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Protein

Solute carrier family 13 member 1

Gene

Slc13a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney.

GO - Molecular functioni

  • sodium:sulfate symporter activity Source: RGD

GO - Biological processi

  • sodium ion transport Source: RGD
  • sulfate transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Sulfate transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-433137. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Protein family/group databases

TCDBi2.A.47.1.2. the divalent anion:na(+) symporter (dass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 1
Alternative name(s):
NaSi-1
Renal sodium/sulfate cotransporter
Short name:
Na(+)/sulfate cotransporter
Gene namesi
Name:Slc13a1
Synonyms:Nas1, Nasi1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi61919. Slc13a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Transmembranei40 – 6021HelicalSequence analysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence analysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence analysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST
Transmembranei283 – 30321HelicalSequence analysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence analysisAdd
BLAST
Transmembranei464 – 48421HelicalSequence analysisAdd
BLAST
Transmembranei491 – 51121HelicalSequence analysisAdd
BLAST
Transmembranei512 – 53221HelicalSequence analysisAdd
BLAST
Transmembranei553 – 57321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 595595Solute carrier family 13 member 1PRO_0000172487Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence analysis
Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ07782.
PRIDEiQ07782.

Expressioni

Tissue specificityi

Kidney and intestine.

Gene expression databases

BgeeiENSRNOG00000008121.
GenevisibleiQ07782. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010788.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ07782.
KOiK14444.
OMAiATSIAKW.
OrthoDBiEOG091G092X.
PhylomeDBiQ07782.
TreeFamiTF312913.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
IPR031312. Na/sul_symport_CS.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLNYAFVY RRFLLVVFTV LVLLPLPLII RSKEAECAYI LFVIATFWIT
60 70 80 90 100
EALPLSITAL LPGLMFPMFG IMSSTHVASA YFKDFHLLLI GVICLATSIE
110 120 130 140 150
KWNLHKRIAL RMVMMVGVNP AWLTLGFMSS TAFLSMWLSN TSTAAMVMPI
160 170 180 190 200
VEAVAQQITS AEAEAEATQM TYFNESAAQG LEVDETIIGQ ETNERKEKTK
210 220 230 240 250
PALGSSNDKG KVSSKMETEK NTVTGAKYRS KKDHMMCKLM CLCIAYSSTI
260 270 280 290 300
GGLTTITGTS TNLIFSEHFN TRYPDCRCLN FGSWFLFSFP VAVILLLLSW
310 320 330 340 350
IWLQWLFLGF NFKEMFKCGK TKTLKEKACA EVIKQEYEKL GPMRYQEIVT
360 370 380 390 400
LVIFIVMALL WFSRDPGFVT GWSVLFSEYP GYVTDSTVAL VAGILFFLIP
410 420 430 440 450
AKKLTKMTST GDIIAFDYSP LITWKEFQSF MPWDIAILVG GGFALADGCQ
460 470 480 490 500
VSGLSSWIGS KLSPLGSLPV WLIILISSLI VTSLTEVASN PATITILFPI
510 520 530 540 550
LSPLAEAIHV NPLHILLPST LCTSFAFLLP VANPPNAIVF SYGHLKVIDM
560 570 580 590
VKAGLGVNIL GVAVVMLGMF TWIEPMFNLH EYPSWAPDIV NQTMP
Length:595
Mass (Da):66,059
Last modified:November 1, 1996 - v1
Checksum:iC905A5898622E317
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19102 mRNA. Translation: AAA41677.1.
U08031 mRNA. Translation: AAB48989.1.
PIRiA47714.
RefSeqiNP_113839.1. NM_031651.1.
UniGeneiRn.9699.

Genome annotation databases

EnsembliENSRNOT00000010788; ENSRNOP00000010788; ENSRNOG00000008121.
GeneIDi58980.
KEGGirno:58980.
UCSCiRGD:61919. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19102 mRNA. Translation: AAA41677.1.
U08031 mRNA. Translation: AAB48989.1.
PIRiA47714.
RefSeqiNP_113839.1. NM_031651.1.
UniGeneiRn.9699.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010788.

Protein family/group databases

TCDBi2.A.47.1.2. the divalent anion:na(+) symporter (dass) family.

Proteomic databases

PaxDbiQ07782.
PRIDEiQ07782.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010788; ENSRNOP00000010788; ENSRNOG00000008121.
GeneIDi58980.
KEGGirno:58980.
UCSCiRGD:61919. rat.

Organism-specific databases

CTDi6561.
RGDi61919. Slc13a1.

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ07782.
KOiK14444.
OMAiATSIAKW.
OrthoDBiEOG091G092X.
PhylomeDBiQ07782.
TreeFamiTF312913.

Enzyme and pathway databases

ReactomeiR-RNO-433137. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Miscellaneous databases

PROiQ07782.

Gene expression databases

BgeeiENSRNOG00000008121.
GenevisibleiQ07782. RN.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
IPR031312. Na/sul_symport_CS.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS13A1_RAT
AccessioniPrimary (citable) accession number: Q07782
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.