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Q07801 (DYR_CRYNJ) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis By similarity.

Catalytic activity

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.

Subunit structure

Monomer.

Sequence similarities

Belongs to the dihydrofolate reductase family.

Contains 1 DHFR (dihydrofolate reductase) domain.

Sequence caution

The sequence AAW45849.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Dihydrofolate reductase
PRO_0000186375

Regions

Domain11 – 227217DHFR
Nucleotide binding23 – 297NADP By similarity
Nucleotide binding64 – 663NADP By similarity
Nucleotide binding86 – 883NADP By similarity
Nucleotide binding127 – 1348NADP By similarity
Region37 – 426Substrate binding By similarity

Sites

Binding site171NADP; via amide nitrogen and carbonyl oxygen By similarity
Binding site801Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07801 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 60D9E4FF66C5F198

FASTA22925,169
        10         20         30         40         50         60 
MQTTAKSSTP SITAVVAATA ENGIGLNGGL PWRLPGEMKY FARVTTGETP SSDPSEQNVV 

        70         80         90        100        110        120 
IMGRKTWESI PSRFRPLKNR RNVVISGKGV DLGTAENSTV YTDIPSALSA LRSTTESGHS 

       130        140        150        160        170        180 
PRIFLIGGAT LYTSSLLPSS VPSLNSSTST SPLPFSRPLI DRILLTRILS PFECDAYLED 

       190        200        210        220 
FAAHTKPDGS KVWKKASIKE FREWIGWDIE EQVEEKGVKY IFEMWVLNQ 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S58802 Genomic DNA. Translation: AAB26198.1.
AE017350 Genomic DNA. Translation: AAW45849.1. Different initiation.
PIRA46049.
RefSeqXP_567366.1. XM_567366.1.

3D structure databases

ProteinModelPortalQ07801.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING214684.CNJ01940.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiAAW45849; AAW45849; CNJ01940.
GeneID3254250.
KEGGcne:CNJ01940.

Phylogenomic databases

eggNOGCOG0262.
KOK00287.
OrthoDBEOG7Q8D07.

Enzyme and pathway databases

UniPathwayUPA00077; UER00158.

Family and domain databases

Gene3D3.40.430.10. 1 hit.
InterProIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamPF00186. DHFR_1. 1 hit.
[Graphical view]
PRINTSPR00070. DHFR.
SUPFAMSSF53597. SSF53597. 1 hit.
PROSITEPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDYR_CRYNJ
AccessionPrimary (citable) accession number: Q07801
Secondary accession number(s): Q5KAF0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 13, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways