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Protein

Galectin-3-binding protein

Gene

Lgals3bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity).By similarity

GO - Molecular functioni

  • scavenger receptor activity Source: MGI

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • receptor-mediated endocytosis Source: GOC
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-3-binding protein
Alternative name(s):
Cyp-C-associated protein
Short name:
CyCAP
Lectin galactoside-binding soluble 3-binding protein
Protein MAMA
Gene namesi
Name:Lgals3bp
Synonyms:Cycap, Mama
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:99554. Lgals3bp.

Subcellular locationi

  • Secreted By similarity
  • Secretedextracellular spaceextracellular matrix 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 577559Galectin-3-binding proteinPRO_0000357035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 113PROSITE-ProRule annotation
Disulfide bondi62 ↔ 123PROSITE-ProRule annotation
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence analysis
Disulfide bondi93 ↔ 103PROSITE-ProRule annotation
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence analysis
Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence analysis
Glycosylationi398 – 3981N-linked (GlcNAc...)Sequence analysis
Glycosylationi543 – 5431N-linked (GlcNAc...)Sequence analysis
Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ07797.
MaxQBiQ07797.
PaxDbiQ07797.
PRIDEiQ07797.

PTM databases

PhosphoSiteiQ07797.

Expressioni

Tissue specificityi

Detected in embryo, liver, spleen, kidney, lung, heart, intestine, thymus and lymph node.2 Publications

Inductioni

Up-regulated by TNF and IFNG.1 Publication

Gene expression databases

BgeeiQ07797.
ExpressionAtlasiQ07797. baseline and differential.
GenevisibleiQ07797. MM.

Interactioni

Subunit structurei

Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID (By similarity). Interacts with PPIC (in vitro).By similarity1 Publication

Protein-protein interaction databases

BioGridi202330. 51 interactions.
IntActiQ07797. 51 interactions.
MINTiMINT-1866818.
STRINGi10090.ENSMUSP00000035579.

Structurei

3D structure databases

ProteinModelPortaliQ07797.
SMRiQ07797. Positions 21-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 124101SRCRPROSITE-ProRule annotationAdd
BLAST
Domaini153 – 22169BTBPROSITE-ProRule annotationAdd
BLAST
Domaini260 – 360101BACKAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 1 SRCR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY2Y. Eukaryota.
ENOG410YBYF. LUCA.
GeneTreeiENSGT00530000063814.
HOGENOMiHOG000113318.
HOVERGENiHBG052323.
InParanoidiQ07797.
KOiK17300.
OMAiRFPMMLP.
OrthoDBiEOG7JDQXP.
PhylomeDBiQ07797.
TreeFamiTF331368.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF56487. SSF56487. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLWLLSVF LLVPGTQGTE DGDMRLVNGA SANEGRVEIF YRGRWGTVCD
60 70 80 90 100
NLWNLLDAHV VCRALGYENA TQALGRAAFG PGKGPIMLDE VECTGTESSL
110 120 130 140 150
ASCRSLGWMV SRCGHEKDAG VVCSNDTTGL HILDLSGELS DALGQIFDSQ
160 170 180 190 200
QGCDLFIQVT GQGYEDLSLC AHTLILRTNP EAQALWQVVG SSVIMRVDAE
210 220 230 240 250
CMPVVRDFLR YFYSRRIEVS MSSVKCLHKL ASAYGATELQ DYCGRLFATL
260 270 280 290 300
LPQDPTFHTP LDLYAYARAT GDSMLEDLCV QFLAWNFEPL TQSESWSAVP
310 320 330 340 350
TTLIQALLPK SELAVSSELD LLKAVDQWST ETIASHEDIE RLVEQVRFPM
360 370 380 390 400
MLPQELFELQ FNLSLYQDHQ ALFQRKTMQA LEFHTVPVEV LAKYKGLNLT
410 420 430 440 450
EDTYKPRLYT SSTWSSLVMA STWRAQRYEY NRYNQLYTYG YGSVARYNSY
460 470 480 490 500
QSFQTPQHPS FLFKDKQISW SATYLPTMQS CWNYGFSCTS NELPVLGLTT
510 520 530 540 550
SSYSNPTIGY ENRVLILCGG YSVVDVTSFE GSKAPIPTAL DTNSSKTPSL
560 570
FPCASGAFSS FRVVIRPFYL TNSTDMV
Length:577
Mass (Da):64,491
Last modified:November 1, 1996 - v1
Checksum:i9D4181A7BEC2BD7C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251R → G in AAA37499 (PubMed:8341703).Curated
Sequence conflicti228 – 2281H → P in AAA37499 (PubMed:8341703).Curated
Sequence conflicti347 – 3471R → C in BAE29246 (PubMed:16141072).Curated
Sequence conflicti370 – 3701Q → K in BAE31894 (PubMed:16141072).Curated
Sequence conflicti465 – 4651D → E in BAE31013 (PubMed:16141072).Curated
Sequence conflicti466 – 4672KQ → NE in AAA37499 (PubMed:8341703).Curated
Sequence conflicti573 – 5775STDMV → LH in AAA37499 (PubMed:8341703).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16894 mRNA. Translation: AAA37499.1.
X67809 mRNA. Translation: CAA48010.1.
AK079915 mRNA. Translation: BAC37782.1.
AK137836 mRNA. Translation: BAE23505.1.
AK150021 mRNA. Translation: BAE29246.1.
AK152182 mRNA. Translation: BAE31013.1.
AK153313 mRNA. Translation: BAE31894.1.
AK153396 mRNA. Translation: BAE31958.1.
AK155031 mRNA. Translation: BAE33003.1.
AL591404 Genomic DNA. Translation: CAM23110.1.
CH466558 Genomic DNA. Translation: EDL34661.1.
CH466558 Genomic DNA. Translation: EDL34662.1.
BC090658 mRNA. Translation: AAH90658.1.
CCDSiCCDS25701.1.
PIRiA53202.
RefSeqiNP_035280.1. NM_011150.2.
UniGeneiMm.3152.

