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Protein

RNA replication protein

Gene
N/A
Organism
Plantago asiatica mosaic potexvirus (P1AMV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

RNA replication. The central part of this protein possibly functions as an ATP-binding helicase (Probable).Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation
ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi665 – 672ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA replication protein
Alternative name(s):
156 kDa protein
ORF1 protein
Including the following 2 domains:
RNA-directed RNA polymerase (EC:2.7.7.48)
Helicase (EC:3.6.4.13)
OrganismiPlantago asiatica mosaic potexvirus (P1AMV)
Taxonomic identifieri28354 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTymoviralesAlphaflexiviridaePotexvirus
Virus hostiPlantago asiatica [TaxID: 197796]
Proteomesi
  • UP000009190 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002225511 – 1385RNA replication proteinAdd BLAST1385

Structurei

3D structure databases

ProteinModelPortaliQ07518.
SMRiQ07518.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 224Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST166
Domaini635 – 791(+)RNA virus helicase ATP-bindingAdd BLAST157
Domaini792 – 925(+)RNA virus helicase C-terminalAdd BLAST134
Domaini1164 – 1271RdRp catalyticPROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG0900004V.

Family and domain databases

InterProiView protein in InterPro
IPR027351. (+)RNA_virus_helicase_core_dom.
IPR002588. Alphavirus-like_MT_dom.
IPR007094. RNA-dir_pol_PSvirus.
IPR001788. Tymovirus_RNA-dep_RNA_pol.
PfamiView protein in Pfam
PF00978. RdRP_2. 1 hit.
PF01443. Viral_helicase1. 1 hit.
PF01660. Vmethyltransf. 1 hit.
PROSITEiView protein in PROSITE
PS51743. ALPHAVIRUS_MT. 1 hit.
PS51657. PSRV_HELICASE. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNVRNVFSQ LTDPSLKAVI QDEAYRVLKR ELAQTRHTNP FAQSPEAADA
60 70 80 90 100
LEALGINSHP YAITSHTHAA AKAIESDLYE VVSHYLPKEN PVSFLFMKPA
110 120 130 140 150
KLRFFHRGPT HGDHFLNAHV EPKDVPRYPQ ETIINRLADI PTQIAFMGDT
160 170 180 190 200
LHFLSPSFLT ALFAHSPRLQ TLYATLVLPP EPSTSRSLYP QIYTLTYSED
210 220 230 240 250
GFMYIPGGHA GASYFHKYDQ LEWLTVGHLT APGCPTVTAQ RLETKGANHL
260 270 280 290 300
FIFQRGNYIT PERRTFATND QYVTVPHIFL PENYNCRTPI SKTTMMQMFF
310 320 330 340 350
YIKSGKEAQR EGHLGQVQQL ISTKELQHYQ PSEITLLVNY FEFTATLDSH
360 370 380 390 400
TCFEDVPPKL APKTTPAPPL GISRILQFFR GRPSFVKLIK ALDWQPITLE
410 420 430 440 450
FPVRDVRTTV RGPPGFKNPF TQPQPVNPED ADISSRFQDF SRATNSTPKP
460 470 480 490 500
TVEAVLEASA ESPDHHTQLK VLCSALSEGQ LEAIHALGHS RCGGPLLPEL
510 520 530 540 550
TAKSTPVEQC PDLPPCPTKS QASPASSNPS GPDAQPTAQN PETLPWVAWL
560 570 580 590 600
PKLNALGFEA LEVQHDPSTG EMIMPITDTQ ELPRATLPAH WQGHNLERIL
610 620 630 640 650
STLRSLNRFP TPWSPDRTRA RAFTSDVKNS RTGKALHRES QTWKETQTML
660 670 680 690 700
TENTQTELAI SVIHGAGGSG KSQALQTLLR QDHSLPIEVV LPTNELRLDW
710 720 730 740 750
LKKLPHNPPE QFRTFERAFV SSHSPVVIFD DYGKLPQGYL EAFALTHANL
760 770 780 790 800
ELVILTGDPR QSTHHESNEE ALISKLPPAT TIYSAFSRYY INATLRNSKF
810 820 830 840 850
LANKLGVYSA NSCPLNVTYG FQPLPGLHLL VPSLMKKAAF TDAGHKVSSY
860 870 880 890 900
AGCQGITAPK VQILLDNDTT MCTKEVLYTA LSRAVDSIHF VNTNAQSSAF
910 920 930 940 950
WEKLEATPYL KTFLSLVRED KITEFQAPAD APKPVTPPVT HFPVEEPATT
960 970 980 990 1000
LDDFKEELRD KFDREIFTSD RGHTNCVQTD DPTTQLFSHQ QAKDEALLWE
1010 1020 1030 1040 1050
MIRARLKIST PEANIEEFRA KKDLGDILWV NYHRAMGLPK EQPDFSEDLW
1060 1070 1080 1090 1100
NRCAEEVQNT YLKKTMAQLK GGERRQSPDF HEHQILIFLK SQWVKKMEKL
1110 1120 1130 1140 1150
GAKEIKPGQT IASFQQHAVM LYGTMARYMR RFRDALSPNN IMINCEKTPQ
1160 1170 1180 1190 1200
DLSRWVLNYW DFSKPSYAND FTAFDQSQDG AMLQFEILKA KYFNLPEWVI
1210 1220 1230 1240 1250
EGYLDIKLSP KIFLGTLSIM RLTGEGPTFD ANTECNIAYT HTRFDIPEGT
1260 1270 1280 1290 1300
AQIYAGDDCA IAQVCPEKPS FALLKNRIAL QAKPAYTPQE RGQWAEFCGY
1310 1320 1330 1340 1350
LITPKGLIKD PLKLHASLEL AKAQKKAGVR DAITNVVANY SLDAKLAYSL
1360 1370 1380
GDDLQDLLSP HQAHLHQVTV RDLVKFGGSP FLNSD
Length:1,385
Mass (Da):155,617
Last modified:November 1, 1995 - v1
Checksum:i66C177E44678A94F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21647 Genomic RNA. Translation: CAA79761.1.
PIRiS34230.
RefSeqiNP_620836.1. NC_003849.1.

Genome annotation databases

GeneIDi944434.
KEGGivg:944434.

Similar proteinsi

Entry informationi

Entry nameiRDRP_P1AMV
AccessioniPrimary (citable) accession number: Q07518
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 10, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families