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Protein

Probable aryl-alcohol dehydrogenase AAD4

Gene

AAD4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei30 – 301Proton donorBy similarity
Sitei57 – 571Lowers pKa of active site TyrBy similarity
Binding sitei105 – 1051SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi190 – 20011NADPBy similarityAdd
BLAST

GO - Molecular functioni

  • aryl-alcohol dehydrogenase (NAD+) activity Source: SGD

GO - Biological processi

  • cellular aldehyde metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Stress response

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciYEAST:YDL243C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aryl-alcohol dehydrogenase AAD4 (EC:1.1.1.-)
Gene namesi
Name:AAD4
Ordered Locus Names:YDL243C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL243C.
SGDiS000002402. AAD4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Probable aryl-alcohol dehydrogenase AAD4PRO_0000070366Add
BLAST

Expressioni

Inductioni

By oxidative stress.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi31869. 23 interactions.
DIPiDIP-5172N.
IntActiQ07747. 1 interaction.
MINTiMINT-504716.

Structurei

3D structure databases

ProteinModelPortaliQ07747.
SMRiQ07747. Positions 5-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00510000049995.
HOGENOMiHOG000250275.
InParanoidiQ07747.
OMAiHALGKGN.
OrthoDBiEOG7DRJCT.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
SUPFAMiSSF51430. SSF51430. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSMNKEQAF ELLDAFYEAG GNCIDTANSY QNEESEIWIG EWMKSRKLRD
60 70 80 90 100
QIVIATKFTG DYKKYEVGGG KSANYCGNHK HSLHVSVRDS LRKLQTDWID
110 120 130 140 150
ILYVHWWDYM SSIEEVMDSL HILVQQGKVL YLGVSDTPAW VVSAANYYAT
160 170 180 190 200
SHGKTPFSIY QGKWNVLNRD FERDIIPMAR HFGMALAPWD VMGGGRFQSK
210 220 230 240 250
KAMEERKKNG EGLRTVSGTS KQTDKEVKIS EALAKVAEEH GTESVTAIAI
260 270 280 290 300
AYVRSKAKNV FPLVGGRKIE HLKQNIEALS IKLTPEQIEY LESIIPFDVG
310 320
FPTNFIGDDP AVTKKASLLT AMSAQISFD
Length:329
Mass (Da):36,977
Last modified:November 1, 1996 - v1
Checksum:i62DBDD0C889610E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74291 Genomic DNA. Translation: CAA98823.1.
BK006938 Genomic DNA. Translation: DAA11624.1.
PIRiS67807.
RefSeqiNP_010038.1. NM_001180303.1.

Genome annotation databases

EnsemblFungiiYDL243C; YDL243C; YDL243C.
GeneIDi851354.
KEGGisce:YDL243C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74291 Genomic DNA. Translation: CAA98823.1.
BK006938 Genomic DNA. Translation: DAA11624.1.
PIRiS67807.
RefSeqiNP_010038.1. NM_001180303.1.

3D structure databases

ProteinModelPortaliQ07747.
SMRiQ07747. Positions 5-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31869. 23 interactions.
DIPiDIP-5172N.
IntActiQ07747. 1 interaction.
MINTiMINT-504716.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL243C; YDL243C; YDL243C.
GeneIDi851354.
KEGGisce:YDL243C.

Organism-specific databases

EuPathDBiFungiDB:YDL243C.
SGDiS000002402. AAD4.

Phylogenomic databases

GeneTreeiENSGT00510000049995.
HOGENOMiHOG000250275.
InParanoidiQ07747.
OMAiHALGKGN.
OrthoDBiEOG7DRJCT.

Enzyme and pathway databases

BioCyciYEAST:YDL243C-MONOMER.

Miscellaneous databases

PROiQ07747.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
SUPFAMiSSF51430. SSF51430. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Analysis of the seven-member AAD gene set demonstrates that genetic redundancy in yeast may be more apparent than real."
    Delneri D., Gardner D.C.J., Oliver S.G.
    Genetics 153:1591-1600(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiAAD4_YEAST
AccessioniPrimary (citable) accession number: Q07747
Secondary accession number(s): D6VRB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.