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Q07798 (SPO75_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sporulation-specific protein 75
Gene names
Name:SPO75
Ordered Locus Names:YLL005C
ORF Names:L1361
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length868 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as an osmosensitive calcium-permeable cation channel By similarity. Required for spore wall assembly and ascus formation. Ref.4 Ref.5

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the CSC1 (TC 1.A.17) family. [View classification]

Ontologies

Keywords
   Biological processIon transport
Sporulation
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandCalcium
   Molecular functionIon channel
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processascospore formation

Inferred from mutant phenotype Ref.4. Source: SGD

ascospore wall assembly

Inferred from mutant phenotype Ref.5. Source: SGD

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 868868Sporulation-specific protein 75
PRO_0000072143

Regions

Topological domain1 – 3434Extracellular Potential
Transmembrane35 – 5521Helical; Potential
Topological domain56 – 12772Cytoplasmic Potential
Transmembrane128 – 14821Helical; Potential
Topological domain149 – 18739Extracellular Potential
Transmembrane188 – 20821Helical; Potential
Topological domain209 – 481273Cytoplasmic Potential
Transmembrane482 – 50221Helical; Potential
Topological domain503 – 52725Extracellular Potential
Transmembrane528 – 54821Helical; Potential
Topological domain549 – 56921Cytoplasmic Potential
Transmembrane570 – 59021Helical; Potential
Topological domain591 – 61121Extracellular Potential
Transmembrane612 – 63221Helical; Potential
Topological domain633 – 66028Cytoplasmic Potential
Transmembrane661 – 68323Helical; Potential
Topological domain684 – 6929Extracellular Potential
Transmembrane693 – 71321Helical; Potential
Topological domain714 – 73017Cytoplasmic Potential
Transmembrane731 – 75121Helical; Potential
Topological domain752 – 7532Extracellular Potential
Transmembrane754 – 77421Helical; Potential
Topological domain775 – 86894Cytoplasmic Potential

Amino acid modifications

Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential
Glycosylation5031N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q07798 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 10E4B5B8C7580653

FASTA868102,170
        10         20         30         40         50         60 
MNATKELTFN LLNKFQDKER FGSAQRHAGI SLKGFISGIL FSFLYFLFQL SLFIILRSRF 

        70         80         90        100        110        120 
KTIYQANVVL KIHPGSKVCF AKKKIKNYWS LFAFLKQLPG RMLDPMEKFE RNERYGLDNY 

       130        140        150        160        170        180 
LFLRFLKLLI FFFAVLSIIN IPILIPIHYF SRDILKENEG ERYEQSFRTT SKLDKWTMSN 

       190        200        210        220        230        240 
LSPNSSNTLI CHLFLSIFVV LWFHFILSSE LRFVNRLGYS VLTKSKYQNI LYLEGFSSKL 

       250        260        270        280        290        300 
VTQSISLETF FQPLHSDCFG VTHFIPKNLK KVHKLEIKLN KLQKSKEQII FEIILEKYFR 

       310        320        330        340        350        360 
RVSIHRHLIA NHKRFFFSKL KNHLLFQYKK LVFLTQFRIS YYCTKIRLRW KKSSIFPLYY 

       370        380        390        400        410        420 
PKLYVNTETI LERKYRILDK IIRKEKLIKF QVNSLKATSE TKQALPDDLS SGTDIYMDKM 

       430        440        450        460        470        480 
FITFKSTLLS NVIGELLSYR LPTQNLKVII GPNVNDIIWR NILDSSPLWK SAKYFSANIL 

       490        500        510        520        530        540 
RIFVIIGWIL PVAFLGLISQ IPNISSLIPF TKIIHFQSPF IREVAKNLIP IVTLIIIIEI 

       550        560        570        580        590        600 
VPYFFRWLSY LRGLKTGAQI EADVQNWYFV FVFIHLFVVV TISSGFSIII ERLLNNPVSI 

       610        620        630        640        650        660 
PALLANDLPK CANFFCSFVL IRGMAYAGGN LLRIKELLFE LFYYKWKRST PHAQFKRLKT 

       670        680        690        700        710        720 
SLFFQLGSIY PIFSVLGCIG IIYSVVAPII LLLCCISFSM VFFSFSYLFK YQYNKENYSE 

       730        740        750        760        770        780 
TFGKLYIQAL MQLYAGIYFM EFCLLGLFTL FDQYTLSTIM LVVFALTVIT HSKISKQIKS 

       790        800        810        820        830        840 
KPQRIPTLEY LSNLTEERKD QFCQESYTFH DIFSICRNSD EIWLPRDKLG ISEEEQSFLE 

       850        860 
KSYHLKFDLN MYSMNLFGDC HLENSHLH 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of the CEN12 region of Saccharomyces cerevisiae on a 43.7 kb fragment of chromosome XII including an open reading frame homologous to the human cystic fibrosis transmembrane conductance regulator protein CFTR."
Miosga T., Zimmermann F.K.
Yeast 12:693-708(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"A screen for genes required for meiosis and spore formation based on whole-genome expression."
Rabitsch K.P., Toth A., Galova M., Schleiffer A., Schaffner G., Aigner E., Rupp C., Penkner A.M., Moreno-Borchart A.C., Primig M., Esposito R.E., Klein F., Knop M., Nasmyth K.
Curr. Biol. 11:1001-1009(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Morphogenetic pathway of spore wall assembly in Saccharomyces cerevisiae."
Coluccio A., Bogengruber E., Conrad M.N., Dresser M.E., Briza P., Neiman A.M.
Eukaryot. Cell 3:1464-1475(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X91488 Genomic DNA. Translation: CAA62764.1.
Z73110 Genomic DNA. Translation: CAA97448.1.
BK006945 Genomic DNA. Translation: DAA09314.1.
PIRS64747.
RefSeqNP_013096.1. NM_001181825.1.

3D structure databases

ProteinModelPortalQ07798.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31246. 13 interactions.
DIPDIP-8843N.
IntActQ07798. 3 interactions.
MINTMINT-2782453.
STRING4932.YLL005C.

Protein family/group databases

TCDB1.A.17.5.7. the calcium-dependent chloride channel (ca-clc) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLL005C; YLL005C; YLL005C.
GeneID850655.
KEGGsce:YLL005C.

Organism-specific databases

CYGDYLL005c.
SGDS000003928. SPO75.

Phylogenomic databases

eggNOGCOG5594.
GeneTreeENSGT00530000068232.
HOGENOMHOG000141747.
OMAENISETH.
OrthoDBEOG71ZP92.

Enzyme and pathway databases

BioCycYEAST:G3O-32110-MONOMER.

Gene expression databases

GenevestigatorQ07798.

Family and domain databases

InterProIPR003864. DUF221.
[Graphical view]
PfamPF02714. DUF221. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio966614.

Entry information

Entry nameSPO75_YEAST
AccessionPrimary (citable) accession number: Q07798
Secondary accession number(s): D6VXZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families