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Q07511

- FDH_SOLTU

UniProt

Q07511 - FDH_SOLTU

Protein

Formate dehydrogenase, mitochondrial

Gene

FDH1

Organism
Solanum tuberosum (Potato)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (06 Dec 2002)
      Previous versions | rss
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    Functioni

    Involved in formate-dependent oxygen uptake coupled to ATP synthesis.

    Catalytic activityi

    Formate + NAD+ = CO2 + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei258 – 2581NAD; via carbonyl oxygenBy similarity
    Active sitei287 – 2871By similarity
    Binding sitei311 – 3111NADBy similarity
    Active sitei335 – 3351Proton donorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi204 – 2052NADBy similarity
    Nucleotide bindingi285 – 2873NADBy similarity
    Nucleotide bindingi335 – 3384NADBy similarity

    GO - Molecular functioni

    1. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro
    3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro

    GO - Biological processi

    1. response to cadmium ion Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate dehydrogenase, mitochondrial (EC:1.2.1.2)
    Alternative name(s):
    NAD-dependent formate dehydrogenase
    Short name:
    FDH
    Gene namesi
    Name:FDH1
    OrganismiSolanum tuberosum (Potato)
    Taxonomic identifieri4113 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
    ProteomesiUP000011115: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast Source: EnsemblPlants/Gramene
    2. mitochondrion Source: UniProtKB-SubCell
    3. thylakoid Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2525Mitochondrion1 PublicationAdd
    BLAST
    Chaini26 – 381356Formate dehydrogenase, mitochondrialPRO_0000007196Add
    BLAST

    Expressioni

    Tissue specificityi

    Found at high levels in developing tubers, at intermediate level in stems, veins, stolons, and stamens, and at low level in leaves and roots.

    Inductioni

    Induced very rapidly by wounding, and slower by darkness, chilling, drought, hypoxia, and treatments with formate, abscisic acid, serine, sarcosine, pyruvate, acetate, ethanol or methanol.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    IntActiQ07511. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07511.
    SMRiQ07511. Positions 33-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    KOiK00122.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view]
    PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
    PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
    PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q07511-1 [UniParc]FASTAAdd to Basket

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    MAMSRVASTA ARAITSPSSL VFTRELQASP GPKKIVGVFY KANEYAEMNP    50
    NFLGCAENAL GIREWLESKG HQYIVTPDKE GPDCELEKHI PDLHVLISTP 100
    FHPAYVTAER IKKAKNLQLL LTAGIGSDHV DLKAAAAAGL TVAEVTGSNT 150
    VSVAEDELMR ILILVRNFLP GHHQVINGEW NVAAIAHRAY DLEGKTVGTV 200
    GAGRIGRLLL QRLKPFNCNL LYHDRLKMDS ELENQIGAKF EEDLDKMLSK 250
    CDIVVINTPL TEKTKGMFDK ERIAKLKKGV LIVNNARGAI MDTQAVVDAC 300
    NSGHIAGYSG DVWYPQPAPK DHPWRYMPNQ AMTPHISGTT IDAQLRYAAG 350
    TKDMLDRYFK GEDFPAENYI VKDGELAPQY R 381
    Length:381
    Mass (Da):42,038
    Last modified:December 6, 2002 - v2
    Checksum:i920D351AC5A3A00E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z99991 mRNA. Translation: CAB17080.1.
    Z99992 Genomic DNA. No translation available.
    Z21493 mRNA. Translation: CAA79702.2.
    PIRiJQ2272.
    RefSeqiNP_001274827.1. NM_001287898.1.
    UniGeneiStu.477.

    Genome annotation databases

    GeneIDi102577429.
    KEGGisot:102577429.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z99991 mRNA. Translation: CAB17080.1 .
    Z99992 Genomic DNA. No translation available.
    Z21493 mRNA. Translation: CAA79702.2 .
    PIRi JQ2272.
    RefSeqi NP_001274827.1. NM_001287898.1.
    UniGenei Stu.477.

    3D structure databases

    ProteinModelPortali Q07511.
    SMRi Q07511. Positions 33-376.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q07511. 1 interaction.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 102577429.
    KEGGi sot:102577429.

    Phylogenomic databases

    KOi K00122.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00065. D_2_HYDROXYACID_DH_1. 1 hit.
    PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
    PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence for multiple copies of formate dehydrogenase genes in plants: isolation of three potato fdh genes fdh1, fdh2 and fdh3."
      Hourton-Cabassa C., Ambard-Bretteville F., Remy R., Colas des Francs-Small C.
      Plant Gene Register PGR98-102
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: cv. BF15.
    2. "Identification of a major soluble protein in mitochondria from nonphotosynthetic tissues as NAD-dependent formate dehydrogenase."
      Colas des Francs-Small C., Ambard-Bretteville F., Small I.D., Remy R.
      Plant Physiol. 102:1171-1177(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-381, PARTIAL PROTEIN SEQUENCE.
      Strain: cv. BF15.
      Tissue: Tuber.
    3. Colas des Francs-Small C.C.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO N-TERMINUS.
      Strain: cv. BF15.
      Tissue: Tuber.
    4. "Variation of the polypeptide composition of mitochondria isolated from different potato tissues."
      Colas des Francs-Small C., Ambard-Bretteville F., Darpas A., Sallantin M., Huet J.-C., Pernollet J.-C., Remy R.
      Plant Physiol. 98:273-278(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 26-54.
      Strain: cv. BF15.
      Tissue: Tuber.
    5. Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiFDH_SOLTU
    AccessioniPrimary (citable) accession number: Q07511
    Secondary accession number(s): Q9ZR28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: December 6, 2002
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Caution

    There are two other putative pseudogenes, FDH2 and FDH3.Curated

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3