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Protein

Homeobox protein DLX-2

Gene

DLX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi152 – 211HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115844-MONOMER.
SIGNORiQ07687.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DLX-2
Gene namesi
Name:DLX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:2915. DLX2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1746.
MalaCardsiDLX2.
OpenTargetsiENSG00000115844.
PharmGKBiPA27370.

Polymorphism and mutation databases

BioMutaiDLX2.
DMDMi2506529.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490231 – 328Homeobox protein DLX-2Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei232PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ07687.
PeptideAtlasiQ07687.
PRIDEiQ07687.

PTM databases

iPTMnetiQ07687.
PhosphoSitePlusiQ07687.

Expressioni

Gene expression databases

BgeeiENSG00000115844.
CleanExiHS_DLX2.
ExpressionAtlasiQ07687. baseline and differential.
GenevisibleiQ07687. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GRNP287993EBI-3908234,EBI-747754

Protein-protein interaction databases

BioGridi108090. 13 interactors.
IntActiQ07687. 3 interactors.
STRINGi9606.ENSP00000234198.

Structurei

3D structure databases

ProteinModelPortaliQ07687.
SMRiQ07687.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 46Poly-Ser6
Compositional biasi75 – 81Poly-Gly7
Compositional biasi251 – 259Poly-Gly9
Compositional biasi309 – 315Poly-His7
Compositional biasi316 – 319Poly-Gly4

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0850. Eukaryota.
ENOG410ZHZR. LUCA.
GeneTreeiENSGT00860000133666.
HOGENOMiHOG000231940.
HOVERGENiHBG005493.
InParanoidiQ07687.
KOiK18488.
OMAiMHSNQIT.
OrthoDBiEOG091G0P17.
PhylomeDBiQ07687.
TreeFamiTF350606.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR022135. Distal-less_N.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF12413. DLL_N. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q07687-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGVFDSLVA DMHSTQIAAS STYHQHQQPP SGGGAGPGGN SSSSSSLHKP
60 70 80 90 100
QESPTLPVST ATDSSYYTNQ QHPAGGGGGG GSPYAHMGSY QYQASGLNNV
110 120 130 140 150
PYSAKSSYDL GYTAAYTSYA PYGTSSSPAN NEPEKEDLEP EIRIVNGKPK
160 170 180 190 200
KVRKPRTIYS SFQLAALQRR FQKTQYLALP ERAELAASLG LTQTQVKIWF
210 220 230 240 250
QNRRSKFKKM WKSGEIPSEQ HPGASASPPC ASPPVSAPAS WDFGVPQRMA
260 270 280 290 300
GGGGPGSGGS GAGSSGSSPS SAASAFLGNY PWYHQTSGSA SHLQATAPLL
310 320
HPTQTPQPHH HHHHHGGGGA PVSAGTIF
Length:328
Mass (Da):34,243
Last modified:November 1, 1997 - v2
Checksum:iBB6A077256F58022
GO
Isoform 2 (identifier: Q07687-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-217: KIWFQNRRSKFKKMWKSGEIP → GLAPCRGEESAGLRWLGSRRV
     218-328: Missing.

Note: No experimental confirmation available.
Show »
Length:217
Mass (Da):23,021
Checksum:iE8A2C00A99499ABA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178A → V in BAG59916 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054287197 – 217KIWFQ…SGEIP → GLAPCRGEESAGLRWLGSRR V in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_054288218 – 328Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51003 Genomic DNA. Translation: AAB40902.1.
AK297503 mRNA. Translation: BAG59916.1.
AK316129 mRNA. Translation: BAH14500.1.
AC104801 Genomic DNA. No translation available.
BC032558 mRNA. Translation: AAH32558.1.
L07919 mRNA. Translation: AAA19663.1.
CCDSiCCDS2248.1. [Q07687-1]
PIRiB53495.
G02469.
RefSeqiNP_004396.1. NM_004405.3. [Q07687-1]
UniGeneiHs.419.

Genome annotation databases

EnsembliENST00000234198; ENSP00000234198; ENSG00000115844. [Q07687-1]
ENST00000466293; ENSP00000446904; ENSG00000115844. [Q07687-2]
GeneIDi1746.
KEGGihsa:1746.
UCSCiuc010zdx.2. human. [Q07687-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51003 Genomic DNA. Translation: AAB40902.1.
AK297503 mRNA. Translation: BAG59916.1.
AK316129 mRNA. Translation: BAH14500.1.
AC104801 Genomic DNA. No translation available.
BC032558 mRNA. Translation: AAH32558.1.
L07919 mRNA. Translation: AAA19663.1.
CCDSiCCDS2248.1. [Q07687-1]
PIRiB53495.
G02469.
RefSeqiNP_004396.1. NM_004405.3. [Q07687-1]
UniGeneiHs.419.

3D structure databases

ProteinModelPortaliQ07687.
SMRiQ07687.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108090. 13 interactors.
IntActiQ07687. 3 interactors.
STRINGi9606.ENSP00000234198.

PTM databases

iPTMnetiQ07687.
PhosphoSitePlusiQ07687.

Polymorphism and mutation databases

BioMutaiDLX2.
DMDMi2506529.

Proteomic databases

PaxDbiQ07687.
PeptideAtlasiQ07687.
PRIDEiQ07687.

Protocols and materials databases

DNASUi1746.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234198; ENSP00000234198; ENSG00000115844. [Q07687-1]
ENST00000466293; ENSP00000446904; ENSG00000115844. [Q07687-2]
GeneIDi1746.
KEGGihsa:1746.
UCSCiuc010zdx.2. human. [Q07687-1]

Organism-specific databases

CTDi1746.
DisGeNETi1746.
GeneCardsiDLX2.
HGNCiHGNC:2915. DLX2.
MalaCardsiDLX2.
MIMi126255. gene.
neXtProtiNX_Q07687.
OpenTargetsiENSG00000115844.
PharmGKBiPA27370.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0850. Eukaryota.
ENOG410ZHZR. LUCA.
GeneTreeiENSGT00860000133666.
HOGENOMiHOG000231940.
HOVERGENiHBG005493.
InParanoidiQ07687.
KOiK18488.
OMAiMHSNQIT.
OrthoDBiEOG091G0P17.
PhylomeDBiQ07687.
TreeFamiTF350606.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115844-MONOMER.
SIGNORiQ07687.

Miscellaneous databases

GeneWikiiDLX2.
GenomeRNAii1746.
PROiQ07687.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115844.
CleanExiHS_DLX2.
ExpressionAtlasiQ07687. baseline and differential.
GenevisibleiQ07687. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR022135. Distal-less_N.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF12413. DLL_N. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDLX2_HUMAN
AccessioniPrimary (citable) accession number: Q07687
Secondary accession number(s): B4DMK4, B7ZA14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.