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Protein

Caspase-12

Gene
N/A
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the activation cascade of caspases responsible for apoptosis execution.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei218 – 2181By similarity
Active sitei266 – 2661By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-12 (EC:3.4.22.-)
Short name:
CASP-12
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 386Caspase-12PRO_0000317440
Propeptidei1 – ?Sequence analysisPRO_0000317439

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei84 – 841PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein, Zymogen

Proteomic databases

PaxDbiQ075B4.

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by two subunits (Potential). May interact with TRAF2 (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000038116.

Structurei

3D structure databases

ProteinModelPortaliQ075B4.
SMRiQ075B4. Positions 132-278, 299-386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9191CARDAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated
Contains 1 CARD domain.Curated

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOVERGENiHBG076981.
KOiK04741.

Family and domain databases

Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR017350. Pept_C14A_CASP1-typ.
IPR015917. Pept_C14A_HD.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF52129. SSF52129. 1 hit.
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q075B4-1) [UniParc]FASTAAdd to basket

Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGKRQSQDP VNAIKVVAST MLNSFLEDLK EKNVLNKQEL QTMGQTVNVI
60 70 80 90 100
TKKTENLVGD LTEKTQVVGK IFKDHFLNSG SLLSLKSHAE NEDECSESSS
110 120 130 140 150
AVLQEIQASQ VKVRKLCPCD HSHEPKITNV HEIYPVMEKE GRTRLALIIC
160 170 180 190 200
NSEFDYLSKR QGSEIDILGM QDLLENLGYS VVVKENLSAL EMKTELKNFA
210 220 230 240 250
ARQEHKFSDS TFLVFMSHGT LDGICGTKHR NEEPDILHDD TIFQIFNNRN
260 270 280 290 300
CRSLKDKPKV IIMQACRGRG DGAVWVTDVG EASAWTCDQP LQCYIFNDAI
310 320 330 340 350
EKTHVEKDFI AFKSSTPHNV SWRLNTDGSL FISHLIHYFR EFSCCHHLEE
360 370 380
IFRKVQNSFE TPNTMIQMPT IERVSMTRYF YLFPGN
Length:386
Mass (Da):44,020
Last modified:February 5, 2008 - v2
Checksum:i7B0E0625946F50C6
GO
Isoform 2 (identifier: Q075B4-2) [UniParc]FASTAAdd to basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGKRQSQDP...NEDECSESSS

Note: No experimental confirmation available.
Show »
Length:485
Mass (Da):54,895
Checksum:iC4BDED50DB8917AE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MAGKRQSQDPVNAIKVVAST MLNSFLEDLKEKNVLNKQEL QTMGQTVNVITKKTENLVGD LTEKTQVVGKIFKDHFLNSG SLLSLKSHAENEDECSESSS in isoform 2. 1 PublicationVSP_030952

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ228670 mRNA. Translation: ABB58696.1.
DQ228671 mRNA. Translation: ABB58697.1.
RefSeqiNP_001070704.1. NM_001077236.1. [Q075B4-2]
UniGeneiCfa.13715.

Genome annotation databases

GeneIDi479458.
KEGGicfa:479458.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ228670 mRNA. Translation: ABB58696.1.
DQ228671 mRNA. Translation: ABB58697.1.
RefSeqiNP_001070704.1. NM_001077236.1. [Q075B4-2]
UniGeneiCfa.13715.

3D structure databases

ProteinModelPortaliQ075B4.
SMRiQ075B4. Positions 132-278, 299-386.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000038116.

Proteomic databases

PaxDbiQ075B4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi479458.
KEGGicfa:479458.

Organism-specific databases

CTDi100506742.

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOVERGENiHBG076981.
KOiK04741.

Miscellaneous databases

NextBioi20854636.

Family and domain databases

Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR017350. Pept_C14A_CASP1-typ.
IPR015917. Pept_C14A_HD.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF52129. SSF52129. 1 hit.
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of dog caspase-12."
    Eckhart L., Uthman A., Sipos W., Tschachler E.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiCASPC_CANLF
AccessioniPrimary (citable) accession number: Q075B4
Secondary accession number(s): Q075B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: April 13, 2016
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.