Q07505 (DLHH_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative carboxymethylenebutenolidase
EC=3.1.1.45

Alternative name(s):
Dienelactone hydrolase
Short name=DLH

Gene names

Ordered Locus Names:

YDL086W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	4-carboxymethylenebut-2-en-4-olide + H2O = 4-oxohex-2-enedioate.
Sequence similarities	Belongs to the dienelactone hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from direct assay. Source: SGD
Molecular function	carboxymethylenebutenolidase activity Inferred from electronic annotation. Source: EC protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PRP40	P33203	2	EBI-5951,EBI-701

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Putative carboxymethylenebutenolidase		PRO_0000161585
Sites
	Active site	130	1	By similarity
	Active site	191	1	By similarity
	Active site	223	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q07505 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 9A4A9B7577243D46	FASTA	273	30,837
	10 20 30 40 50 60 MLITETFHDV QTSYGTTLRI YVYSPKIAGY PQAKFPGVIL YSEIYQVTGP VRRFGQRIAS 70 80 90 100 110 120 EGYVVVAPAI YHNFMGPEAL PYDVQGTDIG NEYKIKKPLE SYDEDNKLCC DLLFQLPQFD 130 140 150 160 170 180 GKRIGSTGMC LGGHLAFRAL LDKRVTCATC FFPTDIHSRT LGLGQNDNSL ERVSKELGNN 190 200 210 220 230 240 QEMVLIFGTA DTHVDPQGRD LIRKTLRDHG VKFTFLEILA AQHAFIRDEF SKGRFDSAIT 250 260 270 QSCLGFLFEQ FNRKLRIDLG EFVDDNTPLE HVC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P. Nature 387:75-78(1997) [PubMed: 9169867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z74134 Genomic DNA. Translation: CAA98652.1. BK006938 Genomic DNA. Translation: DAA11772.1.
PIR	S67622.
RefSeq	NP_010197.1. NM_001180145.1.
3D structure databases
ProteinModelPortal	Q07505.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3879N.
IntAct	Q07505. 10 interactions.
MINT	MINT-483224.
STRING	Q07505.
Proteomic databases
PeptideAtlas	Q07505.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YDL086W; YDL086W; YDL086W.
GeneID	851472.
KEGG	sce:YDL086W.
NMPDR	fig|4932.3.peg.935.
Organism-specific databases
CYGD	YDL086w.
SGD	S000002244. YDL086W.
Phylogenomic databases
eggNOG	fuNOG05367.
GeneTree	EFGT00050000001701.
HOGENOM	HBG312258.
OMA	YATDIHS.
OrthoDB	EOG4XSPZS.
Gene expression databases
ArrayExpress	Q07505.
Genevestigator	Q07505.
GermOnline	YDL086W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR002925. Dienelactn_hydro. [Graphical view]
KO	K01061.
Pfam	PF01738. DLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	968768.

Entry information

Entry name

DLHH_YEAST

Accession

Primary (citable) accession number: Q07505
Secondary accession number(s): D6VRR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program