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Protein

Phosphatase PSR1

Gene

PSR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has phosphatase activity in vitro. Involved in the response to sodium and lithium ion stress (but not to potassium or sorbitol stress) by inducing transcription of the sodium pump ENA1/PMR2. Acts through a calcineurin-independent pathway and is functionally redundant with PSR2. Also involved in the general stress response; acts together with WHI2 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.1 Publication2 Publications

GO - Molecular functioni

  • phosphoprotein phosphatase activity Source: SGD

GO - Biological processi

  • cellular response to salt stress Source: SGD
  • response to heat Source: UniProtKB
  • response to salt stress Source: UniProtKB
  • response to stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:G3O-32115-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatase PSR1 (EC:3.1.3.-)
Alternative name(s):
Plasma membrane sodium response protein 1
Gene namesi
Name:PSR1
Ordered Locus Names:YLL010C
ORF Names:L1341
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL010C.
SGDiS000003933. PSR1.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2G → A: No effect on membrane association. 1 Publication1
Mutagenesisi9 – 10CC → GG: Impairs membrane association. 1 Publication2
Mutagenesisi263D → E: Low residual phosphatase activity. Loss of stress response functions. 1 Publication1
Mutagenesisi265D → E: Low residual phosphatase activity. Loss of stress response functions. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002125761 – 427Phosphatase PSR1Add BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi9S-palmitoyl cysteine1 PublicationSequence analysis1
Lipidationi10S-palmitoyl cysteine1 PublicationSequence analysis1
Modified residuei110PhosphoserineCombined sources1
Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ07800.
PRIDEiQ07800.

PTM databases

iPTMnetiQ07800.
SwissPalmiQ07800.

Interactioni

Subunit structurei

Interacts with WHI2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
WHI2P126113EBI-31129,EBI-20530

Protein-protein interaction databases

BioGridi31241. 35 interactors.
DIPiDIP-4182N.
IntActiQ07800. 1 interactor.
MINTiMINT-513454.

Structurei

3D structure databases

ProteinModelPortaliQ07800.
SMRiQ07800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini253 – 411FCP1 homologyPROSITE-ProRule annotationAdd BLAST159

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi152 – 189Gln-richAdd BLAST38

Sequence similaritiesi

Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000017194.
HOGENOMiHOG000211190.
InParanoidiQ07800.
KOiK15731.
OMAiKYEVDED.
OrthoDBiEOG092C5CYS.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFISSILCC SSETTQSNSN SAYRQQQSSS LNKNRSVKHS NTKSRTRGVH
60 70 80 90 100
QTNSPPSKTN SAATFSSTER STGKSGISTN DNEKKKPSSP TAAVTATTTN
110 120 130 140 150
NMTKVEKRIS KDDLYEEKYE VDEDEEIDDE DNRRSRGIVQ EKGDAVKDTS
160 170 180 190 200
RQKKQQQQQQ QQSQPQPQPQ SQSQSQSQSQ SQQRGPTVQV SSDHLIQDMN
210 220 230 240 250
LSRVSSSSQA SETSNDADDE DDEDEEYIDL TLLQQGQYHA PGYNTLLPPQ
260 270 280 290 300
DESTKGKKCL ILDLDETLVH SSFKYLRSAD FVLSVEIDDQ VHNVYVIKRP
310 320 330 340 350
GVEEFLERVG KLFEVVVFTA SVSRYGDPLL DILDTDKVIH HRLFREACYN
360 370 380 390 400
YEGNYIKNLS QIGRPLSDII ILDNSPASYI FHPQHAIPIS SWFSDTHDNE
410 420
LLDIIPLLED LSVKTSLDVG KILDVTI
Length:427
Mass (Da):47,931
Last modified:November 1, 1996 - v1
Checksum:i402F5C395132A080
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91488 Genomic DNA. Translation: CAA62782.1.
Z73115 Genomic DNA. Translation: CAA97454.1.
BK006945 Genomic DNA. Translation: DAA09308.1.
PIRiS64752.
RefSeqiNP_013091.1. NM_001181830.1.

Genome annotation databases

EnsemblFungiiYLL010C; YLL010C; YLL010C.
GeneIDi850650.
KEGGisce:YLL010C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91488 Genomic DNA. Translation: CAA62782.1.
Z73115 Genomic DNA. Translation: CAA97454.1.
BK006945 Genomic DNA. Translation: DAA09308.1.
PIRiS64752.
RefSeqiNP_013091.1. NM_001181830.1.

3D structure databases

ProteinModelPortaliQ07800.
SMRiQ07800.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31241. 35 interactors.
DIPiDIP-4182N.
IntActiQ07800. 1 interactor.
MINTiMINT-513454.

PTM databases

iPTMnetiQ07800.
SwissPalmiQ07800.

Proteomic databases

MaxQBiQ07800.
PRIDEiQ07800.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLL010C; YLL010C; YLL010C.
GeneIDi850650.
KEGGisce:YLL010C.

Organism-specific databases

EuPathDBiFungiDB:YLL010C.
SGDiS000003933. PSR1.

Phylogenomic databases

GeneTreeiENSGT00390000017194.
HOGENOMiHOG000211190.
InParanoidiQ07800.
KOiK15731.
OMAiKYEVDED.
OrthoDBiEOG092C5CYS.

Enzyme and pathway databases

BioCyciYEAST:G3O-32115-MONOMER.

Miscellaneous databases

PROiQ07800.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSR1_YEAST
AccessioniPrimary (citable) accession number: Q07800
Secondary accession number(s): D6VXZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5620 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.