ID   S3AD_ENTFA              Reviewed;         255 AA.
AC   Q07448;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   16-JUN-2009, entry version 35.
DE   RecName: Full=Streptomycin 3''-adenylyltransferase;
DE            EC=2.7.7.47;
DE   AltName: Full=AAD(9);
GN   Name=spc; Synonyms=aad9;
OS   Enterococcus faecalis (Streptococcus faecalis).
OG   Plasmid pDL55.
OC   Bacteria; Firmicutes; Lactobacillales; Enterococcaceae; Enterococcus.
OX   NCBI_TaxID=1351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LDR55;
RX   MEDLINE=92060938; PubMed=1659306;
RA   Leblanc D.J., Lee L.N., Inamine J.M.;
RT   "Cloning and nucleotide base sequence analysis of a spectinomycin
RT   adenyltransferase AAD(9) determinant from Enterococcus faecalis.";
RL   Antimicrob. Agents Chemother. 35:1804-1810(1991).
CC   -!- FUNCTION: Mediates bacterial resistance to the antibiotics
CC       streptomycin and spectomycin.
CC   -!- CATALYTIC ACTIVITY: ATP + streptomycin = diphosphate + 3''-
CC       adenylylstreptomycin.
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DR   EMBL; M69221; AAA16527.1; -; Unassigned_DNA.
DR   PIR; A61153; A61153.
DR   BRENDA; 2.7.7.47; 704.
DR   GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase acti...; IEA:EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR002934; Nucleotidyltransferase.
DR   Pfam; PF01909; NTP_transf_2; 1.
PE   4: Predicted;
KW   Antibiotic resistance; ATP-binding; Nucleotide-binding;
KW   Nucleotidyltransferase; Plasmid; Transferase.
FT   CHAIN         1    255       Streptomycin 3''-adenylyltransferase.
FT                                /FTId=PRO_0000068582.
SQ   SEQUENCE   255 AA;  29821 MW;  367505B0CA0E68B4 CRC64;
     MRRIYLNTYE QINKVKKILR KHLKNNLIGT YMFGSGVESG LKPNSDLDFL VVVSEPLTDQ
     SKEILIQKIR PISKKIGDKS NLRYIELTII IQQEMVPWNH PPKQEFIYGE WLQELYEQGY
     IPQKELNSDL TIMLYQAKRK NKRIYGNYDL EELLPDIPFS DVRRAIMDSS EELIDNYQDD
     ETNSILTLCR MILTMDTGKI IPKDIAGNAV AESSPLEHRE RILLAVRSYL GENIEWTNEN
     VNLTINYLNN RLKKL
//