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Protein

Formate dehydrogenase, mitochondrial

Gene

FDH1

Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the NAD+-dependent oxidation of formate to carbon dioxide (PubMed:8278546). Involved in the cell stress response. Involved in formate-dependent oxygen uptake coupled to ATP synthesis (PubMed:9490763).UniRule annotation2 Publications

Catalytic activityi

Formate + NAD+ = CO2 + NADH.UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei125Substrate; via amide nitrogenUniRule annotation1
Binding sitei149SubstrateUniRule annotation1
Binding sitei150NADUniRule annotation1
Binding sitei224NADUniRule annotation1
Binding sitei285NAD; via carbonyl oxygenUniRule annotation1
Sitei287Important for catalytic activityUniRule annotation1
Binding sitei311NADUniRule annotation1
Sitei335Important for catalytic activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 205NADUniRule annotation2
Nucleotide bindingi259 – 263NADUniRule annotation5
Nucleotide bindingi335 – 338NADUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase, mitochondrial1 PublicationUniRule annotation (EC:1.2.1.2UniRule annotation)
Short name:
FDHUniRule annotation
Alternative name(s):
NAD-dependent formate dehydrogenase1 PublicationUniRule annotation
Gene namesi
Name:FDH11 Publication
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25Mitochondrion1 PublicationAdd BLAST25
ChainiPRO_000000719626 – 381Formate dehydrogenase, mitochondrialAdd BLAST356

Proteomic databases

PRIDEiQ07511.

PTM databases

iPTMnetiQ07511.

Expressioni

Tissue specificityi

Found at high levels in developing tubers, at intermediate level in stems, veins, stolons, and stamens, and at low level in leaves and roots.1 Publication

Inductioni

Induced very rapidly by wounding, and slower by darkness, chilling, drought, hypoxia, and treatments with formate, abscisic acid, serine, sarcosine, pyruvate, acetate, ethanol or methanol.1 Publication

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ07511. 1 interactor.
STRINGi4113.PGSC0003DMT400001303.

Structurei

3D structure databases

ProteinModelPortaliQ07511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 149CatalyticUniRule annotationAdd BLAST116
Regioni150 – 336Coenzyme-bindingUniRule annotationAdd BLAST187
Regioni337 – 380CatalyticUniRule annotationAdd BLAST44

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0069. Eukaryota.
COG1052. LUCA.
InParanoidiQ07511.
KOiK00122.

Family and domain databases

CDDicd05302. FDH. 1 hit.
Gene3Di3.40.50.720. 2 hits.
HAMAPiMF_03210. Formate_dehydrogenase. 1 hit.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR033689. FDH_NAD-dep.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMSRVASTA ARAITSPSSL VFTRELQASP GPKKIVGVFY KANEYAEMNP
60 70 80 90 100
NFLGCAENAL GIREWLESKG HQYIVTPDKE GPDCELEKHI PDLHVLISTP
110 120 130 140 150
FHPAYVTAER IKKAKNLQLL LTAGIGSDHV DLKAAAAAGL TVAEVTGSNT
160 170 180 190 200
VSVAEDELMR ILILVRNFLP GHHQVINGEW NVAAIAHRAY DLEGKTVGTV
210 220 230 240 250
GAGRIGRLLL QRLKPFNCNL LYHDRLKMDS ELENQIGAKF EEDLDKMLSK
260 270 280 290 300
CDIVVINTPL TEKTKGMFDK ERIAKLKKGV LIVNNARGAI MDTQAVVDAC
310 320 330 340 350
NSGHIAGYSG DVWYPQPAPK DHPWRYMPNQ AMTPHISGTT IDAQLRYAAG
360 370 380
TKDMLDRYFK GEDFPAENYI VKDGELAPQY R
Length:381
Mass (Da):42,038
Last modified:December 6, 2002 - v2
Checksum:i920D351AC5A3A00E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99991 mRNA. Translation: CAB17080.1.
Z99992 Genomic DNA. No translation available.
Z21493 mRNA. Translation: CAA79702.2.
PIRiJQ2272.
RefSeqiNP_001274827.1. NM_001287898.1.
UniGeneiStu.477.

Genome annotation databases

GeneIDi102577429.
KEGGisot:102577429.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99991 mRNA. Translation: CAB17080.1.
Z99992 Genomic DNA. No translation available.
Z21493 mRNA. Translation: CAA79702.2.
PIRiJQ2272.
RefSeqiNP_001274827.1. NM_001287898.1.
UniGeneiStu.477.

3D structure databases

ProteinModelPortaliQ07511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ07511. 1 interactor.
STRINGi4113.PGSC0003DMT400001303.

PTM databases

iPTMnetiQ07511.

Proteomic databases

PRIDEiQ07511.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102577429.
KEGGisot:102577429.

Phylogenomic databases

eggNOGiKOG0069. Eukaryota.
COG1052. LUCA.
InParanoidiQ07511.
KOiK00122.

Family and domain databases

CDDicd05302. FDH. 1 hit.
Gene3Di3.40.50.720. 2 hits.
HAMAPiMF_03210. Formate_dehydrogenase. 1 hit.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR033689. FDH_NAD-dep.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFDH_SOLTU
AccessioniPrimary (citable) accession number: Q07511
Secondary accession number(s): Q9ZR28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 6, 2002
Last modified: November 30, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

There are two other putative pseudogenes, FDH2 and FDH3.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.