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Protein

Keratin-associated protein 1-1

Gene

KRTAP1-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 1-1
Alternative name(s):
High sulfur keratin-associated protein 1.1
Keratin-associated protein 1.1
Keratin-associated protein 1.6
Keratin-associated protein 1.7
Gene namesi
Name:KRTAP1-1
Synonyms:B2A, KAP1.1, KAP1.6, KAP1.7, KRTAP1.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000188581.8.
HGNCiHGNC:16772. KRTAP1-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188581.
PharmGKBiPA38412.

Polymorphism and mutation databases

BioMutaiKRTAP1-1.
DMDMi74722292.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239011 – 177Keratin-associated protein 1-1Add BLAST177

Proteomic databases

PaxDbiQ07627.
PeptideAtlasiQ07627.
PRIDEiQ07627.

Expressioni

Tissue specificityi

Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.1 Publication

Gene expression databases

BgeeiENSG00000188581.
CleanExiHS_KRTAP1-1.
GenevisibleiQ07627. HS.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ07627. 195 interactors.
STRINGi9606.ENSP00000305975.

Structurei

3D structure databases

ProteinModelPortaliQ07627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KRTAP type 1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4726. Eukaryota.
ENOG410XY8D. LUCA.
GeneTreeiENSGT00730000111060.
HOGENOMiHOG000234033.
HOVERGENiHBG008671.
InParanoidiQ07627.
OMAiCDSSCCQ.
PhylomeDBiQ07627.
TreeFamiTF351356.

Family and domain databases

InterProiView protein in InterPro
IPR002494. KAP.
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiView protein in Pfam
PF01500. Keratin_B2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q07627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACCQTSFCG FPSCSTSGTC GSSCCQPSCC ETSSCQPRCC ETSCCQPSCC
60 70 80 90 100
QTSFCGFPSF STGGTCDSSC CQPSCCETSC CQPSCYQTSS CGTGCGIGGG
110 120 130 140 150
IGYGQEGSSG AVSTRIRWCR PDCRVEGTCL PPCCVVSCTP PSCCQLHHAE
160 170
ASCCRPSYCG QSCCRPVCCC YCSEPTC
Length:177
Mass (Da):18,235
Last modified:November 1, 1996 - v1
Checksum:i8CD3613D3DFC3C79
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02534812 – 58PSCST…FCGFP → R in allele KAP1.6. Add BLAST47
Natural variantiVAR_02535319 – 110Missing in allele KAP1.7. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63337 Genomic DNA. Translation: CAA44937.1.
AJ406926 mRNA. Translation: CAC27565.1.
AB052934 mRNA. Translation: BAB61026.1.
AB052868 mRNA. Translation: BAB61024.1.
AB055057 mRNA. Translation: BAB61031.1.
AC007455 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60699.1.
BC105069 mRNA. Translation: AAI05070.1.
BC105071 mRNA. Translation: AAI05072.1.
CCDSiCCDS42324.1.
PIRiS37650.
RefSeqiNP_112229.1. NM_030967.2.
UniGeneiHs.247934.

Genome annotation databases

EnsembliENST00000306271; ENSP00000305975; ENSG00000188581.
ENST00000573871; ENSP00000460787; ENSG00000262808.
GeneIDi81851.
KEGGihsa:81851.
UCSCiuc032fzn.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKRA11_HUMAN
AccessioniPrimary (citable) accession number: Q07627
Secondary accession number(s): A6NC32, Q96S60, Q96S67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families