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Protein

Hydroxyacid oxidase 2

Gene

Hao2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.

Catalytic activityi

(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106FMNPROSITE-ProRule annotation1 Publication1
Binding sitei128FMNPROSITE-ProRule annotation1 Publication1
Binding sitei130Substrate1
Binding sitei156FMNPROSITE-ProRule annotation1 Publication1
Binding sitei165Substrate1
Binding sitei224FMNPROSITE-ProRule annotation1 Publication1
Active sitei248Proton acceptorPROSITE-ProRule annotation1
Binding sitei251SubstratePROSITE-ProRule annotation1
Binding sitei303FMNPROSITE-ProRule annotation1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi279 – 303FMNPROSITE-ProRule annotation1 PublicationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • mandelate metabolic process Source: RGD
  • protein homooligomerization Source: RGD

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN

Enzyme and pathway databases

BRENDAi1.1.3.15 5301
ReactomeiR-RNO-390918 Peroxisomal lipid metabolism
R-RNO-9033241 Peroxisomal protein import
SABIO-RKiQ07523

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyacid oxidase 2 (EC:1.1.3.15)
Short name:
HAOX2
Alternative name(s):
(S)-2-hydroxy-acid oxidase, peroxisomal
Long chain alpha-hydroxy acid oxidase
Long-chain L-2-hydroxy acid oxidase
Gene namesi
Name:Hao2
Synonyms:Hao3, Haox2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi70972 Hao2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2021745

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00002063222 – 353Hydroxyacid oxidase 2Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei133PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ07523
PRIDEiQ07523

PTM databases

iPTMnetiQ07523
PhosphoSitePlusiQ07523

Miscellaneous databases

PMAP-CutDBiQ07523

Expressioni

Gene expression databases

BgeeiENSRNOG00000019470
ExpressionAtlasiQ07523 baseline and differential
GenevisibleiQ07523 RN

Interactioni

Subunit structurei

Homotetramer or homooctamer.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040223

Chemistry databases

BindingDBiQ07523

Structurei

Secondary structure

1353
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 15Combined sources10
Helixi19 – 26Combined sources8
Helixi33 – 43Combined sources11
Beta strandi62 – 64Combined sources3
Beta strandi67 – 75Combined sources9
Helixi81 – 83Combined sources3
Helixi88 – 99Combined sources12
Beta strandi102 – 105Combined sources4
Helixi113 – 119Combined sources7
Beta strandi124 – 128Combined sources5
Helixi135 – 147Combined sources13
Beta strandi153 – 156Combined sources4
Helixi166 – 174Combined sources9
Helixi177 – 180Combined sources4
Helixi207 – 216Combined sources10
Beta strandi221 – 226Combined sources6
Helixi229 – 237Combined sources9
Beta strandi241 – 245Combined sources5
Helixi248 – 250Combined sources3
Helixi259 – 270Combined sources12
Beta strandi273 – 281Combined sources9
Helixi285 – 293Combined sources9
Beta strandi297 – 302Combined sources6
Helixi303 – 335Combined sources33
Helixi340 – 342Combined sources3
Helixi345 – 347Combined sources3
Beta strandi348 – 350Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TB3X-ray2.30A/B/C/D/E/F/G/H2-353[»]
3SGZX-ray1.35A/B/C2-353[»]
ProteinModelPortaliQ07523
SMRiQ07523
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07523

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 353FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd BLAST352

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi351 – 353Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0538 Eukaryota
COG1304 LUCA
GeneTreeiENSGT00390000018717
HOGENOMiHOG000217463
HOVERGENiHBG051881
InParanoidiQ07523
KOiK11517
PhylomeDBiQ07523
TreeFamiTF313363

Family and domain databases

CDDicd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR012133 Alpha-hydoxy_acid_DH_FMN
IPR000262 FMN-dep_DH
IPR037396 FMN_HAD
IPR008259 FMN_hydac_DH_AS
PfamiView protein in Pfam
PF01070 FMN_dh, 1 hit
PIRSFiPIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEiView protein in PROSITE
PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit
PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07523-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLVCLADFK AHAQKQLSKT SWDFIEGEAD DGITYSENIA AFKRIRLRPR
60 70 80 90 100
YLRDMSKVDT RTTIQGQEIS APICISPTAF HSIAWPDGEK STARAAQEAN
110 120 130 140 150
ICYVISSYAS YSLEDIVAAA PEGFRWFQLY MKSDWDFNKQ MVQRAEALGF
160 170 180 190 200
KALVITIDTP VLGNRRRDKR NQLNLEANIL LKDLRALKEE KPTQSVPVSF
210 220 230 240 250
PKASFCWNDL SLLQSITRLP IILKGILTKE DAELAMKHNV QGIVVSNHGG
260 270 280 290 300
RQLDEVSASI DALREVVAAV KGKIEVYMDG GVRTGTDVLK ALALGARCIF
310 320 330 340 350
LGRPILWGLA CKGEDGVKEV LDILTAELHR CMTLSGCQSV AEISPDLIQF

SRL
Length:353
Mass (Da):39,201
Last modified:January 23, 2007 - v2
Checksum:iA2FDD4BF34E269E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67156 mRNA Translation: CAA47629.1
BC078781 mRNA Translation: AAH78781.1
PIRiS33322
RefSeqiNP_114471.1, NM_032082.2
UniGeneiRn.198611

Genome annotation databases

EnsembliENSRNOT00000046942; ENSRNOP00000040223; ENSRNOG00000019470
ENSRNOT00000091444; ENSRNOP00000071695; ENSRNOG00000019470
GeneIDi84029
KEGGirno:84029
UCSCiRGD:70972 rat

Similar proteinsi

Entry informationi

Entry nameiHAOX2_RAT
AccessioniPrimary (citable) accession number: Q07523
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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