Reviewed,
UniProtKB/Swiss-Prot Q07729 (GUAD_YEAST)
Last modified
June 16, 2009.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Probable guanine deaminase Short name=Guanase Short name=Guanine aminase EC=3.5.4.3 Alternative name(s): Guanine aminohydrolase Short name=GAH | ||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4932 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 489 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia By similarity. |
| Catalytic activity | Guanine + H2O = xanthine + NH3. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Pathway | Purine metabolism; guanine degradation; xanthine from guanine: step 1/1. |
| Miscellaneous | Present with 279 molecules/cell in log phase SD medium. Ref.2 |
| Sequence similarities | Belongs to the ATZ/TRZ family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from direct assay. Source: SGD |
| Molecular function | guanine deaminase activity Inferred from direct assay. Source: SGD protein bindingInferred from physical interaction. Source: IntAct zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 489 | 489 | Probable guanine deaminase | PRO_0000122302 | |||||
Sites | |||||||||
| Metal binding | 100 | 1 | Zinc; via tele nitrogen By similarity | ||||||
| Metal binding | 102 | 1 | Zinc; via tele nitrogen By similarity | ||||||
| Metal binding | 258 | 1 | Zinc; via tele nitrogen By similarity | ||||||
| Metal binding | 348 | 1 | Zinc By similarity | ||||||
| Binding site | 105 | 1 | Substrate By similarity | ||||||
| Binding site | 231 | 1 | Substrate By similarity | ||||||
| Binding site | 261 | 1 | Substrate By similarity | ||||||
| Binding site | 297 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. Zaccaria P.Nature 387:75-78(1997) [PubMed: 9169867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [2] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| Z74286 Genomic DNA. Translation: CAA98818.1. | |
| PIR | S67802. |
| RefSeq | NP_010043.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:5170N. |
| IntAct | Q07729. 1 interaction. |
Proteomic databases | |
| PeptideAtlas | Q07729. |
Genome annotation databases | |
| Ensembl | YDL238C. Saccharomyces cerevisiae. [Contig view] |
| GeneID | 851360. |
| GenomeReviews | Gene locus YDL238C in contig Z71256_GR. |
| KEGG | sce:YDL238C. |
| NMPDR | fig|4932.3.peg.776. |
Organism-specific databases | |
| CYGD | YDL238c. |
| SGD | S000002397. GUD1. |
| Yeast-GFP | Search... |
Phylogenomic databases | |
| HOGENOM | Q07729. |
| OMA | Q07729. EDIIAKW. |
Enzyme and pathway databases | |
| BRENDA | 3.5.4.3. 250. |
Gene expression databases | |
| ArrayExpress | Q07729. |
| GermOnline | YDL238C. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR006680. Amidohydro_1. IPR014311. Guanine_deaminase. [Graphical view] |
| PANTHER | PTHR11271:SF6. Guanine_deaminase. 1 hit. |
| Pfam | PF01979. Amidohydro_1. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR02967. guan_deamin. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 968462. |
Entry information
| Entry name | GUAD_YEAST | ||||||||
| Accession | Primary (citable) accession number: Q07729 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |

Clusters with


