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Protein

Ephrin type-B receptor 5

Gene

EPHB5

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for members of the ephrin-B family.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei669ATPPROSITE-ProRule annotation1
Active sitei762Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi643 – 651ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 1306.

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin type-B receptor 5 (EC:2.7.10.1)
Alternative name(s):
EPH-like kinase 9
Short name:
EK9
Short name:
cEK9
Gene namesi
Name:EPHB5
Synonyms:CEK9
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 564ExtracellularSequence analysisAdd BLAST535
Transmembranei565 – 585HelicalSequence analysisAdd BLAST21
Topological domaini586 – 1002CytoplasmicSequence analysisAdd BLAST417

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001683630 – 1002Ephrin type-B receptor 5Add BLAST973

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi446N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ07497.

PTM databases

iPTMnetiQ07497.

Expressioni

Tissue specificityi

Most abundant in thymus and detectable in brain, retina, kidney, lung and heart. Not detected in skeletal muscle and liver.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023737.

Structurei

3D structure databases

ProteinModelPortaliQ07497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 213Eph LBDPROSITE-ProRule annotationAdd BLAST183
Domaini344 – 452Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST109
Domaini453 – 548Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini637 – 900Protein kinasePROSITE-ProRule annotationAdd BLAST264
Domaini929 – 993SAMPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1000 – 1002PDZ-bindingSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi195 – 338Cys-richAdd BLAST144
Compositional biasi862 – 865Poly-Pro4

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation
Contains 1 Eph LBD (Eph ligand-binding) domain.PROSITE-ProRule annotation
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
InParanoidiQ07497.
KOiK05114.
PhylomeDBiQ07497.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF07699. Ephrin_rec_like. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSNADISAR RVSGMDWLWL VCFFHLVTSL EEILLDTTGE TSEIGWTSHP
60 70 80 90 100
PDGWEEVSVR DDKERQIRTF QVCNMDEPGQ NNWLRTHFIE RRGAHRVHVR
110 120 130 140 150
LHFSVRDCAS MRTVASTCKE TFTLYYHQSD VDIASQELPE WHEGPWTKVD
160 170 180 190 200
TIAADESFSQ VDRTGKVVRM NVKVRSFGPL TKHGFYLAFQ DSGACMSLVA
210 220 230 240 250
VQVFFYKCPA VVKGFASFPE TFAGGERTSL VESLGTCVAN AEEASTTGSS
260 270 280 290 300
GVRLHCNGEG EWMVATGRCS CKAGYQSVDN EQACQACPIG SFKASVGDDP
310 320 330 340 350
CLLCPAHSHA PLPLPGSIEC VCQSHYYRSA SDNSDAPCTG IPSAPRDLSY
360 370 380 390 400
EIVGSNVLLT WRLPKDLGGR KDVFFNVICK ECPTRSAGTC VRCGDNVQFE
410 420 430 440 450
PRQVGLTESR VQVSNLLARV QYTFEIQAVN LVTELSSEAP QYATINVSTS
460 470 480 490 500
QSVPSAIPMM HQVSRATSSI TLSWPQPDQP NGVILDYQLR YFDKAEDEDN
510 520 530 540 550
SFTLTSETNM ATILNLSPGK IYVFQVRART AVGYGPYSGK MYFQTLMAGE
560 570 580 590 600
HSEMAQDRLP LIVGSALGGL AFLVIAAIAI LAIIFKSKRR ETPYTDRLQQ
610 620 630 640 650
YISTRGLGVK YYIDPSTYED PNEAIREFAK EIDVSFIKIE EVIGSGEFGE
660 670 680 690 700
VCFGRLKHPG KREYTVAIKT LKSGYTDEQR REFLSEASIM GQFEHPNVIH
710 720 730 740 750
LEGVVTKSRP VMIVTEFMEN GSLDSFLRQK EGQFSVLQLV GMLRGIAAGM
760 770 780 790 800
RYLSDMNYVH RDLAARNILV NSNLVCKVSD FGLSRFLEDD ASNPTYTGAL
810 820 830 840 850
GCKIPIRWTA PEAVQYRKFT SSSDVWSYGI VMWEVMSYGE RPYWDMSNQD
860 870 880 890 900
VINAIDQDYR LPPPPDCPTV LHLLMLDCWQ KDRVQRPKFE QIVSALDKMI
910 920 930 940 950
RKPSALKATG TGSSRPSQPL LSNSPPDFPS LSNAHEWLDA IKMGRYKENF
960 970 980 990 1000
DQAGLITFDV ISRMTLEDLQ RIGITLVGHQ KKILNSIQLM KVHLNQLEPV

EV
Length:1,002
Mass (Da):111,947
Last modified:November 1, 1996 - v1
Checksum:i6D9635B500D8B0DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23783 mRNA. Translation: AAB41054.1.
PIRiS33506.
RefSeqiNP_001004387.1. NM_001004387.1.
UniGeneiGga.633.

Genome annotation databases

GeneIDi418308.
KEGGigga:418308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23783 mRNA. Translation: AAB41054.1.
PIRiS33506.
RefSeqiNP_001004387.1. NM_001004387.1.
UniGeneiGga.633.

3D structure databases

ProteinModelPortaliQ07497.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023737.

PTM databases

iPTMnetiQ07497.

Proteomic databases

PaxDbiQ07497.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi418308.
KEGGigga:418308.

Organism-specific databases

CTDi2051.

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
InParanoidiQ07497.
KOiK05114.
PhylomeDBiQ07497.

Enzyme and pathway databases

BRENDAi2.7.10.1. 1306.

Miscellaneous databases

PROiQ07497.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF07699. Ephrin_rec_like. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEPHB5_CHICK
AccessioniPrimary (citable) accession number: Q07497
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.