Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone acetyltransferase RTT109

Gene

RTT109

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for acetylation of 'Lys-56' of histone H3 (H3K56ac) which occurs in S phase and disappears during G2/M phase of the cell cycle and is involved in transcription DNA repair process. H3K56 acetylation weakens of the interaction between the histone core and the surrounding DNA in the nucleosomal particle and drives chromatin disassembly. Involved in regulation of Ty1 transposition.9 Publications

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: UniProtKB-KW
  • chromatin silencing at centromere Source: GO_Central
  • histone acetylation Source: SGD
  • maintenance of rDNA Source: SGD
  • negative regulation of transposition, RNA-mediated Source: SGD
  • regulation of double-strand break repair via nonhomologous end joining Source: SGD
  • regulation of gene expression Source: SGD
  • regulation of transcription from RNA polymerase II promoter in response to stress Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

DNA damage, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32107-MONOMER.
BRENDAi2.3.1.48. 984.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase RTT109 (EC:2.3.1.48)
Alternative name(s):
Regulator of Ty1 transposition protein 109
Gene namesi
Name:RTT109
Synonyms:KIM2, REM50
Ordered Locus Names:YLL002W
ORF Names:L1377
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL002W.
SGDiS000003925. RTT109.

Subcellular locationi

GO - Cellular componenti

  • chromosome, centromeric region Source: GOC
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi89D → A or N: Losses histone acetylase activity. 1 Publication1
Mutagenesisi287 – 288DD → AA or NN: Reduces histone acetylase activity. 1 Publication2

Chemistry databases

ChEMBLiCHEMBL3414417.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002687381 – 436Histone acetyltransferase RTT109Add BLAST436

Proteomic databases

PRIDEiQ07794.

Expressioni

Inductioni

Expression peaks in cell cycle G1.1 Publication

Interactioni

Subunit structurei

Interacts with ASF1 and VPS75.5 Publications

Protein-protein interaction databases

BioGridi31249. 362 interactors.
DIPiDIP-8842N.
IntActiQ07794. 1 interactor.
MINTiMINT-2781350.

Structurei

Secondary structure

1436
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 10Combined sources8
Beta strandi16 – 23Combined sources8
Beta strandi27 – 29Combined sources3
Beta strandi37 – 40Combined sources4
Beta strandi44 – 57Combined sources14
Beta strandi60 – 77Combined sources18
Beta strandi79 – 90Combined sources12
Helixi100 – 112Combined sources13
Helixi117 – 120Combined sources4
Beta strandi121 – 124Combined sources4
Helixi135 – 137Combined sources3
Helixi144 – 158Combined sources15
Beta strandi159 – 161Combined sources3
Helixi164 – 167Combined sources4
Helixi169 – 174Combined sources6
Beta strandi175 – 177Combined sources3
Helixi182 – 184Combined sources3
Beta strandi186 – 193Combined sources8
Helixi195 – 197Combined sources3
Beta strandi199 – 201Combined sources3
Helixi204 – 206Combined sources3
Beta strandi207 – 209Combined sources3
Helixi215 – 233Combined sources19
Beta strandi239 – 243Combined sources5
Helixi249 – 256Combined sources8
Beta strandi259 – 262Combined sources4
Beta strandi264 – 267Combined sources4
Helixi273 – 276Combined sources4
Helixi278 – 280Combined sources3
Helixi289 – 299Combined sources11
Turni303 – 305Combined sources3
Helixi308 – 318Combined sources11
Helixi320 – 323Combined sources4
Turni324 – 326Combined sources3
Beta strandi328 – 334Combined sources7
Beta strandi336 – 338Combined sources3
Turni346 – 348Combined sources3
Helixi355 – 366Combined sources12
Helixi373 – 391Combined sources19
Beta strandi396 – 399Combined sources4
Helixi411 – 423Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RIMX-ray2.20A1-436[»]
2ZFNX-ray1.90A1-436[»]
3CZ7X-ray2.00A1-127[»]
A171-403[»]
3Q33X-ray2.80A1-436[»]
3Q35X-ray3.30A1-436[»]
3Q66X-ray2.70C1-436[»]
3Q68X-ray2.70C1-436[»]
3QM0X-ray3.10A1-436[»]
ProteinModelPortaliQ07794.
SMRiQ07794.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07794.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 404Rtt109-type HATPROSITE-ProRule annotationAdd BLAST403

Sequence similaritiesi

Belongs to the RTT109 family.Curated
Contains 1 Rtt109-type HAT (histone acetyltransferase) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000001105.
InParanoidiQ07794.
KOiK11309.
OMAiVSKADTN.
OrthoDBiEOG092C2EKY.

