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Protein

Dermatopontin

Gene

DPT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143196-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dermatopontin
Alternative name(s):
Tyrosine-rich acidic matrix protein
Short name:
TRAMP
Gene namesi
Name:DPT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3011. DPT.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: BHF-UCL
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1805.
OpenTargetsiENSG00000143196.
PharmGKBiPA27471.

Polymorphism and mutation databases

BioMutaiDPT.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000000736819 – 201DermatopontinAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acidBy similarity1
Modified residuei23SulfotyrosineSequence analysis1
Disulfide bondi50 ↔ 77By similarity
Disulfide bondi90 ↔ 132Or C-90 with C-133By similarity
Disulfide bondi106 ↔ 133Or C-106 with C-132By similarity
Disulfide bondi139 ↔ 196By similarity
Disulfide bondi143 ↔ 189Sequence analysis
Modified residuei162SulfotyrosineSequence analysis1
Modified residuei164SulfotyrosineSequence analysis1
Modified residuei166SulfotyrosineSequence analysis1
Modified residuei167SulfotyrosineSequence analysis1
Modified residuei194SulfotyrosineSequence analysis1

Post-translational modificationi

Sulfated on tyrosine residue(s).By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDbiQ07507.
PeptideAtlasiQ07507.
PRIDEiQ07507.

PTM databases

iPTMnetiQ07507.
PhosphoSitePlusiQ07507.

Expressioni

Tissue specificityi

Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.2 Publications

Inductioni

Induced by TGFB1, repressed by IL4/interleukin-4.1 Publication

Gene expression databases

BgeeiENSG00000143196.
CleanExiHS_DPT.
GenevisibleiQ07507. HS.

Organism-specific databases

HPAiCAB002615.

Interactioni

Subunit structurei

Interacts with TGFB1, DCN and collagen.By similarity

Protein-protein interaction databases

BioGridi108139. 1 interactor.
IntActiQ07507. 1 interactor.
MINTiMINT-1421146.
STRINGi9606.ENSP00000356791.

Structurei

3D structure databases

ProteinModelPortaliQ07507.
SMRiQ07507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 791-1Add BLAST54
Repeati70 – 752-16
Repeati80 – 1351-2Add BLAST56
Repeati125 – 1302-26
Repeati181 – 1863-36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 1862 X 53-55 AA tandem repeatsAdd BLAST161
Regioni70 – 1863 X 6 AA repeats of D-R-[EQ]-W-[NQK]-[FY]Add BLAST117

Sequence similaritiesi

Belongs to the dermatopontin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IGCN. Eukaryota.
ENOG4111HSK. LUCA.
GeneTreeiENSGT00390000010760.
HOGENOMiHOG000013186.
HOVERGENiHBG005473.
InParanoidiQ07507.
OMAiRRCPYSC.
OrthoDBiEOG091G0L6V.
PhylomeDBiQ07507.
TreeFamiTF328602.

Family and domain databases

InterProiIPR026645. Dermatopontin_fam.
[Graphical view]
PANTHERiPTHR15040. PTHR15040. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07507-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLSLLWVLL PLVTMAWGQY GDYGYPYQQY HDYSDDGWVN LNRQGFSYQC
60 70 80 90 100
PQGQVIVAVR SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM
110 120 130 140 150
EWYQTCSNNG LVAGFQSRYF ESVLDREWQF YCCRYSKRCP YSCWLTTEYP
160 170 180 190 200
GHYGEEMDMI SYNYDYYIRG ATTTFSAVER DRQWKFIMCR MTEYDCEFAN

V
Length:201
Mass (Da):24,005
Last modified:December 13, 2002 - v2
Checksum:iC886D2FB624DDB49
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10L → M in CAA80487 (PubMed:8104875).Curated1
Sequence conflicti147T → I in AAH33736 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048888201V → I.Corresponds to variant rs6698023dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22865 mRNA. Translation: CAA80487.1.
AK292596 mRNA. Translation: BAF85285.1.
AL049798 Genomic DNA. Translation: CAB46693.1.
CH471067 Genomic DNA. Translation: EAW90830.1.
BC033736 mRNA. Translation: AAH33736.1.
CCDSiCCDS1275.1.
PIRiA47220.
RefSeqiNP_001928.2. NM_001937.4.
UniGeneiHs.80552.

Genome annotation databases

EnsembliENST00000367817; ENSP00000356791; ENSG00000143196.
GeneIDi1805.
KEGGihsa:1805.
UCSCiuc001gfp.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22865 mRNA. Translation: CAA80487.1.
AK292596 mRNA. Translation: BAF85285.1.
AL049798 Genomic DNA. Translation: CAB46693.1.
CH471067 Genomic DNA. Translation: EAW90830.1.
BC033736 mRNA. Translation: AAH33736.1.
CCDSiCCDS1275.1.
PIRiA47220.
RefSeqiNP_001928.2. NM_001937.4.
UniGeneiHs.80552.

3D structure databases

ProteinModelPortaliQ07507.
SMRiQ07507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108139. 1 interactor.
IntActiQ07507. 1 interactor.
MINTiMINT-1421146.
STRINGi9606.ENSP00000356791.

PTM databases

iPTMnetiQ07507.
PhosphoSitePlusiQ07507.

Polymorphism and mutation databases

BioMutaiDPT.

Proteomic databases

PaxDbiQ07507.
PeptideAtlasiQ07507.
PRIDEiQ07507.

Protocols and materials databases

DNASUi1805.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367817; ENSP00000356791; ENSG00000143196.
GeneIDi1805.
KEGGihsa:1805.
UCSCiuc001gfp.4. human.

Organism-specific databases

CTDi1805.
DisGeNETi1805.
GeneCardsiDPT.
HGNCiHGNC:3011. DPT.
HPAiCAB002615.
MIMi125597. gene.
neXtProtiNX_Q07507.
OpenTargetsiENSG00000143196.
PharmGKBiPA27471.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGCN. Eukaryota.
ENOG4111HSK. LUCA.
GeneTreeiENSGT00390000010760.
HOGENOMiHOG000013186.
HOVERGENiHBG005473.
InParanoidiQ07507.
OMAiRRCPYSC.
OrthoDBiEOG091G0L6V.
PhylomeDBiQ07507.
TreeFamiTF328602.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143196-MONOMER.

Miscellaneous databases

GeneWikiiDermatopontin.
GenomeRNAii1805.
PROiQ07507.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143196.
CleanExiHS_DPT.
GenevisibleiQ07507. HS.

Family and domain databases

InterProiIPR026645. Dermatopontin_fam.
[Graphical view]
PANTHERiPTHR15040. PTHR15040. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDERM_HUMAN
AccessioniPrimary (citable) accession number: Q07507
Secondary accession number(s): A8K981, Q8N4R2, Q9UIX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 13, 2002
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.