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Q07687

- DLX2_HUMAN

UniProt

Q07687 - DLX2_HUMAN

Protein

Homeobox protein DLX-2

Gene

DLX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi152 – 21160HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: ProtInc
    3. single-stranded RNA binding Source: Ensembl
    4. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. brain development Source: ProtInc
    2. branching morphogenesis of a nerve Source: Ensembl
    3. cartilage development Source: Ensembl
    4. cerebral cortex GABAergic interneuron fate commitment Source: Ensembl
    5. embryonic cranial skeleton morphogenesis Source: Ensembl
    6. hippocampus development Source: Ensembl
    7. negative regulation of Notch signaling pathway Source: Ensembl
    8. negative regulation of oligodendrocyte differentiation Source: Ensembl
    9. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    10. odontogenesis of dentin-containing tooth Source: Ensembl
    11. olfactory bulb development Source: Ensembl
    12. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    13. proximal/distal pattern formation Source: Ensembl
    14. regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment Source: Ensembl
    15. subpallium development Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein DLX-2
    Gene namesi
    Name:DLX2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:2915. DLX2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27370.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328Homeobox protein DLX-2PRO_0000049023Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei232 – 2321Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ07687.
    PRIDEiQ07687.

    PTM databases

    PhosphoSiteiQ07687.

    Expressioni

    Gene expression databases

    ArrayExpressiQ07687.
    BgeeiQ07687.
    CleanExiHS_DLX2.
    GenevestigatoriQ07687.

    Organism-specific databases

    HPAiHPA039071.

    Interactioni

    Protein-protein interaction databases

    BioGridi108090. 9 interactions.
    IntActiQ07687. 1 interaction.
    STRINGi9606.ENSP00000234198.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07687.
    SMRiQ07687. Positions 153-209.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi41 – 466Poly-Ser
    Compositional biasi75 – 817Poly-Gly
    Compositional biasi251 – 2599Poly-Gly
    Compositional biasi309 – 3157Poly-His
    Compositional biasi316 – 3194Poly-Gly

    Sequence similaritiesi

    Belongs to the distal-less homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG263092.
    HOGENOMiHOG000231940.
    HOVERGENiHBG005493.
    InParanoidiQ07687.
    KOiK09315.
    OMAiNDASAIF.
    OrthoDBiEOG70W3F8.
    PhylomeDBiQ07687.
    TreeFamiTF350606.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR022135. Distal-less_N.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF12413. DLL_N. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q07687-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTGVFDSLVA DMHSTQIAAS STYHQHQQPP SGGGAGPGGN SSSSSSLHKP    50
    QESPTLPVST ATDSSYYTNQ QHPAGGGGGG GSPYAHMGSY QYQASGLNNV 100
    PYSAKSSYDL GYTAAYTSYA PYGTSSSPAN NEPEKEDLEP EIRIVNGKPK 150
    KVRKPRTIYS SFQLAALQRR FQKTQYLALP ERAELAASLG LTQTQVKIWF 200
    QNRRSKFKKM WKSGEIPSEQ HPGASASPPC ASPPVSAPAS WDFGVPQRMA 250
    GGGGPGSGGS GAGSSGSSPS SAASAFLGNY PWYHQTSGSA SHLQATAPLL 300
    HPTQTPQPHH HHHHHGGGGA PVSAGTIF 328
    Length:328
    Mass (Da):34,243
    Last modified:November 1, 1997 - v2
    Checksum:iBB6A077256F58022
    GO
    Isoform 2 (identifier: Q07687-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         197-217: KIWFQNRRSKFKKMWKSGEIP → GLAPCRGEESAGLRWLGSRRV
         218-328: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:217
    Mass (Da):23,021
    Checksum:iE8A2C00A99499ABA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti178 – 1781A → V in BAG59916. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei197 – 21721KIWFQ…SGEIP → GLAPCRGEESAGLRWLGSRR V in isoform 2. 1 PublicationVSP_054287Add
    BLAST
    Alternative sequencei218 – 328111Missing in isoform 2. 1 PublicationVSP_054288Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51003 Genomic DNA. Translation: AAB40902.1.
    AK297503 mRNA. Translation: BAG59916.1.
    AK316129 mRNA. Translation: BAH14500.1.
    AC104801 Genomic DNA. No translation available.
    BC032558 mRNA. Translation: AAH32558.1.
    L07919 mRNA. Translation: AAA19663.1.
    CCDSiCCDS2248.1. [Q07687-1]
    PIRiB53495.
    G02469.
    RefSeqiNP_004396.1. NM_004405.3. [Q07687-1]
    UniGeneiHs.419.

