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Protein

Putative Xaa-Pro aminopeptidase FRA1

Gene

FRA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of the iron regulon in responss to decreased mitochondrial iron-sulfur cluster synthesis.1 Publication

Catalytic activityi

Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.

Cofactori

Mn2+CuratedNote: Binds 2 manganese ions per subunit.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi551 – 5511Manganese 2Sequence analysis
Metal bindingi562 – 5621Manganese 1Sequence analysis
Metal bindingi562 – 5621Manganese 2Sequence analysis
Metal bindingi660 – 6601Manganese 1Sequence analysis
Metal bindingi674 – 6741Manganese 1Sequence analysis
Metal bindingi674 – 6741Manganese 2Sequence analysis

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter in response to iron Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32133-MONOMER.

Protein family/group databases

MEROPSiM24.A10.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative Xaa-Pro aminopeptidase FRA1 (EC:3.4.11.9)
Alternative name(s):
Fe repressor of activation 1
Gene namesi
Name:FRA1
Ordered Locus Names:YLL029W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL029W.
SGDiS000003952. FRA1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Putative Xaa-Pro aminopeptidase FRA1PRO_0000185086Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691PhosphoserineCombined sources
Modified residuei92 – 921PhosphoserineCombined sources
Modified residuei95 – 951PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ07825.

PTM databases

iPTMnetiQ07825.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with FRA2.By similarity1 Publication

Protein-protein interaction databases

BioGridi31223. 66 interactions.
DIPiDIP-6443N.
IntActiQ07825. 3 interactions.
MINTiMINT-677232.

Structurei

3D structure databases

ProteinModelPortaliQ07825.
SMRiQ07825. Positions 101-749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M24B family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000013970.
InParanoidiQ07825.
KOiK01262.
OMAiKLYEPEQ.
OrthoDBiEOG092C0W9Y.

Family and domain databases

Gene3Di3.40.350.10. 2 hits.
3.90.230.10. 1 hit.
InterProiIPR029149. Creatin/AminoP/Spt16_NTD.
IPR028980. Creatinase/Aminopeptidase_P_N.
IPR000587. Creatinase_N.
IPR000994. Pept_M24_structural-domain.
IPR032416. Peptidase_M24_C.
IPR001131. Peptidase_M24B_aminopep-P_CS.
[Graphical view]
PfamiPF01321. Creatinase_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
PF16188. Peptidase_M24_C. 1 hit.
[Graphical view]
SUPFAMiSSF53092. SSF53092. 1 hit.
SSF55920. SSF55920. 1 hit.
PROSITEiPS00491. PROLINE_PEPTIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKPSTSDG RAHSISHVPG THMRGTSASH SPRPFRPCAD CTCSPGLLSR
60 70 80 90 100
QGRRASLFLR QLENSRRSSS MLLNELKGAG GGSSAGNGSV YSCDSLCAVN
110 120 130 140 150
REVNTTDRLL KLRQEMKKHD LCCYIVPSCD EHQSEYVSLR DQRRAFISGF
160 170 180 190 200
SGSAGVACIT RDLLNFNDDH PDGKSILSTD GRYFNQARQE LDYNWTLLRQ
210 220 230 240 250
NEDPITWQEW CVREALEMAK GLGNKEGMVL KIGIDPKLIT FNDYVSFRKM
260 270 280 290 300
IDTKYDAKGK VELVPVEENL VDSIWPDFET LPERPCNDLL LLKYEFHGEE
310 320 330 340 350
FKDKKEKLLK KLNDKASSAT TGRNTFIVVA LDEICWLLNL RGSDIDYNPV
360 370 380 390 400
FFSYVAINED ETILFTNNPF NDDISEYFKI NGIEVRPYEQ IWEHLTKITS
410 420 430 440 450
QASSAEHEFL IPDSASWQMV RCLNTSTNAN GAIAKKMTAQ NFAIIHSPID
460 470 480 490 500
VLKSIKNDIE IKNAHKAQVK DAVCLVQYFA WLEQQLVGRE ALIDEYRAAE
510 520 530 540 550
KLTEIRKTQR NFMGNSFETI SSTGSNAAII HYSPPVENSS MIDPTKIYLC
560 570 580 590 600
DSGSQFLEGT TDITRTIHLT KPTKEEMDNY TLVLKGGLAL ERLIFPENTP
610 620 630 640 650
GFNIDAIARQ FLWSRGLDYK HGTGHGIGSF LNVHEGPMGV GFRPHLMNFP
660 670 680 690 700
LRAGNIISNE PGYYKDGEYG IRIESDMLIK KATEKGNFLK FENMTVVPYC
710 720 730 740
RKLINTKLLN EEEKTQINEY HARVWRTIVH FLQPQSISYK WLKRETSPL
Length:749
Mass (Da):84,924
Last modified:November 1, 1996 - v1
Checksum:i372FFF818A5FBDB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73134 Genomic DNA. Translation: CAA97478.1.
BK006945 Genomic DNA. Translation: DAA09291.1.
PIRiS64780.
RefSeqiNP_013071.1. NM_001181849.1.

Genome annotation databases

EnsemblFungiiYLL029W; YLL029W; YLL029W.
GeneIDi850630.
KEGGisce:YLL029W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73134 Genomic DNA. Translation: CAA97478.1.
BK006945 Genomic DNA. Translation: DAA09291.1.
PIRiS64780.
RefSeqiNP_013071.1. NM_001181849.1.

3D structure databases

ProteinModelPortaliQ07825.
SMRiQ07825. Positions 101-749.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31223. 66 interactions.
DIPiDIP-6443N.
IntActiQ07825. 3 interactions.
MINTiMINT-677232.

Protein family/group databases

MEROPSiM24.A10.

PTM databases

iPTMnetiQ07825.

Proteomic databases

MaxQBiQ07825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLL029W; YLL029W; YLL029W.
GeneIDi850630.
KEGGisce:YLL029W.

Organism-specific databases

EuPathDBiFungiDB:YLL029W.
SGDiS000003952. FRA1.

Phylogenomic databases

GeneTreeiENSGT00390000013970.
InParanoidiQ07825.
KOiK01262.
OMAiKLYEPEQ.
OrthoDBiEOG092C0W9Y.

Enzyme and pathway databases

BioCyciYEAST:G3O-32133-MONOMER.

Miscellaneous databases

PROiQ07825.

Family and domain databases

Gene3Di3.40.350.10. 2 hits.
3.90.230.10. 1 hit.
InterProiIPR029149. Creatin/AminoP/Spt16_NTD.
IPR028980. Creatinase/Aminopeptidase_P_N.
IPR000587. Creatinase_N.
IPR000994. Pept_M24_structural-domain.
IPR032416. Peptidase_M24_C.
IPR001131. Peptidase_M24B_aminopep-P_CS.
[Graphical view]
PfamiPF01321. Creatinase_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
PF16188. Peptidase_M24_C. 1 hit.
[Graphical view]
SUPFAMiSSF53092. SSF53092. 1 hit.
SSF55920. SSF55920. 1 hit.
PROSITEiPS00491. PROLINE_PEPTIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFRA1_YEAST
AccessioniPrimary (citable) accession number: Q07825
Secondary accession number(s): D6VXX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3237 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.