Reviewed, UniProtKB/Swiss-Prot Q07623 (NOP6_YEAST)

Names and origin

Protein names

Recommended name:
    Nucleolar protein 6

Gene names

Name:	NOP6
Ordered Locus Names:	YDL213C
ORF Names:	D1018

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Predicted to be involved in rRNA processing. Ref.6
Subcellular location	Nucleus › nucleolus.
Miscellaneous	Present with 8970 molecules/cell in log phase SD medium. Ref.5
Sequence similarities	Belongs to the RRM NOP6 family. Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Biological process	Ribosome biogenesis rRNA processing
Cellular component	Nucleus
Ligand	RNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW ribosomal small subunit biogenesis Inferred from genetic interaction. Source: SGD
Cellular component	nucleolus Ref.4 Inferred from direct assay. Source: SGD
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GAT2	P40209	1	EBI-32695,EBI-7347
UBP10	P53874	1	EBI-32695,EBI-19873

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Nucleolar protein 6		PRO_0000268691
Regions
	Domain	78 – 155	78	RRM
	Compositional bias	7 – 74	68	Lys-rich
Amino acid modifications
	Modified residue	45	1	Phosphoserine Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Q07623-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 2FB6E4C4BB1542B3	FASTA	225	25,216
	10 20 30 40 50 60 MGSEEDKKLT KKQLKAQQFR KSKEEKDQEK DVKKEQAPEG KRPNSAAGND GEEPVKKKRK 70 80 90 100 110 120 TRRGRGGKGK NGKKGNRFIV FVGSLPRDIT AVELQNHFKN SSPDQIRLRA DKGIAFLEFD 130 140 150 160 170 180 ADKDRTGIQR RMDIALLQHG TLLKEKKINV ELTVGGGGNS QERLEKLKNK NIKLDEERKE 190 200 210 220 RLTKMINDGN QKKIAKTTAT AAQTSGTDNK PVPAGIHPDR AKLLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of a 39 kb segment of yeast chromosome IV: 12 new open reading frames, nine known genes and one gene for Gly-tRNA." Bahr A., Moeller-Rieker S., Hankeln T., Kraemer C., Protin U., Schmidt E.R. Yeast 13:163-169(1997) [PubMed: 9046097] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P. Nature 387:75-78(1997) [PubMed: 9169867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Predicting protein functions from redundancies in large-scale protein interaction networks." Samanta M.P., Liang S. Proc. Natl. Acad. Sci. U.S.A. 100:12579-12583(2003) [PubMed: 14566057] [Abstract] Cited for: PREDICTION OF FUNCTION.
[7]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X99000 Genomic DNA. Translation: CAA67478.1. Z74261 Genomic DNA. Translation: CAA98791.1. AY557652 Genomic DNA. Translation: AAS55978.1.
PIR	S67772.
RefSeq	NP_010068.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:1807N.
IntAct	Q07623. 95 interactions.
STRING	Q07623.
Proteomic databases
PeptideAtlas	Q07623.
PRIDE	Q07623.
Genome annotation databases
Ensembl	YDL213C; YDL213C; YDL213C; Saccharomyces cerevisiae. [Genome view]
GeneID	851313.
KEGG	sce:YDL213C.
NMPDR	fig|4932.3.peg.801.
Organism-specific databases
CYGD	YDL213c.
SGD	S000002372. NOP6.
Phylogenomic databases
HOGENOM	Q07623.
OMA	GPRFILF
OrthoDB	EOG9C8999
Gene expression databases
ArrayExpress	Q07623.
Genevestigator	Q07623.
GermOnline	YDL213C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR000504. RRM_RNP1. [Graphical view]
SMART	SM00360. RRM. 1 hit. [Graphical view]
PROSITE	PS50102. RRM. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	968340.

Entry information

Entry name

NOP6_YEAST

Accession

Primary (citable) accession number: Q07623

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	November 1, 1996
Last modified:	November 24, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)