Q07843 (IRC19_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Increased recombination centers protein 19

Alternative name(s):
Respiratory growth protein 4

Gene names

Name:	IRC19
Synonyms:	RRG4
Ordered Locus Names:	YLL033W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in sporulation and maintenance of the mitochondrial DNA. Is probably involved in a pathway contributing to genomic integrity. Ref.5 Ref.6 Ref.8
Induction	During sporulation. Ref.4
Disruption phenotype	Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells. Ref.7
Sequence similarities	Belongs to the IRC19 family.

Ontologies

Keywords
Biological process	Sporulation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ascospore formation Inferred from mutant phenotype Ref.5. Source: SGD mitotic recombination Inferred from mutant phenotype Ref.7. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Increased recombination centers protein 19		PRO_0000247128

Sequences

	Sequence		Length	Mass (Da)
	Q07843 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 4B1D040696A4CF22	FASTA	230	27,378
	10 20 30 40 50 60 MRKPSITITT AKAIITPDYT LIKSHSKYQL PSRFQKLDAD SPERSTVVKL FYRRFMRLKP 70 80 90 100 110 120 FISNVKMVKD TYRDYVRYKF MKENYELKRY LVFNPDGLRS KINLELLSNT KCCERILPVT 130 140 150 160 170 180 EMQRTLEFVL KSCSYLPETK VQKWDIARDN TYCRQILKNL LTMQYEKYRS ILHRGIGHDE 190 200 210 220 230 LDVKFSHLKT TSSPLTKLNK TEKKKIPLFK VFSDFDTTLI YLNETLGTRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D. Nature 387:87-90(1997) [PubMed: 9169871] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"The transcriptional program of sporulation in budding yeast." Chu S., DeRisi J., Eisen M., Mulholland J., Botstein D., Brown P.O., Herskowitz I. Science 282:699-705(1998) [PubMed: 9784122] [Abstract] Cited for: INDUCTION.
[5]	"Parallel phenotypic analysis of sporulation and postgermination growth in Saccharomyces cerevisiae." Deutschbauer A.M., Williams R.M., Chu A.M., Davis R.W. Proc. Natl. Acad. Sci. U.S.A. 99:15530-15535(2002) [PubMed: 12432101] [Abstract] Cited for: FUNCTION.
[6]	"Systematic analysis of sporulation phenotypes in 624 non-lethal homozygous deletion strains of Saccharomyces cerevisiae." Briza P., Bogengruber E., Thuer A., Ruetzler M., Muensterkoetter M., Dawes I.W., Breitenbach M. Yeast 19:403-422(2002) [PubMed: 11921089] [Abstract] Cited for: FUNCTION.
[7]	"Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination." Alvaro D., Lisby M., Rothstein R. PLoS Genet. 3:E228-E228(2007) [PubMed: 18085829] [Abstract] Cited for: DISRUPTION PHENOTYPE.
[8]	"Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae." Merz S., Westermann B. Genome Biol. 10:R95.1-R95.18(2009) [PubMed: 19751518] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z73138 Genomic DNA. Translation: CAA97482.1. AY558188 Genomic DNA. Translation: AAS56514.1. BK006945 Genomic DNA. Translation: DAA09288.1.
PIR	S64784.
RefSeq	NP_013067.1. NM_001181853.1.
3D structure databases
ProteinModelPortal	Q07843.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2875N.
IntAct	Q07843. 2 interactions.
MINT	MINT-520922.
STRING	Q07843.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YLL033W; YLL033W; YLL033W.
GeneID	850626.
KEGG	sce:YLL033W.
NMPDR	fig|4932.3.peg.4058.
Organism-specific databases
CYGD	YLL033w.
SGD	S000003956. IRC19.
Phylogenomic databases
eggNOG	fuNOG12759.
OrthoDB	EOG4N07QP.
Gene expression databases
ArrayExpress	Q07843.
Genevestigator	Q07843.
GermOnline	YLL033W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR016613. UCP013329. [Graphical view]
PIRSF	PIRSF013329. UCP013329. 1 hit.
ProtoNet	Search...
Other
NextBio	966535.

Entry information

Entry name

IRC19_YEAST

Accession

Primary (citable) accession number: Q07843
Secondary accession number(s): D6VXX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program