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Protein

Ephrin type-B receptor 5

Gene

EPHB5

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for members of the ephrin-B family.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei669 – 6691ATPPROSITE-ProRule annotation
Active sitei762 – 7621Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi643 – 6519ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ephrin receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 1306.

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin type-B receptor 5 (EC:2.7.10.1)
Alternative name(s):
EPH-like kinase 9
Short name:
EK9
Short name:
cEK9
Gene namesi
Name:EPHB5
Synonyms:CEK9
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 564535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei565 – 58521HelicalSequence AnalysisAdd
BLAST
Topological domaini586 – 1002417CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 1002973Ephrin type-B receptor 5PRO_0000016836Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ07497.

Expressioni

Tissue specificityi

Most abundant in thymus and detectable in brain, retina, kidney, lung and heart. Not detected in skeletal muscle and liver.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023737.

Structurei

3D structure databases

ProteinModelPortaliQ07497.
SMRiQ07497. Positions 30-209, 457-546, 610-908, 910-997.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 213183Eph LBDPROSITE-ProRule annotationAdd
BLAST
Domaini344 – 452109Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini453 – 54896Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini637 – 900264Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini929 – 99365SAMPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1000 – 10023PDZ-bindingSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi195 – 338144Cys-richAdd
BLAST
Compositional biasi862 – 8654Poly-Pro

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation
Contains 1 Eph LBD (Eph ligand-binding) domain.PROSITE-ProRule annotation
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
InParanoidiQ07497.
KOiK05114.
PhylomeDBiQ07497.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07699. GCC2_GCC3. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07497-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSNADISAR RVSGMDWLWL VCFFHLVTSL EEILLDTTGE TSEIGWTSHP
60 70 80 90 100
PDGWEEVSVR DDKERQIRTF QVCNMDEPGQ NNWLRTHFIE RRGAHRVHVR
110 120 130 140 150
LHFSVRDCAS MRTVASTCKE TFTLYYHQSD VDIASQELPE WHEGPWTKVD
160 170 180 190 200
TIAADESFSQ VDRTGKVVRM NVKVRSFGPL TKHGFYLAFQ DSGACMSLVA
210 220 230 240 250
VQVFFYKCPA VVKGFASFPE TFAGGERTSL VESLGTCVAN AEEASTTGSS
260 270 280 290 300
GVRLHCNGEG EWMVATGRCS CKAGYQSVDN EQACQACPIG SFKASVGDDP
310 320 330 340 350
CLLCPAHSHA PLPLPGSIEC VCQSHYYRSA SDNSDAPCTG IPSAPRDLSY
360 370 380 390 400
EIVGSNVLLT WRLPKDLGGR KDVFFNVICK ECPTRSAGTC VRCGDNVQFE
410 420 430 440 450
PRQVGLTESR VQVSNLLARV QYTFEIQAVN LVTELSSEAP QYATINVSTS
460 470 480 490 500
QSVPSAIPMM HQVSRATSSI TLSWPQPDQP NGVILDYQLR YFDKAEDEDN
510 520 530 540 550
SFTLTSETNM ATILNLSPGK IYVFQVRART AVGYGPYSGK MYFQTLMAGE
560 570 580 590 600
HSEMAQDRLP LIVGSALGGL AFLVIAAIAI LAIIFKSKRR ETPYTDRLQQ
610 620 630 640 650
YISTRGLGVK YYIDPSTYED PNEAIREFAK EIDVSFIKIE EVIGSGEFGE
660 670 680 690 700
VCFGRLKHPG KREYTVAIKT LKSGYTDEQR REFLSEASIM GQFEHPNVIH
710 720 730 740 750
LEGVVTKSRP VMIVTEFMEN GSLDSFLRQK EGQFSVLQLV GMLRGIAAGM
760 770 780 790 800
RYLSDMNYVH RDLAARNILV NSNLVCKVSD FGLSRFLEDD ASNPTYTGAL
810 820 830 840 850
GCKIPIRWTA PEAVQYRKFT SSSDVWSYGI VMWEVMSYGE RPYWDMSNQD
860 870 880 890 900
VINAIDQDYR LPPPPDCPTV LHLLMLDCWQ KDRVQRPKFE QIVSALDKMI
910 920 930 940 950
RKPSALKATG TGSSRPSQPL LSNSPPDFPS LSNAHEWLDA IKMGRYKENF
960 970 980 990 1000
DQAGLITFDV ISRMTLEDLQ RIGITLVGHQ KKILNSIQLM KVHLNQLEPV

EV
Length:1,002
Mass (Da):111,947
Last modified:November 1, 1996 - v1
Checksum:i6D9635B500D8B0DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23783 mRNA. Translation: AAB41054.1.
PIRiS33506.
RefSeqiNP_001004387.1. NM_001004387.1.
UniGeneiGga.633.

Genome annotation databases

GeneIDi418308.
KEGGigga:418308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23783 mRNA. Translation: AAB41054.1.
PIRiS33506.
RefSeqiNP_001004387.1. NM_001004387.1.
UniGeneiGga.633.

3D structure databases

ProteinModelPortaliQ07497.
SMRiQ07497. Positions 30-209, 457-546, 610-908, 910-997.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023737.

Proteomic databases

PaxDbiQ07497.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi418308.
KEGGigga:418308.

Organism-specific databases

CTDi2051.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
InParanoidiQ07497.
KOiK05114.
PhylomeDBiQ07497.

Enzyme and pathway databases

BRENDAi2.7.10.1. 1306.

Miscellaneous databases

NextBioi20821503.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07699. GCC2_GCC3. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Developmental expression and distinctive tyrosine phosphorylation of the Eph-related receptor tyrosine kinase Cek9."
    Soans C., Holash J.A., Pavlova Y., Pasquale E.B.
    J. Cell Biol. 135:781-795(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Five novel avian Eph-related tyrosine kinases are differentially expressed."
    Sajjadi F.G., Pasquale E.B.
    Oncogene 8:1807-1813(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiEPHB5_CHICK
AccessioniPrimary (citable) accession number: Q07497
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.