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Protein

Phosphatase PSR1

Gene

PSR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has phosphatase activity in vitro. Involved in the response to sodium and lithium ion stress (but not to potassium or sorbitol stress) by inducing transcription of the sodium pump ENA1/PMR2. Acts through a calcineurin-independent pathway and is functionally redundant with PSR2. Also involved in the general stress response; acts together with WHI2 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.1 Publication2 Publications

Miscellaneous

Present with 5620 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • phosphoprotein phosphatase activity Source: SGD

GO - Biological processi

  • cellular response to salt stress Source: SGD
  • protein dephosphorylation Source: UniProtKB
  • response to heat Source: SGD
  • response to salt stress Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:G3O-32115-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatase PSR1 (EC:3.1.3.-)
Alternative name(s):
Plasma membrane sodium response protein 1
Gene namesi
Name:PSR1
Ordered Locus Names:YLL010C
ORF Names:L1341
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL010C
SGDiS000003933 PSR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2G → A: No effect on membrane association. 1 Publication1
Mutagenesisi9 – 10CC → GG: Impairs membrane association. 1 Publication2
Mutagenesisi263D → E: Low residual phosphatase activity. Loss of stress response functions. 1 Publication1
Mutagenesisi265D → E: Low residual phosphatase activity. Loss of stress response functions. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002125761 – 427Phosphatase PSR1Add BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi9S-palmitoyl cysteine1 PublicationSequence analysis1
Lipidationi10S-palmitoyl cysteine1 PublicationSequence analysis1
Modified residuei110PhosphoserineCombined sources1
Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ07800
PaxDbiQ07800
PRIDEiQ07800

PTM databases

iPTMnetiQ07800
SwissPalmiQ07800

Interactioni

Subunit structurei

Interacts with WHI2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
WHI2P126114EBI-31129,EBI-20530

Protein-protein interaction databases

BioGridi31241, 129 interactors
DIPiDIP-4182N
IntActiQ07800, 3 interactors
MINTiQ07800
STRINGi4932.YLL010C

Structurei

3D structure databases

ProteinModelPortaliQ07800
SMRiQ07800
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini253 – 411FCP1 homologyPROSITE-ProRule annotationAdd BLAST159

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi152 – 189Gln-richAdd BLAST38

Phylogenomic databases

GeneTreeiENSGT00910000144223
HOGENOMiHOG000211190
InParanoidiQ07800
KOiK15731
OrthoDBiEOG092C5CYS

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR011948 Dullard_phosphatase
IPR004274 FCP1_dom
IPR036412 HAD-like_sf
IPR023214 HAD_sf
PfamiView protein in Pfam
PF03031 NIF, 1 hit
SMARTiView protein in SMART
SM00577 CPDc, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02251 HIF-SF_euk, 1 hit
PROSITEiView protein in PROSITE
PS50969 FCP1, 1 hit

Sequencei

Sequence statusi: Complete.

Q07800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFISSILCC SSETTQSNSN SAYRQQQSSS LNKNRSVKHS NTKSRTRGVH
60 70 80 90 100
QTNSPPSKTN SAATFSSTER STGKSGISTN DNEKKKPSSP TAAVTATTTN
110 120 130 140 150
NMTKVEKRIS KDDLYEEKYE VDEDEEIDDE DNRRSRGIVQ EKGDAVKDTS
160 170 180 190 200
RQKKQQQQQQ QQSQPQPQPQ SQSQSQSQSQ SQQRGPTVQV SSDHLIQDMN
210 220 230 240 250
LSRVSSSSQA SETSNDADDE DDEDEEYIDL TLLQQGQYHA PGYNTLLPPQ
260 270 280 290 300
DESTKGKKCL ILDLDETLVH SSFKYLRSAD FVLSVEIDDQ VHNVYVIKRP
310 320 330 340 350
GVEEFLERVG KLFEVVVFTA SVSRYGDPLL DILDTDKVIH HRLFREACYN
360 370 380 390 400
YEGNYIKNLS QIGRPLSDII ILDNSPASYI FHPQHAIPIS SWFSDTHDNE
410 420
LLDIIPLLED LSVKTSLDVG KILDVTI
Length:427
Mass (Da):47,931
Last modified:November 1, 1996 - v1
Checksum:i402F5C395132A080
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91488 Genomic DNA Translation: CAA62782.1
Z73115 Genomic DNA Translation: CAA97454.1
BK006945 Genomic DNA Translation: DAA09308.1
PIRiS64752
RefSeqiNP_013091.1, NM_001181830.1

Genome annotation databases

EnsemblFungiiYLL010C; YLL010C; YLL010C
GeneIDi850650
KEGGisce:YLL010C

Similar proteinsi

Entry informationi

Entry nameiPSR1_YEAST
AccessioniPrimary (citable) accession number: Q07800
Secondary accession number(s): D6VXZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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