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Protein

Homeobox protein DLX-2

Gene

DLX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi152 – 211HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ07687

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DLX-2
Gene namesi
Name:DLX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115844.10
HGNCiHGNC:2915 DLX2
MIMi126255 gene
neXtProtiNX_Q07687

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1746
OpenTargetsiENSG00000115844
PharmGKBiPA27370

Polymorphism and mutation databases

BioMutaiDLX2
DMDMi2506529

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490231 – 328Homeobox protein DLX-2Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei232PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ07687
PeptideAtlasiQ07687
PRIDEiQ07687
ProteomicsDBi58526

PTM databases

iPTMnetiQ07687
PhosphoSitePlusiQ07687

Expressioni

Gene expression databases

BgeeiENSG00000115844
CleanExiHS_DLX2
ExpressionAtlasiQ07687 baseline and differential
GenevisibleiQ07687 HS

Organism-specific databases

HPAiHPA056965

Interactioni

Subunit structurei

Interacts (via homeobox DNA-binding domain) with POU4F2; this interaction enhances retinal ganglion cell (RGC) differentiation.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GRNP287993EBI-3908234,EBI-747754

Protein-protein interaction databases

BioGridi108090, 13 interactors
IntActiQ07687, 3 interactors
MINTiQ07687
STRINGi9606.ENSP00000234198

Structurei

3D structure databases

ProteinModelPortaliQ07687
SMRiQ07687
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 46Poly-Ser6
Compositional biasi75 – 81Poly-Gly7
Compositional biasi251 – 259Poly-Gly9
Compositional biasi309 – 315Poly-His7
Compositional biasi316 – 319Poly-Gly4

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0850 Eukaryota
ENOG410ZHZR LUCA
GeneTreeiENSGT00920000148979
HOGENOMiHOG000231940
HOVERGENiHBG005493
InParanoidiQ07687
KOiK18488
OMAiFLGNYPW
OrthoDBiEOG091G0P17
PhylomeDBiQ07687
TreeFamiTF350606

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR022135 Distal-less_N
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF12413 DLL_N, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q07687-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGVFDSLVA DMHSTQIAAS STYHQHQQPP SGGGAGPGGN SSSSSSLHKP
60 70 80 90 100
QESPTLPVST ATDSSYYTNQ QHPAGGGGGG GSPYAHMGSY QYQASGLNNV
110 120 130 140 150
PYSAKSSYDL GYTAAYTSYA PYGTSSSPAN NEPEKEDLEP EIRIVNGKPK
160 170 180 190 200
KVRKPRTIYS SFQLAALQRR FQKTQYLALP ERAELAASLG LTQTQVKIWF
210 220 230 240 250
QNRRSKFKKM WKSGEIPSEQ HPGASASPPC ASPPVSAPAS WDFGVPQRMA
260 270 280 290 300
GGGGPGSGGS GAGSSGSSPS SAASAFLGNY PWYHQTSGSA SHLQATAPLL
310 320
HPTQTPQPHH HHHHHGGGGA PVSAGTIF
Length:328
Mass (Da):34,243
Last modified:November 1, 1997 - v2
Checksum:iBB6A077256F58022
GO
Isoform 2 (identifier: Q07687-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-217: KIWFQNRRSKFKKMWKSGEIP → GLAPCRGEESAGLRWLGSRRV
     218-328: Missing.

Note: No experimental confirmation available.
Show »
Length:217
Mass (Da):23,021
Checksum:iE8A2C00A99499ABA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178A → V in BAG59916 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054287197 – 217KIWFQ…SGEIP → GLAPCRGEESAGLRWLGSRR V in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_054288218 – 328Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51003 Genomic DNA Translation: AAB40902.1
AK297503 mRNA Translation: BAG59916.1
AK316129 mRNA Translation: BAH14500.1
AC104801 Genomic DNA No translation available.
BC032558 mRNA Translation: AAH32558.1
L07919 mRNA Translation: AAA19663.1
CCDSiCCDS2248.1 [Q07687-1]
PIRiB53495
G02469
RefSeqiNP_004396.1, NM_004405.3 [Q07687-1]
UniGeneiHs.419

Genome annotation databases

EnsembliENST00000234198; ENSP00000234198; ENSG00000115844 [Q07687-1]
ENST00000466293; ENSP00000446904; ENSG00000115844 [Q07687-2]
GeneIDi1746
KEGGihsa:1746
UCSCiuc010zdx.2 human [Q07687-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDLX2_HUMAN
AccessioniPrimary (citable) accession number: Q07687
Secondary accession number(s): B4DMK4, B7ZA14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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