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Q07660

- BRE4_YEAST

UniProt

Q07660 - BRE4_YEAST

Protein

Protein BRE4

Gene

BRE4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May be involved in intracellular vesicle transport.1 Publication

    GO - Biological processi

    1. endocytosis Source: SGD
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29610-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein BRE4
    Alternative name(s):
    Brefeldin A-sensitivity protein 4
    Gene namesi
    Name:BRE4
    Ordered Locus Names:YDL231C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDL231c.
    SGDiS000002390. BRE4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11251125Protein BRE4PRO_0000239634Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi830 – 8301N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ07660.
    PaxDbiQ07660.

    Expressioni

    Gene expression databases

    GenevestigatoriQ07660.

    Interactioni

    Protein-protein interaction databases

    BioGridi31880. 13 interactions.
    DIPiDIP-5168N.
    MINTiMINT-550590.
    STRINGi4932.YDL231C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07660.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 143143CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini165 – 17612ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini195 – 1984CytoplasmicSequence Analysis
    Topological domaini220 – 2278ExtracellularSequence Analysis
    Topological domaini249 – 2546CytoplasmicSequence Analysis
    Topological domaini276 – 2849ExtracellularSequence Analysis
    Topological domaini306 – 706401CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini728 – 75023ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini772 – 7809CytoplasmicSequence Analysis
    Topological domaini802 – 84342ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini865 – 1125261CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei177 – 19418HelicalSequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei228 – 24821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei285 – 30521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei707 – 72721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei751 – 77121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei781 – 80121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei844 – 86421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BRE4 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG313447.
    HOGENOMiHOG000095257.
    OMAiPFVARHE.
    OrthoDBiEOG78H42T.

    Family and domain databases

    InterProiIPR018820. BRE4-related_DUF2421.
    IPR023244. Brefeldin_A-sensitivity_4.
    [Graphical view]
    PfamiPF10334. DUF2421. 1 hit.
    [Graphical view]
    PRINTSiPR02047. BREFELDNASP4.

    Sequencei

    Sequence statusi: Complete.

    Q07660-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRYERDRSP TPDPDIVKGS YSQTSLRSLH ELNYKNPAGI SGLSFAGSPQ     50
    QSVASLSQMR LENLVKDKHW EEVEDFGLEE LRDGFFDAAF TKPDSKARSP 100
    NSDIDDDNGA ARKKLQSGFT KLSEYVWTAI YRPIIHFPRD IRKNGVSIFK 150
    FFIAYFIAIV ICVIRPSGRW IGHEFRYFLP IAVLIHHPVR NIGVQLEMTI 200
    SSIIGASFGL GWSALAWYIS TATKPTANYQ GGILFQSLTM ALLFAIWLRS 250
    VYRRFFYFTT SFSISIIFTH TVRLASSKFD LKWQIFWDFG ISYLFGLLLS 300
    LLVCVCVSPH SGNAELMEHY NKCLQTTKTF LMALVDTELI KSKEQIYLAQ 350
    VKMVKTLNID LSQGFRDFVN QLTISRFDLQ SLKSLRNSLT AMETSLRVLP 400
    IAPKIFNDDE LKKMYEELEK YRSDSATLSK EASASPQSSG IPTRENTPSA 450
    FKPIGPGLLK NEIYINALKA SFSKSIFNLI LEMIFVLENL SRVLKKYESP 500
    NQKNNLDECV KILSHSHSKL KRKIYKLDVC YRDFVNSSFF SQELLNDEES 550
    VDIFLFLRYL RNSARQLVTV IHDCQVLGEN IHWRIALPSY PLSRALTRLP 600
    KQCVLDEGAG NVLHYFEAKR DVDEIFERVY NTYTSRHKYN KGEEEALRLD 650
    SQGGDEKSQN RKNHTISIRA IDHNDFNFHT TQNPWRFKLW KLSRILSGDE 700
    CKWTLKITFC MIFLCLPTWL PESYHWYQEF HCWWAPLTFY LLAHRRYSGN 750
    WALVMRRLIC GIVGIFWGWA ANQSRHFGSP YVVCTFAGLI VVPFSINFLV 800
    YRNTKSSFTA LMCFTIIALE PYSKPNRHYN LTTAGIWKST WVTGLALIIG 850
    ILVSIPINWI VWPFRARTEL RDSMSSLLAH LGQSYQTVAD RYLYRDADDA 900
    PTDLTFAFSH IREVRLTQSL EAIRELLKKA RHEPIIISNF NPEKYASLIN 950
    SCQFLLSKII EARISGAFFE IWDQDFDIET TRALLSLRRD SVSSVIFVFY 1000
    ILSNCFRSKN KIPRYLPNPI MSRKKLYHFI KKFSEMKDQS HSNLNSGGNS 1050
    MEKNLFKKIY QQKASSSGQQ QLPLPSVANS SEIDSEKMHW TEVHGIAFAR 1100
    AFTDISEALF QVESCAKDIL GEENF 1125
    Length:1,125
    Mass (Da):129,725
    Last modified:November 1, 1996 - v1
    Checksum:i3E0E04F6916A7E74
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z74279 Genomic DNA. Translation: CAA98810.1.
    BK006938 Genomic DNA. Translation: DAA11635.1.
    PIRiS67794.
    RefSeqiNP_010050.1. NM_001180291.1.

    Genome annotation databases

    EnsemblFungiiYDL231C; YDL231C; YDL231C.
    GeneIDi851367.
    KEGGisce:YDL231C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z74279 Genomic DNA. Translation: CAA98810.1 .
    BK006938 Genomic DNA. Translation: DAA11635.1 .
    PIRi S67794.
    RefSeqi NP_010050.1. NM_001180291.1.

    3D structure databases

    ProteinModelPortali Q07660.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31880. 13 interactions.
    DIPi DIP-5168N.
    MINTi MINT-550590.
    STRINGi 4932.YDL231C.

    Proteomic databases

    MaxQBi Q07660.
    PaxDbi Q07660.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDL231C ; YDL231C ; YDL231C .
    GeneIDi 851367.
    KEGGi sce:YDL231C.

    Organism-specific databases

    CYGDi YDL231c.
    SGDi S000002390. BRE4.

    Phylogenomic databases

    eggNOGi NOG313447.
    HOGENOMi HOG000095257.
    OMAi PFVARHE.
    OrthoDBi EOG78H42T.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29610-MONOMER.

    Miscellaneous databases

    NextBioi 968483.

    Gene expression databases

    Genevestigatori Q07660.

    Family and domain databases

    InterProi IPR018820. BRE4-related_DUF2421.
    IPR023244. Brefeldin_A-sensitivity_4.
    [Graphical view ]
    Pfami PF10334. DUF2421. 1 hit.
    [Graphical view ]
    PRINTSi PR02047. BREFELDNASP4.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Identification of yeast deletion strains that are hypersensitive to brefeldin A or monensin, two drugs that affect intracellular transport."
      Muren E., Oeyen M., Barmark G., Ronne H.
      Yeast 18:163-172(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiBRE4_YEAST
    AccessioniPrimary (citable) accession number: Q07660
    Secondary accession number(s): D6VRC5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Deletion of the gene leads to brefeldin A-sensitivity.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3