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Q07687

- DLX2_HUMAN

UniProt

Q07687 - DLX2_HUMAN

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Protein

Homeobox protein DLX-2

Gene

DLX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi152 – 21160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: ProtInc
  4. single-stranded RNA binding Source: Ensembl

GO - Biological processi

  1. brain development Source: ProtInc
  2. branching morphogenesis of a nerve Source: Ensembl
  3. cartilage development Source: Ensembl
  4. cerebral cortex GABAergic interneuron fate commitment Source: Ensembl
  5. embryonic cranial skeleton morphogenesis Source: Ensembl
  6. hippocampus development Source: Ensembl
  7. negative regulation of Notch signaling pathway Source: Ensembl
  8. negative regulation of oligodendrocyte differentiation Source: Ensembl
  9. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  10. odontogenesis of dentin-containing tooth Source: Ensembl
  11. olfactory bulb development Source: Ensembl
  12. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  13. proximal/distal pattern formation Source: Ensembl
  14. regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment Source: Ensembl
  15. subpallium development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DLX-2
Gene namesi
Name:DLX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:2915. DLX2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27370.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Homeobox protein DLX-2PRO_0000049023Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei232 – 2321Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ07687.
PRIDEiQ07687.

PTM databases

PhosphoSiteiQ07687.

Expressioni

Gene expression databases

BgeeiQ07687.
CleanExiHS_DLX2.
ExpressionAtlasiQ07687. baseline and differential.
GenevestigatoriQ07687.

Organism-specific databases

HPAiHPA039071.

Interactioni

Protein-protein interaction databases

BioGridi108090. 14 interactions.
IntActiQ07687. 2 interactions.
STRINGi9606.ENSP00000234198.

Structurei

3D structure databases

ProteinModelPortaliQ07687.
SMRiQ07687. Positions 153-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 466Poly-Ser
Compositional biasi75 – 817Poly-Gly
Compositional biasi251 – 2599Poly-Gly
Compositional biasi309 – 3157Poly-His
Compositional biasi316 – 3194Poly-Gly

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG263092.
GeneTreeiENSGT00760000118844.
HOGENOMiHOG000231940.
HOVERGENiHBG005493.
InParanoidiQ07687.
KOiK18488.
OMAiNDASAIF.
OrthoDBiEOG70W3F8.
PhylomeDBiQ07687.
TreeFamiTF350606.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR022135. Distal-less_N.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF12413. DLL_N. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q07687-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGVFDSLVA DMHSTQIAAS STYHQHQQPP SGGGAGPGGN SSSSSSLHKP
60 70 80 90 100
QESPTLPVST ATDSSYYTNQ QHPAGGGGGG GSPYAHMGSY QYQASGLNNV
110 120 130 140 150
PYSAKSSYDL GYTAAYTSYA PYGTSSSPAN NEPEKEDLEP EIRIVNGKPK
160 170 180 190 200
KVRKPRTIYS SFQLAALQRR FQKTQYLALP ERAELAASLG LTQTQVKIWF
210 220 230 240 250
QNRRSKFKKM WKSGEIPSEQ HPGASASPPC ASPPVSAPAS WDFGVPQRMA
260 270 280 290 300
GGGGPGSGGS GAGSSGSSPS SAASAFLGNY PWYHQTSGSA SHLQATAPLL
310 320
HPTQTPQPHH HHHHHGGGGA PVSAGTIF
Length:328
Mass (Da):34,243
Last modified:November 1, 1997 - v2
Checksum:iBB6A077256F58022
GO
Isoform 2 (identifier: Q07687-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-217: KIWFQNRRSKFKKMWKSGEIP → GLAPCRGEESAGLRWLGSRRV
     218-328: Missing.

Note: No experimental confirmation available.

