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Protein

Solute carrier family 2, facilitated glucose transporter member 3

Gene

Slc2a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei315MonosaccharideBy similarity1
Binding sitei378MonosaccharideBy similarity1
Binding sitei386MonosaccharideBy similarity1

GO - Molecular functioni

  • dehydroascorbic acid transporter activity Source: UniProtKB
  • D-glucose transmembrane transporter activity Source: UniProtKB
  • galactoside binding Source: RGD
  • glucose binding Source: RGD
  • glucose transmembrane transporter activity Source: RGD
  • kinase binding Source: RGD
  • monosaccharide transmembrane transporter activity Source: RGD
  • xylose binding Source: RGD

GO - Biological processi

  • dehydroascorbic acid transport Source: UniProtKB
  • glucose import Source: RGD
  • glucose transport Source: UniProtKB
  • monosaccharide transport Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • response to glucose Source: RGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Protein family/group databases

TCDBi2.A.1.1.12. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 3
Alternative name(s):
Glucose transporter type 3, brain
Short name:
GLUT-3
Gene namesi
Name:Slc2a3
Synonyms:Glut-3, Glut3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3706. Slc2a3.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicBy similarity10
Transmembranei11 – 32Helical; Name=1Sequence analysisBy similarityAdd BLAST22
Topological domaini33 – 64ExtracellularBy similarityAdd BLAST32
Transmembranei65 – 85Helical; Name=2Sequence analysisBy similarityAdd BLAST21
Topological domaini86 – 90CytoplasmicBy similarity5
Transmembranei91 – 111Helical; Name=3Sequence analysisBy similarityAdd BLAST21
Topological domaini112 – 118ExtracellularBy similarity7
Transmembranei119 – 142Helical; Name=4Sequence analysisBy similarityAdd BLAST24
Topological domaini143 – 153CytoplasmicBy similarityAdd BLAST11
Transmembranei154 – 174Helical; Name=5Sequence analysisBy similarityAdd BLAST21
Topological domaini175 – 183ExtracellularBy similarity9
Transmembranei184 – 204Helical; Name=6Sequence analysisBy similarityAdd BLAST21
Topological domaini205 – 269CytoplasmicBy similarityAdd BLAST65
Transmembranei270 – 290Helical; Name=7Sequence analysisBy similarityAdd BLAST21
Topological domaini291 – 304ExtracellularBy similarityAdd BLAST14
Transmembranei305 – 325Helical; Name=8Sequence analysisBy similarityAdd BLAST21
Topological domaini326 – 331CytoplasmicBy similarity6
Transmembranei332 – 352Helical; Name=9Sequence analysisBy similarityAdd BLAST21
Topological domaini353 – 363ExtracellularBy similarityAdd BLAST11
Transmembranei364 – 389Helical; Name=10Sequence analysisBy similarityAdd BLAST26
Topological domaini390 – 399CytoplasmicBy similarity10
Transmembranei400 – 420Helical; Name=11Sequence analysisBy similarityAdd BLAST21
Topological domaini421 – 429ExtracellularBy similarity9
Transmembranei430 – 450Helical; Name=12Sequence analysisBy similarityAdd BLAST21
Topological domaini451 – 493CytoplasmicBy similarityAdd BLAST43

GO - Cellular componenti

  • caveola Source: RGD
  • cytoplasm Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • synaptic vesicle membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503581 – 493Solute carrier family 2, facilitated glucose transporter member 3Add BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...)Sequence analysis1
Modified residuei232PhosphothreonineBy similarity1
Modified residuei471PhosphoserineBy similarity1
Modified residuei475PhosphoserineCombined sources1
Modified residuei482PhosphoserineCombined sources1
Modified residuei489PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ07647.
PRIDEiQ07647.

PTM databases

iPTMnetiQ07647.
PhosphoSitePlusiQ07647.

Expressioni

Tissue specificityi

Brain and osteoblastic cells (at protein level) (PubMed:21076856). Highly expressed in brain (PubMed:7475896, PubMed:21076856).2 Publications

Gene expression databases

BgeeiENSRNOG00000008376.

