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Protein

Trefoil factor 3

Gene

TFF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).1 Publication

GO - Biological processi

  • defense response Source: ProtInc
  • digestion Source: ProtInc
  • wound healing Source: GO_Central

Enzyme and pathway databases

SIGNORiQ07654.

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 3
Alternative name(s):
Intestinal trefoil factor
Short name:
hITF
Polypeptide P1.B
Short name:
hP1.B
Gene namesi
Name:TFF3
Synonyms:ITF, TFI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:11757. TFF3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7033.
PharmGKBiPA36472.

Polymorphism and mutation databases

DMDMi585328.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 212 PublicationsAdd BLAST21
ChainiPRO_000002346522 – 80Trefoil factor 3Add BLAST59

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 58PROSITE-ProRule annotation
Disulfide bondi42 ↔ 57PROSITE-ProRule annotation
Disulfide bondi52 ↔ 69PROSITE-ProRule annotation
Disulfide bondi78Interchain

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ07654.
PeptideAtlasiQ07654.
PRIDEiQ07654.

Expressioni

Tissue specificityi

Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet cells of small and large intestinal epithelia and also by the uterus. Also expressed in the hypothalamus where it is detected in paraventricular, periventricular and supraoptic nuclei (at protein level).2 Publications

Gene expression databases

CleanExiHS_TFF3.

Organism-specific databases

HPAiHPA035464.

Interactioni

Subunit structurei

Monomer. Homodimer; disulfide-linked.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112891. 5 interactors.
IntActiQ07654. 3 interactors.
STRINGi9606.ENSP00000430690.

Structurei

Secondary structure

180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 30Combined sources3
Helixi31 – 33Combined sources3
Beta strandi36 – 39Combined sources4
Turni49 – 51Combined sources3
Helixi52 – 55Combined sources4
Beta strandi56 – 58Combined sources3
Beta strandi64 – 66Combined sources3
Beta strandi68 – 70Combined sources3
Helixi74 – 76Combined sources3
Turni77 – 79Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E9TNMR-A22-80[»]
1PE3NMR-1/222-80[»]
ProteinModelPortaliQ07654.
SMRiQ07654.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07654.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 73P-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0FX. Eukaryota.
ENOG41114KR. LUCA.
HOGENOMiHOG000121778.
HOVERGENiHBG004364.
InParanoidiQ07654.
PhylomeDBiQ07654.
TreeFamiTF336092.

Family and domain databases

CDDicd00111. Trefoil. 1 hit.
InterProiView protein in InterPro
IPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
PfamiView protein in Pfam
PF00088. Trefoil. 1 hit.
PRINTSiPR00680. PTREFOIL.
SMARTiView protein in SMART
SM00018. PD. 1 hit.
PROSITEiView protein in PROSITE
PS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARALCMLG LVLALLSSSS AEEYVGLSAN QCAVPAKDRV DCGYPHVTPK
60 70 80
ECNNRGCCFD SRIPGVPWCF KPLQEAECTF
Length:80
Mass (Da):8,641
Last modified:October 1, 1994 - v1
Checksum:i8E117A58C0342013
GO

Sequence cautioni

The sequence AAH17859 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL28111 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA95531 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB13731 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74 – 76QEA → TRKT in AAA36766 (PubMed:8454642).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15203 mRNA. Translation: AAA59981.1.
U25657, U25654, U25656 Genomic DNA. Translation: AAA83628.1.
AB038162 Genomic DNA. Translation: BAB13731.1. Different initiation.
AP001746 Genomic DNA. Translation: BAA95531.1. Different initiation.
BC017859 mRNA. Translation: AAH17859.1. Different initiation.
AF432265 mRNA. Translation: AAL28111.1. Different initiation.
L08044 mRNA. Translation: AAA36766.1.
PIRiA48284.
RefSeqiNP_003217.3. NM_003226.3.
UniGeneiHs.82961.

Genome annotation databases

GeneIDi7033.
KEGGihsa:7033.

Similar proteinsi

Entry informationi

Entry nameiTFF3_HUMAN
AccessioniPrimary (citable) accession number: Q07654
Secondary accession number(s): E9PBB5, Q96NX0, Q9UDA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 22, 2017
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references