available. CH471061 Genomic DNA. Translation: EAW81834.1. BC008881 mRNA. Translation: AAH08881.1. BK000681 mRNA. Translation: DAA01265.1. Different initiation. BK000682 mRNA. Translation: DAA01266.1. Different initiation. BK000684 mRNA. Translation: DAA01268.1. Different initiation. BK001165 mRNA. Translation: DAA01291.1. Different initiation. BK001166 mRNA. Translation: DAA01292.1. Different initiation. BK001169 mRNA. Translation: DAA01295.1. Different initiation. BK001170 mRNA. Translation: DAA01296.1. Different initiation. BK001171 mRNA. Translation: DAA01297.1. Different initiation.
IPI	IPI00020096. IPI00337465. IPI00394906. IPI00397666. IPI00398708. IPI00412642. IPI00472303. IPI00479424. IPI00921532.
PIR	I53013.
RefSeq	NP_001123579.1. NP_005543.2. NP_891553.2.
UniGene	Hs.20107 Hs.657678
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q07866. 5 interactions.
STRING	Q07866.
PTM databases
PhosphoSite	Q07866.
Proteomic databases
PRIDE	Q07866.
Genome annotation databases
Ensembl	ENST00000246489; ENSP00000246489; ENSG00000126214; Homo sapiens. [Genome view] ENST00000247618; ENSP00000247618; ENSG00000126214; Homo sapiens. [Genome view] ENST00000334553; ENSP00000334523; ENSG00000126214; Homo sapiens. [Genome view] ENST00000347839; ENSP00000334618; ENSG00000126214; Homo sapiens. [Genome view] ENST00000348520; ENSP00000341154; ENSG00000126214; Homo sapiens. [Genome view] ENST00000380038; ENSP00000369377; ENSG00000126214; Homo sapiens. [Genome view] ENST00000389744; ENSP00000374394; ENSG00000126214; Homo sapiens. [Genome view] ENST00000409074; ENSP00000386485; ENSG00000126214; Homo sapiens. [Genome view] ENST00000440963; ENSP00000388067; ENSG00000126214; Homo sapiens. [Genome view] ENST00000443396; ENSP00000402779; ENSG00000126214; Homo sapiens. [Genome view] ENST00000445352; ENSP00000412693; ENSG00000126214; Homo sapiens. [Genome view] ENST00000452929; ENSP00000414982; ENSG00000126214; Homo sapiens. [Genome view] ENST00000458117; ENSP00000408525; ENSG00000126214; Homo sapiens. [Genome view]
GeneID	3831.
KEGG	hsa:3831.
UCSC	uc001ynm.1. human. uc001ynn.1. human. uc001yno.1. human.
Organism-specific databases
CTD	3831.
GeneCards	GC14P103167.
H-InvDB	HIX0012004.
HGNC	HGNC:6387. KLC1.
HPA	CAB009798.
MIM	600025. gene.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q07866.
Gene expression databases
ArrayExpress	Q07866.
Bgee	Q07866.
Genevestigator	Q07866.
GermOnline	ENSG00000126214. Homo sapiens.
Family and domain databases
InterPro	IPR002151. Kinesin_light. IPR015792. Kinesin_light_repeat. IPR015390. Rabaptin_Rab5-bd. IPR001440. TPR-1. IPR011990. TPR-like_helical. IPR013026. TPR_region. IPR019734. TPR_repeat. [Graphical view]
Gene3D	G3DSA:1.25.40.10. TPR-like_helical. 1 hit.
Pfam	PF09311. Rab5-bind. 1 hit. PF00515. TPR_1. 5 hits. [Graphical view]
PRINTS	PR00381. KINESINLIGHT.
SMART	SM00028. TPR. 5 hits. [Graphical view]
PROSITE	PS01160. KINESIN_LIGHT. 4 hits. PS50005. TPR. 6 hits. PS50293. TPR_REGION. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	15055.
SOURCE	Search...

Entry information

Entry name

KLC1_HUMAN

Accession

Primary (citable) accession number: Q07866
Secondary accession number(s): A6NF62 , Q7RTM2, Q7RTM3, Q7RTM5, Q7RTP9, Q7RTQ5, Q7RTQ6, Q86SF5, Q86TF5, Q86V74, Q86V75, Q86V76, Q86V77, Q86V78, Q86V79, Q96H62

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	February 10, 2009
Last modified:	October 13, 2009
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.