Reviewed, UniProtKB/Swiss-Prot Q07786 (DHSO2_YEAST)

Names and origin

Protein names

Recommended name:
    Sorbitol dehydrogenase 2
    EC=1.1.1.14
Alternative name(s):
    L-iditol 2-dehydrogenase 2

Gene names

Name:	SOR2
Ordered Locus Names:	YDL246C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	L-iditol + NAD+ = L-sorbose + NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-iditol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HSP82	P02829	1	EBI-33572,EBI-8659

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Sorbitol dehydrogenase 2		PRO_0000160822
Sites
	Metal binding	43	1	Zinc; catalytic By similarity
	Metal binding	68	1	Zinc; catalytic By similarity
	Metal binding	69	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q07786-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 1684792040A3834A	FASTA	357	38,097
	10 20 30 40 50 60 MSQNSNPAVV LEKVGDIAIE QRPIPTIKDP HYVKLAIKAT GICGSDIHYY RSGGIGKYIL 70 80 90 100 110 120 KAPMVLGHES SGQVVEVGDA VTRVKVGDRV AIEPGVPSRY SDETKEGSYN LCPHMAFAAT 130 140 150 160 170 180 PPIDGTLVKY YLSPEDFLVK LPEGVSYEEG ACVEPLSVGV HSNKLAGVRF GTKVVVFGAG 190 200 210 220 230 240 PVGLLTGAVA RAFGATDVIF VDVFDNKLQR AKDFGATNTF NSSQFSTDKA QDLADGVQKL 250 260 270 280 290 300 LGGNHADVVF ECSGADVCID AAVKTTKVGG TMVQVGMGKN YTNFPIAEVS GKEMKLIGCF 310 320 330 340 350 RYSFGDYRDA VNLVATGKVN VKPLITHKFK FEDAAKAYDY NIAHGGEVVK TIIFGPE

References

[1]

"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P. Nature 387:75-78(1997) [PubMed: 9169867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z74294 Genomic DNA. Translation: CAA98826.1.
PIR	S67811.
RefSeq	NP_010035.1.
3D structure databases
HSSP	HSSP built from PDB template 1E3J based on UniProtKB O96496.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:1512N.
IntAct	Q07786. 10 interactions.
STRING	Q07786.
Genome annotation databases
Ensembl	YDL246C; YDL246C; YDL246C; Saccharomyces cerevisiae. [Genome view]
GeneID	851351.
GenomeReviews	Gene locus YDL246C in contig Z71256_GR.
KEGG	sce:YDL246C.
NMPDR	fig|4932.3.peg.767.
Organism-specific databases
CYGD	YDL246c.
SGD	S000002405. SOR2.
Phylogenomic databases
HOGENOM	Q07786.
Enzyme and pathway databases
BRENDA	1.1.1.14. 250.
Gene expression databases
Genevestigator	Q07786.
GermOnline	YDL246C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR002328. ADH_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
ProDom	PD040557. GroES_related. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	968441.

Entry information

Entry name

DHSO2_YEAST

Accession

Primary (citable) accession number: Q07786

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	November 1, 1996
Last modified:	October 13, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)