Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Binder of sperm protein homolog 1

Gene

BSPH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phospholipid liposomes, and weakly to gelatin. Does not bind chondroitin sulfate B.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fertilization

Names & Taxonomyi

Protein namesi
Recommended name:
Binder of sperm protein homolog 1
Alternative name(s):
Bovine seminal plasma protein homolog 1
Bovine seminal plasma protein-like 1
Gene namesi
Name:BSPH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:33906. BSPH1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164716709.

Polymorphism and mutation databases

BioMutaiBSPH1.
DMDMi121939964.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 132115Binder of sperm protein homolog 1PRO_0000326156Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 69PROSITE-ProRule annotation
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence analysis
Disulfide bondi59 ↔ 82PROSITE-ProRule annotation
Disulfide bondi90 ↔ 116PROSITE-ProRule annotation
Disulfide bondi104 ↔ 131PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ075Z2.
PeptideAtlasiQ075Z2.
PRIDEiQ075Z2.

PTM databases

iPTMnetiQ075Z2.
PhosphoSiteiQ075Z2.

Expressioni

Tissue specificityi

Expressed only in the epididymis.1 Publication

Gene expression databases

BgeeiENSG00000188334.
CleanExiHS_BSPH1.

Organism-specific databases

HPAiHPA058056.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341762.

Structurei

3D structure databases

ProteinModelPortaliQ075Z2.
SMRiQ075Z2. Positions 44-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 8445Fibronectin type-II 1PROSITE-ProRule annotationAdd
BLAST
Domaini85 – 13248Fibronectin type-II 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the seminal plasma protein family.Curated
Contains 2 fibronectin type-II domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00830000128424.
HOGENOMiHOG000060267.
HOVERGENiHBG007070.
InParanoidiQ075Z2.
OMAiFPFWYRR.
OrthoDBiEOG091G116D.
PhylomeDBiQ075Z2.
TreeFamiTF343543.

Family and domain databases

CDDicd00062. FN2. 1 hit.
Gene3Di2.10.10.10. 2 hits.
InterProiIPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
[Graphical view]
PfamiPF00040. fn2. 2 hits.
[Graphical view]
SMARTiSM00059. FN2. 2 hits.
[Graphical view]
SUPFAMiSSF57440. SSF57440. 2 hits.
PROSITEiPS00023. FN2_1. 1 hit.
PS51092. FN2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q075Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLMLLFVE TTRNSSACIF PVILNELSST VETITHFPEV TDGECVFPFH
60 70 80 90 100
YKNGTYYDCI KSKARHKWCS LNKTYEGYWK FCSAEDFANC VFPFWYRRLI
110 120 130
YWECTDDGEA FGKKWCSLTK NFNKDRIWKY CE
Length:132
Mass (Da):15,693
Last modified:October 31, 2006 - v1
Checksum:i5B65371C8AB140CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ227497 mRNA. Translation: ABB71591.1.
AC010330 Genomic DNA. No translation available.
CCDSiCCDS46135.1.
RefSeqiNP_001121798.1. NM_001128326.2.
UniGeneiHs.651072.

Genome annotation databases

EnsembliENST00000344839; ENSP00000341762; ENSG00000188334.
GeneIDi100131137.
KEGGihsa:100131137.
UCSCiuc002phs.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ227497 mRNA. Translation: ABB71591.1.
AC010330 Genomic DNA. No translation available.
CCDSiCCDS46135.1.
RefSeqiNP_001121798.1. NM_001128326.2.
UniGeneiHs.651072.

3D structure databases

ProteinModelPortaliQ075Z2.
SMRiQ075Z2. Positions 44-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341762.

PTM databases

iPTMnetiQ075Z2.
PhosphoSiteiQ075Z2.

Polymorphism and mutation databases

BioMutaiBSPH1.
DMDMi121939964.

Proteomic databases

PaxDbiQ075Z2.
PeptideAtlasiQ075Z2.
PRIDEiQ075Z2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344839; ENSP00000341762; ENSG00000188334.
GeneIDi100131137.
KEGGihsa:100131137.
UCSCiuc002phs.1. human.

Organism-specific databases

CTDi100131137.
GeneCardsiBSPH1.
HGNCiHGNC:33906. BSPH1.
HPAiHPA058056.
MIMi612213. gene.
neXtProtiNX_Q075Z2.
PharmGKBiPA164716709.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00830000128424.
HOGENOMiHOG000060267.
HOVERGENiHBG007070.
InParanoidiQ075Z2.
OMAiFPFWYRR.
OrthoDBiEOG091G116D.
PhylomeDBiQ075Z2.
TreeFamiTF343543.

Miscellaneous databases

GenomeRNAii100131137.
PROiQ075Z2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188334.
CleanExiHS_BSPH1.

Family and domain databases

CDDicd00062. FN2. 1 hit.
Gene3Di2.10.10.10. 2 hits.
InterProiIPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
[Graphical view]
PfamiPF00040. fn2. 2 hits.
[Graphical view]
SMARTiSM00059. FN2. 2 hits.
[Graphical view]
SUPFAMiSSF57440. SSF57440. 2 hits.
PROSITEiPS00023. FN2_1. 1 hit.
PS51092. FN2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBSPH1_HUMAN
AccessioniPrimary (citable) accession number: Q075Z2
Secondary accession number(s): A6NIZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 31, 2006
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.