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Protein

Nucleolar protein 6

Gene

NOP6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Predicted to be involved in rRNA processing.

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • rRNA binding Source: SGD
  • snoRNA binding Source: SGD

GO - Biological processi

  • ribosomal small subunit biogenesis Source: SGD
  • rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29595-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 6
Gene namesi
Name:NOP6
Ordered Locus Names:YDL213C
ORF Names:D1018
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL213C.
SGDiS000002372. NOP6.

Subcellular locationi

GO - Cellular componenti

  • 90S preribosome Source: SGD
  • nucleolus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686911 – 225Nucleolar protein 6Add BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ07623.
PRIDEiQ07623.

PTM databases

iPTMnetiQ07623.

Interactioni

Protein-protein interaction databases

BioGridi31832. 112 interactors.
DIPiDIP-1807N.
IntActiQ07623. 29 interactors.
MINTiMINT-8285156.

Structurei

Secondary structure

1225
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi77 – 83Combined sources7
Helixi91 – 98Combined sources8
Turni99 – 101Combined sources3
Beta strandi107 – 109Combined sources3
Helixi110 – 112Combined sources3
Beta strandi114 – 120Combined sources7
Helixi121 – 123Combined sources3
Turni125 – 127Combined sources3
Helixi128 – 136Combined sources9
Turni137 – 140Combined sources4
Beta strandi149 – 154Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MZJNMR-A75-156[»]
ProteinModelPortaliQ07623.
SMRiQ07623.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 155RRMPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 74Lys-richAdd BLAST68

Sequence similaritiesi

Belongs to the RRM NOP6 family.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000001011.
InParanoidiQ07623.
KOiK14789.
OMAiHHSTLRN.
OrthoDBiEOG092C4X9L.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07623-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSEEDKKLT KKQLKAQQFR KSKEEKDQEK DVKKEQAPEG KRPNSAAGND
60 70 80 90 100
GEEPVKKKRK TRRGRGGKGK NGKKGNRFIV FVGSLPRDIT AVELQNHFKN
110 120 130 140 150
SSPDQIRLRA DKGIAFLEFD ADKDRTGIQR RMDIALLQHG TLLKEKKINV
160 170 180 190 200
ELTVGGGGNS QERLEKLKNK NIKLDEERKE RLTKMINDGN QKKIAKTTAT
210 220
AAQTSGTDNK PVPAGIHPDR AKLLK
Length:225
Mass (Da):25,216
Last modified:November 1, 1996 - v1
Checksum:i2FB6E4C4BB1542B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99000 Genomic DNA. Translation: CAA67478.1.
Z74261 Genomic DNA. Translation: CAA98791.1.
AY557652 Genomic DNA. Translation: AAS55978.1.
BK006938 Genomic DNA. Translation: DAA11651.1.
PIRiS67772.
RefSeqiNP_010068.1. NM_001180273.1.

Genome annotation databases

EnsemblFungiiYDL213C; YDL213C; YDL213C.
GeneIDi851313.
KEGGisce:YDL213C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99000 Genomic DNA. Translation: CAA67478.1.
Z74261 Genomic DNA. Translation: CAA98791.1.
AY557652 Genomic DNA. Translation: AAS55978.1.
BK006938 Genomic DNA. Translation: DAA11651.1.
PIRiS67772.
RefSeqiNP_010068.1. NM_001180273.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MZJNMR-A75-156[»]
ProteinModelPortaliQ07623.
SMRiQ07623.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31832. 112 interactors.
DIPiDIP-1807N.
IntActiQ07623. 29 interactors.
MINTiMINT-8285156.

PTM databases

iPTMnetiQ07623.

Proteomic databases

MaxQBiQ07623.
PRIDEiQ07623.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL213C; YDL213C; YDL213C.
GeneIDi851313.
KEGGisce:YDL213C.

Organism-specific databases

EuPathDBiFungiDB:YDL213C.
SGDiS000002372. NOP6.

Phylogenomic databases

HOGENOMiHOG000001011.
InParanoidiQ07623.
KOiK14789.
OMAiHHSTLRN.
OrthoDBiEOG092C4X9L.

Enzyme and pathway databases

BioCyciYEAST:G3O-29595-MONOMER.

Miscellaneous databases

PROiQ07623.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNOP6_YEAST
AccessioniPrimary (citable) accession number: Q07623
Secondary accession number(s): D6VRE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8970 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.