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Protein

Putative carboxymethylenebutenolidase

Gene

YDL086W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

4-carboxymethylenebut-2-en-4-olide + H2O = 4-oxohex-2-enedioate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei130By similarity1
Active sitei191By similarity1
Active sitei223By similarity1

GO - Molecular functioni

  • carboxymethylenebutenolidase activity Source: SGD

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciYEAST:YDL086W-MONOMER.

Protein family/group databases

ESTHERiyeast-dlhh. Dienelactone_hydrolase.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative carboxymethylenebutenolidase (EC:3.1.1.45)
Alternative name(s):
Dienelactone hydrolase
Short name:
DLH
Gene namesi
Ordered Locus Names:YDL086W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL086W.
SGDiS000002244. YDL086W.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001615851 – 273Putative carboxymethylenebutenolidaseAdd BLAST273

Proteomic databases

MaxQBiQ07505.
PRIDEiQ07505.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRP40P332032EBI-5951,EBI-701

Protein-protein interaction databases

BioGridi31974. 42 interactors.
DIPiDIP-3879N.
IntActiQ07505. 7 interactors.
MINTiMINT-483224.
STRINGi4932.YDL086W.

Structurei

3D structure databases

ProteinModelPortaliQ07505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dienelactone hydrolase family.Curated

Phylogenomic databases

HOGENOMiHOG000157122.
InParanoidiQ07505.
KOiK01061.
OMAiHTFMRDD.
OrthoDBiEOG092C44SV.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR002925. Dienelactn_hydro.
PfamiView protein in Pfam
PF01738. DLH. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07505-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLITETFHDV QTSYGTTLRI YVYSPKIAGY PQAKFPGVIL YSEIYQVTGP
60 70 80 90 100
VRRFGQRIAS EGYVVVAPAI YHNFMGPEAL PYDVQGTDIG NEYKIKKPLE
110 120 130 140 150
SYDEDNKLCC DLLFQLPQFD GKRIGSTGMC LGGHLAFRAL LDKRVTCATC
160 170 180 190 200
FFPTDIHSRT LGLGQNDNSL ERVSKELGNN QEMVLIFGTA DTHVDPQGRD
210 220 230 240 250
LIRKTLRDHG VKFTFLEILA AQHAFIRDEF SKGRFDSAIT QSCLGFLFEQ
260 270
FNRKLRIDLG EFVDDNTPLE HVC
Length:273
Mass (Da):30,837
Last modified:November 1, 1996 - v1
Checksum:i9A4A9B7577243D46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74134 Genomic DNA. Translation: CAA98652.1.
BK006938 Genomic DNA. Translation: DAA11772.1.
PIRiS67622.
RefSeqiNP_010197.1. NM_001180145.1.

Genome annotation databases

EnsemblFungiiYDL086W; YDL086W; YDL086W.
GeneIDi851472.
KEGGisce:YDL086W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDLHH_YEAST
AccessioniPrimary (citable) accession number: Q07505
Secondary accession number(s): D6VRR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names