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Protein

Nucleoside diphosphate kinase 1

Gene

NDKR

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. This NDK is microtubule-associated.

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9ATPBy similarity1
Binding sitei57ATPBy similarity1
Binding sitei85ATPBy similarity1
Binding sitei91ATPBy similarity1
Binding sitei102ATPBy similarity1
Binding sitei112ATPBy similarity1
Active sitei115Pros-phosphohistidine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.4.6. 4460.
ReactomeiR-OSA-499943. Interconversion of nucleotide di- and triphosphates.
R-OSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase 1 (EC:2.7.4.6)
Alternative name(s):
Nucleoside diphosphate kinase I
Short name:
NDK I
Short name:
NDP kinase I
Short name:
NDPK I
Gene namesi
Name:NDKR
Ordered Locus Names:Os07g0492000, LOC_Os07g30970
ORF Names:OJ1218_C12.24, OsJ_023347, P0038F10.104
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001371411 – 149Nucleoside diphosphate kinase 1Add BLAST149

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ07661.
PRIDEiQ07661.

Expressioni

Inductioni

By salicylic acid, benzo (1,2,3) thiadiazole-7-carbothioc acid S-methyl ester, jasmonic acid, and abscisic acid.1 Publication

Gene expression databases

GenevisibleiQ07661. OS.

Interactioni

Subunit structurei

Homohexamer.1 Publication

Protein-protein interaction databases

STRINGi39947.LOC_Os07g30970.1.

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi10 – 14Combined sources5
Helixi18 – 28Combined sources11
Beta strandi31 – 38Combined sources8
Helixi42 – 48Combined sources7
Helixi50 – 52Combined sources3
Helixi58 – 66Combined sources9
Beta strandi70 – 77Combined sources8
Helixi80 – 88Combined sources9
Helixi93 – 95Combined sources3
Helixi101 – 105Combined sources5
Beta strandi113 – 116Combined sources4
Helixi120 – 130Combined sources11
Helixi143 – 146Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PKUX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-149[»]
ProteinModelPortaliQ07661.
SMRiQ07661.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07661.

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
InParanoidiQ07661.
KOiK00940.
OMAiWADGGQH.
OrthoDBiEOG09360QL0.

Family and domain databases

Gene3Di3.30.70.141. 1 hit.
HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiView protein in InterPro
IPR034907. NDK-like_dom.
IPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
PfamiView protein in Pfam
PF00334. NDK. 1 hit.
PRINTSiPR01243. NUCDPKINASE.
SMARTiView protein in SMART
SM00562. NDK. 1 hit.
SUPFAMiSSF54919. SSF54919. 1 hit.
PROSITEiView protein in PROSITE
PS00469. NDP_KINASES. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07661-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQSFIMIKP DGVQRGLIGD IISRFEKKGF YLRGMKFMNV ERSFAQQHYA
60 70 80 90 100
DLSDKPFFPG LVEYIISGPV VAMVWEGKDV VATGRRIIGA TRPWEAAPGT
110 120 130 140
IRADYAVEVG RNVIHGSDSV DNGKKEIALW FPEGLAEWRS NLHPWIYES
Length:149
Mass (Da):16,861
Last modified:October 1, 1994 - v1
Checksum:i6CD140D220B00920
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31Y → F in AAT70416 (PubMed:15650338).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16292 mRNA. Translation: BAA03798.1.
AY649743 mRNA. Translation: AAT70416.1.
AP004051 Genomic DNA. Translation: BAC83301.1.
AP004266 Genomic DNA. Translation: BAD30551.1.
AP008213 Genomic DNA. Translation: BAF21596.1.
AP014963 Genomic DNA. Translation: BAT01561.1.
CM000144 Genomic DNA. Translation: EAZ39864.1.
PIRiS43330.
RefSeqiXP_015647142.1. XM_015791656.1.
UniGeneiOs.146.

Genome annotation databases

EnsemblPlantsiOS07T0492000-01; OS07T0492000-01; OS07G0492000.
GeneIDi4343275.
GrameneiOS07T0492000-01; OS07T0492000-01; OS07G0492000.
KEGGiosa:4343275.

Similar proteinsi

Entry informationi

Entry nameiNDK1_ORYSJ
AccessioniPrimary (citable) accession number: Q07661
Secondary accession number(s): A0A0P0X6I2
, Q0D6C7, Q6DQV1, Q6ZHK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: August 30, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families