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Q07511 (FDH_SOLTU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate dehydrogenase, mitochondrial

EC=1.2.1.2
Alternative name(s):
NAD-dependent formate dehydrogenase
Short name=FDH
Gene names
Name:FDH1
OrganismSolanum tuberosum (Potato) [Reference proteome]
Taxonomic identifier4113 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in formate-dependent oxygen uptake coupled to ATP synthesis.

Catalytic activity

Formate + NAD+ = CO2 + NADH.

Subunit structure

Homodimer.

Subcellular location

Mitochondrion.

Tissue specificity

Found at high levels in developing tubers, at intermediate level in stems, veins, stolons, and stamens, and at low level in leaves and roots.

Induction

Induced very rapidly by wounding, and slower by darkness, chilling, drought, hypoxia, and treatments with formate, abscisic acid, serine, sarcosine, pyruvate, acetate, ethanol or methanol.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.

Caution

There are two other putative pseudogenes, FDH2 and FDH3.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2525Mitochondrion Ref.4
Chain26 – 381356Formate dehydrogenase, mitochondrial
PRO_0000007196

Regions

Nucleotide binding204 – 2052NAD By similarity
Nucleotide binding285 – 2873NAD By similarity
Nucleotide binding335 – 3384NAD By similarity

Sites

Active site2871 By similarity
Active site3351Proton donor By similarity
Binding site2581NAD; via carbonyl oxygen By similarity
Binding site3111NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07511 [UniParc].

Last modified December 6, 2002. Version 2.
Checksum: 920D351AC5A3A00E

FASTA38142,038
        10         20         30         40         50         60 
MAMSRVASTA ARAITSPSSL VFTRELQASP GPKKIVGVFY KANEYAEMNP NFLGCAENAL 

        70         80         90        100        110        120 
GIREWLESKG HQYIVTPDKE GPDCELEKHI PDLHVLISTP FHPAYVTAER IKKAKNLQLL 

       130        140        150        160        170        180 
LTAGIGSDHV DLKAAAAAGL TVAEVTGSNT VSVAEDELMR ILILVRNFLP GHHQVINGEW 

       190        200        210        220        230        240 
NVAAIAHRAY DLEGKTVGTV GAGRIGRLLL QRLKPFNCNL LYHDRLKMDS ELENQIGAKF 

       250        260        270        280        290        300 
EEDLDKMLSK CDIVVINTPL TEKTKGMFDK ERIAKLKKGV LIVNNARGAI MDTQAVVDAC 

       310        320        330        340        350        360 
NSGHIAGYSG DVWYPQPAPK DHPWRYMPNQ AMTPHISGTT IDAQLRYAAG TKDMLDRYFK 

       370        380 
GEDFPAENYI VKDGELAPQY R 

« Hide

References

[1]"Evidence for multiple copies of formate dehydrogenase genes in plants: isolation of three potato fdh genes fdh1, fdh2 and fdh3."
Hourton-Cabassa C., Ambard-Bretteville F., Remy R., Colas des Francs-Small C.
Plant Gene Register PGR98-102
Cited for: NUCLEOTIDE SEQUENCE.
Strain: cv. BF15.
[2]"Identification of a major soluble protein in mitochondria from nonphotosynthetic tissues as NAD-dependent formate dehydrogenase."
Colas des Francs-Small C., Ambard-Bretteville F., Small I.D., Remy R.
Plant Physiol. 102:1171-1177(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-381, PARTIAL PROTEIN SEQUENCE.
Strain: cv. BF15.
Tissue: Tuber.
[3]Colas des Francs-Small C.C.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO N-TERMINUS.
Strain: cv. BF15.
Tissue: Tuber.
[4]"Variation of the polypeptide composition of mitochondria isolated from different potato tissues."
Colas des Francs-Small C., Ambard-Bretteville F., Darpas A., Sallantin M., Huet J.-C., Pernollet J.-C., Remy R.
Plant Physiol. 98:273-278(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 26-54.
Strain: cv. BF15.
Tissue: Tuber.
[5]"Stress induction of mitochondrial formate dehydrogenase in potato leaves."
Hourton-Cabassa C., Ambard-Bretteville F., Moreau F., Davy de Virville J., Remy R., Colas des Francs-Small C.
Plant Physiol. 116:627-635(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z99991 mRNA. Translation: CAB17080.1.
Z99992 Genomic DNA. No translation available.
Z21493 mRNA. Translation: CAA79702.2.
PIRJQ2272.
RefSeqNP_001274827.1. NM_001287898.1.
UniGeneStu.477.

3D structure databases

ProteinModelPortalQ07511.
SMRQ07511. Positions 33-376.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ07511. 1 interaction.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID102577429.
KEGGsot:102577429.

Phylogenomic databases

KOK00122.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDH_SOLTU
AccessionPrimary (citable) accession number: Q07511
Secondary accession number(s): Q9ZR28
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 6, 2002
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families