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Protein

Putative Xaa-Pro aminopeptidase FRA1

Gene

FRA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of the iron regulon in responss to decreased mitochondrial iron-sulfur cluster synthesis.1 Publication

Miscellaneous

Present with 3237 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.

Cofactori

Mn2+CuratedNote: Binds 2 manganese ions per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi551Manganese 2Sequence analysis1
Metal bindingi562Manganese 1Sequence analysis1
Metal bindingi562Manganese 2Sequence analysis1
Metal bindingi660Manganese 1Sequence analysis1
Metal bindingi674Manganese 1Sequence analysis1
Metal bindingi674Manganese 2Sequence analysis1

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter in response to iron Source: SGD

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32133-MONOMER
ReactomeiR-SCE-163125 Post-translational modification: synthesis of GPI-anchored proteins

Protein family/group databases

MEROPSiM24.A10

Names & Taxonomyi

Protein namesi
Recommended name:
Putative Xaa-Pro aminopeptidase FRA1 (EC:3.4.11.9)
Alternative name(s):
Fe repressor of activation 1
Gene namesi
Name:FRA1
Ordered Locus Names:YLL029W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL029W
SGDiS000003952 FRA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001850861 – 749Putative Xaa-Pro aminopeptidase FRA1Add BLAST749

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei95PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ07825
PaxDbiQ07825
PRIDEiQ07825

PTM databases

iPTMnetiQ07825

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with FRA2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP82P028292EBI-32387,EBI-8659

Protein-protein interaction databases

BioGridi31223, 182 interactors
DIPiDIP-6443N
IntActiQ07825, 20 interactors
MINTiQ07825
STRINGi4932.YLL029W

Structurei

3D structure databases

ProteinModelPortaliQ07825
SMRiQ07825
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M24B family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000013970
InParanoidiQ07825
KOiK01262
OMAiYWKKMAK
OrthoDBiEOG092C0W9Y

Family and domain databases

CDDicd01085 APP, 1 hit
Gene3Di3.40.350.10, 2 hits
InterProiView protein in InterPro
IPR029149 Creatin/AminoP/Spt16_NTD
IPR036005 Creatinase/aminopeptidase-like
IPR000587 Creatinase_N
IPR000994 Pept_M24
IPR033740 Pept_M24B
IPR032416 Peptidase_M24_C
IPR001131 Peptidase_M24B_aminopep-P_CS
PfamiView protein in Pfam
PF01321 Creatinase_N, 1 hit
PF00557 Peptidase_M24, 1 hit
PF16188 Peptidase_M24_C, 1 hit
SUPFAMiSSF53092 SSF53092, 1 hit
SSF55920 SSF55920, 1 hit
PROSITEiView protein in PROSITE
PS00491 PROLINE_PEPTIDASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q07825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKPSTSDG RAHSISHVPG THMRGTSASH SPRPFRPCAD CTCSPGLLSR
60 70 80 90 100
QGRRASLFLR QLENSRRSSS MLLNELKGAG GGSSAGNGSV YSCDSLCAVN
110 120 130 140 150
REVNTTDRLL KLRQEMKKHD LCCYIVPSCD EHQSEYVSLR DQRRAFISGF
160 170 180 190 200
SGSAGVACIT RDLLNFNDDH PDGKSILSTD GRYFNQARQE LDYNWTLLRQ
210 220 230 240 250
NEDPITWQEW CVREALEMAK GLGNKEGMVL KIGIDPKLIT FNDYVSFRKM
260 270 280 290 300
IDTKYDAKGK VELVPVEENL VDSIWPDFET LPERPCNDLL LLKYEFHGEE
310 320 330 340 350
FKDKKEKLLK KLNDKASSAT TGRNTFIVVA LDEICWLLNL RGSDIDYNPV
360 370 380 390 400
FFSYVAINED ETILFTNNPF NDDISEYFKI NGIEVRPYEQ IWEHLTKITS
410 420 430 440 450
QASSAEHEFL IPDSASWQMV RCLNTSTNAN GAIAKKMTAQ NFAIIHSPID
460 470 480 490 500
VLKSIKNDIE IKNAHKAQVK DAVCLVQYFA WLEQQLVGRE ALIDEYRAAE
510 520 530 540 550
KLTEIRKTQR NFMGNSFETI SSTGSNAAII HYSPPVENSS MIDPTKIYLC
560 570 580 590 600
DSGSQFLEGT TDITRTIHLT KPTKEEMDNY TLVLKGGLAL ERLIFPENTP
610 620 630 640 650
GFNIDAIARQ FLWSRGLDYK HGTGHGIGSF LNVHEGPMGV GFRPHLMNFP
660 670 680 690 700
LRAGNIISNE PGYYKDGEYG IRIESDMLIK KATEKGNFLK FENMTVVPYC
710 720 730 740
RKLINTKLLN EEEKTQINEY HARVWRTIVH FLQPQSISYK WLKRETSPL
Length:749
Mass (Da):84,924
Last modified:November 1, 1996 - v1
Checksum:i372FFF818A5FBDB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73134 Genomic DNA Translation: CAA97478.1
BK006945 Genomic DNA Translation: DAA09291.1
PIRiS64780
RefSeqiNP_013071.1, NM_001181849.1

Genome annotation databases

EnsemblFungiiYLL029W; YLL029W; YLL029W
GeneIDi850630
KEGGisce:YLL029W

Similar proteinsi

Entry informationi

Entry nameiFRA1_YEAST
AccessioniPrimary (citable) accession number: Q07825
Secondary accession number(s): D6VXX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health