Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Movement and silencing protein TGBp1

Gene

ORF2

Organism
Plantago asiatica mosaic potexvirus (P1AMV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).By similarity

Miscellaneous

TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-cell propagation. TGBp1 is the main movement protein that physically cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would facilitate TGBp1 function.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding, Suppressor of RNA silencing, Viral movement protein
Biological processHost-virus interaction, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Movement and silencing protein TGBp1
Alternative name(s):
25 kDa protein
Silencing suppressor P25
Triple gene block 1 protein
Short name:
TGBp1
Gene namesi
ORF Names:ORF2
OrganismiPlantago asiatica mosaic potexvirus (P1AMV)
Taxonomic identifieri28354 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTymoviralesAlphaflexiviridaePotexvirus
Virus hostiPlantago asiatica [TaxID: 197796]
Proteomesi
  • UP000009190 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002225681 – 230Movement and silencing protein TGBp1Add BLAST230

Interactioni

Subunit structurei

Homodimer and homooligomer. Interacts with capsid protein. Interacts with host AGO1; this interaction targets the host protein for degradation, thereby suppressing the antiviral RNA silencing (By similarity).By similarity

Structurei

3D structure databases

SMRiQ07517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 114(+)RNA virus helicase ATP-bindingAdd BLAST114
Domaini115 – 230(+)RNA virus helicase C-terminalAdd BLAST116

Sequence similaritiesi

Belongs to the Tymovirales TGBp1 protein family.Curated

Phylogenomic databases

OrthoDBiVOG090000NV.

Family and domain databases

InterProiView protein in InterPro
IPR027351. (+)RNA_virus_helicase_core_dom.
PfamiView protein in Pfam
PF01443. Viral_helicase1. 1 hit.
PROSITEiView protein in PROSITE
PS51657. PSRV_HELICASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07517-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSIINALTS NNFQRTNTPI SKPLVVHAVA GAGKTTLIQN LLPEHPNLAA
60 70 80 90 100
QTAGSPQTPN LTGAFIRKLT CPESNKINLL DEYAALQPLK GSWDVVLADP
110 120 130 140 150
LQHPGLALRP HFIKSVSHRL CPATTRLISK LVCPCTSSRT EESTIQFSGL
160 170 180 190 200
FEGPLLGTVI ALDQTTQALL TAHGAHFLCP TAALGLEFDT VTVVSALPLE
210 220 230
EVADKVGLYI SLSRHRSQLH VRSPPPHPSH
Length:230
Mass (Da):24,687
Last modified:November 1, 1995 - v1
Checksum:iF8D2BC14EC9A812C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27H → L in AAB26348 (PubMed:8477237).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21647 Genomic RNA. Translation: CAA79762.1.
S61526 Genomic RNA. Translation: AAB26348.1.
PIRiS34231.
RefSeqiNP_620837.1. NC_003849.1.

Genome annotation databases

GeneIDi944433.
KEGGivg:944433.

Similar proteinsi

Entry informationi

Entry nameiTGB1_P1AMV
AccessioniPrimary (citable) accession number: Q07517
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 12, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families