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Protein

Sorbitol dehydrogenase 2

Gene

SOR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-iditol + NAD+ = L-sorbose + NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi43Zinc; catalyticBy similarity1
Binding sitei49SubstrateBy similarity1
Metal bindingi68Zinc; catalyticBy similarity1
Metal bindingi69Zinc; catalyticBy similarity1
Binding sitei154SubstrateBy similarity1
Binding sitei301SubstrateBy similarity1
Binding sitei302SubstrateBy similarity1

GO - Molecular functioni

  • L-iditol 2-dehydrogenase activity Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • hexose metabolic process Source: SGD

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29621-MONOMER
ReactomeiR-SCE-5652227 Fructose biosynthesis
R-SCE-5661270 Catabolism of glucuronate to xylulose-5-phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Sorbitol dehydrogenase 2 (EC:1.1.1.14)
Alternative name(s):
L-iditol 2-dehydrogenase 2
Gene namesi
Name:SOR2
Ordered Locus Names:YDL246C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL246C
SGDiS000002405 SOR2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001608221 – 357Sorbitol dehydrogenase 2Add BLAST357

Proteomic databases

PaxDbiQ07786
PRIDEiQ07786

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi31866, 73 interactors
DIPiDIP-1512N
IntActiQ07786, 7 interactors
MINTiQ07786
STRINGi4932.YDL246C

Structurei

3D structure databases

ProteinModelPortaliQ07786
SMRiQ07786
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000074781
HOGENOMiHOG000294670
InParanoidiQ07786
KOiK00008
OMAiTNCCLKA
OrthoDBiEOG092C2LBV

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q07786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQNSNPAVV LEKVGDIAIE QRPIPTIKDP HYVKLAIKAT GICGSDIHYY
60 70 80 90 100
RSGGIGKYIL KAPMVLGHES SGQVVEVGDA VTRVKVGDRV AIEPGVPSRY
110 120 130 140 150
SDETKEGSYN LCPHMAFAAT PPIDGTLVKY YLSPEDFLVK LPEGVSYEEG
160 170 180 190 200
ACVEPLSVGV HSNKLAGVRF GTKVVVFGAG PVGLLTGAVA RAFGATDVIF
210 220 230 240 250
VDVFDNKLQR AKDFGATNTF NSSQFSTDKA QDLADGVQKL LGGNHADVVF
260 270 280 290 300
ECSGADVCID AAVKTTKVGG TMVQVGMGKN YTNFPIAEVS GKEMKLIGCF
310 320 330 340 350
RYSFGDYRDA VNLVATGKVN VKPLITHKFK FEDAAKAYDY NIAHGGEVVK

TIIFGPE
Length:357
Mass (Da):38,097
Last modified:November 1, 1996 - v1
Checksum:i1684792040A3834A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74294 Genomic DNA Translation: CAA98826.1
BK006938 Genomic DNA Translation: DAA11621.1
PIRiS67811
RefSeqiNP_010035.1, NM_001180306.1

Genome annotation databases

EnsemblFungiiYDL246C; YDL246C; YDL246C
GeneIDi851351
KEGGisce:YDL246C

Similar proteinsi

Entry informationi

Entry nameiDHSO2_YEAST
AccessioniPrimary (citable) accession number: Q07786
Secondary accession number(s): D6VRB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health