Solute carrier family 2, facilitated glucose transporter member 3

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Reviewed, UniProtKB/Swiss-Prot Q07647 (GTR3_RAT)

Last modified February 9, 2010. Version 79. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 3
Alternative name(s):
    Glucose transporter type 3, brain
      Short name=GLUT-3

Gene names

Name:	Slc2a3
Synonyms:	Glut-3, Glut3

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Facilitative glucose transporter. Probably a neuronal glucose transporter.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in brain.
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]

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Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Membrane
Domain	Transmembrane
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	dehydroascorbic acid transport Inferred from direct assay. Source: UniProtKB glucose import Inferred from direct assay. Source: RGD negative regulation of apoptosis Inferred from direct assay. Source: RGD transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	caveola Inferred from direct assay. Source: RGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell synaptic vesicle membrane Inferred from direct assay. Source: RGD
Molecular function	D-glucose transmembrane transporter activity Inferred from direct assay. Source: UniProtKB dehydroascorbic acid transporter activity Inferred from direct assay. Source: UniProtKB galactoside binding Inferred from direct assay. Source: RGD glucose binding Inferred from direct assay. Source: RGD kinase binding Inferred from physical interaction. Source: RGD xylose binding Inferred from direct assay. Source: RGD
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 493

493

Solute carrier family 2, facilitated glucose transporter member 3

PRO_0000050358

Regions

Topological domain

1 – 10

Cytoplasmic Potential

Transmembrane

11 – 31

1 Potential

Topological domain

32 – 64

Extracellular Potential

Transmembrane

65 – 85

2 Potential

Topological domain

86 – 93

Cytoplasmic Potential

Transmembrane

94 – 114

3 Potential

Topological domain

115 – 124

Extracellular Potential

Transmembrane

125 – 145

4 Potential

Topological domain

146 – 153

Cytoplasmic Potential

Transmembrane

154 – 174

5 Potential

Topological domain

175 – 183

Extracellular Potential

Transmembrane

184 – 204

6 Potential

Topological domain

205 – 269

Cytoplasmic Potential

Transmembrane

270 – 290

7 Potential

Topological domain

291 – 304

Extracellular Potential

Transmembrane

305 – 325

8 Potential

Topological domain

326 – 334

Cytoplasmic Potential

Transmembrane

335 – 355

9 Potential

Topological domain

356 – 363

Extracellular Potential

Transmembrane

364 – 384

10 Potential

Topological domain

385 – 399

Cytoplasmic Potential

Transmembrane

400 – 420

11 Potential

Topological domain

421 – 424

Extracellular Potential

Transmembrane

425 – 445

12 Potential

Topological domain

446 – 493

Cytoplasmic Potential

Region

277 – 279

Defines substrate specificity By similarity

Amino acid modifications

Modified residue

482

Phosphoserine By similarity

Glycosylation

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

R → S in AAA62503. Ref.2

Sequence conflict

447

S → F in AAA62503. Ref.2

Sequence conflict

470

H → Q in AAA62503. Ref.2

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Sequences

Sequence

Length

Mass (Da)

Tools

Q07647-1 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 745446B59BDF4399
Show »

FASTA

493

53,581

        10         20         30         40         50         60 
MGTAKVTPSL VFAVTVATIG SFQFGYNTGV INAPETIIKD FLNYTLEERL EDLPREGLLT 

        70         80         90        100        110        120 
TLWSLCVAIF SVGGMIGSFS VGLFVNRFGR RNSMLLVNLI AILGGCLMGF AKIAESVEML 

       130        140        150        160        170        180 
ILGRLIIGIF CGLCTGFVPM YIGEVSPTAL RGAFGTLNQL GIVVGILVAQ VFGLDFILGS 

       190        200        210        220        230        240 
EELWPGLLGL TIIPAILQSA ALPFCPESPR FLLINRKEED QATEILQRLW GTPDVIQEIQ 

       250        260        270        280        290        300 
EMKDESIRMS QEKQVTVLEL FKSPSYFQPL LISVVLQLSQ QFSGINAVFY YSTGIFQDAG 

       310        320        330        340        350        360 
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAVCSVFMT ISLLLKDEYE 

       370        380        390        400        410        420 
AMSFVCIVAI LVYVAFFEIG PGPIPWFIVA ELFSQGPRPA AMAVAGCSNW TSNFLVGMFF 

       430        440        450        460        470        480 
PSAAAYLGAY VFIIFAAFLV FFLIFTSFKV PETKGRTFED ITRAFEGQAH SGKGSAGVEL 

       490 
NSMQPVKETP GNA

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References

[1]	"Neuron-specific glucose transporter (NSGT): CNS distribution of GLUT3 rat glucose transporter (RGT3) in rat central neurons." Nagamatsu S., Sawa H., Kamada K., Nakamichi Y., Yoshimoto K., Hoshino T. FEBS Lett. 334:289-295(1993) [PubMed: 8243635] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of glucose transporter-3 (GLUT3) cDNA from rat brain." Krishnan S.N., Haddad G.G. Life Sci. 56:1193-1197(1995) [PubMed: 7475896] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Brain.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	D13962 mRNA. Translation: BAA03065.1. U17978 mRNA. Translation: AAA62503.1.
IPI	IPI00198723.
PIR	S38981.
RefSeq	NP_058798.2.
UniGene	Rn.95055
3D structure databases
SMR	Q07647. Positions 56-407, 60-456.
ModBase	Search...
Protein-protein interaction databases
STRING	Q07647.
Protein family/group databases
TCDB	2.A.1.1.12. major facilitator superfamily (MFS).
PTM databases
PhosphoSite	Q07647.
Genome annotation databases
Ensembl	ENSRNOT00000011298; ENSRNOP00000011298; ENSRNOG00000008376; Rattus norvegicus. [Genome view]
GeneID	25551.
KEGG	rno:25551.
UCSC	NM_017102. rat.
Organism-specific databases
CTD	25551.
RGD	3706. Slc2a3.
Phylogenomic databases
eggNOG	roNOG09613.
HOVERGEN	Q07647.
InParanoid	Q07647.
PhylomeDB	Q07647.
Gene expression databases
Genevestigator	Q07647.
GermOnline	ENSRNOG00000008376. Rattus norvegicus.
Family and domain databases
InterPro	IPR002945. Glc_transpt_3. IPR016196. MFS_general_subst_transpt. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
PANTHER	PTHR11600:SF113. Glu_transpt3. 1 hit.
PRINTS	PR01192. GLUCTRSPORT3. PR00171. SUGRTRNSPORT.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	607101.

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Entry information

Entry name

GTR3_RAT

Accession

Primary (citable) accession number: Q07647
Secondary accession number(s): Q62729

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	February 9, 2010
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents