Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytokinesis protein 3

Gene

CYK3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cytokinesis by recruiting INN1 to the bud neck. Cooperates with INN1 to stimulate the synthesis of the primary septum (PS) by CHS2.3 Publications

GO - Molecular functioni

  • enzyme regulator activity Source: SGD

GO - Biological processi

  • barrier septum assembly Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciYEAST:G3O-29517-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokinesis protein 3
Gene namesi
Name:CYK3
Ordered Locus Names:YDL117W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL117W.
SGDiS000002275. CYK3.

Subcellular locationi

  • Cytoplasm
  • Bud neck

  • Note: Found in association with the actin ring and the cortex at the mother-bud neck.

GO - Cellular componenti

  • cellular bud neck Source: SGD
  • cellular bud neck contractile ring Source: SGD
  • HICS complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000797511 – 885Cytokinesis protein 3Add BLAST885

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei209PhosphoserineCombined sources1
Modified residuei292PhosphoserineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1
Modified residuei391PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ07533.
PRIDEiQ07533.

PTM databases

iPTMnetiQ07533.

Interactioni

Subunit structurei

Interacts with INN1.2 Publications

Protein-protein interaction databases

BioGridi31945. 169 interactors.
DIPiDIP-6625N.
IntActiQ07533. 22 interactors.
MINTiMINT-598450.

Structurei

3D structure databases

ProteinModelPortaliQ07533.
SMRiQ07533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 70SH3PROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Belongs to the CYK3 family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

HOGENOMiHOG000112129.
InParanoidiQ07533.
OMAiCTPYELT.
OrthoDBiEOG092C0ZZR.

Family and domain databases

InterProiIPR001452. SH3_domain.
IPR002931. Transglutaminase-like.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
SM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATNLTSLKP PFKVKARYGW SGQTKGDLGF LEGDIMEVTR IAGSWFYGKL
60 70 80 90 100
LRNKKCSGYF PHNFVILLEE RLNSSTENGR QPSKIVESFE KSNKVVIPPV
110 120 130 140 150
PSRYSDERPR PKKKLSSSMP NSPKKPVDSL TKARKAKSKE MVNEKNIYNT
160 170 180 190 200
QSSRHHNNSA PNLPLASHSK PQVRNFEESM NNPLPPLPPL PDLDNMRKTD
210 220 230 240 250
KRAPKKSYSA NDLHMARSSR EYNYYKDNQK FYDGFIPEKR YSLEEDSISS
260 270 280 290 300
GLFSNSQYLN DSACSSENSF ALMSDFSATS AGSFARHKYA QSFSDSLQRS
310 320 330 340 350
QNANGCSTKI NDSQEFGDSN ASSRNGKMGD ILRKIIIPKR NTNIYSSSVS
360 370 380 390 400
SPKSPKAYPK LPDIQNLNLS ATPDEARDWI AVKCHLNRAR TLTKYDKHPR
410 420 430 440 450
YMRALEENRD LILHPQDSIY NGLNTNEVKG NTKPGLVDVE LAELNIEYID
460 470 480 490 500
KMTWKRCIRD GTMTLDSWAQ TTFSARYSTV LEKLRGIYIF CTEMFALTDD
510 520 530 540 550
NGTSDFSAEP QNLEKILYRK HCTPYELTWL FKKLANSLGI TCEIVIGFLK
560 570 580 590 600
TPSAINWEFK YNHCWLRILV NKEWRFIDVI LGNVTNPIHE FVNNRKIKKA
610 620 630 640 650
ENSYFLMAPL EMIYTHIPPR EFEQHIVPSI DQLSALYLPL VFPSFFKNEL
660 670 680 690 700
KLYKFSTALS FLEDSEIYEC SLEIPNDVEV FASVVIPTDN EEASSAYRNM
710 720 730 740 750
ELALTQIKKQ KAESGRRIAL IKAVLPPNVN KGSLYIHSGV RGTQTSIANI
760 770 780 790 800
HPLSMMVPLT HKGSNMKYEF VIKIPSESIQ KIELYIVEPQ SRYLFVGNEY
810 820 830 840 850
SFEVIQSPSD GIVYSSDEGP NQNRKQPMAI KSPSGRVHEL VKSDPHFPYG
860 870 880
TWKGSIKIKE PGVWSALVIA DSGIGWSVFA EWLCV
Length:885
Mass (Da):100,621
Last modified:November 1, 1996 - v1
Checksum:iA1B7FD5B7076EC7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74165 Genomic DNA. Translation: CAA98685.1.
BK006938 Genomic DNA. Translation: DAA11743.1.
PIRiS67660.
RefSeqiNP_010166.1. NM_001180176.1.

Genome annotation databases

EnsemblFungiiYDL117W; YDL117W; YDL117W.
GeneIDi851440.
KEGGisce:YDL117W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74165 Genomic DNA. Translation: CAA98685.1.
BK006938 Genomic DNA. Translation: DAA11743.1.
PIRiS67660.
RefSeqiNP_010166.1. NM_001180176.1.

3D structure databases

ProteinModelPortaliQ07533.
SMRiQ07533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31945. 169 interactors.
DIPiDIP-6625N.
IntActiQ07533. 22 interactors.
MINTiMINT-598450.

PTM databases

iPTMnetiQ07533.

Proteomic databases

MaxQBiQ07533.
PRIDEiQ07533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL117W; YDL117W; YDL117W.
GeneIDi851440.
KEGGisce:YDL117W.

Organism-specific databases

EuPathDBiFungiDB:YDL117W.
SGDiS000002275. CYK3.

Phylogenomic databases

HOGENOMiHOG000112129.
InParanoidiQ07533.
OMAiCTPYELT.
OrthoDBiEOG092C0ZZR.

Enzyme and pathway databases

BioCyciYEAST:G3O-29517-MONOMER.

Miscellaneous databases

PROiQ07533.

Family and domain databases

InterProiIPR001452. SH3_domain.
IPR002931. Transglutaminase-like.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
SM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYK3_YEAST
AccessioniPrimary (citable) accession number: Q07533
Secondary accession number(s): D6VRN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 377 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.