Bcl-2-like protein 1 - Gallus gallus (Chicken)

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Molecule processing

Regions

Natural variations

Preferred order of sections

Molecule processing

Regions

Natural variations

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

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Q07816 (B2CL1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 92. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Protein names

Recommended name:
Bcl-2-like protein 1
Short name=Bcl2-L-1

Alternative name(s):
Apoptosis regulator Bcl-X

Gene names

Name:	BCL2L1
Synonyms:	BCL-X, BCLX

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Function	Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis By similarity.
Subcellular location	Mitochondrion membrane; Single-pass membrane protein By similarity. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side By similarity. Cytoplasm › cytoskeleton › centrosome By similarity. Note: Mitochondrial membranes and perinuclear envelope By similarity.
Tissue specificity	Highest expression in organs with lymphoid development.
Domain	The BH4 motif seems to be involved in the anti-apoptotic function. Intact BH1 and BH2 motifs are required for anti-apoptotic activity By similarity.
Sequence similarities	Belongs to the Bcl-2 family.

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm Cytoskeleton Membrane Mitochondrion Nucleus
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cytokinesis Inferred from sequence or structural similarity. Source: UniProtKB mitotic cell cycle G2/M transition checkpoint Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	centrosome Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Chain

1 – 229

229

Bcl-2-like protein 1

PRO_0000143061

Transmembrane

206 – 223

Helical; Potential

Motif

4 – 24

BH4

Motif

82 – 96

BH3

Motif

125 – 144

BH1

Motif

176 – 191

BH2

Alternative sequence

185 – 229

ERFVD…LLSRK → VRTALP in isoform Short.

VSP_000514

Sequence		Length	Mass (Da)
Isoform Long [UniParc]. Last modified November 1, 1997. Version 2. Checksum: A97D3A4D04C0E9DA Show »	FASTA	229	25,733
10 20 30 40 50 60 MSSSNRELVI DFVSYKLSQR GHCWSELEEE DENRTDTAAE AEMDSVLNGS PSWHPPAGHV 70 80 90 100 110 120 VNGATVHRSS LEVHEIVRAS DVRQALRDAG DEFELRYRRA FSDLTSQLHI TPGTAYQSFE 130 140 150 160 170 180 QVVNELFHDG VNWGRIVAFF SFGGALCVES VDKEMRVLVG RIVSWMTTYL TDHLDPWIQE 190 200 210 220 NGGWERFVDL YGNNAAAELR KGQETFNKWL LTGATVAGVL LLGSLLSRK « Hide
Isoform Short [UniParc]. Checksum: 88F5AC2C5ABDF1AA Show »	FASTA	190	21,467
10 20 30 40 50 60 MSSSNRELVI DFVSYKLSQR GHCWSELEEE DENRTDTAAE AEMDSVLNGS PSWHPPAGHV 70 80 90 100 110 120 VNGATVHRSS LEVHEIVRAS DVRQALRDAG DEFELRYRRA FSDLTSQLHI TPGTAYQSFE 130 140 150 160 170 180 QVVNELFHDG VNWGRIVAFF SFGGALCVES VDKEMRVLVG RIVSWMTTYL TDHLDPWIQE 190 NGGWVRTALP « Hide

[1]	"bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death." Boise L.H., Gonzalez-Garcia M., Postema C.E., Ding L., Lindsten T., Turka L.A., Mao X., Nunez G., Thompson C.B. Cell 74:597-608(1993) [PubMed: 8358789] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM SHORT).
[2]	"Differential expression of bcl-2 and bcl-x during chicken spermatogenesis." Vilagrasa X., Mezquita C., Mezquita J. Mol. Reprod. Dev. 47:26-29(1997) [PubMed: 9110311] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG). Strain: Hubbard White Mountain. Tissue: Testis.
+	Additional computationally mapped references.

Sequence databases
EMBL GenBank DDBJ	Z23110 Genomic DNA. Translation: CAA80657.1. U26645 mRNA. Translation: AAB07677.1.
IPI	IPI00576590. IPI00594932.
PIR	A47537.
RefSeq	NP_001020475.1. NM_001025304.1.
UniGene	Gga.4944.
3D structure databases
ProteinModelPortal	Q07816.
SMR	Q07816. Positions 1-204.
ModBase	Search...
Protein-protein interaction databases
STRING	Q07816.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000010073; ENSGALP00000010059; ENSGALG00000006211.
GeneID	373954.
KEGG	gga:373954.
Organism-specific databases
CTD	598.
Phylogenomic databases
eggNOG	veNOG15148.
HOGENOM	HBG717457.
InParanoid	Q07816.
OMA	NGSPSWH.
Family and domain databases
InterPro	IPR013279. Apop_reg_BclX. IPR002475. Bcl2-like_apoptosis. IPR000712. Bcl2_BH. IPR020717. Bcl2_BH1_motif_CS. IPR020726. Bcl2_BH2_motif_CS. IPR020728. Bcl2_BH3_motif_CS. IPR003093. Bcl2_BH4. IPR020731. Bcl2_BH4_motif_CS. IPR004725. Bcl2_reg. [Graphical view]
KO	K04570.
Pfam	PF00452. Bcl-2. 1 hit. PF02180. BH4. 1 hit. [Graphical view]
PRINTS	PR01864. APOPREGBCLX. PR01862. BCL2FAMILY.
SMART	SM00337. BCL. 1 hit. [Graphical view]
TIGRFAMs	TIGR00865. Bcl-2. 1 hit.
PROSITE	PS50062. BCL2_FAMILY. 1 hit. PS01080. BH1. 1 hit. PS01258. BH2. 1 hit. PS01259. BH3. 1 hit. PS01260. BH4_1. 1 hit. PS50063. BH4_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry name

B2CL1_CHICK

Accession

Primary (citable) accession number: Q07816
Secondary accession number(s): Q98908

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Long (identifier: Q07816-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Short (identifier: Q07816-2)

The sequence of this isoform differs from the canonical sequence as follows:
185-229: ERFVDLYGNNAAAELRKGQETFNKWLLTGATVAGVLLLGSLLSRK → VRTALP