Q07786 (DHSO2_YEAST) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 102.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Sorbitol dehydrogenase 2 EC=1.1.1.14 Alternative name(s): L-iditol 2-dehydrogenase 2 | ||||
| Gene names |
| ||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome] | ||||
| Taxonomic identifier | 559292 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › ![]() |
Protein attributes
| Sequence length | 357 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | L-iditol + NAD+ = L-sorbose + NADH. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Subunit structure | Homotetramer By similarity. |
| Sequence similarities | Belongs to the zinc-containing alcohol dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding NAD Zinc |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | hexose metabolic process Inferred from sequence or structural similarity PubMed 10938079. Source: SGD |
| Molecular_function | L-iditol 2-dehydrogenase activity Inferred from sequence or structural similarity PubMed 10938079. Source: SGD nucleotide bindingInferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 357 | 357 | Sorbitol dehydrogenase 2 | PRO_0000160822 | |||||
Sites | |||||||||
| Metal binding | 43 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 68 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 69 | 1 | Zinc; catalytic By similarity | ||||||
| Binding site | 49 | 1 | Substrate By similarity | ||||||
| Binding site | 154 | 1 | Substrate By similarity | ||||||
| Binding site | 301 | 1 | Substrate By similarity | ||||||
| Binding site | 302 | 1 | Substrate By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. Zaccaria P.Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [2] | Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z74294 Genomic DNA. Translation: CAA98826.1. BK006938 Genomic DNA. Translation: DAA11621.1. |
| PIR | S67811. |
| RefSeq | NP_010035.1. NM_001180306.1. |
3D structure databases | |
| ProteinModelPortal | Q07786. |
| SMR | Q07786. Positions 2-339. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-1512N. |
| IntAct | Q07786. 6 interactions. |
| MINT | MINT-390932. |
| STRING | 4932.YDL246C. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | YDL246C; YDL246C; YDL246C. |
| GeneID | 851351. |
| KEGG | sce:YDL246C. |
Organism-specific databases | |
| CYGD | YDL246c. |
| SGD | S000002405. SOR2. |
Phylogenomic databases | |
| eggNOG | COG1063. |
| GeneTree | ENSGT00550000074781. |
| HOGENOM | HOG000294670. |
| KO | K00008. |
| OMA | DAACANG. |
| OrthoDB | EOG4SFDFJ. |
Gene expression databases | |
| Genevestigator | Q07786. |
| GermOnline | YDL246C. Saccharomyces cerevisiae. |
Family and domain databases | |
| Gene3D | 3.40.50.720. 1 hit. |
| InterPro | IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| PANTHER | PTHR11695. PTHR11695. 1 hit. |
| Pfam | PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view] |
| SUPFAM | SSF50129. GroES_like. 1 hit. |
| PROSITE | PS00059. ADH_ZINC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 968441. |
Entry information
| Entry name | DHSO2_YEAST | ||||||||
| Accession | Primary (citable) accession number: Q07786 Secondary accession number(s): D6VRB1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome IV Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with
