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Protein

Neuronal regeneration-related protein

Gene

Nrep

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May have roles in cellular differentiation. Ectopic expression induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis. May also have neural functions. Promotes axonal regeneration and augments motility of gliomas. Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play a role in the regulation of alveolar generation.4 Publications

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal regeneration-related protein
Alternative name(s):
Neuronal protein 3.1
Protein p311
Gene namesi
Name:Nrep
Synonyms:D0H4S114, P311
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:99444. Nrep.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Normal heat and mechanical sensitivity, as well as normal formalin-induced inflammatory pain. Reduced formalin-induced avoidance behavior, which reflects pain-related negative emotion, indicating a role in the affective, but not in the sensory component of the pain. Also exhibits altered behavioral responses in learning and memory.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6868Neuronal regeneration-related proteinPRO_0000057938Add
BLAST

Post-translational modificationi

Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ07475.
PRIDEiQ07475.

PTM databases

PhosphoSiteiQ07475.

Expressioni

Tissue specificityi

Expressed in brain and fetal lung.2 Publications

Developmental stagei

Expressed mainly in neurons belonging to a late migration wave. During adulthood, it persists at a high level in the granular layer of the cerebellum, the hippocampus and the olfactory bulb. In lung, detected at low levels at the pseudoglandular stage (E14.5), with expression starting to increase at the beginning of distal lung development (E16.5) and remaining at the same level during saccular development (E18.5). The expression levels are highest at the beginning of and during alveolar development (P5-P14) before decreasing again to low levels at the end of alveolization (P30).2 Publications

Inductioni

Down-regulated in lungs by dexamethasone treatment.1 Publication

Gene expression databases

BgeeiQ07475.
CleanExiMM_D0H4S114.
ExpressionAtlasiQ07475. baseline and differential.
GenevisibleiQ07475. MM.

Interactioni

Subunit structurei

Interacts with FLNA (By similarity). Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a decrease in TGFB autoinduction.By similarity1 Publication

Protein-protein interaction databases

BioGridi205307. 2 interactions.
STRINGi10090.ENSMUSP00000058132.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J38C. Eukaryota.
ENOG4111AXH. LUCA.
HOGENOMiHOG000237339.
HOVERGENiHBG052654.
InParanoidiQ07475.
OMAiYPELLVW.
OrthoDBiEOG7CCBTZ.
PhylomeDBiQ07475.
TreeFamiTF336368.

Family and domain databases

InterProiIPR024417. Neuronal_3.1.
[Graphical view]
PANTHERiPTHR17102. PTHR17102. 1 hit.
PfamiPF11092. Alveol-reg_P311. 1 hit.
[Graphical view]
ProDomiPD019364. PD019364. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q07475-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYYPELLVW VSQEPFAYKE MEGGLIKGRL PVPKEVNRKK MEETGAASLT
60
PPGSREFTSP ATSYLHPF
Length:68
Mass (Da):7,688
Last modified:November 1, 1995 - v1
Checksum:iFAC111CFE0AEFEAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70398 mRNA. Translation: CAA49848.1.
AK020629 mRNA. Translation: BAB32157.1.
BC054762 mRNA. Translation: AAH54762.1.
CCDSiCCDS37756.1.
PIRiS29993.
RefSeqiNP_001103458.1. NM_001109988.1.
NP_001103459.1. NM_001109989.2.
NP_001254646.1. NM_001267717.1.
NP_444308.1. NM_053078.4.
UniGeneiMm.407415.

Genome annotation databases

EnsembliENSMUST00000051087; ENSMUSP00000058132; ENSMUSG00000042834.
ENSMUST00000168890; ENSMUSP00000130297; ENSMUSG00000042834.
ENSMUST00000171533; ENSMUSP00000127787; ENSMUSG00000042834.
GeneIDi27528.
KEGGimmu:27528.
UCSCiuc008ejt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70398 mRNA. Translation: CAA49848.1.
AK020629 mRNA. Translation: BAB32157.1.
BC054762 mRNA. Translation: AAH54762.1.
CCDSiCCDS37756.1.
PIRiS29993.
RefSeqiNP_001103458.1. NM_001109988.1.
NP_001103459.1. NM_001109989.2.
NP_001254646.1. NM_001267717.1.
NP_444308.1. NM_053078.4.
UniGeneiMm.407415.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205307. 2 interactions.
STRINGi10090.ENSMUSP00000058132.

PTM databases

PhosphoSiteiQ07475.

Proteomic databases

PaxDbiQ07475.
PRIDEiQ07475.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051087; ENSMUSP00000058132; ENSMUSG00000042834.
ENSMUST00000168890; ENSMUSP00000130297; ENSMUSG00000042834.
ENSMUST00000171533; ENSMUSP00000127787; ENSMUSG00000042834.
GeneIDi27528.
KEGGimmu:27528.
UCSCiuc008ejt.2. mouse.

Organism-specific databases

CTDi9315.
MGIiMGI:99444. Nrep.

Phylogenomic databases

eggNOGiENOG410J38C. Eukaryota.
ENOG4111AXH. LUCA.
HOGENOMiHOG000237339.
HOVERGENiHBG052654.
InParanoidiQ07475.
OMAiYPELLVW.
OrthoDBiEOG7CCBTZ.
PhylomeDBiQ07475.
TreeFamiTF336368.

Miscellaneous databases

PROiQ07475.
SOURCEiSearch...

Gene expression databases

BgeeiQ07475.
CleanExiMM_D0H4S114.
ExpressionAtlasiQ07475. baseline and differential.
GenevisibleiQ07475. MM.

Family and domain databases

InterProiIPR024417. Neuronal_3.1.
[Graphical view]
PANTHERiPTHR17102. PTHR17102. 1 hit.
PfamiPF11092. Alveol-reg_P311. 1 hit.
[Graphical view]
ProDomiPD019364. PD019364. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An abundant mRNA of the embryonic brain persists at a high level in cerebellum, hippocampus and olfactory bulb during adulthood."
    Studler J.-M., Glowinski J., Levi-Strauss M.
    Eur. J. Neurosci. 5:614-623(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Urinary bladder.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  4. "P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype."
    Pan D., Zhe X., Jakkaraju S., Taylor G.A., Schuger L.
    J. Clin. Invest. 110:1349-1358(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2."
    Paliwal S., Shi J., Dhru U., Zhou Y., Schuger L.
    Biochem. Biophys. Res. Commun. 315:1104-1109(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TGFB1 AND TGFB2.
  6. "Identification of P311 as a potential gene regulating alveolar generation."
    Zhao L., Leung J.K., Yamamoto H., Goswami S., Kheradmand F., Vu T.H.
    Am. J. Respir. Cell Mol. Biol. 35:48-54(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
  7. "P311-induced myofibroblasts exhibit ameboid-like migration through RalA activation."
    Shi J., Badri K.R., Choudhury R., Schuger L.
    Exp. Cell Res. 312:3432-3442(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. Cited for: DISRUPTION PHENOTYPE.
  9. "P311 functions in an alternative pathway of lipid accumulation that is induced by retinoic acid."
    Leung J.K., Cases S., Vu T.H.
    J. Cell Sci. 121:2751-2758(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Involvement of P311 in the affective, but not in the sensory component of pain."
    Sun Y.-G., Gao Y.-J., Zhao Z.-Q., Huang B., Yin J., Taylor G.A., Chen Z.-F.
    Mol. Pain 4:23-23(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiNREP_MOUSE
AccessioniPrimary (citable) accession number: Q07475
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.