Q07687 (DLX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein DLX-2

Gene names

Name:

DLX2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the distal-less homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Traceable author statement PubMed 7590232. Source: ProtInc branching morphogenesis of a nerve Inferred from electronic annotation. Source: Compara cartilage development Inferred from electronic annotation. Source: Compara cerebral cortex GABAergic interneuron fate commitment Inferred from electronic annotation. Source: Compara embryonic cranial skeleton morphogenesis Inferred from electronic annotation. Source: Compara hippocampus development Inferred from electronic annotation. Source: Compara negative regulation of oligodendrocyte differentiation Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara odontogenesis of dentin-containing tooth Inferred from electronic annotation. Source: Compara olfactory bulb development Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara proximal/distal pattern formation Inferred from electronic annotation. Source: Compara regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	chromatin binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Traceable author statement PubMed 1354641. Source: ProtInc single-stranded RNA binding Inferred from electronic annotation. Source: Compara transcription regulatory region sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 328	328	Homeobox protein DLX-2		PRO_0000049023
Regions
	DNA binding	152 – 211	60	Homeobox
	Compositional bias	41 – 46	6	Poly-Ser
	Compositional bias	75 – 81	7	Poly-Gly
	Compositional bias	251 – 259	9	Poly-Gly
	Compositional bias	309 – 315	7	Poly-His
	Compositional bias	316 – 319	4	Poly-Gly
Amino acid modifications
	Modified residue	232	1	Phosphoserine Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q07687 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: BB6A077256F58022	FASTA	328	34,243
	10 20 30 40 50 60 MTGVFDSLVA DMHSTQIAAS STYHQHQQPP SGGGAGPGGN SSSSSSLHKP QESPTLPVST 70 80 90 100 110 120 ATDSSYYTNQ QHPAGGGGGG GSPYAHMGSY QYQASGLNNV PYSAKSSYDL GYTAAYTSYA 130 140 150 160 170 180 PYGTSSSPAN NEPEKEDLEP EIRIVNGKPK KVRKPRTIYS SFQLAALQRR FQKTQYLALP 190 200 210 220 230 240 ERAELAASLG LTQTQVKIWF QNRRSKFKKM WKSGEIPSEQ HPGASASPPC ASPPVSAPAS 250 260 270 280 290 300 WDFGVPQRMA GGGGPGSGGS GAGSSGSSPS SAASAFLGNY PWYHQTSGSA SHLQATAPLL 310 320 HPTQTPQPHH HHHHHGGGGA PVSAGTIF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus." McGuinness T., Porteus M.H., Smiga S., Bulfone A., Kingsley C., Qiu M., Liu J.K., Long J.E., Xu D., Rubenstein J.L.R. Genomics 35:473-485(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Duodenum.
[3]	"The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue." Selski D.J., Thomas N.E., Coleman P.D., Rogers K.E. Gene 132:301-303(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-328. Tissue: Brain.
[4]	"Cloning and characterization of two members of the vertebrate Dlx gene family." Simeone A., Acampora D., Pannese M., D'Esposito M., Stornaiuolo A., Gulisano M., Mallamaci A., Kastury K., Druck T., Huebner K., Boncinelli E. Proc. Natl. Acad. Sci. U.S.A. 91:2250-2254(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 152-217. Tissue: Embryo.
[5]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U51003 Genomic DNA. Translation: AAB40902.1. BC032558 mRNA. Translation: AAH32558.1. L07919 mRNA. Translation: AAA19663.1.
IPI	IPI00018974.
PIR	B53495. G02469.
RefSeq	NP_004396.1. NM_004405.3.
UniGene	Hs.419.
3D structure databases
ProteinModelPortal	Q07687.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q07687. 1 interaction.
STRING	9606.ENSP00000234198.
PTM databases
PhosphoSite	Q07687.
Polymorphism databases
DMDM	2506529.
Proteomic databases
PaxDb	Q07687.
PRIDE	Q07687.
Protocols and materials databases
DNASU	1746.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000234198; ENSP00000234198; ENSG00000115844.
GeneID	1746.
KEGG	hsa:1746.
UCSC	uc002uhn.3. human.
Organism-specific databases
CTD	1746.
GeneCards	GC02M172964.
HGNC	HGNC:2915. DLX2.
HPA	HPA039071.
MIM	126255. gene.
neXtProt	NX_Q07687.
PharmGKB	PA27370.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG263092.
HOGENOM	HOG000231940.
HOVERGEN	HBG005493.
InParanoid	Q07687.
KO	K09315.
OMA	SAFLGNY.
OrthoDB	EOG4DZ1W4.
PhylomeDB	Q07687.
Gene expression databases
ArrayExpress	Q07687.
Bgee	Q07687.
CleanEx	HS_DLX2.
Genevestigator	Q07687.
GermOnline	ENSG00000115844. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR022135. Distal-less_N. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR000047. HTH_motif. [Graphical view]
Pfam	PF12413. DLL_N. 1 hit. PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX. PR00031. HTHREPRESSR.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1746.
NextBio	7083.
SOURCE	Search...

Entry information

Entry name

DLX2_HUMAN

Accession

Primary (citable) accession number: Q07687

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.