Interactioni

GO - Molecular functioni

  • kinase binding Source: RGD

Protein-protein interaction databases

BioGridi247582. 1 interactor.
IntActiQ07647. 1 interactor.
STRINGi10116.ENSRNOP00000066684.

Structurei

3D structure databases

ProteinModelPortaliQ07647.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni277 – 279Important for selectivity against fructoseBy similarity3
Regioni280 – 286Monosaccharide bindingBy similarity7

Domaini

Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiQ07647.
KOiK08142.
PhylomeDBiQ07647.
TreeFamiTF313762.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002945. Glc_transpt_3.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01192. GLUCTRSPORT3.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07647-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTAKVTPSL VFAVTVATIG SFQFGYNTGV INAPETIIKD FLNYTLEERL
60 70 80 90 100
EDLPREGLLT TLWSLCVAIF SVGGMIGSFS VGLFVNRFGR RNSMLLVNLI
110 120 130 140 150
AILGGCLMGF AKIAESVEML ILGRLIIGIF CGLCTGFVPM YIGEVSPTAL
160 170 180 190 200
RGAFGTLNQL GIVVGILVAQ VFGLDFILGS EELWPGLLGL TIIPAILQSA
210 220 230 240 250
ALPFCPESPR FLLINRKEED QATEILQRLW GTPDVIQEIQ EMKDESIRMS
260 270 280 290 300
QEKQVTVLEL FKSPSYFQPL LISVVLQLSQ QFSGINAVFY YSTGIFQDAG
310 320 330 340 350
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAVCSVFMT
360 370 380 390 400
ISLLLKDEYE AMSFVCIVAI LVYVAFFEIG PGPIPWFIVA ELFSQGPRPA
410 420 430 440 450
AMAVAGCSNW TSNFLVGMFF PSAAAYLGAY VFIIFAAFLV FFLIFTSFKV
460 470 480 490
PETKGRTFED ITRAFEGQAH SGKGSAGVEL NSMQPVKETP GNA
Length:493
Mass (Da):53,581
Last modified:October 1, 1994 - v1
Checksum:i745446B59BDF4399
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55R → S in AAA62503 (PubMed:7475896).Curated1
Sequence conflicti447S → F in AAA62503 (PubMed:7475896).Curated1
Sequence conflicti470H → Q in AAA62503 (PubMed:7475896).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13962 mRNA. Translation: BAA03065.1.
U17978 mRNA. Translation: AAA62503.1.
PIRiS38981.
RefSeqiNP_058798.2. NM_017102.2.
XP_003749881.1. XM_003749833.4.
XP_017458346.1. XM_017602857.1.
UniGeneiRn.95055.

Genome annotation databases

GeneIDi100909595.
25551.
KEGGirno:100909595.
rno:25551.
UCSCiRGD:3706. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13962 mRNA. Translation: BAA03065.1.
U17978 mRNA. Translation: AAA62503.1.
PIRiS38981.
RefSeqiNP_058798.2. NM_017102.2.
XP_003749881.1. XM_003749833.4.
XP_017458346.1. XM_017602857.1.
UniGeneiRn.95055.

3D structure databases

ProteinModelPortaliQ07647.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247582. 1 interactor.
IntActiQ07647. 1 interactor.
STRINGi10116.ENSRNOP00000066684.

Protein family/group databases

TCDBi2.A.1.1.12. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ07647.
PhosphoSitePlusiQ07647.

Proteomic databases

PaxDbiQ07647.
PRIDEiQ07647.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100909595.
25551.
KEGGirno:100909595.
rno:25551.
UCSCiRGD:3706. rat.

Organism-specific databases

CTDi6515.
RGDi3706. Slc2a3.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiQ07647.
KOiK08142.
PhylomeDBiQ07647.
TreeFamiTF313762.

Miscellaneous databases

PROiQ07647.

Gene expression databases

BgeeiENSRNOG00000008376.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002945. Glc_transpt_3.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01192. GLUCTRSPORT3.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR3_RAT
AccessioniPrimary (citable) accession number: Q07647
Secondary accession number(s): Q62729
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.