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Protein

Signal transducer CD24

Gene

Cd24

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).By similarity

GO - Molecular functioni

  • carbohydrate binding Source: RGD
  • protein kinase binding Source: UniProtKB
  • protein tyrosine kinase activator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer CD24
Alternative name(s):
Heat-stable antigen
Short name:
HSA
Nectadrin
CD_antigen: CD24
Gene namesi
Name:Cd24
Synonyms:Cd24a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi2298. Cd24.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PeptideiPRO_000002089727 – 56Signal transducer CD24Add BLAST30
PropeptideiPRO_000002089857 – 76Removed in mature formBy similarityAdd BLAST20

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi56GPI-anchor amidated serineSequence analysis1

Post-translational modificationi

Extensively O-glycosylated (By similarity). The carbohydrate structure may be regulated in a tissue-specific and developmental stage-specific manner.By similarity

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ07490.

Expressioni

Tissue specificityi

Expressed in the central nervous system, in postmitotic cells of spinal cord, hindbrain, midbrain and forebrain. Expressed in epithelium during the development of non-neural tissues. Expressed in tooth development, specifically in mesenchymal cells differentiating into odontoblast in dental papilla, as well as in the developing eye and hair follicle.

Developmental stagei

Detected in primitive ectoderm, mesoderm and ventral endoderm; down-regulated when organogenesis is completed.

Gene expression databases

BgeeiENSRNOG00000000321.
GenevisibleiQ07490. RN.

Interactioni

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000352.

Family & Domainsi

Sequence similaritiesi

Belongs to the CD24 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JF9E. Eukaryota.
ENOG4111B8V. LUCA.
GeneTreeiENSGT00390000018829.
HOGENOMiHOG000111484.
HOVERGENiHBG005274.
InParanoidiQ07490.
KOiK06469.
OMAiQTSVAPF.
OrthoDBiEOG091G1CCU.
PhylomeDBiQ07490.
TreeFamiTF338512.

Family and domain databases

InterProiView protein in InterPro
IPR028029. CD24.
PANTHERiPTHR16676. PTHR16676. 1 hit.
PfamiView protein in Pfam
PF14984. CD24. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRAMVVRLG LGLLLLALLL PTQIYCNQTS VAPFSGNQSI SAAPNPTNAT
60 70
TRSGCSSLQS TAGLLALSLS LLHLYC
Length:76
Mass (Da):7,862
Last modified:November 1, 1995 - v1
Checksum:i42846E70EC39D958
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11663 mRNA. Translation: CAA77731.1.
U49062 mRNA. Translation: AAA91470.1.
BC064439 mRNA. Translation: AAH64439.1.
BC081851 mRNA. Translation: AAH81851.1.
PIRiI53107.
RefSeqiNP_036884.1. NM_012752.3.
UniGeneiRn.6007.

Genome annotation databases

EnsembliENSRNOT00000000352; ENSRNOP00000000352; ENSRNOG00000000321.
GeneIDi25145.
KEGGirno:25145.
UCSCiRGD:2298. rat.

Similar proteinsi

Entry informationi

Entry nameiCD24_RAT
AccessioniPrimary (citable) accession number: Q07490
Secondary accession number(s): Q0P5T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 22, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families