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Q07497 (EPHB5_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ephrin type-B receptor 5
EC=2.7.10.1
Alternative name(s):
EPH-like kinase 9
Short name=EK9
Short name=cEK9
Gene names
Name:EPHB5
Synonyms:CEK9
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length1002 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for members of the ephrin-B family.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Most abundant in thymus and detectable in brain, retina, kidney, lung and heart. Not detected in skeletal muscle and liver.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.

Contains 1 Eph LBD (Eph ligand-binding) domain.

Contains 2 fibronectin type-III domains.

Contains 1 protein kinase domain.

Contains 1 SAM (sterile alpha motif) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 1002973Ephrin type-B receptor 5
PRO_0000016836

Regions

Topological domain30 – 564535Extracellular Potential
Transmembrane565 – 58521Helical; Potential
Topological domain586 – 1002417Cytoplasmic Potential
Domain31 – 213183Eph LBD
Domain342 – 444103Fibronectin type-III 1
Domain454 – 54592Fibronectin type-III 2
Domain637 – 900264Protein kinase
Domain929 – 99365SAM
Nucleotide binding643 – 6519ATP By similarity
Motif1000 – 10023PDZ-binding Potential
Compositional bias195 – 338144Cys-rich
Compositional bias862 – 8654Poly-Pro

Sites

Active site7621Proton acceptor By similarity
Binding site6691ATP By similarity

Amino acid modifications

Glycosylation4461N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q07497 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 6D9635B500D8B0DA

FASTA1,002111,947
        10         20         30         40         50         60 
MDSNADISAR RVSGMDWLWL VCFFHLVTSL EEILLDTTGE TSEIGWTSHP PDGWEEVSVR 

        70         80         90        100        110        120 
DDKERQIRTF QVCNMDEPGQ NNWLRTHFIE RRGAHRVHVR LHFSVRDCAS MRTVASTCKE 

       130        140        150        160        170        180 
TFTLYYHQSD VDIASQELPE WHEGPWTKVD TIAADESFSQ VDRTGKVVRM NVKVRSFGPL 

       190        200        210        220        230        240 
TKHGFYLAFQ DSGACMSLVA VQVFFYKCPA VVKGFASFPE TFAGGERTSL VESLGTCVAN 

       250        260        270        280        290        300 
AEEASTTGSS GVRLHCNGEG EWMVATGRCS CKAGYQSVDN EQACQACPIG SFKASVGDDP 

       310        320        330        340        350        360 
CLLCPAHSHA PLPLPGSIEC VCQSHYYRSA SDNSDAPCTG IPSAPRDLSY EIVGSNVLLT 

       370        380        390        400        410        420 
WRLPKDLGGR KDVFFNVICK ECPTRSAGTC VRCGDNVQFE PRQVGLTESR VQVSNLLARV 

       430        440        450        460        470        480 
QYTFEIQAVN LVTELSSEAP QYATINVSTS QSVPSAIPMM HQVSRATSSI TLSWPQPDQP 

       490        500        510        520        530        540 
NGVILDYQLR YFDKAEDEDN SFTLTSETNM ATILNLSPGK IYVFQVRART AVGYGPYSGK 

       550        560        570        580        590        600 
MYFQTLMAGE HSEMAQDRLP LIVGSALGGL AFLVIAAIAI LAIIFKSKRR ETPYTDRLQQ 

       610        620        630        640        650        660 
YISTRGLGVK YYIDPSTYED PNEAIREFAK EIDVSFIKIE EVIGSGEFGE VCFGRLKHPG 

       670        680        690        700        710        720 
KREYTVAIKT LKSGYTDEQR REFLSEASIM GQFEHPNVIH LEGVVTKSRP VMIVTEFMEN 

       730        740        750        760        770        780 
GSLDSFLRQK EGQFSVLQLV GMLRGIAAGM RYLSDMNYVH RDLAARNILV NSNLVCKVSD 

       790        800        810        820        830        840 
FGLSRFLEDD ASNPTYTGAL GCKIPIRWTA PEAVQYRKFT SSSDVWSYGI VMWEVMSYGE 

       850        860        870        880        890        900 
RPYWDMSNQD VINAIDQDYR LPPPPDCPTV LHLLMLDCWQ KDRVQRPKFE QIVSALDKMI 

       910        920        930        940        950        960 
RKPSALKATG TGSSRPSQPL LSNSPPDFPS LSNAHEWLDA IKMGRYKENF DQAGLITFDV 

       970        980        990       1000 
ISRMTLEDLQ RIGITLVGHQ KKILNSIQLM KVHLNQLEPV EV

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References

[1]"Developmental expression and distinctive tyrosine phosphorylation of the Eph-related receptor tyrosine kinase Cek9."
Soans C., Holash J.A., Pavlova Y., Pasquale E.B.
J. Cell Biol. 135:781-795(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Five novel avian Eph-related tyrosine kinases are differentially expressed."
Sajjadi F.G., Pasquale E.B.
Oncogene 8:1807-1813(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U23783 mRNA. Translation: AAB41054.1.
IPIIPI00581943.
PIRS33506.
RefSeqNP_001004387.1. NM_001004387.1.
UniGeneGga.633.

3D structure databases

ProteinModelPortalQ07497.
SMRQ07497. Positions 30-209, 457-546, 610-908, 910-997.
ModBaseSearch...

Proteomic databases

PaxDbQ07497.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID418308.
KEGGgga:418308.

Organism-specific databases

CTD2051.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233856.
HOVERGENHBG062180.
InParanoidQ07497.
KOK05114.
OrthoDBEOG405S09.

Enzyme and pathway databases

BRENDA2.7.10.1. 1306.

Family and domain databases

Gene3D1.10.150.50. 1 hit.
2.60.40.10. 2 hits.
InterProIPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. Fibronectin_type3.
IPR008979. Galactose-bd-like.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamPF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07699. GCC2_GCC3. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PIRSFPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00615. EPH_lbd. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 2 hits.
SSF49785. Gal_bind_like. 1 hit.
SSF56112. Kinase_like. 1 hit.
SSF47769. SAM_homology. 1 hit.
PROSITEPS01186. EGF_2. 1 hit. Uncertain.
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20821503.

Entry information

Entry nameEPHB5_CHICK
AccessionPrimary (citable) accession number: Q07497
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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