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Q07507

- DERM_HUMAN

UniProt

Q07507 - DERM_HUMAN

Protein

Dermatopontin

Gene

DPT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (13 Dec 2002)
      Previous versions | rss
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    Functioni

    Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation By similarity.By similarity

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. collagen fibril organization Source: Ensembl
    3. negative regulation of cell proliferation Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dermatopontin
    Alternative name(s):
    Tyrosine-rich acidic matrix protein
    Short name:
    TRAMP
    Gene namesi
    Name:DPT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:3011. DPT.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: BHF-UCL
    2. extracellular vesicular exosome Source: UniProt
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27471.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Chaini19 – 201183DermatopontinPRO_0000007368Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei19 – 191Pyrrolidone carboxylic acidBy similarity
    Modified residuei23 – 231SulfotyrosineSequence Analysis
    Disulfide bondi50 ↔ 77By similarity
    Disulfide bondi90 ↔ 132Or C-90 with C-133By similarity
    Disulfide bondi106 ↔ 133Or C-106 with C-132By similarity
    Disulfide bondi139 ↔ 196By similarity
    Disulfide bondi143 ↔ 189Sequence Analysis
    Modified residuei162 – 1621SulfotyrosineSequence Analysis
    Modified residuei164 – 1641SulfotyrosineSequence Analysis
    Modified residuei166 – 1661SulfotyrosineSequence Analysis
    Modified residuei167 – 1671SulfotyrosineSequence Analysis
    Modified residuei194 – 1941SulfotyrosineSequence Analysis

    Post-translational modificationi

    Sulfated on tyrosine residue(s).By similarity

    Keywords - PTMi

    Disulfide bond, Pyrrolidone carboxylic acid, Sulfation

    Proteomic databases

    PaxDbiQ07507.
    PRIDEiQ07507.

    PTM databases

    PhosphoSiteiQ07507.

    Expressioni

    Tissue specificityi

    Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.2 Publications

    Inductioni

    Induced by TGFB1, repressed by IL4/interleukin-4.1 Publication

    Gene expression databases

    BgeeiQ07507.
    CleanExiHS_DPT.
    GenevestigatoriQ07507.

    Interactioni

    Subunit structurei

    Interacts with TGFB1, DCN and collagen.By similarity

    Protein-protein interaction databases

    BioGridi108139. 1 interaction.
    IntActiQ07507. 1 interaction.
    MINTiMINT-1421146.
    STRINGi9606.ENSP00000356791.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07507.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati26 – 79541-1Add
    BLAST
    Repeati70 – 7562-1
    Repeati80 – 135561-2Add
    BLAST
    Repeati125 – 13062-2
    Repeati181 – 18663-3

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni26 – 1861612 X 53-55 AA tandem repeatsAdd
    BLAST
    Regioni70 – 1861173 X 6 AA repeats of D-R-[EQ]-W-[NQK]-[FY]Add
    BLAST

    Sequence similaritiesi

    Belongs to the dermatopontin family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG39338.
    HOGENOMiHOG000013186.
    HOVERGENiHBG005473.
    InParanoidiQ07507.
    OMAiIMCRMTD.
    OrthoDBiEOG75J0PB.
    PhylomeDBiQ07507.
    TreeFamiTF328602.

    Family and domain databases

    InterProiIPR026645. Dermatopontin_fam.
    [Graphical view]
    PANTHERiPTHR15040. PTHR15040. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q07507-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLSLLWVLL PLVTMAWGQY GDYGYPYQQY HDYSDDGWVN LNRQGFSYQC    50
    PQGQVIVAVR SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM 100
    EWYQTCSNNG LVAGFQSRYF ESVLDREWQF YCCRYSKRCP YSCWLTTEYP 150
    GHYGEEMDMI SYNYDYYIRG ATTTFSAVER DRQWKFIMCR MTEYDCEFAN 200
    V 201
    Length:201
    Mass (Da):24,005
    Last modified:December 13, 2002 - v2
    Checksum:iC886D2FB624DDB49
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti10 – 101L → M in CAA80487. (PubMed:8104875)Curated
    Sequence conflicti147 – 1471T → I in AAH33736. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti201 – 2011V → I.
    Corresponds to variant rs6698023 [ dbSNP | Ensembl ].
    VAR_048888

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22865 mRNA. Translation: CAA80487.1.
    AK292596 mRNA. Translation: BAF85285.1.
    AL049798 Genomic DNA. Translation: CAB46693.1.
    CH471067 Genomic DNA. Translation: EAW90830.1.
    BC033736 mRNA. Translation: AAH33736.1.
    CCDSiCCDS1275.1.
    PIRiA47220.
    RefSeqiNP_001928.2. NM_001937.4.
    UniGeneiHs.80552.

    Genome annotation databases

    EnsembliENST00000367817; ENSP00000356791; ENSG00000143196.
    GeneIDi1805.
    KEGGihsa:1805.
    UCSCiuc001gfp.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22865 mRNA. Translation: CAA80487.1 .
    AK292596 mRNA. Translation: BAF85285.1 .
    AL049798 Genomic DNA. Translation: CAB46693.1 .
    CH471067 Genomic DNA. Translation: EAW90830.1 .
    BC033736 mRNA. Translation: AAH33736.1 .
    CCDSi CCDS1275.1.
    PIRi A47220.
    RefSeqi NP_001928.2. NM_001937.4.
    UniGenei Hs.80552.

    3D structure databases

    ProteinModelPortali Q07507.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108139. 1 interaction.
    IntActi Q07507. 1 interaction.
    MINTi MINT-1421146.
    STRINGi 9606.ENSP00000356791.

    PTM databases

    PhosphoSitei Q07507.

    Proteomic databases

    PaxDbi Q07507.
    PRIDEi Q07507.

    Protocols and materials databases

    DNASUi 1805.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367817 ; ENSP00000356791 ; ENSG00000143196 .
    GeneIDi 1805.
    KEGGi hsa:1805.
    UCSCi uc001gfp.3. human.

    Organism-specific databases

    CTDi 1805.
    GeneCardsi GC01M168664.
    HGNCi HGNC:3011. DPT.
    MIMi 125597. gene.
    neXtProti NX_Q07507.
    PharmGKBi PA27471.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39338.
    HOGENOMi HOG000013186.
    HOVERGENi HBG005473.
    InParanoidi Q07507.
    OMAi IMCRMTD.
    OrthoDBi EOG75J0PB.
    PhylomeDBi Q07507.
    TreeFami TF328602.

    Miscellaneous databases

    GeneWikii Dermatopontin.
    GenomeRNAii 1805.
    NextBioi 7357.
    PROi Q07507.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q07507.
    CleanExi HS_DPT.
    Genevestigatori Q07507.

    Family and domain databases

    InterProi IPR026645. Dermatopontin_fam.
    [Graphical view ]
    PANTHERi PTHR15040. PTHR15040. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complementary DNA sequence and chromosomal mapping of a human proteoglycan-binding cell-adhesion protein (dermatopontin)."
      Superti-Furga A., Rocchi M., Schaefer B.W., Gitzelmann R.
      Genomics 17:463-467(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Lung.
    6. "Dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen."
      Kuroda K., Okamoto O., Shinkai H.
      J. Invest. Dermatol. 112:706-710(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.

    Entry informationi

    Entry nameiDERM_HUMAN
    AccessioniPrimary (citable) accession number: Q07507
    Secondary accession number(s): A8K981, Q8N4R2, Q9UIX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: December 13, 2002
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3