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Protein

Beta-2-microglobulin

Gene

B2M

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-SSC-2172127. DAP12 interactions.
R-SSC-2424491. DAP12 signaling.
R-SSC-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulin
Alternative name(s):
Lactollin
Gene namesi
Name:B2M
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MHC I, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 11898Beta-2-microglobulinPRO_0000018787Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 99PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ07717.

Expressioni

Gene expression databases

GenevisibleiQ07717. SS.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005050.

Structurei

Secondary structure

1
118
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 338Combined sources
Beta strandi41 – 5313Combined sources
Beta strandi56 – 616Combined sources
Beta strandi81 – 899Combined sources
Beta strandi97 – 1026Combined sources
Beta strandi110 – 1134Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QQ3X-ray2.59B/E21-118[»]
3QQ4X-ray2.10B21-118[»]
ProteinModelPortaliQ07717.
SMRiQ07717. Positions 21-117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 11288Ig-like C1-typeAdd
BLAST

Sequence similaritiesi

Belongs to the beta-2-microglobulin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
GeneTreeiENSGT00690000102227.
HOGENOMiHOG000043084.
HOVERGENiHBG006197.
InParanoidiQ07717.
KOiK08055.
OMAiPNFLNCY.
OrthoDBiEOG7RFTKJ.
TreeFamiTF334167.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 1 hit.
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLVALVLL GLLSLSGLDA VARPPKVQVY SRHPAENGKP NYLNCYVSGF
60 70 80 90 100
HPPQIEIDLL KNGEKMNAEQ SDLSFSKDWS FYLLVHTEFT PNAVDQYSCR
110
VKHVTLDKPK IVKWDRDH
Length:118
Mass (Da):13,362
Last modified:November 1, 1995 - v1
Checksum:i81FE20183B22D449
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701Q → S in CAA23304 (PubMed:8672129).Curated
Sequence conflicti85 – 851V → A in AAL48289 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13854 mRNA. Translation: AAA16252.1.
F14868 mRNA. Translation: CAA23304.1.
AF452448 Genomic DNA. Translation: AAL48289.1.
PIRiI46609.
RefSeqiNP_999143.1. NM_213978.1.
XP_013848513.1. XM_013993059.1.
XP_013848514.1. XM_013993060.1.
UniGeneiSsc.73773.

Genome annotation databases

EnsembliENSSSCT00000005169; ENSSSCP00000005043; ENSSSCG00000004687.
ENSSSCT00000005170; ENSSSCP00000005044; ENSSSCG00000004682.
ENSSSCT00000005176; ENSSSCP00000005050; ENSSSCG00000004687.
GeneIDi106504143.
397033.
KEGGissc:397033.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13854 mRNA. Translation: AAA16252.1.
F14868 mRNA. Translation: CAA23304.1.
AF452448 Genomic DNA. Translation: AAL48289.1.
PIRiI46609.
RefSeqiNP_999143.1. NM_213978.1.
XP_013848513.1. XM_013993059.1.
XP_013848514.1. XM_013993060.1.
UniGeneiSsc.73773.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QQ3X-ray2.59B/E21-118[»]
3QQ4X-ray2.10B21-118[»]
ProteinModelPortaliQ07717.
SMRiQ07717. Positions 21-117.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005050.

Proteomic databases

PaxDbiQ07717.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000005169; ENSSSCP00000005043; ENSSSCG00000004687.
ENSSSCT00000005170; ENSSSCP00000005044; ENSSSCG00000004682.
ENSSSCT00000005176; ENSSSCP00000005050; ENSSSCG00000004687.
GeneIDi106504143.
397033.
KEGGissc:397033.

Organism-specific databases

CTDi567.

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
GeneTreeiENSGT00690000102227.
HOGENOMiHOG000043084.
HOVERGENiHBG006197.
InParanoidiQ07717.
KOiK08055.
OMAiPNFLNCY.
OrthoDBiEOG7RFTKJ.
TreeFamiTF334167.

Enzyme and pathway databases

ReactomeiR-SSC-2172127. DAP12 interactions.
R-SSC-2424491. DAP12 signaling.
R-SSC-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Gene expression databases

GenevisibleiQ07717. SS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 1 hit.
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a clone for pig beta 2-microglobulin cDNA."
    Milland J., Loveland B.E., McKenzie I.F.C.
    Immunogenetics 38:464-464(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones."
    Winteroe A.K., Fredholm M., Davies W.
    Mamm. Genome 7:509-517(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  3. "Sus scrofa beta-2-microglobulin (B2M) gene."
    Keene C.D., Ni H.-T., Low W.C.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.

Entry informationi

Entry nameiB2MG_PIG
AccessioniPrimary (citable) accession number: Q07717
Secondary accession number(s): Q8WN08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 16, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.