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Q07497

- EPHB5_CHICK

UniProt

Q07497 - EPHB5_CHICK

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Protein
Ephrin type-B receptor 5
Gene
EPHB5, CEK9
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for members of the ephrin-B family.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei669 – 6691ATP By similarity
Active sitei762 – 7621Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi643 – 6519ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ephrin receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.1. 1306.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ephrin type-B receptor 5 (EC:2.7.10.1)
    Alternative name(s):
    EPH-like kinase 9
    Short name:
    EK9
    Short name:
    cEK9
    Gene namesi
    Name:EPHB5
    Synonyms:CEK9
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 564535Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei565 – 58521Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini586 – 1002417Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of plasma membrane Source: InterPro
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929 Reviewed prediction
    Add
    BLAST
    Chaini30 – 1002973Ephrin type-B receptor 5
    PRO_0000016836Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi446 – 4461N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ07497.

    Expressioni

    Tissue specificityi

    Most abundant in thymus and detectable in brain, retina, kidney, lung and heart. Not detected in skeletal muscle and liver.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000023737.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07497.
    SMRiQ07497. Positions 30-209, 457-546, 610-908, 910-997.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 213183Eph LBD
    Add
    BLAST
    Domaini344 – 452109Fibronectin type-III 1
    Add
    BLAST
    Domaini453 – 54896Fibronectin type-III 2
    Add
    BLAST
    Domaini637 – 900264Protein kinase
    Add
    BLAST
    Domaini929 – 99365SAM
    Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1000 – 10023PDZ-binding Reviewed prediction

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi195 – 338144Cys-rich
    Add
    BLAST
    Compositional biasi862 – 8654Poly-Pro

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233856.
    HOVERGENiHBG062180.
    InParanoidiQ07497.
    KOiK05114.
    PhylomeDBiQ07497.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    InterProiIPR027936. Eph_TM.
    IPR001090. Ephrin_rcpt_lig-bd_dom.
    IPR003961. Fibronectin_type3.
    IPR008979. Galactose-bd-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR013783. Ig-like_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR011510. SAM_2.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016257. Tyr_kinase_ephrin_rcpt.
    IPR001426. Tyr_kinase_rcpt_V_CS.
    [Graphical view]
    PfamiPF14575. EphA2_TM. 1 hit.
    PF01404. Ephrin_lbd. 1 hit.
    PF00041. fn3. 2 hits.
    PF07699. GCC2_GCC3. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF07647. SAM_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00615. EPH_lbd. 1 hit.
    SM00060. FN3. 2 hits.
    SM00454. SAM. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF49265. SSF49265. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEiPS01186. EGF_2. 1 hit.
    PS51550. EPH_LBD. 1 hit.
    PS50853. FN3. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
    PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q07497-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSNADISAR RVSGMDWLWL VCFFHLVTSL EEILLDTTGE TSEIGWTSHP     50
    PDGWEEVSVR DDKERQIRTF QVCNMDEPGQ NNWLRTHFIE RRGAHRVHVR 100
    LHFSVRDCAS MRTVASTCKE TFTLYYHQSD VDIASQELPE WHEGPWTKVD 150
    TIAADESFSQ VDRTGKVVRM NVKVRSFGPL TKHGFYLAFQ DSGACMSLVA 200
    VQVFFYKCPA VVKGFASFPE TFAGGERTSL VESLGTCVAN AEEASTTGSS 250
    GVRLHCNGEG EWMVATGRCS CKAGYQSVDN EQACQACPIG SFKASVGDDP 300
    CLLCPAHSHA PLPLPGSIEC VCQSHYYRSA SDNSDAPCTG IPSAPRDLSY 350
    EIVGSNVLLT WRLPKDLGGR KDVFFNVICK ECPTRSAGTC VRCGDNVQFE 400
    PRQVGLTESR VQVSNLLARV QYTFEIQAVN LVTELSSEAP QYATINVSTS 450
    QSVPSAIPMM HQVSRATSSI TLSWPQPDQP NGVILDYQLR YFDKAEDEDN 500
    SFTLTSETNM ATILNLSPGK IYVFQVRART AVGYGPYSGK MYFQTLMAGE 550
    HSEMAQDRLP LIVGSALGGL AFLVIAAIAI LAIIFKSKRR ETPYTDRLQQ 600
    YISTRGLGVK YYIDPSTYED PNEAIREFAK EIDVSFIKIE EVIGSGEFGE 650
    VCFGRLKHPG KREYTVAIKT LKSGYTDEQR REFLSEASIM GQFEHPNVIH 700
    LEGVVTKSRP VMIVTEFMEN GSLDSFLRQK EGQFSVLQLV GMLRGIAAGM 750
    RYLSDMNYVH RDLAARNILV NSNLVCKVSD FGLSRFLEDD ASNPTYTGAL 800
    GCKIPIRWTA PEAVQYRKFT SSSDVWSYGI VMWEVMSYGE RPYWDMSNQD 850
    VINAIDQDYR LPPPPDCPTV LHLLMLDCWQ KDRVQRPKFE QIVSALDKMI 900
    RKPSALKATG TGSSRPSQPL LSNSPPDFPS LSNAHEWLDA IKMGRYKENF 950
    DQAGLITFDV ISRMTLEDLQ RIGITLVGHQ KKILNSIQLM KVHLNQLEPV 1000
    EV 1002
    Length:1,002
    Mass (Da):111,947
    Last modified:November 1, 1996 - v1
    Checksum:i6D9635B500D8B0DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U23783 mRNA. Translation: AAB41054.1.
    PIRiS33506.
    RefSeqiNP_001004387.1. NM_001004387.1.
    UniGeneiGga.633.

