##gff-version 3 Q07864 UniProtKB Chain 1 2286 . . . ID=PRO_0000046455;Note=DNA polymerase epsilon catalytic subunit A Q07864 UniProtKB Zinc finger 2158 2190 . . . Note=CysA-type;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15436 Q07864 UniProtKB Region 1 30 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q07864 UniProtKB Region 1939 1969 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q07864 UniProtKB Motif 2221 2238 . . . Note=CysB motif;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15436 Q07864 UniProtKB Compositional bias 1948 1969 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q07864 UniProtKB Binding site 2158 2158 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15436 Q07864 UniProtKB Binding site 2161 2161 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15436 Q07864 UniProtKB Binding site 2187 2187 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15436 Q07864 UniProtKB Binding site 2190 2190 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15436 Q07864 UniProtKB Binding site 2221 2221 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15436 Q07864 UniProtKB Binding site 2224 2224 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15436 Q07864 UniProtKB Binding site 2236 2236 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15436 Q07864 UniProtKB Binding site 2238 2238 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15436 Q07864 UniProtKB Modified residue 1184 1184 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 Q07864 UniProtKB Modified residue 1297 1297 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q07864 UniProtKB Modified residue 1317 1317 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q07864 UniProtKB Modified residue 1940 1940 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17525332;Dbxref=PMID:17525332 Q07864 UniProtKB Natural variant 31 31 . . . ID=VAR_061138;Note=A->S;Dbxref=dbSNP:rs34047482 Q07864 UniProtKB Natural variant 99 99 . . . ID=VAR_028429;Note=P->L;Dbxref=dbSNP:rs5744739 Q07864 UniProtKB Natural variant 189 189 . . . ID=VAR_069339;Note=Found in a colorectal sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=PMID:23263490 Q07864 UniProtKB Natural variant 231 231 . . . ID=VAR_069340;Note=Found in a colorectal sample%3B somatic mutation. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=dbSNP:rs1060500835,PMID:23263490 Q07864 UniProtKB Natural variant 252 252 . . . ID=VAR_020276;Note=A->V;Dbxref=dbSNP:rs5744751 Q07864 UniProtKB Natural variant 260 260 . . . ID=VAR_028430;Note=R->Q;Dbxref=dbSNP:rs5744752 Q07864 UniProtKB Natural variant 286 286 . . . ID=VAR_069341;Note=Found in a colorectal sample%3B somatic mutation. P->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=dbSNP:rs1057519943,PMID:23263490 Q07864 UniProtKB Natural variant 286 286 . . . ID=VAR_077349;Note=Found in a colorectal sample%3B somatic mutation. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27612425;Dbxref=dbSNP:rs1057519943,PMID:27612425 Q07864 UniProtKB Natural variant 336 336 . . . ID=VAR_020277;Note=N->S;Dbxref=dbSNP:rs5744760 Q07864 UniProtKB Natural variant 367 367 . . . ID=VAR_069342;Note=Found in a colorectal sample%3B somatic mutation. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=PMID:23263490 Q07864 UniProtKB Natural variant 411 411 . . . ID=VAR_069343;Note=In CRCS12%3B uncertain significance. V->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23263490,ECO:0000269|PubMed:27573199;Dbxref=dbSNP:rs1057519945,PMID:23263490,PMID:27573199 Q07864 UniProtKB Natural variant 424 424 . . . ID=VAR_069344;Note=In CRCS12. L->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23263490,ECO:0000269|PubMed:24501277;Dbxref=dbSNP:rs483352909,PMID:23263490,PMID:24501277 Q07864 UniProtKB Natural variant 436 436 . . . ID=VAR_069345;Note=Found in a colorectal sample%3B somatic mutation. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=dbSNP:rs864622766,PMID:23263490 Q07864 UniProtKB Natural variant 458 458 . . . ID=VAR_077350;Note=In CRCS12%3B uncertain significance. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25860647;Dbxref=PMID:25860647 Q07864 UniProtKB Natural variant 459 459 . . . ID=VAR_069346;Note=Found in a colorectal sample%3B somatic mutation. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=PMID:23263490 Q07864 UniProtKB Natural variant 683 2286 . . . ID=VAR_081996;Note=In IMAGEI. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30503519;Dbxref=PMID:30503519 Q07864 UniProtKB Natural variant 695 695 . . . ID=VAR_020278;Note=F->I;Dbxref=dbSNP:rs5744799 Q07864 UniProtKB Natural variant 762 762 . . . ID=VAR_069347;Note=Found in a colorectal sample%3B somatic mutation. