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Q07622 (ACK1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Activator of C kinase protein 1
Gene names
Name:ACK1
Ordered Locus Names:YDL203C
ORF Names:D1066
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length623 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Miscellaneous

Present with 98 molecules/cell in log phase SD medium. Ref.4

Sequence similarities

Contains 4 Sel1-like repeats.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RSP5P399402EBI-38674,EBI-16219

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 623623Activator of C kinase protein 1
PRO_0000242166

Regions

Repeat318 – 36144Sel1-like 1
Repeat408 – 44437Sel1-like 2
Repeat495 – 53137Sel1-like 3
Repeat576 – 61136Sel1-like 4
Compositional bias68 – 769Poly-Ser

Amino acid modifications

Modified residue1431Phosphoserine Ref.6
Modified residue1551Phosphoserine Ref.7
Cross-link184Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q07622 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 5CBB9D907443EC2E

FASTA62369,371
        10         20         30         40         50         60 
MVNQGQPQPN LYDKHINMFP PARARESSHK LGNANSDRHG LPAQNIVPAP YPVDDSIVEL 

        70         80         90        100        110        120 
TPAIPFTSPS SSSSLSLPLS ALNFTDGNAD GGQLGTPVTI NSNNGMDIFN SKPTGEIGYA 

       130        140        150        160        170        180 
NNGTNSTGSR YELPFNFSST KESLGSPAVQ DASISSGNRI SESVRDNSAP PPYEESESRI 

       190        200        210        220        230        240 
LQEKVYRTEE KAPIRPLNNN PVPPQKINQP PTGSAKTDDN GSSGGEDKLS SYSPEALAFY 

       250        260        270        280        290        300 
QVYKKTITDS SKFTPEIQMQ WCETLLTYAF NEDFISQYNI NAEKLKRSLK PEEMLKNQKV 

       310        320        330        340        350        360 
ILEHSFKVLT KLITLKWPPA MYLMGTLYSH QPYLPIKNKN IVIKNDEKAL EYYCKAAKLN 

       370        380        390        400        410        420 
NSDACYRAGV CFEYQRGTSS LDPSPTKEQC IKKAFQYYQH GAEVCSNSAC MYKLGMSHLY 

       430        440        450        460        470        480 
GLNMQKTDVL LAIKWFDKAA QKGDSPQTLY ELGKIYEFSV LPPEIQNLLF ANGIRKDSQL 

       490        500        510        520        530        540 
AIKYYQQCAK DFEYPLAQWK LGNCYEFGDL GLPVVAKKSI YWYSKAAAAQ PKGNPMAMLS 

       550        560        570        580        590        600 
LSGWYLTGAP NILKPNNKEA FNWALKSSKC SDGKLARTEF ALGFYYEKGV GCEVDLDLAK 

       610        620 
QYYQRAARMG FRKAVDALRS LTN

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of a 39 kb segment of yeast chromosome IV: 12 new open reading frames, nine known genes and one gene for Gly-tRNA."
Bahr A., Moeller-Rieker S., Hankeln T., Kraemer C., Protin U., Schmidt E.R.
Yeast 13:163-169(1997) [PubMed: 9046097] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed: 9169867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"A proteomics approach to understanding protein ubiquitination."
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D., Marsischky G., Roelofs J., Finley D., Gygi S.P.
Nat. Biotechnol. 21:921-926(2003) [PubMed: 12872131] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-184, MASS SPECTROMETRY.
Strain: SUB592.
[6]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143, MASS SPECTROMETRY.
[7]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X99000 Genomic DNA. Translation: CAA67465.1.
Z74251 Genomic DNA. Translation: CAA98781.1.
BK006938 Genomic DNA. Translation: DAA11661.1.
PIRS67762.
RefSeqNP_010078.1. NM_001180263.1.

3D structure databases

ProteinModelPortalQ07622.
SMRQ07622. Positions 302-621.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-1805N.
IntActQ07622. 8 interactions.
MINTMINT-393415.
STRINGQ07622.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDL203C; YDL203C; YDL203C.
GeneID851324.
KEGGsce:YDL203C.
NMPDRfig|4932.3.peg.811.

Organism-specific databases

CYGDYDL203c.
SGDS000002362. ACK1.

Phylogenomic databases

eggNOGfuNOG04893.
GeneTreeEFGT00050000000230.
HOGENOMHBG203205.
OMAMYKLGMF.
OrthoDBEOG4W11NX.

Gene expression databases

ArrayExpressQ07622.
GenevestigatorQ07622.
GermOnlineYDL203C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR006597. Sel1-like.
IPR011990. TPR-like_helical.
[Graphical view]
Gene3DG3DSA:1.25.40.10. TPR-like_helical. 1 hit.
KOK07126.
PfamPF08238. Sel1. 7 hits.
[Graphical view]
SMARTSM00671. SEL1. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio968372.

Entry information

Entry nameACK1_YEAST
AccessionPrimary (citable) accession number: Q07622
Secondary accession number(s): D6VRF1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents