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Q07798

- SPO75_YEAST

UniProt

Q07798 - SPO75_YEAST

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Protein

Sporulation-specific protein 75

Gene

SPO75

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Acts as an osmosensitive calcium-permeable cation channel (By similarity). Required for spore wall assembly and ascus formation.By similarity2 Publications

GO - Biological processi

  1. ascospore formation Source: SGD
  2. ascospore wall assembly Source: SGD
  3. ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Sporulation, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciYEAST:G3O-32110-MONOMER.

Protein family/group databases

TCDBi1.A.17.5.7. the calcium-dependent chloride channel (ca-clc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sporulation-specific protein 75
Gene namesi
Name:SPO75
Ordered Locus Names:YLL005C
ORF Names:L1361
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLL005c.
SGDiS000003928. SPO75.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 868868Sporulation-specific protein 75PRO_0000072143Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

GenevestigatoriQ07798.

Interactioni

Protein-protein interaction databases

BioGridi31246. 13 interactions.
DIPiDIP-8843N.
IntActiQ07798. 3 interactions.
MINTiMINT-2782453.
STRINGi4932.YLL005C.

Structurei

3D structure databases

ProteinModelPortaliQ07798.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
BLAST
Topological domaini56 – 12772CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini149 – 18739ExtracellularSequence AnalysisAdd
BLAST
Topological domaini209 – 481273CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini503 – 52725ExtracellularSequence AnalysisAdd
BLAST
Topological domaini549 – 56921CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini591 – 61121ExtracellularSequence AnalysisAdd
BLAST
Topological domaini633 – 66028CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini684 – 6929ExtracellularSequence Analysis
Topological domaini714 – 73017CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini752 – 7532ExtracellularSequence Analysis
Topological domaini775 – 86894CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Transmembranei128 – 14821HelicalSequence AnalysisAdd
BLAST
Transmembranei188 – 20821HelicalSequence AnalysisAdd
BLAST
Transmembranei482 – 50221HelicalSequence AnalysisAdd
BLAST
Transmembranei528 – 54821HelicalSequence AnalysisAdd
BLAST
Transmembranei570 – 59021HelicalSequence AnalysisAdd
BLAST
Transmembranei612 – 63221HelicalSequence AnalysisAdd
BLAST
Transmembranei661 – 68323HelicalSequence AnalysisAdd
BLAST
Transmembranei693 – 71321HelicalSequence AnalysisAdd
BLAST
Transmembranei731 – 75121HelicalSequence AnalysisAdd
BLAST
Transmembranei754 – 77421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5594.
GeneTreeiENSGT00530000068232.
HOGENOMiHOG000141747.
InParanoidiQ07798.
OMAiENISETH.
OrthoDBiEOG71ZP92.