Family and domain databases

InterProiIPR013178. Histone_AcTrfase_Rtt109/CBP.
IPR016849. Rtt109.
[Graphical view]
PANTHERiPTHR31571:SF2. PTHR31571:SF2. 2 hits.
PfamiPF08214. HAT_KAT11. 1 hit.
[Graphical view]
PIRSFiPIRSF027124. Histone_acetylase_Rtt109. 1 hit.
SMARTiSM01250. KAT11. 1 hit.
[Graphical view]
PROSITEiPS51728. RTT109_HAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNDFLSSV LPVSEQFEYL SLQSIPLETH AVVTPNKDDK RVPKSTIKTQ
60 70 80 90 100
HFFSLFHQGK VFFSLEVYVY VTLWDEADAE RLIFVSKADT NGYCNTRVSV
110 120 130 140 150
RDITKIILEF ILSIDPNYYL QKVKPAIRSY KKISPELISA ASTPARTLRI
160 170 180 190 200
LARRLKQSGS TVLKEIESPR FQQDLYLSFT CPREILTKIC LFTRPASQYL
210 220 230 240 250
FPDSSKNSKK HILNGEELMK WWGFILDRLL IECFQNDTQA KLRIPGEDPA
260 270 280 290 300
RVRSYLRGMK YPLWQVGDIF TSKENSLAVY NIPLFPDDPK ARFIHQLAEE
310 320 330 340 350
DRLLKVSLSS FWIELQERQE FKLSVTSSVM GISGYSLATP SLFPSSADVI
360 370 380 390 400
VPKSRKQFRA IKKYITGEEY DTEEGAIEAF TNIRDFLLLR MATNLQSLTG
410 420 430
KREHRERNQP VPASNINTLA ITMLKPRKKA KALPKT
Length:436
Mass (Da):50,096
Last modified:November 1, 1996 - v1
Checksum:i17825D6EF97C4BB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91488 Genomic DNA. Translation: CAA62768.1.
Z73107 Genomic DNA. Translation: CAA97445.1.
BK006945 Genomic DNA. Translation: DAA09317.1.
PIRiS64744.
RefSeqiNP_013099.1. NM_001181822.1.

Genome annotation databases

EnsemblFungiiYLL002W; YLL002W; YLL002W.
GeneIDi850658.
KEGGisce:YLL002W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91488 Genomic DNA. Translation: CAA62768.1.
Z73107 Genomic DNA. Translation: CAA97445.1.
BK006945 Genomic DNA. Translation: DAA09317.1.
PIRiS64744.
RefSeqiNP_013099.1. NM_001181822.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RIMX-ray2.20A1-436[»]
2ZFNX-ray1.90A1-436[»]
3CZ7X-ray2.00A1-127[»]
A171-403[»]
3Q33X-ray2.80A1-436[»]
3Q35X-ray3.30A1-436[»]
3Q66X-ray2.70C1-436[»]
3Q68X-ray2.70C1-436[»]
3QM0X-ray3.10A1-436[»]
ProteinModelPortaliQ07794.
SMRiQ07794.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31249. 362 interactors.
DIPiDIP-8842N.
IntActiQ07794. 1 interactor.
MINTiMINT-2781350.

Chemistry databases

ChEMBLiCHEMBL3414417.

Proteomic databases

PRIDEiQ07794.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLL002W; YLL002W; YLL002W.
GeneIDi850658.
KEGGisce:YLL002W.

Organism-specific databases

EuPathDBiFungiDB:YLL002W.
SGDiS000003925. RTT109.

Phylogenomic databases

HOGENOMiHOG000001105.
InParanoidiQ07794.
KOiK11309.
OMAiVSKADTN.
OrthoDBiEOG092C2EKY.

Enzyme and pathway databases

BioCyciYEAST:G3O-32107-MONOMER.
BRENDAi2.3.1.48. 984.

Miscellaneous databases

EvolutionaryTraceiQ07794.
PROiQ07794.

Family and domain databases

InterProiIPR013178. Histone_AcTrfase_Rtt109/CBP.
IPR016849. Rtt109.
[Graphical view]
PANTHERiPTHR31571:SF2. PTHR31571:SF2. 2 hits.
PfamiPF08214. HAT_KAT11. 1 hit.
[Graphical view]
PIRSFiPIRSF027124. Histone_acetylase_Rtt109. 1 hit.
SMARTiSM01250. KAT11. 1 hit.
[Graphical view]
PROSITEiPS51728. RTT109_HAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRT109_YEAST
AccessioniPrimary (citable) accession number: Q07794
Secondary accession number(s): D6VY01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1140 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.