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Q07660

- BRE4_YEAST

UniProt

Q07660 - BRE4_YEAST

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Protein

Protein BRE4

Gene
BRE4, YDL231C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in intracellular vesicle transport.1 Publication

GO - Biological processi

  1. endocytosis Source: SGD
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29610-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BRE4
Alternative name(s):
Brefeldin A-sensitivity protein 4
Gene namesi
Name:BRE4
Ordered Locus Names:YDL231C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDL231c.
SGDiS000002390. BRE4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 143143Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei144 – 16421Helical; Reviewed predictionAdd
BLAST
Topological domaini165 – 17612Extracellular Reviewed predictionAdd
BLAST
Transmembranei177 – 19418Helical; Reviewed predictionAdd
BLAST
Topological domaini195 – 1984Cytoplasmic Reviewed prediction
Transmembranei199 – 21921Helical; Reviewed predictionAdd
BLAST
Topological domaini220 – 2278Extracellular Reviewed prediction
Transmembranei228 – 24821Helical; Reviewed predictionAdd
BLAST
Topological domaini249 – 2546Cytoplasmic Reviewed prediction
Transmembranei255 – 27521Helical; Reviewed predictionAdd
BLAST
Topological domaini276 – 2849Extracellular Reviewed prediction
Transmembranei285 – 30521Helical; Reviewed predictionAdd
BLAST
Topological domaini306 – 706401Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei707 – 72721Helical; Reviewed predictionAdd
BLAST
Topological domaini728 – 75023Extracellular Reviewed predictionAdd
BLAST
Transmembranei751 – 77121Helical; Reviewed predictionAdd
BLAST
Topological domaini772 – 7809Cytoplasmic Reviewed prediction
Transmembranei781 – 80121Helical; Reviewed predictionAdd
BLAST
Topological domaini802 – 84342Extracellular Reviewed predictionAdd
BLAST
Transmembranei844 – 86421Helical; Reviewed predictionAdd
BLAST
Topological domaini865 – 1125261Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11251125Protein BRE4PRO_0000239634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi830 – 8301N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ07660.
PaxDbiQ07660.

Expressioni

Gene expression databases

GenevestigatoriQ07660.

Interactioni

Protein-protein interaction databases

BioGridi31880. 13 interactions.
DIPiDIP-5168N.
MINTiMINT-550590.
STRINGi4932.YDL231C.

Structurei

3D structure databases

ProteinModelPortaliQ07660.

Family & Domainsi

Sequence similaritiesi

Belongs to the BRE4 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG313447.
HOGENOMiHOG000095257.
OMAiPFVARHE.
OrthoDBiEOG78H42T.

Family and domain databases

InterProiIPR018820. BRE4-related_DUF2421.
IPR023244. Brefeldin_A-sensitivity_4.
[Graphical view]
PfamiPF10334. DUF2421. 1 hit.
[Graphical view]
PRINTSiPR02047. BREFELDNASP4.

Sequencei

Sequence statusi: Complete.

