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Protein

Cell division control protein 2 homolog

Gene

CRK2

Organism
Plasmodium falciparum (isolate K1 / Thailand)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32ATPPROSITE-ProRule annotation1
Active sitei125Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 4889.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
PfPK5
Gene namesi
Name:CRK2
Synonyms:PK5
OrganismiPlasmodium falciparum (isolate K1 / Thailand)
Taxonomic identifieri5839 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2189145.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857421 – 288Cell division control protein 2 homologAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphothreonineBy similarity1
Modified residuei15PhosphotyrosineBy similarity1
Modified residuei158Phosphothreonine; by CAKBy similarity1

Keywords - PTMi

Phosphoprotein

Expressioni

Developmental stagei

Present in approximately constant amounts throughout the intra-erythrocytic asexual reproductive stage of the life cycle.

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin.By similarity

Structurei

Secondary structure

1288
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 13Combined sources11
Beta strandi16 – 23Combined sources8
Beta strandi28 – 34Combined sources7
Helixi39 – 41Combined sources3
Helixi45 – 52Combined sources8
Helixi53 – 56Combined sources4
Beta strandi65 – 70Combined sources6
Beta strandi75 – 80Combined sources6
Beta strandi83 – 85Combined sources3
Helixi86 – 91Combined sources6
Beta strandi93 – 96Combined sources4
Helixi99 – 118Combined sources20
Helixi128 – 130Combined sources3
Beta strandi131 – 133Combined sources3
Beta strandi139 – 141Combined sources3
Helixi146 – 150Combined sources5
Beta strandi152 – 155Combined sources4
Turni159 – 161Combined sources3
Helixi169 – 172Combined sources4
Helixi181 – 196Combined sources16
Helixi206 – 217Combined sources12
Turni222 – 224Combined sources3
Helixi228 – 230Combined sources3
Helixi246 – 248Combined sources3
Helixi255 – 264Combined sources10
Turni269 – 271Combined sources3
Helixi275 – 279Combined sources5
Helixi282 – 285Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LCHmodel-A1-288[»]
1OB3X-ray1.90A/B1-288[»]
1V0BX-ray2.20A/B1-288[»]
1V0OX-ray1.90A/B1-288[»]
1V0PX-ray2.00A/B1-288[»]
ProteinModelPortaliQ07785.
SMRiQ07785.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07785.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 284Protein kinasePROSITE-ProRule annotationAdd BLAST281

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07785-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYHGLEKI GEGTYGVVYK AQNNYGETFA LKKIRLEKED EGIPSTTIRE
60 70 80 90 100
ISILKELKHS NIVKLYDVIH TKKRLVLVFE HLDQDLKKLL DVCEGGLESV
110 120 130 140 150
TAKSFLLQLL NGIAYCHDRR VLHRDLKPQN LLINREGELK IADFGLARAF
160 170 180 190 200
GIPVRKYTHE VVTLWYRAPD VLMGSKKYST TIDIWSVGCI FAEMVNGTPL
210 220 230 240 250
FPGVSEADQL MRIFRILGTP NSKNWPNVTE LPKYDPNFTV YEPLPWESFL
260 270 280
KGLDESGIDL LSKMLKLDPN QRITAKQALE HAYFKENN
Length:288
Mass (Da):32,996
Last modified:October 1, 1994 - v1
Checksum:iBF8C2935F872F6F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61921 Genomic DNA. Translation: CAA43923.1.
PIRiS42566.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61921 Genomic DNA. Translation: CAA43923.1.
PIRiS42566.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LCHmodel-A1-288[»]
1OB3X-ray1.90A/B1-288[»]
1V0BX-ray2.20A/B1-288[»]
1V0OX-ray1.90A/B1-288[»]
1V0PX-ray2.00A/B1-288[»]
ProteinModelPortaliQ07785.
SMRiQ07785.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL2189145.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.7.11.22. 4889.

Miscellaneous databases

EvolutionaryTraceiQ07785.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDC2H_PLAFK
AccessioniPrimary (citable) accession number: Q07785
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.