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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila immigrans (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotation
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 33NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
OrganismiDrosophila immigrans (Fruit fly)
Taxonomic identifieri7250 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Organism-specific databases

FlyBaseiFBgn0012411. Dimm\Adh.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000544682 – 254Alcohol dehydrogenaseAdd BLAST253

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ07588.
SMRiQ07588.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR036291. NAD(P)-bd_dom_sf.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIANKNIIF VAGLGGIGLD TSKGIVKAGP KNLVILDRIE NPAAIAELKA
60 70 80 90 100
INPKVTVTFY PYDVTVPLAE TKKLLTTIFA KLKTVDLLIN GAGILNDHQI
110 120 130 140 150
ELTIAINFTG LVNTTTAIMD FWDKRKGGPG GAIANICSVT GFNAIYQVPV
160 170 180 190 200
YSASKAAVVS FTSSLAKLAP ITGVIAYSIN PGITKTTLVH KFNSWLDVEP
210 220 230 240 250
RVAELLDEHP TQTTTQCSQN FVKAIEANQN GAIWKLDLGR LDAVNWTKHW

DSGI
Length:254
Mass (Da):27,273
Last modified:January 23, 2007 - v2
Checksum:i24459D38FDAED601
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97638 Genomic DNA. Translation: AAA28357.1.
PIRiJN0566.

Similar proteinsi

Entry informationi

Entry nameiADH_DROIM
AccessioniPrimary (citable) accession number: Q07588
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families