Q07660-1 [UniParc]FASTAAdd to Basket

« Hide

MKRYERDRSP TPDPDIVKGS YSQTSLRSLH ELNYKNPAGI SGLSFAGSPQ     50
QSVASLSQMR LENLVKDKHW EEVEDFGLEE LRDGFFDAAF TKPDSKARSP 100
NSDIDDDNGA ARKKLQSGFT KLSEYVWTAI YRPIIHFPRD IRKNGVSIFK 150
FFIAYFIAIV ICVIRPSGRW IGHEFRYFLP IAVLIHHPVR NIGVQLEMTI 200
SSIIGASFGL GWSALAWYIS TATKPTANYQ GGILFQSLTM ALLFAIWLRS 250
VYRRFFYFTT SFSISIIFTH TVRLASSKFD LKWQIFWDFG ISYLFGLLLS 300
LLVCVCVSPH SGNAELMEHY NKCLQTTKTF LMALVDTELI KSKEQIYLAQ 350
VKMVKTLNID LSQGFRDFVN QLTISRFDLQ SLKSLRNSLT AMETSLRVLP 400
IAPKIFNDDE LKKMYEELEK YRSDSATLSK EASASPQSSG IPTRENTPSA 450
FKPIGPGLLK NEIYINALKA SFSKSIFNLI LEMIFVLENL SRVLKKYESP 500
NQKNNLDECV KILSHSHSKL KRKIYKLDVC YRDFVNSSFF SQELLNDEES 550
VDIFLFLRYL RNSARQLVTV IHDCQVLGEN IHWRIALPSY PLSRALTRLP 600
KQCVLDEGAG NVLHYFEAKR DVDEIFERVY NTYTSRHKYN KGEEEALRLD 650
SQGGDEKSQN RKNHTISIRA IDHNDFNFHT TQNPWRFKLW KLSRILSGDE 700
CKWTLKITFC MIFLCLPTWL PESYHWYQEF HCWWAPLTFY LLAHRRYSGN 750
WALVMRRLIC GIVGIFWGWA ANQSRHFGSP YVVCTFAGLI VVPFSINFLV 800
YRNTKSSFTA LMCFTIIALE PYSKPNRHYN LTTAGIWKST WVTGLALIIG 850
ILVSIPINWI VWPFRARTEL RDSMSSLLAH LGQSYQTVAD RYLYRDADDA 900
PTDLTFAFSH IREVRLTQSL EAIRELLKKA RHEPIIISNF NPEKYASLIN 950
SCQFLLSKII EARISGAFFE IWDQDFDIET TRALLSLRRD SVSSVIFVFY 1000
ILSNCFRSKN KIPRYLPNPI MSRKKLYHFI KKFSEMKDQS HSNLNSGGNS 1050
MEKNLFKKIY QQKASSSGQQ QLPLPSVANS SEIDSEKMHW TEVHGIAFAR 1100
AFTDISEALF QVESCAKDIL GEENF 1125
Length:1,125
Mass (Da):129,725
Last modified:November 1, 1996 - v1
Checksum:i3E0E04F6916A7E74
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z74279 Genomic DNA. Translation: CAA98810.1.
BK006938 Genomic DNA. Translation: DAA11635.1.
PIRiS67794.
RefSeqiNP_010050.1. NM_001180291.1.

Genome annotation databases

EnsemblFungiiYDL231C; YDL231C; YDL231C.
GeneIDi851367.
KEGGisce:YDL231C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z74279 Genomic DNA. Translation: CAA98810.1 .
BK006938 Genomic DNA. Translation: DAA11635.1 .
PIRi S67794.
RefSeqi NP_010050.1. NM_001180291.1.

3D structure databases

ProteinModelPortali Q07660.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31880. 13 interactions.
DIPi DIP-5168N.
MINTi MINT-550590.
STRINGi 4932.YDL231C.

Proteomic databases

MaxQBi Q07660.
PaxDbi Q07660.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDL231C ; YDL231C ; YDL231C .
GeneIDi 851367.
KEGGi sce:YDL231C.

Organism-specific databases

CYGDi YDL231c.
SGDi S000002390. BRE4.

Phylogenomic databases

eggNOGi NOG313447.
HOGENOMi HOG000095257.
OMAi PFVARHE.
OrthoDBi EOG78H42T.

Enzyme and pathway databases

BioCyci YEAST:G3O-29610-MONOMER.

Miscellaneous databases

NextBioi 968483.

Gene expression databases

Genevestigatori Q07660.

Family and domain databases

InterProi IPR018820. BRE4-related_DUF2421.
IPR023244. Brefeldin_A-sensitivity_4.
[Graphical view ]
Pfami PF10334. DUF2421. 1 hit.
[Graphical view ]
PRINTSi PR02047. BREFELDNASP4.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Identification of yeast deletion strains that are hypersensitive to brefeldin A or monensin, two drugs that affect intracellular transport."
    Muren E., Oeyen M., Barmark G., Ronne H.
    Yeast 18:163-172(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiBRE4_YEAST
AccessioniPrimary (citable) accession number: Q07660
Secondary accession number(s): D6VRC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Deletion of the gene leads to brefeldin A-sensitivity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

Similar proteinsi