Show »
Length:217
Mass (Da):23,021
Checksum:iE8A2C00A99499ABA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti178 – 1781A → V in BAG59916. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei197 – 21721KIWFQ…SGEIP → GLAPCRGEESAGLRWLGSRR V in isoform 2. 1 PublicationVSP_054287Add
BLAST
Alternative sequencei218 – 328111Missing in isoform 2. 1 PublicationVSP_054288Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51003 Genomic DNA. Translation: AAB40902.1.
AK297503 mRNA. Translation: BAG59916.1.
AK316129 mRNA. Translation: BAH14500.1.
AC104801 Genomic DNA. No translation available.
BC032558 mRNA. Translation: AAH32558.1.
L07919 mRNA. Translation: AAA19663.1.
CCDSiCCDS2248.1. [Q07687-1]
PIRiB53495.
G02469.
RefSeqiNP_004396.1. NM_004405.3. [Q07687-1]
UniGeneiHs.419.

Genome annotation databases

EnsembliENST00000234198; ENSP00000234198; ENSG00000115844. [Q07687-1]
ENST00000466293; ENSP00000446904; ENSG00000115844. [Q07687-2]
GeneIDi1746.
KEGGihsa:1746.
UCSCiuc002uhn.3. human. [Q07687-1]

Polymorphism databases

DMDMi2506529.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51003 Genomic DNA. Translation: AAB40902.1 .
AK297503 mRNA. Translation: BAG59916.1 .
AK316129 mRNA. Translation: BAH14500.1 .
AC104801 Genomic DNA. No translation available.
BC032558 mRNA. Translation: AAH32558.1 .
L07919 mRNA. Translation: AAA19663.1 .
CCDSi CCDS2248.1. [Q07687-1 ]
PIRi B53495.
G02469.
RefSeqi NP_004396.1. NM_004405.3. [Q07687-1 ]
UniGenei Hs.419.

3D structure databases

ProteinModelPortali Q07687.
SMRi Q07687. Positions 153-209.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108090. 14 interactions.
IntActi Q07687. 2 interactions.
STRINGi 9606.ENSP00000234198.

PTM databases

PhosphoSitei Q07687.

Polymorphism databases

DMDMi 2506529.

Proteomic databases

PaxDbi Q07687.
PRIDEi Q07687.

Protocols and materials databases

DNASUi 1746.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000234198 ; ENSP00000234198 ; ENSG00000115844 . [Q07687-1 ]
ENST00000466293 ; ENSP00000446904 ; ENSG00000115844 . [Q07687-2 ]
GeneIDi 1746.
KEGGi hsa:1746.
UCSCi uc002uhn.3. human. [Q07687-1 ]

Organism-specific databases

CTDi 1746.
GeneCardsi GC02M172964.
HGNCi HGNC:2915. DLX2.
HPAi HPA039071.
MIMi 126255. gene.
neXtProti NX_Q07687.
PharmGKBi PA27370.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG263092.
GeneTreei ENSGT00760000118844.
HOGENOMi HOG000231940.
HOVERGENi HBG005493.
InParanoidi Q07687.
KOi K18488.
OMAi NDASAIF.
OrthoDBi EOG70W3F8.
PhylomeDBi Q07687.
TreeFami TF350606.

Miscellaneous databases

GeneWikii DLX2.
GenomeRNAii 1746.
NextBioi 35473354.
PROi Q07687.
SOURCEi Search...

Gene expression databases

Bgeei Q07687.
CleanExi HS_DLX2.
ExpressionAtlasi Q07687. baseline and differential.
Genevestigatori Q07687.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR022135. Distal-less_N.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF12413. DLL_N. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus."
    McGuinness T., Porteus M.H., Smiga S., Bulfone A., Kingsley C., Qiu M., Liu J.K., Long J.E., Xu D., Rubenstein J.L.R.
    Genomics 35:473-485(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain and Tongue.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Duodenum.
  5. "The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue."
    Selski D.J., Thomas N.E., Coleman P.D., Rogers K.E.
    Gene 132:301-303(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-328 (ISOFORM 1).
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE OF 152-217.
    Tissue: Embryo.
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiDLX2_HUMAN
AccessioniPrimary (citable) accession number: Q07687
Secondary accession number(s): B4DMK4, B7ZA14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3