Reviewed, UniProtKB/Swiss-Prot Q07587 (ADHR_DROLE)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase-related 31 kDa protein

Gene names

Name:	Adhr
Synonyms:	Adh-dup

Organism

Drosophila lebanonensis (Fruit fly) (Scaptodrosophila lebanonensis)

Taxonomic identifier

7225 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Scaptodrosophila

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: InterPro binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Alcohol dehydrogenase-related 31 kDa protein		PRO_0000054506
Regions
	Nucleotide binding	11 – 34	24	NAD or NADP By similarity
Sites
	Active site	152	1	Proton acceptor By similarity
	Binding site	139	1	Substrate By similarity
Experimental info
	Sequence conflict	265 – 269	5	DKEDD → TKRMIRQIRSFQKTIYI in CAA45249. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q07587-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 5206A5F06FE4F844	FASTA	269	29,658
	10 20 30 40 50 60 MFDLTGKNVC YVADCGGIAL ETCKVLMTKN IAKLAILHSV ENPQAIAQLQ SLKPSTQIFF 70 80 90 100 110 120 WTYDVTMARA DMQKYFDEVM VQMDYIDVLI YGATLCDETD IDGTINTNLT GMMNTCATVL 130 140 150 160 170 180 PHMDKKKDGS GGLILNVTSV IGLDPSPVFC AYSASKFGVI GFTRSLADPL YYTQNGVAVM 190 200 210 220 230 240 AVCCGPTKVF VDRELTAFLP YGQSFADRLR TAPCQSTAVC GQNIVRAIER GENGQIWIAD 250 260 KGGLELVKLQ SYWHMADVFL HYMQDKEDD

References

[1]	"Adh and Adh-dup sequences of Drosophila lebanonensis and D. immigrans: interspecies comparisons." Albalat R., Gonzalez-Duarte R. Gene 126:171-178(1993) [PubMed: 8482531] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Nucleotide sequence of the genomic region encompassing Adh and Adh-dup genes of D. lebanonensis (Scaptodrosophila): gene expression and evolutionary relationships." Juan E., Papaceit M., Quintana A. J. Mol. Evol. 38:455-467(1994) [PubMed: 8028024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M97637 Genomic DNA. Translation: AAA28356.1. X63716 Genomic DNA. Translation: CAA45249.1.
PIR	JN0565.
3D structure databases
HSSP	HSSP built from PDB template 1B16 based on UniProtKB P10807.
ModBase	Search...
Organism-specific databases
FlyBase	FBgn0012439. Dleb\Adhr.
Family and domain databases
InterPro	IPR002427. ADH-rel. IPR002198. DH_sc/Rdtase_SDR. IPR002424. Insect_AlcDH_fam. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01170. ADHRELATED. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADHR_DROLE

Accession

Primary (citable) accession number: Q07587

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project