Family and domain databases

InterProiIPR003864. DUF221.
[Graphical view]
PfamiPF02714. DUF221. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07798 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNATKELTFN LLNKFQDKER FGSAQRHAGI SLKGFISGIL FSFLYFLFQL
60 70 80 90 100
SLFIILRSRF KTIYQANVVL KIHPGSKVCF AKKKIKNYWS LFAFLKQLPG
110 120 130 140 150
RMLDPMEKFE RNERYGLDNY LFLRFLKLLI FFFAVLSIIN IPILIPIHYF
160 170 180 190 200
SRDILKENEG ERYEQSFRTT SKLDKWTMSN LSPNSSNTLI CHLFLSIFVV
210 220 230 240 250
LWFHFILSSE LRFVNRLGYS VLTKSKYQNI LYLEGFSSKL VTQSISLETF
260 270 280 290 300
FQPLHSDCFG VTHFIPKNLK KVHKLEIKLN KLQKSKEQII FEIILEKYFR
310 320 330 340 350
RVSIHRHLIA NHKRFFFSKL KNHLLFQYKK LVFLTQFRIS YYCTKIRLRW
360 370 380 390 400
KKSSIFPLYY PKLYVNTETI LERKYRILDK IIRKEKLIKF QVNSLKATSE
410 420 430 440 450
TKQALPDDLS SGTDIYMDKM FITFKSTLLS NVIGELLSYR LPTQNLKVII
460 470 480 490 500
GPNVNDIIWR NILDSSPLWK SAKYFSANIL RIFVIIGWIL PVAFLGLISQ
510 520 530 540 550
IPNISSLIPF TKIIHFQSPF IREVAKNLIP IVTLIIIIEI VPYFFRWLSY
560 570 580 590 600
LRGLKTGAQI EADVQNWYFV FVFIHLFVVV TISSGFSIII ERLLNNPVSI
610 620 630 640 650
PALLANDLPK CANFFCSFVL IRGMAYAGGN LLRIKELLFE LFYYKWKRST
660 670 680 690 700
PHAQFKRLKT SLFFQLGSIY PIFSVLGCIG IIYSVVAPII LLLCCISFSM
710 720 730 740 750
VFFSFSYLFK YQYNKENYSE TFGKLYIQAL MQLYAGIYFM EFCLLGLFTL
760 770 780 790 800
FDQYTLSTIM LVVFALTVIT HSKISKQIKS KPQRIPTLEY LSNLTEERKD
810 820 830 840 850
QFCQESYTFH DIFSICRNSD EIWLPRDKLG ISEEEQSFLE KSYHLKFDLN
860
MYSMNLFGDC HLENSHLH
Length:868
Mass (Da):102,170
Last modified:November 1, 1996 - v1
Checksum:i10E4B5B8C7580653
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X91488 Genomic DNA. Translation: CAA62764.1.
Z73110 Genomic DNA. Translation: CAA97448.1.
BK006945 Genomic DNA. Translation: DAA09314.1.
PIRiS64747.
RefSeqiNP_013096.1. NM_001181825.1.

Genome annotation databases

EnsemblFungiiYLL005C; YLL005C; YLL005C.
GeneIDi850655.
KEGGisce:YLL005C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X91488 Genomic DNA. Translation: CAA62764.1 .
Z73110 Genomic DNA. Translation: CAA97448.1 .
BK006945 Genomic DNA. Translation: DAA09314.1 .
PIRi S64747.
RefSeqi NP_013096.1. NM_001181825.1.

3D structure databases

ProteinModelPortali Q07798.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31246. 13 interactions.
DIPi DIP-8843N.
IntActi Q07798. 3 interactions.
MINTi MINT-2782453.
STRINGi 4932.YLL005C.

Protein family/group databases

TCDBi 1.A.17.5.7. the calcium-dependent chloride channel (ca-clc) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLL005C ; YLL005C ; YLL005C .
GeneIDi 850655.
KEGGi sce:YLL005C.

Organism-specific databases

CYGDi YLL005c.
SGDi S000003928. SPO75.

Phylogenomic databases

eggNOGi COG5594.
GeneTreei ENSGT00530000068232.
HOGENOMi HOG000141747.
InParanoidi Q07798.
OMAi ENISETH.
OrthoDBi EOG71ZP92.

Enzyme and pathway databases

BioCyci YEAST:G3O-32110-MONOMER.

Miscellaneous databases

NextBioi 966614.

Gene expression databases

Genevestigatori Q07798.

Family and domain databases

InterProi IPR003864. DUF221.
[Graphical view ]
Pfami PF02714. DUF221. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the CEN12 region of Saccharomyces cerevisiae on a 43.7 kb fragment of chromosome XII including an open reading frame homologous to the human cystic fibrosis transmembrane conductance regulator protein CFTR."
    Miosga T., Zimmermann F.K.
    Yeast 12:693-708(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: FUNCTION.
  5. "Morphogenetic pathway of spore wall assembly in Saccharomyces cerevisiae."
    Coluccio A., Bogengruber E., Conrad M.N., Dresser M.E., Briza P., Neiman A.M.
    Eukaryot. Cell 3:1464-1475(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiSPO75_YEAST
AccessioniPrimary (citable) accession number: Q07798
Secondary accession number(s): D6VXZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3