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Q07660

- BRE4_YEAST

UniProt

Q07660 - BRE4_YEAST

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Protein

Protein BRE4

Gene

BRE4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in intracellular vesicle transport.1 Publication

GO - Biological processi

  1. endocytosis Source: SGD
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29610-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BRE4
Alternative name(s):
Brefeldin A-sensitivity protein 4
Gene namesi
Name:BRE4
Ordered Locus Names:YDL231C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDL231c.
SGDiS000002390. BRE4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 143143CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST
Topological domaini165 – 17612ExtracellularSequence AnalysisAdd
BLAST
Transmembranei177 – 19418HelicalSequence AnalysisAdd
BLAST
Topological domaini195 – 1984CytoplasmicSequence Analysis
Transmembranei199 – 21921HelicalSequence AnalysisAdd
BLAST
Topological domaini220 – 2278ExtracellularSequence Analysis
Transmembranei228 – 24821HelicalSequence AnalysisAdd
BLAST
Topological domaini249 – 2546CytoplasmicSequence Analysis
Transmembranei255 – 27521HelicalSequence AnalysisAdd
BLAST
Topological domaini276 – 2849ExtracellularSequence Analysis
Transmembranei285 – 30521HelicalSequence AnalysisAdd
BLAST
Topological domaini306 – 706401CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei707 – 72721HelicalSequence AnalysisAdd
BLAST
Topological domaini728 – 75023ExtracellularSequence AnalysisAdd
BLAST
Transmembranei751 – 77121HelicalSequence AnalysisAdd
BLAST
Topological domaini772 – 7809CytoplasmicSequence Analysis
Transmembranei781 – 80121HelicalSequence AnalysisAdd
BLAST
Topological domaini802 – 84342ExtracellularSequence AnalysisAdd
BLAST
Transmembranei844 – 86421HelicalSequence AnalysisAdd
BLAST
Topological domaini865 – 1125261CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11251125Protein BRE4PRO_0000239634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi830 – 8301N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ07660.
PaxDbiQ07660.

Expressioni

Gene expression databases

GenevestigatoriQ07660.

Interactioni

Protein-protein interaction databases

BioGridi31880. 13 interactions.
DIPiDIP-5168N.
MINTiMINT-550590.
STRINGi4932.YDL231C.

Structurei

3D structure databases

ProteinModelPortaliQ07660.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BRE4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG313447.
HOGENOMiHOG000095257.
InParanoidiQ07660.
OMAiPFVARHE.
OrthoDBiEOG78H42T.

Family and domain databases

InterProiIPR018820. BRE4-related_DUF2421.
IPR023244. Brefeldin_A-sensitivity_4.
[Graphical view]
PfamiPF10334. DUF2421. 1 hit.
[Graphical view]
PRINTSiPR02047. BREFELDNASP4.

Sequencei

Sequence statusi: Complete.

