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Q07507

- DERM_HUMAN

UniProt

Q07507 - DERM_HUMAN

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Protein

Dermatopontin

Gene

DPT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).By similarity

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. collagen fibril organization Source: Ensembl
  3. negative regulation of cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Dermatopontin
Alternative name(s):
Tyrosine-rich acidic matrix protein
Short name:
TRAMP
Gene namesi
Name:DPT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:3011. DPT.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: BHF-UCL
  2. extracellular vesicular exosome Source: UniProt
  3. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27471.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 201183DermatopontinPRO_0000007368Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Pyrrolidone carboxylic acidBy similarity
Modified residuei23 – 231SulfotyrosineSequence Analysis
Disulfide bondi50 ↔ 77By similarity
Disulfide bondi90 ↔ 132Or C-90 with C-133By similarity
Disulfide bondi106 ↔ 133Or C-106 with C-132By similarity
Disulfide bondi139 ↔ 196By similarity
Disulfide bondi143 ↔ 189Sequence Analysis
Modified residuei162 – 1621SulfotyrosineSequence Analysis
Modified residuei164 – 1641SulfotyrosineSequence Analysis
Modified residuei166 – 1661SulfotyrosineSequence Analysis
Modified residuei167 – 1671SulfotyrosineSequence Analysis
Modified residuei194 – 1941SulfotyrosineSequence Analysis

Post-translational modificationi

Sulfated on tyrosine residue(s).By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDbiQ07507.
PRIDEiQ07507.

PTM databases

PhosphoSiteiQ07507.

Expressioni

Tissue specificityi

Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.2 Publications

Inductioni

Induced by TGFB1, repressed by IL4/interleukin-4.1 Publication

Gene expression databases

BgeeiQ07507.
CleanExiHS_DPT.
GenevestigatoriQ07507.

Interactioni

Subunit structurei

Interacts with TGFB1, DCN and collagen.By similarity

Protein-protein interaction databases

BioGridi108139. 1 interaction.
IntActiQ07507. 1 interaction.
MINTiMINT-1421146.
STRINGi9606.ENSP00000356791.

Structurei

3D structure databases

ProteinModelPortaliQ07507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 79541-1Add
BLAST
Repeati70 – 7562-1
Repeati80 – 135561-2Add
BLAST
Repeati125 – 13062-2
Repeati181 – 18663-3

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 1861612 X 53-55 AA tandem repeatsAdd
BLAST
Regioni70 – 1861173 X 6 AA repeats of D-R-[EQ]-W-[NQK]-[FY]Add
BLAST

Sequence similaritiesi

Belongs to the dermatopontin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG39338.
GeneTreeiENSGT00390000010760.
HOGENOMiHOG000013186.
HOVERGENiHBG005473.
InParanoidiQ07507.
OMAiIMCRMTD.
OrthoDBiEOG75J0PB.
PhylomeDBiQ07507.
TreeFamiTF328602.

Family and domain databases

InterProiIPR026645. Dermatopontin_fam.
[Graphical view]
PANTHERiPTHR15040. PTHR15040. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07507-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLSLLWVLL PLVTMAWGQY GDYGYPYQQY HDYSDDGWVN LNRQGFSYQC
60 70 80 90 100
PQGQVIVAVR SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM
110 120 130 140 150
EWYQTCSNNG LVAGFQSRYF ESVLDREWQF YCCRYSKRCP YSCWLTTEYP
160 170 180 190 200
GHYGEEMDMI SYNYDYYIRG ATTTFSAVER DRQWKFIMCR MTEYDCEFAN

V
Length:201
Mass (Da):24,005
Last modified:December 13, 2002 - v2
Checksum:iC886D2FB624DDB49
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101L → M in CAA80487. (PubMed:8104875)Curated
Sequence conflicti147 – 1471T → I in AAH33736. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti201 – 2011V → I.
Corresponds to variant rs6698023 [ dbSNP | Ensembl ].
VAR_048888

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22865 mRNA. Translation: CAA80487.1.
AK292596 mRNA. Translation: BAF85285.1.
AL049798 Genomic DNA. Translation: CAB46693.1.
CH471067 Genomic DNA. Translation: EAW90830.1.
BC033736 mRNA. Translation: AAH33736.1.
CCDSiCCDS1275.1.
PIRiA47220.
RefSeqiNP_001928.2. NM_001937.4.
UniGeneiHs.80552.

Genome annotation databases

EnsembliENST00000367817; ENSP00000356791; ENSG00000143196.
GeneIDi1805.
KEGGihsa:1805.
UCSCiuc001gfp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22865 mRNA. Translation: CAA80487.1 .
AK292596 mRNA. Translation: BAF85285.1 .
AL049798 Genomic DNA. Translation: CAB46693.1 .
CH471067 Genomic DNA. Translation: EAW90830.1 .
BC033736 mRNA. Translation: AAH33736.1 .
CCDSi CCDS1275.1.
PIRi A47220.
RefSeqi NP_001928.2. NM_001937.4.
UniGenei Hs.80552.

3D structure databases

ProteinModelPortali Q07507.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108139. 1 interaction.
IntActi Q07507. 1 interaction.
MINTi MINT-1421146.
STRINGi 9606.ENSP00000356791.

PTM databases

PhosphoSitei Q07507.

Proteomic databases

PaxDbi Q07507.
PRIDEi Q07507.

Protocols and materials databases

DNASUi 1805.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367817 ; ENSP00000356791 ; ENSG00000143196 .
GeneIDi 1805.
KEGGi hsa:1805.
UCSCi uc001gfp.3. human.

Organism-specific databases

CTDi 1805.
GeneCardsi GC01M168664.
HGNCi HGNC:3011. DPT.
MIMi 125597. gene.
neXtProti NX_Q07507.
PharmGKBi PA27471.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39338.
GeneTreei ENSGT00390000010760.
HOGENOMi HOG000013186.
HOVERGENi HBG005473.
InParanoidi Q07507.
OMAi IMCRMTD.
OrthoDBi EOG75J0PB.
PhylomeDBi Q07507.
TreeFami TF328602.

Miscellaneous databases

GeneWikii Dermatopontin.
GenomeRNAii 1805.
NextBioi 7357.
PROi Q07507.
SOURCEi Search...

Gene expression databases

Bgeei Q07507.
CleanExi HS_DPT.
Genevestigatori Q07507.

Family and domain databases

InterProi IPR026645. Dermatopontin_fam.
[Graphical view ]
PANTHERi PTHR15040. PTHR15040. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complementary DNA sequence and chromosomal mapping of a human proteoglycan-binding cell-adhesion protein (dermatopontin)."
    Superti-Furga A., Rocchi M., Schaefer B.W., Gitzelmann R.
    Genomics 17:463-467(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung.
  6. "Dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen."
    Kuroda K., Okamoto O., Shinkai H.
    J. Invest. Dermatol. 112:706-710(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiDERM_HUMAN
AccessioniPrimary (citable) accession number: Q07507
Secondary accession number(s): A8K981, Q8N4R2, Q9UIX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 13, 2002
Last modified: October 29, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3