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Protein

Solute carrier family 13 member 1

Gene

Slc13a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney.

GO - Molecular functioni

  • sodium:sulfate symporter activity Source: RGD

GO - Biological processi

  • sodium ion transport Source: RGD
  • sulfate transport Source: RGD

Keywordsi

Biological processIon transport, Sodium transport, Sulfate transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-RNO-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters

Protein family/group databases

TCDBi2.A.47.1.2 the divalent anion:na(+) symporter (dass) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 1
Alternative name(s):
NaSi-1
Renal sodium/sulfate cotransporter
Short name:
Na(+)/sulfate cotransporter
Gene namesi
Name:Slc13a1
Synonyms:Nas1, Nasi1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi61919 Slc13a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Transmembranei512 – 532HelicalSequence analysisAdd BLAST21
Transmembranei553 – 573HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001724871 – 595Solute carrier family 13 member 1Add BLAST595

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi591N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ07782
PRIDEiQ07782

Expressioni

Tissue specificityi

Kidney and intestine.

Gene expression databases

BgeeiENSRNOG00000008121
GenevisibleiQ07782 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010788

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1281 Eukaryota
COG0471 LUCA
GeneTreeiENSGT00550000074480
HOGENOMiHOG000278432
HOVERGENiHBG055339
InParanoidiQ07782
KOiK14444
OMAiSWIWLQW
OrthoDBiEOG091G092X
PhylomeDBiQ07782
TreeFamiTF312913

Family and domain databases

InterProiView protein in InterPro
IPR031312 Na/sul_symport_CS
IPR001898 SLC13A/DASS
PfamiView protein in Pfam
PF00939 Na_sulph_symp, 1 hit
PROSITEiView protein in PROSITE
PS01271 NA_SULFATE, 1 hit

Sequencei

Sequence statusi: Complete.

Q07782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLNYAFVY RRFLLVVFTV LVLLPLPLII RSKEAECAYI LFVIATFWIT
60 70 80 90 100
EALPLSITAL LPGLMFPMFG IMSSTHVASA YFKDFHLLLI GVICLATSIE
110 120 130 140 150
KWNLHKRIAL RMVMMVGVNP AWLTLGFMSS TAFLSMWLSN TSTAAMVMPI
160 170 180 190 200
VEAVAQQITS AEAEAEATQM TYFNESAAQG LEVDETIIGQ ETNERKEKTK
210 220 230 240 250
PALGSSNDKG KVSSKMETEK NTVTGAKYRS KKDHMMCKLM CLCIAYSSTI
260 270 280 290 300
GGLTTITGTS TNLIFSEHFN TRYPDCRCLN FGSWFLFSFP VAVILLLLSW
310 320 330 340 350
IWLQWLFLGF NFKEMFKCGK TKTLKEKACA EVIKQEYEKL GPMRYQEIVT
360 370 380 390 400
LVIFIVMALL WFSRDPGFVT GWSVLFSEYP GYVTDSTVAL VAGILFFLIP
410 420 430 440 450
AKKLTKMTST GDIIAFDYSP LITWKEFQSF MPWDIAILVG GGFALADGCQ
460 470 480 490 500
VSGLSSWIGS KLSPLGSLPV WLIILISSLI VTSLTEVASN PATITILFPI
510 520 530 540 550
LSPLAEAIHV NPLHILLPST LCTSFAFLLP VANPPNAIVF SYGHLKVIDM
560 570 580 590
VKAGLGVNIL GVAVVMLGMF TWIEPMFNLH EYPSWAPDIV NQTMP
Length:595
Mass (Da):66,059
Last modified:November 1, 1996 - v1
Checksum:iC905A5898622E317
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19102 mRNA Translation: AAA41677.1
U08031 mRNA Translation: AAB48989.1
PIRiA47714
RefSeqiNP_113839.1, NM_031651.1
UniGeneiRn.9699

Genome annotation databases

EnsembliENSRNOT00000010788; ENSRNOP00000010788; ENSRNOG00000008121
GeneIDi58980
KEGGirno:58980
UCSCiRGD:61919 rat

Similar proteinsi

Entry informationi

Entry nameiS13A1_RAT
AccessioniPrimary (citable) accession number: Q07782
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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