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Q07497

- EPHB5_CHICK

UniProt

Q07497 - EPHB5_CHICK

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Protein

Ephrin type-B receptor 5

Gene
EPHB5, CEK9
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for members of the ephrin-B family.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei669 – 6691ATP By similarity
Active sitei762 – 7621Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi643 – 6519ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ephrin receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 1306.

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin type-B receptor 5 (EC:2.7.10.1)
Alternative name(s):
EPH-like kinase 9
Short name:
EK9
Short name:
cEK9
Gene namesi
Name:EPHB5
Synonyms:CEK9
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 564535Extracellular Reviewed predictionAdd
BLAST
Transmembranei565 – 58521Helical; Reviewed predictionAdd
BLAST
Topological domaini586 – 1002417Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed predictionAdd
BLAST
Chaini30 – 1002973Ephrin type-B receptor 5PRO_0000016836Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi446 – 4461N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ07497.

Expressioni

Tissue specificityi

Most abundant in thymus and detectable in brain, retina, kidney, lung and heart. Not detected in skeletal muscle and liver.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023737.

Structurei

3D structure databases

ProteinModelPortaliQ07497.
SMRiQ07497. Positions 30-209, 457-546, 610-908, 910-997.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 213183Eph LBDAdd
BLAST
Domaini344 – 452109Fibronectin type-III 1Add
BLAST
Domaini453 – 54896Fibronectin type-III 2Add
BLAST
Domaini637 – 900264Protein kinaseAdd
BLAST
Domaini929 – 99365SAMAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1000 – 10023PDZ-binding Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi195 – 338144Cys-richAdd
BLAST
Compositional biasi862 – 8654Poly-Pro

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
InParanoidiQ07497.
KOiK05114.
PhylomeDBiQ07497.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. Fibronectin_type3.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07699. GCC2_GCC3. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07497-1 [UniParc]FASTAAdd to Basket

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MDSNADISAR RVSGMDWLWL VCFFHLVTSL EEILLDTTGE TSEIGWTSHP     50
PDGWEEVSVR DDKERQIRTF QVCNMDEPGQ NNWLRTHFIE RRGAHRVHVR 100
LHFSVRDCAS MRTVASTCKE TFTLYYHQSD VDIASQELPE WHEGPWTKVD 150
TIAADESFSQ VDRTGKVVRM NVKVRSFGPL TKHGFYLAFQ DSGACMSLVA 200
VQVFFYKCPA VVKGFASFPE TFAGGERTSL VESLGTCVAN AEEASTTGSS 250
GVRLHCNGEG EWMVATGRCS CKAGYQSVDN EQACQACPIG SFKASVGDDP 300
CLLCPAHSHA PLPLPGSIEC VCQSHYYRSA SDNSDAPCTG IPSAPRDLSY 350
EIVGSNVLLT WRLPKDLGGR KDVFFNVICK ECPTRSAGTC VRCGDNVQFE 400
PRQVGLTESR VQVSNLLARV QYTFEIQAVN LVTELSSEAP QYATINVSTS 450
QSVPSAIPMM HQVSRATSSI TLSWPQPDQP NGVILDYQLR YFDKAEDEDN 500
SFTLTSETNM ATILNLSPGK IYVFQVRART AVGYGPYSGK MYFQTLMAGE 550
HSEMAQDRLP LIVGSALGGL AFLVIAAIAI LAIIFKSKRR ETPYTDRLQQ 600
YISTRGLGVK YYIDPSTYED PNEAIREFAK EIDVSFIKIE EVIGSGEFGE 650
VCFGRLKHPG KREYTVAIKT LKSGYTDEQR REFLSEASIM GQFEHPNVIH 700
LEGVVTKSRP VMIVTEFMEN GSLDSFLRQK EGQFSVLQLV GMLRGIAAGM 750
RYLSDMNYVH RDLAARNILV NSNLVCKVSD FGLSRFLEDD ASNPTYTGAL 800
GCKIPIRWTA PEAVQYRKFT SSSDVWSYGI VMWEVMSYGE RPYWDMSNQD 850
VINAIDQDYR LPPPPDCPTV LHLLMLDCWQ KDRVQRPKFE QIVSALDKMI 900
RKPSALKATG TGSSRPSQPL LSNSPPDFPS LSNAHEWLDA IKMGRYKENF 950
DQAGLITFDV ISRMTLEDLQ RIGITLVGHQ KKILNSIQLM KVHLNQLEPV 1000
EV 1002
Length:1,002
Mass (Da):111,947
Last modified:November 1, 1996 - v1
Checksum:i6D9635B500D8B0DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U23783 mRNA. Translation: AAB41054.1.
PIRiS33506.
RefSeqiNP_001004387.1. NM_001004387.1.
UniGeneiGga.633.

Genome annotation databases

GeneIDi418308.
KEGGigga:418308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U23783 mRNA. Translation: AAB41054.1 .
PIRi S33506.
RefSeqi NP_001004387.1. NM_001004387.1.
UniGenei Gga.633.

3D structure databases

ProteinModelPortali Q07497.
SMRi Q07497. Positions 30-209, 457-546, 610-908, 910-997.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000023737.

Proteomic databases

PaxDbi Q07497.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 418308.
KEGGi gga:418308.

Organism-specific databases

CTDi 2051.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233856.
HOVERGENi HBG062180.
InParanoidi Q07497.
KOi K05114.
PhylomeDBi Q07497.

Enzyme and pathway databases

BRENDAi 2.7.10.1. 1306.

Miscellaneous databases

NextBioi 20821503.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProi IPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. Fibronectin_type3.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view ]
Pfami PF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07699. GCC2_GCC3. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00615. EPH_lbd. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEi PS01186. EGF_2. 1 hit.
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Developmental expression and distinctive tyrosine phosphorylation of the Eph-related receptor tyrosine kinase Cek9."
    Soans C., Holash J.A., Pavlova Y., Pasquale E.B.
    J. Cell Biol. 135:781-795(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Five novel avian Eph-related tyrosine kinases are differentially expressed."
    Sajjadi F.G., Pasquale E.B.
    Oncogene 8:1807-1813(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiEPHB5_CHICK
AccessioniPrimary (citable) accession number: Q07497
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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