    Genome annotation databases

    GeneIDi418308.
    KEGGigga:418308.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U23783 mRNA. Translation: AAB41054.1 .
    PIRi S33506.
    RefSeqi NP_001004387.1. NM_001004387.1.
    UniGenei Gga.633.

    3D structure databases

    ProteinModelPortali Q07497.
    SMRi Q07497. Positions 30-209, 457-546, 610-908, 910-997.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000023737.

    Proteomic databases

    PaxDbi Q07497.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 418308.
    KEGGi gga:418308.

    Organism-specific databases

    CTDi 2051.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233856.
    HOVERGENi HBG062180.
    InParanoidi Q07497.
    KOi K05114.
    PhylomeDBi Q07497.

    Enzyme and pathway databases

    BRENDAi 2.7.10.1. 1306.

    Miscellaneous databases

    NextBioi 20821503.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    InterProi IPR027936. Eph_TM.
    IPR001090. Ephrin_rcpt_lig-bd_dom.
    IPR003961. Fibronectin_type3.
    IPR008979. Galactose-bd-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR013783. Ig-like_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR011510. SAM_2.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016257. Tyr_kinase_ephrin_rcpt.
    IPR001426. Tyr_kinase_rcpt_V_CS.
    [Graphical view ]
    Pfami PF14575. EphA2_TM. 1 hit.
    PF01404. Ephrin_lbd. 1 hit.
    PF00041. fn3. 2 hits.
    PF07699. GCC2_GCC3. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF07647. SAM_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000666. TyrPK_ephrin_receptor. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00615. EPH_lbd. 1 hit.
    SM00060. FN3. 2 hits.
    SM00454. SAM. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF49265. SSF49265. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEi PS01186. EGF_2. 1 hit.
    PS51550. EPH_LBD. 1 hit.
    PS50853. FN3. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
    PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Developmental expression and distinctive tyrosine phosphorylation of the Eph-related receptor tyrosine kinase Cek9."
      Soans C., Holash J.A., Pavlova Y., Pasquale E.B.
      J. Cell Biol. 135:781-795(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Five novel avian Eph-related tyrosine kinases are differentially expressed."
      Sajjadi F.G., Pasquale E.B.
      Oncogene 8:1807-1813(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiEPHB5_CHICK
    AccessioniPrimary (citable) accession number: Q07497
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: April 16, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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