Q07660-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRYERDRSP TPDPDIVKGS YSQTSLRSLH ELNYKNPAGI SGLSFAGSPQ
60 70 80 90 100
QSVASLSQMR LENLVKDKHW EEVEDFGLEE LRDGFFDAAF TKPDSKARSP
110 120 130 140 150
NSDIDDDNGA ARKKLQSGFT KLSEYVWTAI YRPIIHFPRD IRKNGVSIFK
160 170 180 190 200
FFIAYFIAIV ICVIRPSGRW IGHEFRYFLP IAVLIHHPVR NIGVQLEMTI
210 220 230 240 250
SSIIGASFGL GWSALAWYIS TATKPTANYQ GGILFQSLTM ALLFAIWLRS
260 270 280 290 300
VYRRFFYFTT SFSISIIFTH TVRLASSKFD LKWQIFWDFG ISYLFGLLLS
310 320 330 340 350
LLVCVCVSPH SGNAELMEHY NKCLQTTKTF LMALVDTELI KSKEQIYLAQ
360 370 380 390 400
VKMVKTLNID LSQGFRDFVN QLTISRFDLQ SLKSLRNSLT AMETSLRVLP
410 420 430 440 450
IAPKIFNDDE LKKMYEELEK YRSDSATLSK EASASPQSSG IPTRENTPSA
460 470 480 490 500
FKPIGPGLLK NEIYINALKA SFSKSIFNLI LEMIFVLENL SRVLKKYESP
510 520 530 540 550
NQKNNLDECV KILSHSHSKL KRKIYKLDVC YRDFVNSSFF SQELLNDEES
560 570 580 590 600
VDIFLFLRYL RNSARQLVTV IHDCQVLGEN IHWRIALPSY PLSRALTRLP
610 620 630 640 650
KQCVLDEGAG NVLHYFEAKR DVDEIFERVY NTYTSRHKYN KGEEEALRLD
660 670 680 690 700
SQGGDEKSQN RKNHTISIRA IDHNDFNFHT TQNPWRFKLW KLSRILSGDE
710 720 730 740 750
CKWTLKITFC MIFLCLPTWL PESYHWYQEF HCWWAPLTFY LLAHRRYSGN
760 770 780 790 800
WALVMRRLIC GIVGIFWGWA ANQSRHFGSP YVVCTFAGLI VVPFSINFLV
810 820 830 840 850
YRNTKSSFTA LMCFTIIALE PYSKPNRHYN LTTAGIWKST WVTGLALIIG
860 870 880 890 900
ILVSIPINWI VWPFRARTEL RDSMSSLLAH LGQSYQTVAD RYLYRDADDA
910 920 930 940 950
PTDLTFAFSH IREVRLTQSL EAIRELLKKA RHEPIIISNF NPEKYASLIN
960 970 980 990 1000
SCQFLLSKII EARISGAFFE IWDQDFDIET TRALLSLRRD SVSSVIFVFY
1010 1020 1030 1040 1050
ILSNCFRSKN KIPRYLPNPI MSRKKLYHFI KKFSEMKDQS HSNLNSGGNS
1060 1070 1080 1090 1100
MEKNLFKKIY QQKASSSGQQ QLPLPSVANS SEIDSEKMHW TEVHGIAFAR
1110 1120
AFTDISEALF QVESCAKDIL GEENF
Length:1,125
Mass (Da):129,725
Last modified:November 1, 1996 - v1
Checksum:i3E0E04F6916A7E74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74279 Genomic DNA. Translation: CAA98810.1.
BK006938 Genomic DNA. Translation: DAA11635.1.
PIRiS67794.
RefSeqiNP_010050.1. NM_001180291.1.

Genome annotation databases

EnsemblFungiiYDL231C; YDL231C; YDL231C.
GeneIDi851367.
KEGGisce:YDL231C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74279 Genomic DNA. Translation: CAA98810.1 .
BK006938 Genomic DNA. Translation: DAA11635.1 .
PIRi S67794.
RefSeqi NP_010050.1. NM_001180291.1.

3D structure databases

ProteinModelPortali Q07660.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31880. 13 interactions.
DIPi DIP-5168N.
MINTi MINT-550590.
STRINGi 4932.YDL231C.

Proteomic databases

MaxQBi Q07660.
PaxDbi Q07660.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDL231C ; YDL231C ; YDL231C .
GeneIDi 851367.
KEGGi sce:YDL231C.

Organism-specific databases

CYGDi YDL231c.
SGDi S000002390. BRE4.

Phylogenomic databases

eggNOGi NOG313447.
HOGENOMi HOG000095257.
InParanoidi Q07660.
OMAi PFVARHE.
OrthoDBi EOG78H42T.

Enzyme and pathway databases

BioCyci YEAST:G3O-29610-MONOMER.

Miscellaneous databases

NextBioi 968483.

Gene expression databases

Genevestigatori Q07660.

Family and domain databases

InterProi IPR018820. BRE4-related_DUF2421.
IPR023244. Brefeldin_A-sensitivity_4.
[Graphical view ]
Pfami PF10334. DUF2421. 1 hit.
[Graphical view ]
PRINTSi PR02047. BREFELDNASP4.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Identification of yeast deletion strains that are hypersensitive to brefeldin A or monensin, two drugs that affect intracellular transport."
    Muren E., Oeyen M., Barmark G., Ronne H.
    Yeast 18:163-172(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiBRE4_YEAST
AccessioniPrimary (citable) accession number: Q07660
Secondary accession number(s): D6VRC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Deletion of the gene leads to brefeldin A-sensitivity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3