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Protein

Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

Gene

ALDH6A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

Catalytic activityi

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH.
3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei319 – 3191NucleophilePROSITE-ProRule annotation
Binding sitei419 – 4191NADSequence analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi211 – 2155NADSequence analysis
Nucleotide bindingi263 – 2686NADSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (EC:1.2.1.18, EC:1.2.1.27)
Short name:
MMSDH
Short name:
Malonate-semialdehyde dehydrogenase [acylating]
Alternative name(s):
Aldehyde dehydrogenase family 6 member A1
Gene namesi
Name:ALDH6A1
Synonyms:MMSDH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434MitochondrionBy similarityAdd
BLAST
Chaini35 – 537503Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrialPRO_0000007188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491N6-acetyllysine; alternateBy similarity
Modified residuei49 – 491N6-succinyllysine; alternateBy similarity
Modified residuei54 – 541N6-acetyllysine; alternateBy similarity
Modified residuei54 – 541N6-succinyllysine; alternateBy similarity
Modified residuei57 – 571N6-acetyllysine; alternateBy similarity
Modified residuei57 – 571N6-succinyllysine; alternateBy similarity
Modified residuei78 – 781N6-acetyllysine; alternateBy similarity
Modified residuei78 – 781N6-succinyllysine; alternateBy similarity
Modified residuei89 – 891N6-acetyllysineBy similarity
Modified residuei119 – 1191N6-acetyllysine; alternateBy similarity
Modified residuei119 – 1191N6-succinyllysine; alternateBy similarity
Modified residuei131 – 1311N6-acetyllysine; alternateBy similarity
Modified residuei131 – 1311N6-succinyllysine; alternateBy similarity
Modified residuei264 – 2641PhosphoserineBy similarity
Modified residuei300 – 3001N6-acetyllysineBy similarity
Modified residuei332 – 3321N6-acetyllysineBy similarity
Modified residuei333 – 3331N6-acetyllysineBy similarity
Modified residuei366 – 3661N6-acetyllysine; alternateBy similarity
Modified residuei366 – 3661N6-succinyllysine; alternateBy similarity
Modified residuei378 – 3781N6-acetyllysine; alternateBy similarity
Modified residuei378 – 3781N6-succinyllysine; alternateBy similarity
Modified residuei382 – 3821PhosphoserineBy similarity
Modified residuei393 – 3931N6-succinyllysineBy similarity
Modified residuei502 – 5021N6-acetyllysineBy similarity
Modified residuei519 – 5191N6-succinyllysineBy similarity

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ07536.
PeptideAtlasiQ07536.
PRIDEiQ07536.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024584.

Structurei

3D structure databases

ProteinModelPortaliQ07536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2449. Eukaryota.
ENOG410XNP1. LUCA.
HOGENOMiHOG000271507.
HOVERGENiHBG105023.
InParanoidiQ07536.
KOiK00140.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
[Graphical view]
PANTHERiPTHR11699:SF183. PTHR11699:SF183. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01722. MMSDH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVAVAAAA AALRARILQV SSKVNSSWQP ASSFSSSSVP TVKLFIDGKF
60 70 80 90 100
IESKSDKWID IHNPATNEVI GRVPESTKAE MDAAVSSCKR TFPAWADTSI
110 120 130 140 150
LSRQQVLLRY QQLIKENLKE IARLIMLEQG KTLADAEGDV FRGLQVVEHA
160 170 180 190 200
CSVTSLMLGD TMPSITKDMD LYSYRLPLGV CAGIAPFNFP AMIPLWMFPM
210 220 230 240 250
AMVCGNTFLM KPSERVPGAT MLLAKLFQDS GAPDGTLNII HGQHEAVNFI
260 270 280 290 300
CDHPDIKAIS FVGSNQAGEY IFERGSRHGK RVQANMGAKN HGVVMPDANK
310 320 330 340 350
ENTLNQLVGA AFGAAGQRCM ALSTAILVGE AKKWLPELVE RAKKLRVNAG
360 370 380 390 400
DQPGADLGPL ITPQAKERVC NLIDSGTKEG ASILLDGRSI KVKGYENGNF
410 420 430 440 450
VGPTIISNVK PNMTCYKEEI FGPVLVVLET DTLDEAIKIV NDNPYGNGTA
460 470 480 490 500
IFTTNGATAR KYSHLVDVGQ VGVNVPIPVP LPMFSFTGSR ASFRGDTNFY
510 520 530
GKQGIQFYTQ LKTITSQWKE EDASLSSPAV VMPTMGR
Length:537
Mass (Da):58,063
Last modified:February 1, 1995 - v1
Checksum:i69DF39506E62F9C0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1272ML → TD AA sequence (PubMed:8514806).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08643 mRNA. Translation: AAA30650.1.
PIRiA46600.
RefSeqiNP_787005.1. NM_175811.2.
UniGeneiBt.98765.

Genome annotation databases

GeneIDi327692.
KEGGibta:327692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08643 mRNA. Translation: AAA30650.1.
PIRiA46600.
RefSeqiNP_787005.1. NM_175811.2.
UniGeneiBt.98765.

3D structure databases

ProteinModelPortaliQ07536.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024584.

Proteomic databases

PaxDbiQ07536.
PeptideAtlasiQ07536.
PRIDEiQ07536.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi327692.
KEGGibta:327692.

Organism-specific databases

CTDi4329.

Phylogenomic databases

eggNOGiKOG2449. Eukaryota.
ENOG410XNP1. LUCA.
HOGENOMiHOG000271507.
HOVERGENiHBG105023.
InParanoidiQ07536.
KOiK00140.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
[Graphical view]
PANTHERiPTHR11699:SF183. PTHR11699:SF183. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01722. MMSDH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMMSA_BOVIN
AccessioniPrimary (citable) accession number: Q07536
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.