Q07747 (AAD4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable aryl-alcohol dehydrogenase AAD4
EC=1.1.1.-

Gene names

Name:	AAD4
Ordered Locus Names:	YDL243C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Induction	By oxidative stress. Ref.3
Sequence similarities	Belongs to the aldo/keto reductase 2 family.

Ontologies

Keywords
Biological process	Stress response
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 329	329	Probable aryl-alcohol dehydrogenase AAD4		PRO_0000070366
Regions
	Nucleotide binding	190 – 200	11	NADP By similarity
Sites
	Active site	30	1	Proton donor By similarity
	Binding site	105	1	Substrate By similarity
	Site	57	1	Lowers pKa of active site Tyr By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q07747 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 62DBDD0C889610E0	FASTA	329	36,977
	10 20 30 40 50 60 MGSMNKEQAF ELLDAFYEAG GNCIDTANSY QNEESEIWIG EWMKSRKLRD QIVIATKFTG 70 80 90 100 110 120 DYKKYEVGGG KSANYCGNHK HSLHVSVRDS LRKLQTDWID ILYVHWWDYM SSIEEVMDSL 130 140 150 160 170 180 HILVQQGKVL YLGVSDTPAW VVSAANYYAT SHGKTPFSIY QGKWNVLNRD FERDIIPMAR 190 200 210 220 230 240 HFGMALAPWD VMGGGRFQSK KAMEERKKNG EGLRTVSGTS KQTDKEVKIS EALAKVAEEH 250 260 270 280 290 300 GTESVTAIAI AYVRSKAKNV FPLVGGRKIE HLKQNIEALS IKLTPEQIEY LESIIPFDVG 310 320 FPTNFIGDDP AVTKKASLLT AMSAQISFD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P. Nature 387:75-78(1997) [PubMed: 9169867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Analysis of the seven-member AAD gene set demonstrates that genetic redundancy in yeast may be more apparent than real." Delneri D., Gardner D.C.J., Oliver S.G. Genetics 153:1591-1600(1999) [PubMed: 10581269] [Abstract] Cited for: INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z74291 Genomic DNA. Translation: CAA98823.1. BK006938 Genomic DNA. Translation: DAA11624.1.
PIR	S67807.
RefSeq	NP_010038.1. NM_001180303.1.
3D structure databases
ProteinModelPortal	Q07747.
SMR	Q07747. Positions 2-297.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5172N.
IntAct	Q07747. 1 interaction.
MINT	MINT-504716.
STRING	Q07747.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YDL243C; YDL243C; YDL243C.
GeneID	851354.
KEGG	sce:YDL243C.
NMPDR	fig|4932.3.peg.770.
Organism-specific databases
CYGD	YDL243c.
SGD	S000002402. AAD4.
Phylogenomic databases
eggNOG	fuNOG05818.
GeneTree	EFGT00050000001340.
HOGENOM	HBG605727.
OrthoDB	EOG45TGWW.
Gene expression databases
ArrayExpress	Q07747.
Genevestigator	Q07747.
GermOnline	YDL243C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001395. Aldo/ket_red. IPR023210. NADP_OxRdtase_dom. [Graphical view]
Gene3D	G3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
KO	K00100.
PANTHER	PTHR11732. Aldo/ket_red. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
ProtoNet	Search...
Other
NextBio	968450.

Entry information

Entry name

AAD4_YEAST

Accession

Primary (citable) accession number: Q07747
Secondary accession number(s): D6VRB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program