Genome annotation databases

EnsembliENSMUST00000043722; ENSMUSP00000035579; ENSMUSG00000033880.
GeneIDi19039.
KEGGimmu:19039.
UCSCiuc007moz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16894 mRNA. Translation: AAA37499.1.
X67809 mRNA. Translation: CAA48010.1.
AK079915 mRNA. Translation: BAC37782.1.
AK137836 mRNA. Translation: BAE23505.1.
AK150021 mRNA. Translation: BAE29246.1.
AK152182 mRNA. Translation: BAE31013.1.
AK153313 mRNA. Translation: BAE31894.1.
AK153396 mRNA. Translation: BAE31958.1.
AK155031 mRNA. Translation: BAE33003.1.
AL591404 Genomic DNA. Translation: CAM23110.1.
CH466558 Genomic DNA. Translation: EDL34661.1.
CH466558 Genomic DNA. Translation: EDL34662.1.
BC090658 mRNA. Translation: AAH90658.1.
CCDSiCCDS25701.1.
PIRiA53202.
RefSeqiNP_035280.1. NM_011150.2.
UniGeneiMm.3152.

3D structure databases

ProteinModelPortaliQ07797.
SMRiQ07797. Positions 21-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202330. 51 interactions.
IntActiQ07797. 51 interactions.
MINTiMINT-1866818.
STRINGi10090.ENSMUSP00000035579.

PTM databases

PhosphoSiteiQ07797.

Proteomic databases

EPDiQ07797.
MaxQBiQ07797.
PaxDbiQ07797.
PRIDEiQ07797.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043722; ENSMUSP00000035579; ENSMUSG00000033880.
GeneIDi19039.
KEGGimmu:19039.
UCSCiuc007moz.1. mouse.

Organism-specific databases

CTDi3959.
MGIiMGI:99554. Lgals3bp.

Phylogenomic databases

eggNOGiENOG410IY2Y. Eukaryota.
ENOG410YBYF. LUCA.
GeneTreeiENSGT00530000063814.
HOGENOMiHOG000113318.
HOVERGENiHBG052323.
InParanoidiQ07797.
KOiK17300.
OMAiRFPMMLP.
OrthoDBiEOG7JDQXP.
PhylomeDBiQ07797.
TreeFamiTF331368.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiLgals3bp. mouse.
PROiQ07797.
SOURCEiSearch...

Gene expression databases

BgeeiQ07797.
ExpressionAtlasiQ07797. baseline and differential.
GenevisibleiQ07797. MM.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF56487. SSF56487. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of cyclophilin C-associated protein: a candidate natural cellular ligand for cyclophilin C."
    Friedman J.S., Trahey M., Weissman I.L.
    Proc. Natl. Acad. Sci. U.S.A. 90:6815-6819(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, INTERACTION WITH PPIC, GLYCOSYLATION, TISSUE SPECIFICITY.
    Strain: BALB/cJ.
    Tissue: Bone marrow.
  2. "Cloning and expression of a mouse macrophage cDNA coding for a membrane glycoprotein of the scavenger receptor cysteine-rich domain family."
    Chicheportiche Y., Vassalli P.
    J. Biol. Chem. 269:5512-5517(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: BALB/cJ.
    Tissue: Bone marrow macrophage.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/cJ, C57BL/6J and NOD.
    Tissue: Aorta, Bone marrow, Thymus and Vein.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiLG3BP_MOUSE
AccessioniPrimary (citable) accession number: Q07797
Secondary accession number(s): O35649
, Q3U631, Q3U8K4, Q3UDL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.