Solute carrier family 2, facilitated glucose transporter member 3

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Q07647 (GTR3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 94. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Solute carrier family 2, facilitated glucose transporter member 3

Alternative name(s):
Glucose transporter type 3, brain
Short name=GLUT-3

Gene names

Name:	Slc2a3
Synonyms:	Glut-3, Glut3

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Facilitative glucose transporter. Probably a neuronal glucose transporter.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Brain and osteoblastic cells (at protein level). Highly expressed in brain. Ref.3
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glucose import Inferred from direct assay. Source: RGD negative regulation of apoptotic process Inferred from direct assay. Source: RGD response to glucose stimulus Inferred from expression pattern. Source: RGD
Cellular component	caveola Inferred from direct assay. Source: RGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW synaptic vesicle membrane Inferred from direct assay. Source: RGD
Molecular function	D-glucose transmembrane transporter activity Inferred from direct assay. Source: UniProtKB dehydroascorbic acid transporter activity Inferred from direct assay. Source: UniProtKB galactoside binding Inferred from direct assay. Source: RGD glucose binding Inferred from direct assay. Source: RGD kinase binding Inferred from physical interaction. Source: RGD xylose binding Inferred from direct assay. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 493

493

Solute carrier family 2, facilitated glucose transporter member 3

PRO_0000050358

Regions

Topological domain

1 – 10

Cytoplasmic Potential

Transmembrane

11 – 31

Helical; Name=1; Potential

Topological domain

32 – 64

Extracellular Potential

Transmembrane

65 – 85

Helical; Name=2; Potential

Topological domain

86 – 93

Cytoplasmic Potential

Transmembrane

94 – 114

Helical; Name=3; Potential

Topological domain

115 – 124

Extracellular Potential

Transmembrane

125 – 145

Helical; Name=4; Potential

Topological domain

146 – 153

Cytoplasmic Potential

Transmembrane

154 – 174

Helical; Name=5; Potential

Topological domain

175 – 183

Extracellular Potential

Transmembrane

184 – 204

Helical; Name=6; Potential

Topological domain

205 – 269

Cytoplasmic Potential

Transmembrane

270 – 290

Helical; Name=7; Potential

Topological domain

291 – 304

Extracellular Potential

Transmembrane

305 – 325

Helical; Name=8; Potential

Topological domain

326 – 334

Cytoplasmic Potential

Transmembrane

335 – 355

Helical; Name=9; Potential

Topological domain

356 – 363

Extracellular Potential

Transmembrane

364 – 384

Helical; Name=10; Potential

Topological domain

385 – 399

Cytoplasmic Potential

Transmembrane

400 – 420

Helical; Name=11; Potential

Topological domain

421 – 424

Extracellular Potential

Transmembrane

425 – 445

Helical; Name=12; Potential

Topological domain

446 – 493

Cytoplasmic Potential

Region

277 – 279

Defines substrate specificity By similarity

Amino acid modifications

Modified residue

482

Phosphoserine By similarity

Glycosylation

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

R → S in AAA62503. Ref.2

Sequence conflict

447

S → F in AAA62503. Ref.2

Sequence conflict

470

H → Q in AAA62503. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q07647 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 745446B59BDF4399
Show »

FASTA

493

53,581

        10         20         30         40         50         60 
MGTAKVTPSL VFAVTVATIG SFQFGYNTGV INAPETIIKD FLNYTLEERL EDLPREGLLT 

        70         80         90        100        110        120 
TLWSLCVAIF SVGGMIGSFS VGLFVNRFGR RNSMLLVNLI AILGGCLMGF AKIAESVEML 

       130        140        150        160        170        180 
ILGRLIIGIF CGLCTGFVPM YIGEVSPTAL RGAFGTLNQL GIVVGILVAQ VFGLDFILGS 

       190        200        210        220        230        240 
EELWPGLLGL TIIPAILQSA ALPFCPESPR FLLINRKEED QATEILQRLW GTPDVIQEIQ 

       250        260        270        280        290        300 
EMKDESIRMS QEKQVTVLEL FKSPSYFQPL LISVVLQLSQ QFSGINAVFY YSTGIFQDAG 

       310        320        330        340        350        360 
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAVCSVFMT ISLLLKDEYE 

       370        380        390        400        410        420 
AMSFVCIVAI LVYVAFFEIG PGPIPWFIVA ELFSQGPRPA AMAVAGCSNW TSNFLVGMFF 

       430        440        450        460        470        480 
PSAAAYLGAY VFIIFAAFLV FFLIFTSFKV PETKGRTFED ITRAFEGQAH SGKGSAGVEL 

       490 
NSMQPVKETP GNA

« Hide

References

[1]	"Neuron-specific glucose transporter (NSGT): CNS distribution of GLUT3 rat glucose transporter (RGT3) in rat central neurons." Nagamatsu S., Sawa H., Kamada K., Nakamichi Y., Yoshimoto K., Hoshino T. FEBS Lett. 334:289-295(1993) [PubMed: 8243635] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of glucose transporter-3 (GLUT3) cDNA from rat brain." Krishnan S.N., Haddad G.G. Life Sci. 56:1193-1197(1995) [PubMed: 7475896] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Brain.
[3]	"Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I." Zoidis E., Ghirlanda-Keller C., Schmid C. Mol. Cell. Biochem. 348:33-42(2011) [PubMed: 21076856] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D13962 mRNA. Translation: BAA03065.1. U17978 mRNA. Translation: AAA62503.1.
IPI	IPI00198723.
PIR	S38981.
RefSeq	NP_058798.2. NM_017102.2.
UniGene	Rn.95055.
3D structure databases
ProteinModelPortal	Q07647.
ModBase	Search...
Protein-protein interaction databases
STRING	Q07647.
Protein family/group databases
TCDB	2.A.1.1.12. major facilitator superfamily (MFS).
PTM databases
PhosphoSite	Q07647.
Proteomic databases
PRIDE	Q07647.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000011298; ENSRNOP00000011298; ENSRNOG00000008376.
GeneID	25551.
KEGG	rno:25551.
UCSC	NM_017102. rat.
Organism-specific databases
CTD	6515.
RGD	3706. Slc2a3.
Phylogenomic databases
eggNOG	roNOG09613.
GeneTree	ENSGT00600000084007.
HOVERGEN	HBG014816.
InParanoid	Q07647.
OrthoDB	EOG4QNMW2.
PhylomeDB	Q07647.
Gene expression databases
Genevestigator	Q07647.
GermOnline	ENSRNOG00000008376. Rattus norvegicus.
Family and domain databases
InterPro	IPR002945. Glc_transpt_3. IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
KO	K08142.
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
PRINTS	PR01192. GLUCTRSPORT3. PR00171. SUGRTRNSPORT.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	607101.

Entry information

Entry name

GTR3_RAT

Accession

Primary (citable) accession number: Q07647
Secondary accession number(s): Q62729

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	November 16, 2011
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents