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Protein

Ribosome biogenesis ATPase RIX7

Gene

RIX7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in ribosome biogenesis. Seems to be required for restructuring nucleoplasmic 60S pre-ribosomal particles to make them competent for nuclear export.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi246 – 2538ATPSequence analysis
Nucleotide bindingi574 – 5818ATPSequence analysis

GO - Molecular functioni

  • ATPase activity Source: SGD
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • ribosomal large subunit biogenesis Source: SGD
  • ribosomal large subunit export from nucleus Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32137-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis ATPase RIX7
Gene namesi
Name:RIX7
Ordered Locus Names:YLL034C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL034C.
SGDiS000003957. RIX7.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: SGD
  • nucleus Source: SGD
  • preribosome, large subunit precursor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 837837Ribosome biogenesis ATPase RIX7PRO_0000084762Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ07844.
PeptideAtlasiQ07844.

PTM databases

iPTMnetiQ07844.

Interactioni

Protein-protein interaction databases

BioGridi31219. 62 interactions.
DIPiDIP-6385N.
IntActiQ07844. 56 interactions.
MINTiMINT-621241.

Structurei

3D structure databases

ProteinModelPortaliQ07844.
SMRiQ07844. Positions 188-823.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00570000079239.
HOGENOMiHOG000223225.
InParanoidiQ07844.
KOiK14571.
OMAiMQGLWST.
OrthoDBiEOG71CFVP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKVKSKKNS LTSSLDNKIV DLIYRLLEEK TLDRKRSLRQ ESQGEEGENN
60 70 80 90 100
EGEEDEDIFE SMFFAKDLTA GEIFTFCLTK DLSLQRVKKV VLQKTIDRML
110 120 130 140 150
KDVIESELEE FGSYPGYNNE EEEKPSLEEE LAKKNMMIER DTNEMNKRIT
160 170 180 190 200
STWSKSGSVS ESITETDDPK TEEVKKSKKR SKEGTCKVKR QKIKEDRSPP
210 220 230 240 250
NSSLKSLGGM DDVVAQLMEL IGLPILHPEI FLSTGVEPPR GVLLHGPPGC
260 270 280 290 300
GKTSIANALA GELQVPFISI SAPSVVSGMS GESEKKIRDL FDEARSLAPC
310 320 330 340 350
LVFFDEIDAI TPKRDGGAQR EMERRIVAQL LTSMDELTME KTNGKPVIII
360 370 380 390 400
GATNRPDSLD AALRRAGRFD REICLNVPNE VSRLHILKKM SDNLKIDGAI
410 420 430 440 450
DFAKLAKLTP GFVGADLKAL VTAAGTCAIK RIFQTYANIK STPTTATDSS
460 470 480 490 500
EDNMEIDETA NGDESSLKNT ANMIDPLPLS VVQQFIRNYP EPLSGEQLSL
510 520 530 540 550
LSIKYEDFLK ALPTIQPTAK REGFATVPDV TWANVGALQR VRLELNMAIV
560 570 580 590 600
QPIKRPELYE KVGISAPGGV LLWGPPGCGK TLLAKAVANE SRANFISIKG
610 620 630 640 650
PELLNKYVGE SERSIRQVFT RARASVPCVI FFDELDALVP RRDTSLSESS
660 670 680 690 700
SRVVNTLLTE LDGLNDRRGI FVIGATNRPD MIDPAMLRPG RLDKSLFIEL
710 720 730 740 750
PNTEEKLDII KTLTKSHGTP LSSDVDFEEI IRNEKCNNFS GADLAALVRE
760 770 780 790 800
SSVLALKRKF FQSEEIQSVL DNDLDKEFED LSVGVSGEEI IVTMSDFRSA
810 820 830
LRKIKPSVSD KDRLKYDRLN KKMGLTEEMK DAEEMKQ
Length:837
Mass (Da):93,069
Last modified:November 1, 1997 - v1
Checksum:i133528B9D0987103
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73139 Genomic DNA. Translation: CAA97483.1.
BK006945 Genomic DNA. Translation: DAA09287.1.
PIRiS64785.
RefSeqiNP_013066.1. NM_001181854.1.

Genome annotation databases

EnsemblFungiiYLL034C; YLL034C; YLL034C.
GeneIDi850625.
KEGGisce:YLL034C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73139 Genomic DNA. Translation: CAA97483.1.
BK006945 Genomic DNA. Translation: DAA09287.1.
PIRiS64785.
RefSeqiNP_013066.1. NM_001181854.1.

3D structure databases

ProteinModelPortaliQ07844.
SMRiQ07844. Positions 188-823.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31219. 62 interactions.
DIPiDIP-6385N.
IntActiQ07844. 56 interactions.
MINTiMINT-621241.

PTM databases

iPTMnetiQ07844.

Proteomic databases

MaxQBiQ07844.
PeptideAtlasiQ07844.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLL034C; YLL034C; YLL034C.
GeneIDi850625.
KEGGisce:YLL034C.

Organism-specific databases

EuPathDBiFungiDB:YLL034C.
SGDiS000003957. RIX7.

Phylogenomic databases

GeneTreeiENSGT00570000079239.
HOGENOMiHOG000223225.
InParanoidiQ07844.
KOiK14571.
OMAiMQGLWST.
OrthoDBiEOG71CFVP.

Enzyme and pathway databases

BioCyciYEAST:G3O-32137-MONOMER.

Miscellaneous databases

NextBioi966532.
PROiQ07844.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "A nuclear AAA-type ATPase (Rix7p) is required for biogenesis and nuclear export of 60S ribosomal subunits."
    Gadal O., Strauss D., Braspenning J., Hoepfner D., Petfalski E., Philippsen P., Tollervey D., Hurt E.
    EMBO J. 20:3695-3704(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRIX7_YEAST
AccessioniPrimary (citable) accession number: Q07844
Secondary accession number(s): D6VXX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 11, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4490 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.