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=dbSNP:rs1064794759,PMID:23263490 Q07864 UniProtKB Natural variant 777 777 . . . ID=VAR_069348;Note=Found in a colorectal sample%3B somatic mutation. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=PMID:23263490 Q07864 UniProtKB Natural variant 1007 1007 . . . ID=VAR_081997;Note=In IMAGEI%3B uncertain significance. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30503519;Dbxref=dbSNP:rs747692201,PMID:30503519 Q07864 UniProtKB Natural variant 1008 1008 . . . ID=VAR_069349;Note=Found in a colorectal sample%3B somatic mutation. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=PMID:23263490 Q07864 UniProtKB Natural variant 1255 1255 . . . ID=VAR_069350;Note=Found in a colorectal sample%3B somatic mutation. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=PMID:23263490 Q07864 UniProtKB Natural variant 1368 1368 . . . ID=VAR_069351;Note=Found in a colorectal sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=dbSNP:rs770558983,PMID:23263490 Q07864 UniProtKB Natural variant 1382 1382 . . . ID=VAR_028431;Note=Found in a colorectal sample%3B somatic mutation. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27612425;Dbxref=dbSNP:rs5744904,PMID:27612425 Q07864 UniProtKB Natural variant 1395 1395 . . . ID=VAR_020279;Note=Y->C;Dbxref=dbSNP:rs5744933 Q07864 UniProtKB Natural variant 1396 1396 . . . ID=VAR_020280;Note=N->S;Dbxref=dbSNP:rs5744934 Q07864 UniProtKB Natural variant 1399 1399 . . . ID=VAR_020281;Note=E->Q;Dbxref=dbSNP:rs5744935 Q07864 UniProtKB Natural variant 1421 1421 . . . ID=VAR_069352;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=PMID:23263490 Q07864 UniProtKB Natural variant 1577 1577 . . . ID=VAR_028432;Note=E->A;Dbxref=dbSNP:rs5744948 Q07864 UniProtKB Natural variant 1712 1712 . . . ID=VAR_028433;Note=A->V;Dbxref=dbSNP:rs5744950 Q07864 UniProtKB Natural variant 1752 1752 . . . ID=VAR_069353;Note=Found in a colorectal sample%3B somatic mutation. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=dbSNP:rs1335665224,PMID:23263490 Q07864 UniProtKB Natural variant 1857 1857 . . . ID=VAR_028434;Note=K->R;Dbxref=dbSNP:rs5744971 Q07864 UniProtKB Natural variant 1925 1925 . . . ID=VAR_077351;Note=Found in a colorectal sample%3B somatic mutation. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27612425;Dbxref=PMID:27612425 Q07864 UniProtKB Natural variant 1935 1935 . . . ID=VAR_028435;Note=C->Y;Dbxref=dbSNP:rs5744991 Q07864 UniProtKB Natural variant 1980 2286 . . . ID=VAR_081998;Note=In IMAGEI. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30503519;Dbxref=PMID:30503519 Q07864 UniProtKB Natural variant 2013 2013 . . . ID=VAR_069354;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=PMID:23263490 Q07864 UniProtKB Natural variant 2040 2040 . . . ID=VAR_020282;Note=A->V;Dbxref=dbSNP:rs5745021 Q07864 UniProtKB Natural variant 2056 2056 . . . ID=VAR_069355;Note=Found in a colorectal sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=dbSNP:rs58916399,PMID:23263490 Q07864 UniProtKB Natural variant 2140 2140 . . . ID=VAR_048881;Note=E->K;Dbxref=dbSNP:rs5745066 Q07864 UniProtKB Natural variant 2159 2159 . . . ID=VAR_048882;Note=R->C;Dbxref=dbSNP:rs5745067 Q07864 UniProtKB Natural variant 2165 2165 . . . ID=VAR_020283;Note=R->H;Dbxref=dbSNP:rs5745068 Q07864 UniProtKB Natural variant 2213 2213 . . . ID=VAR_069356;Note=Found in a colorectal sample%3B somatic mutation. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23263490;Dbxref=PMID:23263490 Q07864 UniProtKB Sequence conflict 2237 2237 . . . Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q07864 UniProtKB Beta strand 2152 2157 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VBN Q07864 UniProtKB Turn 2159 2161 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VBN Q07864 UniProtKB Beta strand 2164 2168 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VBN Q07864 UniProtKB Turn 2169 2171 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VBN Q07864 UniProtKB Beta strand 2188 2190 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VBN Q07864 UniProtKB Helix 2196 2216 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VBN Q07864 UniProtKB Beta strand 2219 2224 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VBN Q07864 UniProtKB Beta strand 2230 2232 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VBN Q07864 UniProtKB Beta strand 2237 2239 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VBN Q07864 UniProtKB Beta strand 2241 2246 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VBN Q07864 UniProtKB Helix 2248 2265 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VBN Q07864 UniProtKB Helix 2268 2279 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VBN