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Protein

Signal transducer CD24

Gene

Cd24

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May have a pivotal role in cell differentiation. The triggering mechanism of signal transduction may be due to the interactions of differentiating cells with the matrix substrate via the carbohydrate structure of the molecule. In this way, the signal transducer can play very different roles in different cell types as a direct consequence of its glycosylation.

GO - Molecular functioni

  • carbohydrate binding Source: Ensembl
  • protein kinase binding Source: UniProtKB
  • protein tyrosine kinase activator activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer CD24
Alternative name(s):
Heat-stable antigen
Short name:
HSA
Nectadrin
CD_antigen: CD24
Gene namesi
Name:Cd24
Synonyms:Cd24a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi2298. Cd24.

Subcellular locationi

GO - Cellular componenti

  • anchored component of external side of plasma membrane Source: MGI
  • anchored component of plasma membrane Source: RGD
  • cell surface Source: UniProtKB
  • ciliary membrane Source: Ensembl
  • external side of plasma membrane Source: MGI
  • membrane Source: UniProtKB
  • membrane raft Source: UniProtKB
  • microvillus membrane Source: Ensembl
  • synapse Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PeptideiPRO_000002089727 – 56Signal transducer CD24Add BLAST30
PropeptideiPRO_000002089857 – 76Removed in mature formBy similarityAdd BLAST20

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Lipidationi56GPI-anchor amidated serineSequence analysis1

Post-translational modificationi

Extensively O-glycosylated (By similarity). The carbohydrate structure may be regulated in a tissue-specific and developmental stage-specific manner.By similarity

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ07490.

Expressioni

Tissue specificityi

Expressed in the central nervous system, in postmitotic cells of spinal cord, hindbrain, midbrain and forebrain. Expressed in epithelium during the development of non-neural tissues. Expressed in tooth development, specifically in mesenchymal cells differentiating into odontoblast in dental papilla, as well as in the developing eye and hair follicle.

Developmental stagei

Detected in primitive ectoderm, mesoderm and ventral endoderm; down-regulated when organogenesis is completed.

Gene expression databases

BgeeiENSRNOG00000000321.
GenevisibleiQ07490. RN.

Interactioni

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000352.

Family & Domainsi

Sequence similaritiesi

Belongs to the CD24 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JF9E. Eukaryota.
ENOG4111B8V. LUCA.
GeneTreeiENSGT00390000018829.
HOGENOMiHOG000111484.
HOVERGENiHBG005274.
InParanoidiQ07490.
KOiK06469.
OMAiQTSVAPF.
OrthoDBiEOG091G1CCU.
PhylomeDBiQ07490.
TreeFamiTF338512.

Family and domain databases

InterProiIPR028029. CD24.
[Graphical view]
PfamiPF14984. CD24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRAMVVRLG LGLLLLALLL PTQIYCNQTS VAPFSGNQSI SAAPNPTNAT
60 70
TRSGCSSLQS TAGLLALSLS LLHLYC
Length:76
Mass (Da):7,862
Last modified:November 1, 1995 - v1
Checksum:i42846E70EC39D958
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11663 mRNA. Translation: CAA77731.1.
U49062 mRNA. Translation: AAA91470.1.
BC064439 mRNA. Translation: AAH64439.1.
BC081851 mRNA. Translation: AAH81851.1.
PIRiI53107.
RefSeqiNP_036884.1. NM_012752.3.
UniGeneiRn.6007.

Genome annotation databases

EnsembliENSRNOT00000000352; ENSRNOP00000000352; ENSRNOG00000000321.
GeneIDi25145.
KEGGirno:25145.
UCSCiRGD:2298. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11663 mRNA. Translation: CAA77731.1.
U49062 mRNA. Translation: AAA91470.1.
BC064439 mRNA. Translation: AAH64439.1.
BC081851 mRNA. Translation: AAH81851.1.
PIRiI53107.
RefSeqiNP_036884.1. NM_012752.3.
UniGeneiRn.6007.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000352.

Proteomic databases

PaxDbiQ07490.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000352; ENSRNOP00000000352; ENSRNOG00000000321.
GeneIDi25145.
KEGGirno:25145.
UCSCiRGD:2298. rat.

Organism-specific databases

CTDi100133941.
RGDi2298. Cd24.

Phylogenomic databases

eggNOGiENOG410JF9E. Eukaryota.
ENOG4111B8V. LUCA.
GeneTreeiENSGT00390000018829.
HOGENOMiHOG000111484.
HOVERGENiHBG005274.
InParanoidiQ07490.
KOiK06469.
OMAiQTSVAPF.
OrthoDBiEOG091G1CCU.
PhylomeDBiQ07490.
TreeFamiTF338512.

Miscellaneous databases

PROiQ07490.

Gene expression databases

BgeeiENSRNOG00000000321.
GenevisibleiQ07490. RN.

Family and domain databases

InterProiIPR028029. CD24.
[Graphical view]
PfamiPF14984. CD24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD24_RAT
AccessioniPrimary (citable) accession number: Q07490
Secondary accession number(s): Q0P5T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.