Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase prp4

Gene

prp4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in pre-mRNA splicing and is essential for growth. Phosphorylates srp1.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei188 – 1881ATPPROSITE-ProRule annotation
Active sitei286 – 2861Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi165 – 1739ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • mRNA cis splicing, via spliceosome Source: PomBase
  • negative regulation of G0 to G1 transition Source: PomBase
  • peptidyl-serine phosphorylation Source: PomBase
  • protein phosphorylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 5613.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase prp4 (EC:2.7.11.1)
Gene namesi
Name:prp4
ORF Names:SPCC777.14
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC777.14.
PomBaseiSPCC777.14. prp4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Serine/threonine-protein kinase prp4PRO_0000086585Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei92 – 921Phosphoserine1 Publication
Modified residuei320 – 3201Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ07538.

PTM databases

iPTMnetiQ07538.

Interactioni

Protein-protein interaction databases

BioGridi275879. 236 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ07538.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini159 – 477319Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000197082.
InParanoidiQ07538.
KOiK08827.
OMAiMSMNLRD.
OrthoDBiEOG7PGF0M.
PhylomeDBiQ07538.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07538-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDDRFAEDE IIQQRRKRRL EILKKYQQTG NGHSDLSIPE KKLKEDVDQV
60 70 80 90 100
STTKPIEAVP KMKTNASKIE INKEGSNSNT KLDVTNSTTS DSPSIKSSVQ
110 120 130 140 150
IEDTEDDMFA DSPSPSVKRQ NTGKGISTLT RSFADMQDNW DDIEGYYKVV
160 170 180 190 200
LMEELDSRYI VQSNLGKGMF STVVSALDRN RNQTFAIKII RNNEVMYKEG
210 220 230 240 250
LKEVSILERL QAADREGKQH IIHYERHFMH KNHLCMVFEM LSLNLRDILK
260 270 280 290 300
KFGRNVGLSI KAVRLYAYQM FMALDLLKQC NVIHSDIKPD NMLVNEKRNI
310 320 330 340 350
LKICDLGSAS DASENEITPY LVSRFYRAPE IILGFPYSCP IDTWSVGCSL
360 370 380 390 400
YELYTGQILF PGRTNNQMLR YMMECKGKFS HKMLKRSQFL NDHFDADFNF
410 420 430 440 450
IQIDHDPITN QETRKPVKFS KPTKDIRSRL KEVPTSTDEE FIIRQELMDL
460 470
LEKCLELNPE KRVPPEVALK HPFFIKK
Length:477
Mass (Da):55,222
Last modified:July 15, 1998 - v2
Checksum:iF08979F0A0CEA350
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10739 Genomic DNA. Translation: AAB48343.1.
CU329672 Genomic DNA. Translation: CAA20718.1.
PIRiT11720.
RefSeqiNP_588261.1. NM_001023251.2.

Genome annotation databases

EnsemblFungiiSPCC777.14.1; SPCC777.14.1:pep; SPCC777.14.
GeneIDi2539312.
KEGGispo:SPCC777.14.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10739 Genomic DNA. Translation: AAB48343.1.
CU329672 Genomic DNA. Translation: CAA20718.1.
PIRiT11720.
RefSeqiNP_588261.1. NM_001023251.2.

3D structure databases

ProteinModelPortaliQ07538.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275879. 236 interactions.

PTM databases

iPTMnetiQ07538.

Proteomic databases

MaxQBiQ07538.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC777.14.1; SPCC777.14.1:pep; SPCC777.14.
GeneIDi2539312.
KEGGispo:SPCC777.14.

Organism-specific databases

EuPathDBiFungiDB:SPCC777.14.
PomBaseiSPCC777.14. prp4.

Phylogenomic databases

HOGENOMiHOG000197082.
InParanoidiQ07538.
KOiK08827.
OMAiMSMNLRD.
OrthoDBiEOG7PGF0M.
PhylomeDBiQ07538.

Enzyme and pathway databases

BRENDAi2.7.11.1. 5613.

Miscellaneous databases

PROiQ07538.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The fission yeast prp4+ gene involved in pre-mRNA splicing codes for a predicted serine/threonine kinase and is essential for growth."
    Alahari S.K., Schmidt H., Kaeufer N.F.
    Nucleic Acids Res. 21:4079-4083(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Kaeufer N.F.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO C-TERMINUS.
  3. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92 AND TYR-320, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPRP4_SCHPO
AccessioniPrimary (citable) accession number: Q07538
Secondary accession number(s): P87202
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 15, 1998
Last modified: June 8, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.