    Genome annotation databases

    EnsembliENST00000234198; ENSP00000234198; ENSG00000115844. [Q07687-1]
    ENST00000466293; ENSP00000446904; ENSG00000115844. [Q07687-2]
    GeneIDi1746.
    KEGGihsa:1746.
    UCSCiuc002uhn.3. human. [Q07687-1]

    Polymorphism databases

    DMDMi2506529.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51003 Genomic DNA. Translation: AAB40902.1 .
    AK297503 mRNA. Translation: BAG59916.1 .
    AK316129 mRNA. Translation: BAH14500.1 .
    AC104801 Genomic DNA. No translation available.
    BC032558 mRNA. Translation: AAH32558.1 .
    L07919 mRNA. Translation: AAA19663.1 .
    CCDSi CCDS2248.1. [Q07687-1 ]
    PIRi B53495.
    G02469.
    RefSeqi NP_004396.1. NM_004405.3. [Q07687-1 ]
    UniGenei Hs.419.

    3D structure databases

    ProteinModelPortali Q07687.
    SMRi Q07687. Positions 153-209.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108090. 9 interactions.
    IntActi Q07687. 1 interaction.
    STRINGi 9606.ENSP00000234198.

    PTM databases

    PhosphoSitei Q07687.

    Polymorphism databases

    DMDMi 2506529.

    Proteomic databases

    PaxDbi Q07687.
    PRIDEi Q07687.

    Protocols and materials databases

    DNASUi 1746.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000234198 ; ENSP00000234198 ; ENSG00000115844 . [Q07687-1 ]
    ENST00000466293 ; ENSP00000446904 ; ENSG00000115844 . [Q07687-2 ]
    GeneIDi 1746.
    KEGGi hsa:1746.
    UCSCi uc002uhn.3. human. [Q07687-1 ]

    Organism-specific databases

    CTDi 1746.
    GeneCardsi GC02M172964.
    HGNCi HGNC:2915. DLX2.
    HPAi HPA039071.
    MIMi 126255. gene.
    neXtProti NX_Q07687.
    PharmGKBi PA27370.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG263092.
    HOGENOMi HOG000231940.
    HOVERGENi HBG005493.
    InParanoidi Q07687.
    KOi K09315.
    OMAi NDASAIF.
    OrthoDBi EOG70W3F8.
    PhylomeDBi Q07687.
    TreeFami TF350606.

    Miscellaneous databases

    GeneWikii DLX2.
    GenomeRNAii 1746.
    NextBioi 35473354.
    PROi Q07687.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q07687.
    Bgeei Q07687.
    CleanExi HS_DLX2.
    Genevestigatori Q07687.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR022135. Distal-less_N.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF12413. DLL_N. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus."
      McGuinness T., Porteus M.H., Smiga S., Bulfone A., Kingsley C., Qiu M., Liu J.K., Long J.E., Xu D., Rubenstein J.L.R.
      Genomics 35:473-485(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain and Tongue.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Duodenum.
    5. "The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue."
      Selski D.J., Thomas N.E., Coleman P.D., Rogers K.E.
      Gene 132:301-303(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-328 (ISOFORM 1).
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE OF 152-217.
      Tissue: Embryo.
    7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiDLX2_HUMAN
    AccessioniPrimary (citable) accession number: Q07687
    Secondary accession number(s): B4DMK4, B7ZA14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3