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Protein

Trefoil factor 3

Gene

TFF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).1 Publication

Caution

It is uncertain whether Met-1 or Met-15 is the initiator.Curated

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-9018519 Estrogen-dependent gene expression
SIGNORiQ07654

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 3
Alternative name(s):
Intestinal trefoil factor
Short name:
hITF
Polypeptide P1.B
Short name:
hP1.B
Gene namesi
Name:TFF3
Synonyms:ITF, TFI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000160180.15
HGNCiHGNC:11757 TFF3
MIMi600633 gene
neXtProtiNX_Q07654

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7033
OpenTargetsiENSG00000160180
PharmGKBiPA36472

Polymorphism and mutation databases

DMDMi585328

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 352 PublicationsAdd BLAST35
ChainiPRO_000002346536 – 94Trefoil factor 3Add BLAST59

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 72PROSITE-ProRule annotation
Disulfide bondi56 ↔ 71PROSITE-ProRule annotation
Disulfide bondi66 ↔ 83PROSITE-ProRule annotation
Disulfide bondi92Interchain

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ07654
PeptideAtlasiQ07654
PRIDEiQ07654

Expressioni

Tissue specificityi

Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet cells of small and large intestinal epithelia and also by the uterus. Also expressed in the hypothalamus where it is detected in paraventricular, periventricular and supraoptic nuclei (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000160180
CleanExiHS_TFF3

Organism-specific databases

HPAiHPA035464

Interactioni

Subunit structurei

Monomer. Homodimer; disulfide-linked.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112891, 5 interactors
IntActiQ07654, 3 interactors
STRINGi9606.ENSP00000430690

Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 44Combined sources3
Helixi45 – 47Combined sources3
Beta strandi50 – 53Combined sources4
Turni63 – 65Combined sources3
Helixi66 – 69Combined sources4
Beta strandi70 – 72Combined sources3
Beta strandi78 – 80Combined sources3
Beta strandi82 – 84Combined sources3
Helixi88 – 90Combined sources3
Turni91 – 93Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E9TNMR-A36-94[»]
1PE3NMR-1/236-94[»]
ProteinModelPortaliQ07654
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07654

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 87P-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0FX Eukaryota
ENOG41114KR LUCA
GeneTreeiENSGT00840000129881
HOGENOMiHOG000121778
HOVERGENiHBG004364
InParanoidiQ07654
KOiK22454
OMAiPLQETEC
PhylomeDBiQ07654
TreeFamiTF336092

Family and domain databases

CDDicd00111 Trefoil, 1 hit
InterProiView protein in InterPro
IPR017994 P_trefoil_chordata
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom
PfamiView protein in Pfam
PF00088 Trefoil, 1 hit
PRINTSiPR00680 PTREFOIL
SMARTiView protein in SMART
SM00018 PD, 1 hit
PROSITEiView protein in PROSITE
PS00025 P_TREFOIL_1, 1 hit
PS51448 P_TREFOIL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRVLSCVPE PTVVMAARAL CMLGLVLALL SSSSAEEYVG LSANQCAVPA
60 70 80 90
KDRVDCGYPH VTPKECNNRG CCFDSRIPGV PWCFKPLQEA ECTF
Length:94
Mass (Da):10,181
Last modified:March 28, 2018 - v2
Checksum:i02276443AEE4CEA5
GO

Sequence cautioni

The sequence AAA59981 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA83628 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH17859 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL28111 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA95531 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB13731 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88 – 90QEA → TRKT in AAA36766 (PubMed:8454642).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25657, U25654, U25656 Genomic DNA Translation: AAA83628.1 Different initiation.
AB038162 Genomic DNA Translation: BAB13731.1 Different initiation.
AP001746 Genomic DNA Translation: BAA95531.1 Different initiation.
AP001623 Genomic DNA No translation available.
AF432265 mRNA Translation: AAL28111.1 Different initiation.
L15203 mRNA Translation: AAA59981.1 Different initiation.
BC017859 mRNA Translation: AAH17859.1 Different initiation.
L08044 mRNA Translation: AAA36766.1
CCDSiCCDS33565.2
PIRiA48284
RefSeqiNP_003217.3, NM_003226.3
UniGeneiHs.82961

Genome annotation databases

EnsembliENST00000518498; ENSP00000430690; ENSG00000160180
GeneIDi7033
KEGGihsa:7033

Similar proteinsi

Entry informationi

Entry nameiTFF3_HUMAN
AccessioniPrimary (citable) accession number: Q07654
Secondary accession number(s): A0A0A6YYJ4
, E9PBB5, Q96NX0, Q9UDA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health