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Q07785 (CDC2H_PLAFK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division control protein 2 homolog

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
PfPK5
Gene names
Name:CRK2
Synonyms:PK5
OrganismPlasmodium falciparum (isolate K1 / Thailand)
Taxonomic identifier5839 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulation

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it By similarity.

Subunit structure

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.

Subcellular location

Cytoplasm.

Developmental stage

Present in approximately constant amounts throughout the intra-erythrocytic asexual reproductive stage of the life cycle.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Cell division control protein 2 homolog
PRO_0000085742

Regions

Domain4 – 284281Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1251Proton acceptor By similarity
Binding site321ATP By similarity

Amino acid modifications

Modified residue141Phosphothreonine By similarity
Modified residue151Phosphotyrosine By similarity
Modified residue1581Phosphothreonine; by CAK By similarity

Secondary structure

...................................................... 288
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q07785 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: BF8C2935F872F6F0

FASTA28832,996
        10         20         30         40         50         60 
MEKYHGLEKI GEGTYGVVYK AQNNYGETFA LKKIRLEKED EGIPSTTIRE ISILKELKHS 

        70         80         90        100        110        120 
NIVKLYDVIH TKKRLVLVFE HLDQDLKKLL DVCEGGLESV TAKSFLLQLL NGIAYCHDRR 

       130        140        150        160        170        180 
VLHRDLKPQN LLINREGELK IADFGLARAF GIPVRKYTHE VVTLWYRAPD VLMGSKKYST 

       190        200        210        220        230        240 
TIDIWSVGCI FAEMVNGTPL FPGVSEADQL MRIFRILGTP NSKNWPNVTE LPKYDPNFTV 

       250        260        270        280 
YEPLPWESFL KGLDESGIDL LSKMLKLDPN QRITAKQALE HAYFKENN 

« Hide

References

[1]"Isolation and expression of a gene specifying a cdc2-like protein kinase from the human malaria parasite Plasmodium falciparum."
Ross-Macdonald P.B., Graeser R., Kappes B., Franklin R., Williamson D.H.
Eur. J. Biochem. 220:693-701(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X61921 Genomic DNA. Translation: CAA43923.1.
PIRS42566.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1LCHmodel-A1-288[»]
1OB3X-ray1.90A/B1-288[»]
1V0BX-ray2.20A/B1-288[»]
1V0OX-ray1.90A/B1-288[»]
1V0PX-ray2.00A/B1-288[»]
ProteinModelPortalQ07785.
SMRQ07785. Positions 1-286.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ07785.
ChEMBLCHEMBL2189145.

Proteomic databases

PRIDEQ07785.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0515.

Enzyme and pathway databases

BRENDA2.7.11.22. 4889.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ07785.

Entry information

Entry nameCDC2H_PLAFK
AccessionPrimary (citable) accession number: Q07785
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references